Gene Page:TNF

概括?
GeneID 7124
Symbol TNF
Synonyms DIF|TNF-alpha|TNFA|TNFSF2|TNLG1F
Description tumor necrosis factor
Reference MIM:191160|HGNC:HGNC:11892|Ensembl:ENSG00000232810|HPRD：01855|Vega:OTTHUMG00000031194
Gene type protein-coding
Map location 6p21.3
Pascal p-value 9.517E-9

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008），协会研究 2 Link to SZGene
GSMA_I Genome scan meta-analysis PSR：0.033
文学 High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

第一节遗传学和表观遗传学注释


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NUDT18 0.90 0.85
ACOT8 0.89 0.92
MECR 0.89 0.91
PGP 0.89 0.90
ALKBH6 0.89 0.88
TMEM111 0.88 0.91
DHRS7B 0.88 0.90
KLHDC3 0.87 0.88
SH3GLB2 0.87 0.87
FDX1L 0.87 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
THOC2 -0.53 -0.51
EIF5B -0.52 -0.62
UPF3A -0.51 -0.55
MAP4K4 -0.51 -0.47
UPF3B -0.50 -0.52
AC005035.1 -0.50 -0.47
AC005921.3 -0.49 -0.72
ZNF326 -0.49 -0.47
RBMX2 -0.49 -0.55
KIAA1949 -0.48 -0.37

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005125 cytokine activity IEA -
GO:0005164 肿瘤坏死因子受体结合 IEA -
GO:0042802 identical protein binding IDA 14512626
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0032800 receptor biosynthetic process IDA Neurotransmitter (GO term level: 5) 10443688
GO:0000060 protein import into nucleus, translocation IDA 16280327
GO：0000122 negative regulation of transcription from RNA polymerase II promoter IEA -
GO:0000187 activation of MAPK activity IDA 10748004
GO:0002740 negative regulation of cytokine secretion during immune response IDA 10443688
去：0002439 chronic inflammatory response to antigenic stimulus 小鬼 14512626
GO:0001934 positive regulation of protein amino acid phosphorylation IDA 10748004
GO:0008625 induction of apoptosis via death domain receptors IEA -
GO:0006006 glucose metabolic process IEA -
GO:0009887 organ morphogenesis IEA -
去：0006927 transformed cell apoptosis IDA 3883195
GO:0009615 response to virus IDA 10490959
GO:0006959 体液免疫反应 IEA -
GO:0006954 inflammatory response IDA 10748004
去：0006919 caspase activation IDA 14512626
去：0006916 anti-apoptosis IDA 10748004
GO:0007275 multicellular organismal development IEA -
GO:0042346 positive regulation of NF-kappaB import into nucleus IDA 17922812
GO:0016481 negative regulation of transcription IDA 16895791
GO:0033209 tumor necrosis factor-mediated signaling pathway 小鬼 10748004
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 16280327
GO:0051023 regulation of immunoglobulin secretion IEA -
GO:0042127 regulation of cell proliferation IEA -
GO:0050901 leukocyte tethering or rolling IDA 10820279
GO:0043193 positive regulation of gene-specific transcription IDA 14512626
GO:0042742 对细菌的防御反应 IEA -
GO:0032722 趋化因子的阳性调节 IDA 10490959
GO:0032715 negative regulation of interleukin-6 production IDA 10443688
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEA -
GO:0045941 positive regulation of transcription IEA -
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA -
GO:0050715 positive regulation of cytokine secretion IDA 10443688
GO:0045080 positive regulation of chemokine biosynthetic process IDA 10490959
GO:0045071 negative regulation of viral genome replication IDA 10490959
GO:0045670 regulation of osteoclast differentiation IEA -
GO:0045994 积极的监管translational initiation by iron IEA -
GO：0046325 negative regulation of glucose import IEA -
去：0046330 positive regulation of JNK cascade IEA -
GO:0048661 positive regulation of smooth muscle cell proliferation IDA 16518841
GO:0045429 一氧化氮生物合成过程的阳性调节 IDA 8383325
GO:0050796 regulation of insulin secretion IDA 8383325
GO:0051384 response to glucocorticoid stimulus IDA 10443688
GO:0051798 毛囊发育的积极调节 IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO：0055037 recycling endosome ISS -
GO:0001891 phagocytic cup ISS -
GO:0005576 extracellular region IEA -
GO:0005615 extracellular space IEA -
GO:0016021 integral to membrane IEA -
GO:0009897 质膜的外侧 ISS -
GO:0005886 plasma membrane EXP 2848815|7758105|12887920
GO:0005886 plasma membrane IEA -

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 资源 PubMed ID
BGN DSPG1 | PG-S1 | PGI | SLRR1A biglycan - HPRD,BioGRID 12387878
CSF1 MCSF | MGC31930 colony stimulating factor 1 (macrophage) - HPRD,BioGRID 8336080
DCN CSCD | DSPG2 | PG40 | PGII | PGS2 | SLRR1B decorin - HPRD,BioGRID 12387878
KHSRP FBP2 | FUBP2 | KSRP | MGC99676 KH-type splicing regulatory protein KSRP interacts with AREtnf. This interaction was modeled on a demonstrated interaction between KSRP from human and AREtnf from an unspecified species. BIND 15175153
POU2F1 OCT1 | OTF1 POU class 2 homeobox 1 Reconstituted Complex BioGRID 12019209
PRTN3 ACPA | AGP7 | C-ANCA | MBT | P29 | PR-3 proteinase 3 - HPRD,BioGRID 10339575
RALBP1 RIP1 | RLIP1 | RLIP76 ralA binding protein 1 Affinity Capture-Western BioGRID 12887920
TNF DIF | TNF-alpha | TNFA | TNFSF2 tumor necrosis factor (TNF superfamily, member 2) Interaction between TNF (PDB ID: 1A8M_C) and TNF (PDB ID: 1A8M_B). BIND 8869635|9488135
TNF DIF | TNF-alpha | TNFA | TNFSF2 tumor necrosis factor (TNF superfamily, member 2) Interaction between TNF (PDB ID: 1A8M_C) and TNF (PDB ID: 1A8M_A). BIND 8869635|9488135
TNF DIF | TNF-alpha | TNFA | TNFSF2 tumor necrosis factor (TNF superfamily, member 2) Interaction between TNF (PDB ID: 1A8M_B) and TNF (PDB ID: 1A8M_A). BIND 8869635|9488135
TNF DIF | TNF-alpha | TNFA | TNFSF2 tumor necrosis factor (TNF superfamily, member 2) - HPRD,BioGRID 1331108
TNFRSF1A CD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60 tumor necrosis factor receptor superfamily, member 1A - HPRD 1331108|2158863
TNFRSF1A CD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60 tumor necrosis factor receptor superfamily, member 1A 亲和力捕获ms
Affinity Capture-Western		 BioGRID 12887920|14743216
TNFRSF1A CD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60 tumor necrosis factor receptor superfamily, member 1A TNF-alpha interacts with TNFR1. BIND 7852363
TNFRSF1B CD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFR tumor necrosis factor receptor superfamily, member 1B 亲和力捕获ms BioGRID 14743216
TNFRSF1B CD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFR tumor necrosis factor receptor superfamily, member 1B - HPRD 8590321|9552007
TNFRSF1B CD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFR tumor necrosis factor receptor superfamily, member 1B TNF-alpha interacts with TNFR-2. BIND 7852363
TRADD Hs.89862 | MGC11078 TNFRSF1A-associated via death domain Affinity Capture-Western BioGRID 12887920
TRAF2 MGC:45012 | TRAP | TRAP3 TNF receptor-associated factor 2 Affinity Capture-Western BioGRID 12887920


V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 该途径中的所有SZGR 2.0基因
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 该途径中的所有SZGR 2.0基因
KEGG APOPTOSIS 88 62 该途径中的所有SZGR 2.0基因
KEGG TGF BETA SIGNALING PATHWAY 86 64 该途径中的所有SZGR 2.0基因
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 该途径中的所有SZGR 2.0基因
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 62 47 该途径中的所有SZGR 2.0基因
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 71 51 该途径中的所有SZGR 2.0基因
KEGG HEMATOPOIETIC CELL LINEAGE 88 60 该途径中的所有SZGR 2.0基因
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 该途径中的所有SZGR 2.0基因
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 该途径中的所有SZGR 2.0基因
KEGG FC EPSILON RI SIGNALING PATHWAY 79 58 该途径中的所有SZGR 2.0基因
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 67 57 该途径中的所有SZGR 2.0基因
KEGG TYPE II DIABETES MELLITUS 47 41 该途径中的所有SZGR 2.0基因
KEGG TYPE I DIABETES MELLITUS 44 38 该途径中的所有SZGR 2.0基因
KEGG ALZHEIMERS DISEASE 169 110 该途径中的所有SZGR 2.0基因
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 53 43 该途径中的所有SZGR 2.0基因
Kegg Leishmania感染 72 56 该途径中的所有SZGR 2.0基因
KEGG ASTHMA 30 25 该途径中的所有SZGR 2.0基因
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 140 100 该途径中的所有SZGR 2.0基因
KEGG ALLOGRAFT REJECTION 38 34 该途径中的所有SZGR 2.0基因
KEGG GRAFT VERSUS HOST DISEASE 42 31 该途径中的所有SZGR 2.0基因
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 该途径中的所有SZGR 2.0基因
KEGG DILATED CARDIOMYOPATHY 92 68 该途径中的所有SZGR 2.0基因
BIOCARTARELA PATHWAY 16 12 该途径中的所有SZGR 2.0基因
BIOCARTAGRANULOCYTES PATHWAY 14 9 该途径中的所有SZGR 2.0基因
BIOCARTACDMAC PATHWAY 16 15 该途径中的所有SZGR 2.0基因
BIOCARTALAIR PATHWAY 17 12 该途径中的所有SZGR 2.0基因
BIOCARTATID PATHWAY 19 15 该途径中的所有SZGR 2.0基因
BIOCARTACYTOKINE PATHWAY 22 16 该途径中的所有SZGR 2.0基因
BIOCARTAINFLAM PATHWAY 29 24 该途径中的所有SZGR 2.0基因
Biocarta自由途径 10 7 该途径中的所有SZGR 2.0基因
BIOCARTAHIVNEF PATHWAY 58 43 该途径中的所有SZGR 2.0基因
BIOCARTAIL10 PATHWAY 17 14 该途径中的所有SZGR 2.0基因
BIOCARTAKERATINOCYTE PATHWAY 46 38 该途径中的所有SZGR 2.0基因
BIOCARTAPPARA PATHWAY 58 43 该途径中的所有SZGR 2.0基因
BIOCARTANTHI PATHWAY 24 20 该途径中的所有SZGR 2.0基因
BIOCARTANFKB PATHWAY 23 19 该途径中的所有SZGR 2.0基因
BIOCARTAPML PATHWAY 17 12 该途径中的所有SZGR 2.0基因
Biocarta IL1R途径 33 29 该途径中的所有SZGR 2.0基因
BIOCARTASODD PATHWAY 10 7 该途径中的所有SZGR 2.0基因
BIOCARTAHSP27 PATHWAY 15 11 该途径中的所有SZGR 2.0基因
BIOCARTA应力路径 25 18 该途径中的所有SZGR 2.0基因
BIOCARTATNFR1 PATHWAY 29 21 该途径中的所有SZGR 2.0基因
ST TUMOR NECROSIS FACTOR PATHWAY 29 20 该途径中的所有SZGR 2.0基因
SA MMP CYTOKINE CONNECTION 15 9 该途径中的所有SZGR 2.0基因
PID IL27 PATHWAY 26 20 该途径中的所有SZGR 2.0基因
PID NFKAPPAB规范途径 23 20 该途径中的所有SZGR 2.0基因
PID NFAT TFPATHWAY 47 39 该途径中的所有SZGR 2.0基因
PID ANGIOPOIETIN RECEPTOR PATHWAY 50 41 该途径中的所有SZGR 2.0基因
PID HDAC CLASSI PATHWAY 66 50 该途径中的所有SZGR 2.0基因
PID TNF途径 46 33 该途径中的所有SZGR 2.0基因
PID CERAMIDE PATHWAY 48 37 该途径中的所有SZGR 2.0基因
PID AMB2 NEUTROPHILS PATHWAY 41 32 该途径中的所有SZGR 2.0基因
PID RXR VDR PATHWAY 26 24 该途径中的所有SZGR 2.0基因
PID IL23 PATHWAY 37 30 该途径中的所有SZGR 2.0基因
PID HIV NEF途径 35 26 该途径中的所有SZGR 2.0基因
PID CASPASE PATHWAY 52 39 该途径中的所有SZGR 2.0基因
PID ANTHRAX PATHWAY 17 15 该途径中的所有SZGR 2.0基因
PID CD8 TCR DOWNSTREAM PATHWAY 65 56 该途径中的所有SZGR 2.0基因
REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS 13 8 该途径中的所有SZGR 2.0基因
REACTOME DEVELOPMENTAL BIOLOGY 396 292 该途径中的所有SZGR 2.0基因
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 72 53 该途径中的所有SZGR 2.0基因
反应组凋亡 148 94 该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 该途径中的所有SZGR 2.0基因
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 该途径中的所有SZGR 2.0基因
周炎性反应lps up 431 237 该途径中的所有SZGR 2.0基因
NUNODA RESPONSE TO DASATINIB IMATINIB DN 13 10 该途径中的所有SZGR 2.0基因
MARKS HDAC TARGETS DN 15 11 该途径中的所有SZGR 2.0基因
DUTTA APOPTOSIS VIA NFKB 33 25 该途径中的所有SZGR 2.0基因
DEBOSSCHER NFKB TARGETS REPRESSED BY GLUCOCORTICOIDS 24 18 该途径中的所有SZGR 2.0基因
DIRMEIER LMP1 RESPONSE EARLY 66 48 该途径中的所有SZGR 2.0基因
Amundson遗传毒性签名 105 68 该途径中的所有SZGR 2.0基因
HOWLIN PUBERTAL MAMMARY GLAND 69 40 该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK 1652 1023 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
GOUYER TATI TARGETS UP 10 7 该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS DN 357 212 该途径中的所有SZGR 2.0基因
SHIN B CELL LYMPHOMA CLUSTER 5 18 11 该途径中的所有SZGR 2.0基因
BROWN MYELOID CELL DEVELOPMENT UP 165 100 该途径中的所有SZGR 2.0基因
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 85 67 该途径中的所有SZGR 2.0基因
NEMETH INFLAMMATORY RESPONSE LPS UP 88 64 该途径中的所有SZGR 2.0基因
LENAOUR DENDRITIC CELL MATURATION DN 128 90 该途径中的所有SZGR 2.0基因
THEILGAARD NEUTROPHIL AT SKIN WOUND UP 77 52 该途径中的所有SZGR 2.0基因
NPM1的Verhaak AML突变 183 111 该途径中的所有SZGR 2.0基因
Taci的Moreaux多发性骨髓瘤 412 249 该途径中的所有SZGR 2.0基因
HADDAD T LYMPHOCYTE AND NK PROGENITOR DN 63 41 该途径中的所有SZGR 2.0基因
Basso CD40信号向上 101 76 该途径中的所有SZGR 2.0基因
在胰腺癌中被甲基化沉默的Sato 2 50 34 该途径中的所有SZGR 2.0基因
DAZARD RESPONSE TO UV SCC UP 123 75 该途径中的所有SZGR 2.0基因
在胰腺癌中被甲基化沉默的Sato 1 419 273 该途径中的所有SZGR 2.0基因
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 该途径中的所有SZGR 2.0基因
GAURNIER PSMD4 TARGETS 73 55 该途径中的所有SZGR 2.0基因
QI PLASMACYTOMA UP 259 185 该途径中的所有SZGR 2.0基因
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 该途径中的所有SZGR 2.0基因
RAY ALZHEIMERS DISEASE 13 7 该途径中的所有SZGR 2.0基因
LINDSTEDT DENDRITIC CELL MATURATION A 67 52 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
VANTVEER BREAST CANCER ESR1 DN 240 153 该途径中的所有SZGR 2.0基因
HINATA NFKB TARGETS KERATINOCYTE UP 91 63 该途径中的所有SZGR 2.0基因
CHEN METABOLIC SYNDROM NETWORK 1210 725 该途径中的所有SZGR 2.0基因
Zhan早期分化基因dn 42 29 该途径中的所有SZGR 2.0基因
BUDHU LIVER CANCER METASTASIS DN 7 7 该途径中的所有SZGR 2.0基因
MIKKELSEN MCV6 ICP WITH H3K27ME3 74 46 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF ICP WITH H3K27ME3 206 108 该途径中的所有SZGR 2.0基因
MIKKELSEN IPS ICP WITH H3K27ME3 54 32 该途径中的所有SZGR 2.0基因
SEIKE LUNG CANCER POOR SURVIVAL 11 8 该途径中的所有SZGR 2.0基因
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 44 30 该途径中的所有SZGR 2.0基因
DANG BOUND BY MYC 1103 714 该途径中的所有SZGR 2.0基因
Mikkelsen ES ICP与H3K27me3 42 27 该途径中的所有SZGR 2.0基因
LI INDUCED T TO NATURAL KILLER UP 307 182 该途径中的所有SZGR 2.0基因
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 88 59 该途径中的所有SZGR 2.0基因
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 该途径中的所有SZGR 2.0基因
WINZEN DEGRADED VIA KHSRP 100 70 该途径中的所有SZGR 2.0基因
YANG BCL3 TARGETS UP 364 236 该途径中的所有SZGR 2.0基因
LIM MAMMARY STEM CELL DN 428 246 该途径中的所有SZGR 2.0基因
SMIRNOV RESPONSE TO IR 6HR DN 114 69 该途径中的所有SZGR 2.0基因
NABA SECRETED FACTORS 344 197 该途径中的所有SZGR 2.0基因
NABA MATRISOME ASSOCIATED 753 411 该途径中的所有SZGR 2.0基因
NABA MATRISOME 1028 559 该途径中的所有SZGR 2.0基因