Gene Page:TNNI3
Summary?
| GeneID | 7137 |
| Symbol | TNNI3 |
| Synonyms | CMD1FF|CMD2A|CMH7|RCM1|TNNC1|cTnI |
| Description | troponin I3, cardiac type |
| Reference | MIM:191044|HGNC:HGNC:11947|Ensembl:ENSG00000129991|HPRD:11769|Vega:OTTHUMG00000180589 |
| Gene type | protein-coding |
| Map location | 19q13.4 |
| Pascal p-value | 0.009 |
| eGene | 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003779 | actin binding | IDA | 10806205 | |
| GO:0048306 | calcium-dependent protein binding | 新闻学会 | 7957210 | |
| GO:0019855 | calcium channel inhibitor activity | 新闻学会 | 12809519 | |
| GO:0030172 | troponin C binding | 新闻学会 | 7957210|11735257|15542288 |
|
| GO:0019904 | protein domain specific binding | 新闻学会 | 11984006 | |
| GO:0031014 | troponin T binding | 新闻学会 | 15542288 | |
| GO:0019901 | protein kinase binding | 新闻学会 | 12721663 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions | ISS | Brain (GO term level: 9) | - |
| GO:0001570 | vasculogenesis | ISS | - | |
| GO:0055010 | ventricular cardiac muscle morphogenesis | IMP | 11815426 | |
| GO:0007507 | heart development | ISS | - | |
| GO:0006937 | regulation of muscle contraction | IEA | - | |
| GO:0006874 | cellular calcium ion homeostasis | ISS | - | |
| GO:0032780 | negative regulation of ATPase activity | IDA | 7957210|11735257 | |
| GO:0032780 | negative regulation of ATPase activity | IMP | 10806205 | |
| GO:0060048 | cardiac muscle contraction | IMP | 11735257 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005861 | troponin complex | IDA | 7957210|10806205|10850966 |12093807 |
|
| GO:0030017 | sarcomere | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CARDIAC MUSCLE CONTRACTION | 80 | 51 | All SZGR 2.0 genes in this pathway |
| KEGG HYPERTROPHIC CARDIOMYOPATHY HCM | 85 | 65 | All SZGR 2.0 genes in this pathway |
| KEGG DILATED CARDIOMYOPATHY | 92 | 68 | All SZGR 2.0 genes in this pathway |
| REACTOME STRIATED MUSCLE CONTRACTION | 27 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME MUSCLE CONTRACTION | 48 | 24 | All SZGR 2.0 genes in this pathway |
| PIEPOLI LGI1 TARGETS DN | 14 | 6 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL DN | 186 | 107 | All SZGR 2.0 genes in this pathway |
| RASHI RESPONSE TO IONIZING RADIATION 3 | 48 | 31 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| AFFAR YY1 TARGETS DN | 234 | 137 | All SZGR 2.0 genes in this pathway |
| ZHU CMV 24 HR DN | 91 | 64 | All SZGR 2.0 genes in this pathway |
| KAAB HEART ATRIUM VS VENTRICLE DN | 261 | 183 | All SZGR 2.0 genes in this pathway |
| ZHU CMV ALL DN | 128 | 93 | All SZGR 2.0 genes in this pathway |
| ZAMORA NOS2 TARGETS DN | 96 | 71 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER LUMINAL B UP | 172 | 109 | All SZGR 2.0 genes in this pathway |
| MUELLER PLURINET | 299 | 189 | All SZGR 2.0 genes in this pathway |
| VART KSHV INFECTION ANGIOGENIC MARKERS UP | 165 | 118 | All SZGR 2.0 genes in this pathway |
| MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS DN | 435 | 289 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS HCP WITH H3 UNMETHYLATED | 80 | 50 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP | 271 | 165 | All SZGR 2.0 genes in this pathway |