Gene Page:TNNT1

Summary?
GeneID 7138
Symbol TNNT1
Synonyms ANM|NEM5|STNT|TNT|TNTS
Description troponin T1, slow skeletal type
Reference MIM:191041|HGNC:HGNC:11948|运用:ENSG00000105048|HPRD:01841|Vega:OTTHUMG00000180542
Gene type protein-coding
Map location 19q13.4
Pascal p-value 0.009
Sherlock p-value 0.893
Fetal beta -2.257
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed的共病的基因with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg19393762 19 55661872 TNNT1 3.61E-6 -0.446 0.009 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7258577 chr19 55186254 TNNT1 7138 0.16 cis
rs17714747 chr2 205010190 TNNT1 7138 0.15 trans
rs9313483 chr5 169448229 TNNT1 7138 0.05 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PRPF39 0.87 0.89
PEX1 0.87 0.88
CCDC82 0.86 0.84
WDR75 0.86 0.86
SLC35A1 0.85 0.84
TUBE1 0.85 0.82
SMC6 0.85 0.85
MFN1 0.84 0.84
ZNF187 0.84 0.86
UTP6 0.84 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.65 -0.74
AF347015.31 -0.65 -0.75
AF347015.27 -0.64 -0.72
MT-CYB -0.63 -0.73
AF347015.8 -0.63 -0.74
HLA-F -0.62 -0.66
AF347015.33 -0.62 -0.71
AF347015.15 -0.61 -0.73
IFI27 -0.61 -0.73
AF347015.2 -0.60 -0.74

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CCDC85B DIPA coiled-coil domain containing 85B Two-hybrid BioGRID 16189514
FXR2 FMR1L2 fragile X mental retardation, autosomal homolog 2 Two-hybrid BioGRID 16189514
PLEKHF1 APPD | MGC4090 | PHAFIN1 | ZFYVE15 pleckstrin homology domain containing, family F (with FYVE domain) member 1 Two-hybrid BioGRID 16189514
PPFIA1 FLJ41337 | FLJ42630 | FLJ43474 | LIP.1 | LIP1 | LIPRIN | MGC26800 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Two-hybrid BioGRID 16189514
PRKG1 CGKI | DKFZp686K042 | FLJ36117 | MGC71944 | PGK | PKG | PRKG1B | PRKGR1B | cGKI-BETA | cGKI-alpha protein kinase, cGMP-dependent, type I Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid		 BioGRID 10601315
PSMC5 S8 | SUG1 | TBP10 | TRIP1 | p45 | p45/SUG proteasome (prosome, macropain) 26S subunit, ATPase, 5 Two-hybrid BioGRID 16189514
RP4-691N24.1 FLJ11792 | KIAA0980 | NLP | dJ691N24.1 ninein-like Two-hybrid BioGRID 16189514
TNNC1 CMD1Z | TNC | TNNC troponin C type 1 (slow) Two-hybrid BioGRID 9448267
TNNI3 CMD2A | CMH7 | MGC116817 | TNNC1 | cTnI troponin I type 3 (cardiac) - HPRD 11904166
TNNT1 ANM | FLJ98147 | MGC104241 | STNT | TNT | TNTS troponin T type 1 (skeletal, slow) Two-hybrid BioGRID 16189514
TPM1 C15orf13 | CMD1Y | HTM-alpha | TMSA tropomyosin 1 (alpha) Reconstituted Complex BioGRID 6822572
ZMYND19 MIZIP | RP11-48C7.4 zinc finger, MYND-type containing 19 Two-hybrid BioGRID 16189514


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME STRIATED MUSCLE CONTRACTION 27 12 All SZGR 2.0 genes in this pathway
REACTOME MUSCLE CONTRACTION 48 24 All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP 112 72 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204 140 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157 104 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 136 94 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186 107 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP 118 66 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 142 93 All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169 112 All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL 89 60 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM UP 38 30 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261 183 All SZGR 2.0 genes in this pathway
KUNINGER IGF1 VS PDGFB TARGETS UP 82 51 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
YEGNASUBRAMANIAN PROSTATE CANCER 128 60 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 118 65 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP 172 109 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 89 56 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 116 74 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
WANG NFKB TARGETS 25 15 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266 142 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS UP 35 16 All SZGR 2.0 genes in this pathway