Gene Page:TPI1

Summary?
GeneID 7167
Symbol TPI1
Synonyms HEL-S-49|TIM|TPI|TPID
Description triosephosphate isomerase 1
Reference MIM:190450|HGNC:HGNC:12009|Ensembl:ENSG00000111669|HPRD:01833|Vega:OTTHUMG00000133767
Gene type protein-coding
Map location 12p13
Pascal p-value 0.448
Sherlock p-value 0.406
Fetal beta -1.091
eGene Anterior cingulate cortex BA24
Support G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Expression Meta-analysis of gene expression Pvalue: 2.052
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs145835685 12 6038541 TPI1 ENSG00000111669.10 1.18286E-6 0.02 -937742 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004807 triose-phosphate isomerase activity EXP 6434534
GO:0004807 triose-phosphate isomerase activity NAS 2876430
GO:0004807 triose-phosphate isomerase activity TAS 2579079
GO:0016853 isomerase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006098 pentose-phosphate shunt IEA -
GO:0006096 glycolysis IEA -
GO:0006094 gluconeogenesis IEA -
GO:0008152 metabolic process IEA -
GO:0006633 fatty acid biosynthetic process IEA -
GO:0019682 glyceraldehyde-3-phosphate metabolic process IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 6434534

部分诉通路注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCOLYSIS GLUCONEOGENESIS 62 41 All SZGR 2.0 genes in this pathway
KEGG FRUCTOSE AND MANNOSE METABOLISM 34 23 All SZGR 2.0 genes in this pathway
KEGG INOSITOL PHOSPHATE METABOLISM 54 42 All SZGR 2.0 genes in this pathway
BIOCARTA FEEDER PATHWAY 9 8 All SZGR 2.0 genes in this pathway
BIOCARTA GLYCOLYSIS PATHWAY 10 9 All SZGR 2.0 genes in this pathway
REACTOME GLYCOLYSIS 29 18 All SZGR 2.0 genes in this pathway
REACTOME GLUCONEOGENESIS 34 21 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247 154 All SZGR 2.0 genes in this pathway
REACTOME GLUCOSE METABOLISM 69 42 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA UP 92 57 All SZGR 2.0 genes in this pathway
KORKOLA EMBRYONAL CARCINOMA UP 41 27 All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR UP 20 14 All SZGR 2.0 genes in this pathway
KORKOLA CHORIOCARCINOMA UP 6 5 All SZGR 2.0 genes in this pathway
KORKOLA SEMINOMA UP 44 27 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 127 78 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244 153 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP 112 68 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
BERENJENO改变了RHOA UP 536 340 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176 111 All SZGR 2.0 genes in this pathway
GROSS HIF1A TARGETS DN 25 15 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP 142 104 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517 309 All SZGR 2.0 genes in this pathway
CHEN LUNG CANCER SURVIVAL 28 22 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
KIM HYPOXIA 25 21 All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL 63 50 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA 50 31 All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS 36 32 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE 77 50 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM 66 47 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 132 93 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6 91 44 All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP 134 84 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN 79 45 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242 168 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE UP 79 40 All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346 192 All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP 212 128 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
YAMANAKA GLIOBLASTOMA SURVIVAL UP 11 7 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
MOOTHA GLUCONEOGENESIS 32 23 All SZGR 2.0 genes in this pathway
MOOTHA GLYCOLYSIS 21 13 All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN 207 139 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN 146 90 All SZGR 2.0 genes in this pathway
WANG ADIPOGENIC GENES REPRESSED BY SIRT1 28 21 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 UP 89 50 All SZGR 2.0 genes in this pathway
FARDIN HYPOXIA 11 32 29 All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 DN 92 60 All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS DN 109 71 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-133 171 177 m8 hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA