Gene Page:C3
Summary？
| 基因 | 718 |
| 象征 | C3 |
| Synonyms | AHUS5 | ARMD9 | ASP | C3A | C3B | CPAMD1 | HEL-S-62P |
| Description | complement component 3 |
| Reference | MIM:120700|HGNC：HGNC：1318|Ensembl:ENSG00000125730|HPRD:00400|Vega:OTTHUMG00000150335 |
| 基因类型 | 蛋白质编码 |
| Map location | 19p13.3-p13.2 |
| Pascal p-value | 0.903 |
| Sherlock p-value | 0.47 |
| 胎儿β | -1.719 |
| 主持人 | Myers' cis & trans |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| Association | A combined odds ratio method (Sun等。2008), association studies | 2 | Link to SZGene |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypal | 点击显示详细信息 |
| go_annotation | 将与神经相关的关键字映射到基因本体论注释 | 与神经相关的关键字的命中：1 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS10014722 | CHR4 | 54588016 | C3 | 718 | 0.2 | 反式 | ||
| RS17319860 | CHR4 | 160647108 | C3 | 718 | 0.08 | 反式 | ||
| rs11216720 | Chr11 | 117909100 | C3 | 718 | 0.2 | 反式 | ||
| RS12223165 | Chr11 | 117910016 | C3 | 718 | 0.2 | 反式 | ||
| rs11216730 | Chr11 | 117918701 | C3 | 718 | 0.06 | 反式 | ||
| RS17076272 | CHR13 | 22726361 | C3 | 718 | 0.11 | 反式 | ||
| RS17076274 | CHR13 | 22726381 | C3 | 718 | 0.11 | 反式 |
第二节。转录组注释
一般基因表达（GTEX）
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
No co-expressed genes in brain regions
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0005102 | receptor binding | TAS | 神经递质（GO期限：4） | 9164946 |
| GO:0004866 | 内肽酶抑制剂活性 | IEA | - | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO:0001798 | IIA型超敏反应的积极调节 | IEA | - | |
| GO:0007186 | G蛋白偶联受体蛋白信号通路 | TAS | 9164946 | |
| GO:0007165 | 信号转导 | TAS | 10085065 | |
| 去：0006957 | complement activation, alternative pathway | 经验 | 162484 | |
| 去：0006957 | complement activation, alternative pathway | IEA | - | |
| 去：0006958 | 补体激活，经典途径 | IEA | - | |
| 去：0006954 | inflammatory response | IEA | - | |
| GO：0050766 | 吞噬作用的阳性调节 | IEA | - | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0005576 | 细胞外区域 | 经验 | 279011|3052276|6912277 |12878586|15199963 |
|
| 去：0005576 | 细胞外区域 | IEA | - |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL |JTK7 |BCR/ABL |c-abl |P150 |V-ABL | C-ABL癌基因1，受体酪氨酸激酶 | - | HPRD | 4062888 |
| C2 | CO2 | DKFZp779M0311 | complement component 2 | - | HPRD,BioGRID | 3546307 |
| C3AR1 | AZ3B | C3AR | HNFAG09 | complement component 3a receptor 1 | - | HPRD,BioGRID | 11342658 |
| C5 | CPAMD4 | FLJ17816 | FLJ17822 | MGC142298 | complement component 5 | - | HPRD,BioGRID | 11367533 |
| CD46 | MCP |MGC26544 |MIC10 |TLX |Tra2.10 | CD46分子，补体调节蛋白 | - | HPRD,BioGRID | 1717583 |
| CFB | BF | BFD | CFAB | FB | FBI12 | GBG | H2-Bf | PBF2 | 补体因子b | - | HPRD,BioGRID | 8648130|10610782 |11367533 |
| CFH | Armd4 |武器1 |CFHL3 |FH |FHL1 |HF |HF1 |HF2 |HUS |MGC88246 | 补体因子h | - | HPRD,BioGRID | 9988761 |
| CFHR3 | CFHL3 |下降16 |FHR-3 |FHR3 |HLF4 | 补体因子H相关3 | - | HPRD,BioGRID | 10622723 |
| CFHR4 | CFHL4 | FHR-4 | FHR4 | RP4-608O15.2 | 补体因子H相关4 | - | HPRD,BioGRID | 10622723 |
| CFHR5 | CFHL5 |FHR-5 |FHR5 |FLJ10549 |MGC133240 | 补体因子H相关5 | - | HPRD,BioGRID | 11058592 |
| CFI | C3B-ina |fi |如果|KAF | 补体因子i | 生化活动 体外 重构的复合物 |
Biogrid | 1401896|8648130 |9291131 |
| CFI | C3B-ina |fi |如果|KAF | 补体因子i | - | HPRD | 1401896|9291131 |
| CFP | BFD |PFC |PFD |适当的 | 补体因子适当的 | 重构的复合物 | Biogrid | 3421908|11513971 |
| CPN1 | CPN |FLJ40792 |SCPN | 羧肽酶N，多肽1 | - | HPRD,BioGRID | 11939578 |
| CR1 | C3BR | CD35 | KN | 补体成分（3b/4b）受体1（诺普斯血组） | - | HPRD | 9988761|10382758 |
| CR1 | C3BR | CD35 | KN | 补体成分（3b/4b）受体1（诺普斯血组） | - | HPRD,BioGRID | 9988761 |
| CR2 | C3DR |CD21 |SLEB9 | complement component (3d/Epstein Barr virus) receptor 2 | - | HPRD | 11684127 |
| CR2 | C3DR |CD21 |SLEB9 | complement component (3d/Epstein Barr virus) receptor 2 | - | HPRD,BioGRID | 1830068|11684127 |
| GC | DBP |DBP/GC |VDBG |VDBP | 组特异性成分（维生素D结合蛋白） | - | HPRD,BioGRID | 2824652 |
| GPR77 | C5L2 |GPF77 | G蛋白偶联受体77 | - | HPRD | 11773063 |
| itgam | CD11B | CR3A | MAC-1 | MAC1A | MGC117044 | MO1A | SLEB6 | integrin, alpha M (complement component 3 receptor 3 subunit) | - | HPRD,BioGRID | 4062888|11073102 |
| itgax | CD11C | SLEB6 | integrin, alpha X (complement component 3 receptor 4 subunit) | - | HPRD | 7512600 |
| itgax | CD11C | SLEB6 | integrin, alpha X (complement component 3 receptor 4 subunit) | 重构的复合物 | Biogrid | 4062888 |
| LRP1 | A2MR |apoer |APR |CD91 |FLJ16451 |IGFBP3R |LRP |MGC88725 |TGFBR5 | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | - | HPRD | 10608878 |
| MASP1 | CRARF | CRARF1 | DKFZp686I01199 | FLJ26383 | MASP | MGC126283 | MGC126284 | PRSS5 | RaRF | Mannan结合凝集素丝氨酸肽酶1（RA反应因子的C4/C2激活成分） | - | HPRD | 9719152 |
| OLFM4 | GC1 |GW112 |KIAA4294 |OLM4 |OLFD |UNQ362 |BA209J19.1 |HGC-1 |霍尔夫 | olfactomedin 4 | - | HPRD,BioGRID | 2824652 |
| 帕帕 | asbabp2 |Dipla1 |IGFBP-4ase |爸爸|PAPP-A |Pappa1 | 妊娠相关血浆蛋白A，Pappalysin 1 | - | HPRD,BioGRID | 6203109 |
Section V. Pathway annotation
| 路径名 | 路径大小 | # SZGR 2.0 genes in pathway | 信息 |
|---|---|---|---|
| KEGG补充凝血级联 | 69 | 49 | All SZGR 2.0 genes in this pathway |
| KEGG LEISHMANIA INFECTION | 72 | 56 | All SZGR 2.0 genes in this pathway |
| kegg系统性狼疮红斑 | 140 | 100 | All SZGR 2.0 genes in this pathway |
| Biocarta Lair Pathway | 17 | 12 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CLASSIC PATHWAY | 14 | 11 | All SZGR 2.0 genes in this pathway |
| Biocarta Comp Pathway | 19 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA LECTIN PATHWAY | 12 | 10 | All SZGR 2.0 genes in this pathway |
| PID ERB基因组途径 | 15 | 8 | All SZGR 2.0 genes in this pathway |
| PID Integin2途径 | 29 | 18 | All SZGR 2.0 genes in this pathway |
| PID ERA GENOMIC PATHWAY | 65 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | 70 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF COMPLEMENT CASCADE | 14 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | 188 | 108 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA I SIGNALLING EVENTS | 195 | 114 | All SZGR 2.0 genes in this pathway |
| Reactome GPCR配体结合 | 408 | 246 | All SZGR 2.0 genes in this pathway |
| Reactome先天免疫系统 | 279 | 178 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME COMPLEMENT CASCADE | 32 | 22 | All SZGR 2.0 genes in this pathway |
| Reactome适应性免疫系统 | 539 | 350 | All SZGR 2.0 genes in this pathway |
| REACTOME INITIAL TRIGGERING OF COMPLEMENT | 16 | 10 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR MARKERS DN | 20 | 14 | All SZGR 2.0 genes in this pathway |
| 中村肿瘤区周围与中央DN | 634 | 384 | All SZGR 2.0 genes in this pathway |
| PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP | 205 | 140 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | All SZGR 2.0 genes in this pathway |
| Senese HDAC1靶向 | 457 | 269 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 AND HDAC2 TARGETS UP | 238 | 144 | All SZGR 2.0 genes in this pathway |
| WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 DN | 67 | 43 | All SZGR 2.0 genes in this pathway |
| 甲状腺癌 | 443 | 294 | All SZGR 2.0 genes in this pathway |
| Chiaradonna肿瘤转化KRAS CDC25 DN | 51 | 35 | All SZGR 2.0 genes in this pathway |
| CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP | 120 | 73 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP | 211 | 136 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS G UP | 238 | 135 | All SZGR 2.0 genes in this pathway |
| 悍马皮肤癌进度DN | 100 | 64 | All SZGR 2.0 genes in this pathway |
| Dauer Stat3靶向 | 49 | 35 | All SZGR 2.0 genes in this pathway |
| TSUNODA CISPLATIN RESISTANCE DN | 51 | 38 | All SZGR 2.0 genes in this pathway |
| Wood EBV EBNA1靶向 | 110 | 71 | All SZGR 2.0 genes in this pathway |
| WATTEL AUTONOMOUS THYROID ADENOMA DN | 55 | 29 | All SZGR 2.0 genes in this pathway |
| 通过ELK3 DN的缺氧总缺氧 | 156 | 106 | All SZGR 2.0 genes in this pathway |
| GROSS HIF1A TARGETS UP | 8 | 5 | All SZGR 2.0 genes in this pathway |
| INGRAM SHH TARGETS DN | 64 | 41 | All SZGR 2.0 genes in this pathway |
| MANTOVANI NFKB TARGETS UP | 43 | 33 | All SZGR 2.0 genes in this pathway |
| MANTOVANI VIRAL GPCR SIGNALING UP | 86 | 54 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 2 DN | 464 | 276 | All SZGR 2.0 genes in this pathway |
| 通过CTNNB1发出的CDH1信号传导 | 83 | 58 | All SZGR 2.0 genes in this pathway |
| Shepard BMYB Morpholino DN | 200 | 112 | All SZGR 2.0 genes in this pathway |
| 宁慢性阻塞性肺疾病DN | 121 | 79 | All SZGR 2.0 genes in this pathway |
| 棕色髓样细胞的发育 | 165 | 100 | All SZGR 2.0 genes in this pathway |
| HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
| Lenaour树突状细胞成熟DN | 128 | 90 | All SZGR 2.0 genes in this pathway |
| GERY CEBP TARGETS | 126 | 90 | All SZGR 2.0 genes in this pathway |
| KANG IMMORTALIZED BY TERT UP | 89 | 61 | All SZGR 2.0 genes in this pathway |
| Iglesias E2F目标 | 151 | 103 | All SZGR 2.0 genes in this pathway |
| LIANG SILENCED BY METHYLATION 2 | 53 | 34 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS MATURE CELL | 293 | 160 | All SZGR 2.0 genes in this pathway |
| 伯顿成生成5 | 126 | 78 | All SZGR 2.0 genes in this pathway |
| 麦克拉克兰牙齿龋齿DN | 245 | 144 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY NO BLOOD UP | 222 | 139 | All SZGR 2.0 genes in this pathway |
| LIANG SILENCED BY METHYLATION UP | 32 | 18 | All SZGR 2.0 genes in this pathway |
| SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 | 419 | 273 | All SZGR 2.0 genes in this pathway |
| Han Jnk Singaling DN | 39 | 27 | All SZGR 2.0 genes in this pathway |
| MCLACHLAN DENTAL CARIES UP | 253 | 147 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
| Heller HDAC靶向被甲基化的沉默 | 461 | 298 | All SZGR 2.0 genes in this pathway |
| 阿塞维多肝癌DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN | 274 | 165 | All SZGR 2.0 genes in this pathway |
| SMID乳腺癌腔B DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
| Smid乳腺癌正常 | 476 | 285 | All SZGR 2.0 genes in this pathway |
| GAURNIER PSMD4 TARGETS | 73 | 55 | All SZGR 2.0 genes in this pathway |
| BUCKANOVICH T LYMPHOCYTE HOMING ON TUMOR UP | 24 | 11 | All SZGR 2.0 genes in this pathway |
| Zheng IL22发出信号 | 56 | 36 | All SZGR 2.0 genes in this pathway |
| Boquest干细胞向上 | 260 | 174 | All SZGR 2.0 genes in this pathway |
| BOQUEST STEM CELL CULTURED VS FRESH DN | 31 | 25 | All SZGR 2.0 genes in this pathway |
| LABBE TARGETS OF TGFB1 AND WNT3A DN | 108 | 68 | All SZGR 2.0 genes in this pathway |
| NAKAMURA METASTASIS MODEL DN | 43 | 28 | All SZGR 2.0 genes in this pathway |
| 西肾上腺皮质肿瘤DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| Boylan多发性骨髓瘤C D DN | 252 | 155 | All SZGR 2.0 genes in this pathway |
| GOLDRATH ANTIGEN RESPONSE | 346 | 192 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO CSF2RB AND IL4 DN | 315 | 201 | All SZGR 2.0 genes in this pathway |
| Rutella对HGF的反应 | 418 | 282 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP | 408 | 276 | All SZGR 2.0 genes in this pathway |
| 甜肺癌Kras DN | 435 | 289 | All SZGR 2.0 genes in this pathway |
| 4EBP1和4EBP2的COLINA目标 | 356 | 214 | All SZGR 2.0 genes in this pathway |
| Liu Vav3前列腺致癌作用 | 89 | 61 | All SZGR 2.0 genes in this pathway |
| Schoen NFKB信号 | 34 | 26 | All SZGR 2.0 genes in this pathway |
| 黑元对癌细胞病毒的反应 | 44 | 30 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA PCA1 UP | 101 | 66 | All SZGR 2.0 genes in this pathway |
| 开罗肝脏发展DN | 222 | 141 | All SZGR 2.0 genes in this pathway |
| NAKAYAMA SOFT TISSUE TUMORS PCA1 UP | 76 | 46 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 6 | 75 | 48 | All SZGR 2.0 genes in this pathway |
| 乳腺癌的王转移ESR1 DN | 30 | 18 | All SZGR 2.0 genes in this pathway |
| li诱导了自然杀手DN | 116 | 83 | All SZGR 2.0 genes in this pathway |
| Chicas RB1靶向衰老 | 572 | 352 | All SZGR 2.0 genes in this pathway |
| Demagalhaes老化 | 55 | 39 | All SZGR 2.0 genes in this pathway |
| Johnstone Parvb目标3 | 430 | 288 | All SZGR 2.0 genes in this pathway |
| Kim Glis2靶向 | 84 | 61 | All SZGR 2.0 genes in this pathway |
| Kasler HDAC7目标1 DN | 17 | 13 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| lim乳腺腔祖先 | 58 | 30 | All SZGR 2.0 genes in this pathway |