Gene Page:TRAF5

Summary?
GeneID 7188
Symbol TRAF5
Synonyms MGC:39780|RNF84
Description TNF receptor associated factor 5
Reference MIM:602356|HGNC:HGNC:12035|Ensembl:ENSG00000082512|HPRD:03834|Vega:OTTHUMG00000036997
Gene type protein-coding
Map location 1q32
Sherlock p-value 0.518
Fetal beta 0.095
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg11131549 1 211500852 TRAF5 7.82E-5 0.504 0.025 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CD27 MGC20393 | S152 | T14 | TNFRSF7 | Tp55 CD27 molecule - HPRD,BioGRID 9582383
CD40 Bp50 | CDW40 | MGC9013 | TNFRSF5 | p50 CD40 molecule, TNF receptor superfamily member 5 - HPRD,BioGRID 8790348|9990007
LTBR CD18 | D12S370 | LT-BETA-R | TNF-R-III | TNFCR | TNFR-RP | TNFR2-RP | TNFRSF3 lymphotoxin beta receptor (TNFR superfamily, member 3) Reconstituted Complex BioGRID 9162022
LTBR CD18 | D12S370 | LT-BETA-R | TNF-R-III | TNFCR | TNFR-RP | TNFR2-RP | TNFRSF3 lymphotoxin beta receptor (TNFR superfamily, member 3) - HPRD 8663299
MAP3K14 FTDCR1B | HS | HSNIK | NIK mitogen-activated protein kinase kinase kinase 14 NIK interacts with TRAF5. This interaction was modeled on a demonstrated interaction between human NIK and TRAF5 from an unspecified species. BIND 9275204
MAP3K5 ASK1 | MAPKKK5 | MEKK5 mitogen-activated protein kinase kinase kinase 5 - HPRD,BioGRID 10523862
NGFR CD271 | Gp80-LNGFR | TNFRSF16 | p75(NTR) | p75NTR nerve growth factor receptor (TNFR superfamily, member 16) Affinity Capture-Western BioGRID 10514511
RIPK1 FLJ39204 | RIP | RIP1 受体(TNFRSF)交互serine-threonine亲属ase 1 - HPRD,BioGRID 11479302
RIPK2 CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2 receptor-interacting serine-threonine kinase 2 - HPRD,BioGRID 9642260
TNFRSF11A CD265 | FEO | LOH18CR1 | ODFR | OFE | OPTB7 | OSTS | PDB2 | RANK | TRANCER tumor necrosis factor receptor superfamily, member 11a, NFKB activator - HPRD 9774460|10025951
TNFRSF11A CD265 | FEO | LOH18CR1 | ODFR | OFE | OPTB7 | OSTS | PDB2 | RANK | TRANCER tumor necrosis factor receptor superfamily, member 11a, NFKB activator Reconstituted Complex BioGRID 9685412|9852070
|10075662
TNFRSF13B CD267 | CVID | FLJ39942 | MGC133214 | MGC39952 | TACI | TNFRSF14B tumor necrosis factor receptor superfamily, member 13B - HPRD,BioGRID 10880535
TNFRSF14 ATAR | HVEA | HVEM | LIGHTR | TR2 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 9153189|9162022
TNFRSF19 TAJ | TAJ-alpha | TRADE | TROY tumor necrosis factor receptor superfamily, member 19 - HPRD,BioGRID 10809768
TNFRSF4 ACT35 | CD134 | OX40 | TXGP1L tumor necrosis factor receptor superfamily, member 4 - HPRD,BioGRID 9488716
TNFRSF8 CD30 | D1S166E | KI-1 tumor necrosis factor receptor superfamily, member 8 - HPRD,BioGRID 8943059|8999898
TNFRSF8 CD30 | D1S166E | KI-1 tumor necrosis factor receptor superfamily, member 8 - HPRD 8943059|8999898|8999898
|11971184
TRIM37 KIAA0898 | MUL | POB1 | TEF3 tripartite motif-containing 37 - HPRD,BioGRID 11279055
TTRAP AD022 | EAP2 | MGC111021 | MGC9099 | dJ30M3.3 TRAF and TNF receptor associated protein - HPRD,BioGRID 10764746
USP7 HAUSP | TEF1 ubiquitin specific peptidase 7 (herpes virus-associated) - HPRD,BioGRID 11279055


部分诉通路注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 84 67 All SZGR 2.0 genes in this pathway
BIOCARTA TALL1 PATHWAY 15 15 All SZGR 2.0 genes in this pathway
SIG CD40PATHWAYMAP 34 28 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241 146 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP 95 64 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP 194 112 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE UP 85 57 All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP 55 40 All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207 128 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390 236 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236 139 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY UP 109 69 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE DN 77 49 All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 110 69 All SZGR 2.0 genes in this pathway
KLEIN PRIMARY EFFUSION LYMPHOMA DN 58 42 All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA DN 45 28 All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169 112 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD2 UP 45 32 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246 180 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA UP 6 5 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235 144 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245 150 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN 42 29 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 181 97 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY DN 26 14 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA LB DN 44 23 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
WANG NFKB TARGETS 25 15 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR DN 114 69 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway