基因页：TRAF6

Summary?
GeneID 7189
Symbol TRAF6
同义词 MGC:3310|RNF85
描述 TNF receptor associated factor 6
参考 MIM:602355|HGNC:HGNC:12036|HPRD：03833|
Gene type protein-coding
地图位置 11p12
Pascal P值 5.373E-4

Gene in Data Sources
Gene set name 基因组方法 描述 Info
简历：PGCNP 全基因组协会研究 GWAS
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1
网络 Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.4462

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

无法使用

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 11244088|11397809|11751921
|15125833
GO:0004842 ubiquitin-protein ligase activity 艾达 15125833
去：0008270 zinc ion binding IEA -
GO:0046872 金属离子结合 IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0043011 myeloid dendritic cell differentiation IEA dendrite (GO term level: 10) -
去：0000209 蛋白质多泛素化 艾达 15125833
去：0001503 ossification IEA -
去：0002726 T细胞因子的阳性调节 小鬼 15125833
去：0001843 neural tube closure IEA -
GO:0006511 泛素依赖性蛋白质分解代谢过程 IEA -
GO:0007250 activation of NF-kappaB-inducing kinase activity 小鬼 15125833
GO:0009887 organ morphogenesis IEA -
去：0007165 signal transduction IEA -
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IEA -
GO:0048468 cell development IEA -
GO:0006955 immune response IEA -
GO:0042981 regulation of apoptosis IEA -
GO:0051023 regulation of immunoglobulin secretion IEA -
GO：0042475 odontogenesis of dentine-containing tooth IEA -
GO：0050852 T cell receptor signaling pathway 小鬼 15125833
GO:0050870 positive regulation of T cell activation IC 15125833
GO:0042088 T-helper 1 type immune response IEA -
GO:0032743 positive regulation of interleukin-2 production 小鬼 15125833
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEP 12761501
GO:0045084 positive regulation of interleukin-12 biosynthetic process IEA -
GO:0045410 positive regulation of interleukin-6 biosynthetic process IEA -
细胞分量 GO term Evidence Neuro keywords PubMed ID
去：0005829 cytosol EXP 9162092|9744859|10066798
|10465784|12138165
|12609980|15125833
去：0005829 cytosol IEA -
GO:0005624 膜分数 IEA -
GO:0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ASXL2 ASXH2 | DKFZp686C1968 | FLJ10898 | KIAA1685 额外的性梳子，例如2（果蝇） Affinity Capture-MS BioGRID 17353931
ATP2A2 atp2b |dar |DD |DKFZP686P0211 |FLJ20293 |FLJ38063 |MGC45367 |SERCA2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 - HPRD 14743216
CD40 Bp50 | CDW40 | MGC9013 | TNFRSF5 | p50 CD40molecule, TNF receptor superfamily member 5 Reconstituted Complex BioGRID 9384571|9990007
CD40 Bp50 | CDW40 | MGC9013 | TNFRSF5 | p50 CD40molecule, TNF receptor superfamily member 5 - HPRD 10075662|10411888
CTPS - CTP synthase Affinity Capture-MS BioGRID 17353931
ddx3x DBX | DDX14 | DDX3 | HLP2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked Affinity Capture-MS BioGRID 17353931
ECSIT sitpec ECSIT homolog (Drosophila) - HPRD，Biogrid 10465784
EDA2R EDA-A2R |EDAA2R |TNFRSF27 |Xedar ectodysplasin A2 receptor - HPRD，Biogrid 12060722
EIF4E2 4E-LP | 4EHP | EIF4EL3 | IF4e eukaryotic translation initiation factor 4E family member 2 Affinity Capture-MS BioGRID 17353931
eppk1 Epipl |EPIPL1 Epiplakin 1 Affinity Capture-MS BioGRID 17353931
GANAB G2an |Gluii |KIAA0088 glucosidase, alpha; neutral AB Affinity Capture-MS BioGRID 17353931
HSPA8 HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71 heat shock 70kDa protein 8 - HPRD 14743216
IARS FLJ20736 | IARS1 | ILRS | PRO0785 isoleucyl-tRNA synthetase Affinity Capture-MS BioGRID 17353931
IL17RB CRL4 |EVI27 |IL17BR |IL17RH1 |MGC5245 白介素17受体B - HPRD，Biogrid 10748240
irak1 IRAK | pelle interleukin-1 receptor-associated kinase 1 TRAF6 interacts with IRAK1. This interaction was modeled on a demonstrated interaction between TRAF6 and IRAK1, both from unspecified species. BIND 15894263
irak1 IRAK | pelle interleukin-1 receptor-associated kinase 1 - HPRD，Biogrid 8837778
irak2 IRAK-2 | MGC150550 interleukin-1 receptor-associated kinase 2 IRAK-2 interacts with TRAF6. BIND 10383454
irak2 IRAK-2 | MGC150550 interleukin-1 receptor-associated kinase 2 - HPRD，Biogrid 9374458
irak3 ASRT5 |irak-m |irakm interleukin-1 receptor-associated kinase 3 IRAK-M interacts with TRAF6. BIND 10383454
irak3 ASRT5 |irak-m |irakm interleukin-1 receptor-associated kinase 3 - HPRD，Biogrid 10383454
irak4 IPD1 |NY-REN-64 |Ren64 interleukin-1 receptor-associated kinase 4 - HPRD，Biogrid 11960013
IRF7 IRF-7H |IRF7A interferon regulatory factor 7 IRF7 intereacts with TRAF6. This interaction was modeled on a demonstrated interaction between mouse IRF7 and human TRAF6. BIND 15361868
KCNQ1 ATFB1 | FLJ26167 | JLNS1 | KCNA8 | KCNA9 | KVLQT1 | Kv1.9 | Kv7.1 | LQT | LQT1 | RWS | SQT2 | WRS potassium voltage-gated channel, KQT-like subfamily, member 1 Affinity Capture-MS BioGRID 14743216
MALT1 DKFZP434L132 |MLT |MLT1 粘膜相关的淋巴组织淋巴瘤易位基因1 TRAF6 interacts with MALT1. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and MALT1 from human. BIND 15125833
MAP3K14 FTDCR1B | HS | HSNIK | NIK mitogen-activated protein kinase kinase kinase 14 - HPRD，Biogrid 11278268
MAP3K14 FTDCR1B | HS | HSNIK | NIK mitogen-activated protein kinase kinase kinase 14 Nik与TRAF6相互作用。这种相互作用是基于未指定物种的人Nik和Traf6之间的相互作用进行建模的。 BIND 9275204
MAP3K5 ASK1 | MAPKKK5 | MEKK5 mitogen-activated protein kinase kinase kinase 5 - HPRD，Biogrid 10523862
MAP3K7 tak1 |TGF1A mitogen-activated protein kinase kinase kinase 7 - HPRD，Biogrid 10094049
MAP3K7IP1 3'-Tab1 | MGC57664 | TAB1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1 - HPRD，Biogrid 10094049
MAP3K7IP2 FLJ21885 |KIAA0733 |TAB2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2 - HPRD，Biogrid 10882101
MAP3K7IP3 MGC45404 | NAP1 | TAB3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3 TAB3与TRAF6相互作用。 BIND 15327770
MAP3K7IP3 MGC45404 | NAP1 | TAB3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3 - HPRD，Biogrid 14633987
mast2 FLJ39200 | KIAA0807 | MAST205 | MTSSK | RP4-533D7.1 microtubule associated serine/threonine kinase 2 - HPRD，Biogrid 15308666
MCM7 CDABP0042 |cdc47 |MCM2 |P1.1-MCM3 |P1CDC47 |p85mcm |PNAS-146 minichromosome maintenance complex component 7 Affinity Capture-MS BioGRID 17353931
MTHFD1 MTHFC | MTHFD 甲基苯甲酸叶酸脱氢酶（NADP+依赖性）1，甲苯基四氢叶酸环醇酶，甲基四氢叶酸合成酸合成酶 Affinity Capture-MS BioGRID 17353931
nasp DKFZp547F162 | FLB7527 | FLJ31599 | FLJ35510 | MGC19722 | MGC20372 | MGC2297 | PRO1999 核自身抗原精子蛋白（组蛋白结合） Affinity Capture-MS BioGRID 17353931
NGFR CD271 | Gp80-LNGFR | TNFRSF16 | p75(NTR) | p75NTR nerve growth factor receptor (TNFR superfamily, member 16) - HPRD，Biogrid 10514511
NTSR1 ntr neurotensin receptor 1 (high affinity) - HPRD 10514511
otud7b 塞尚|ZA20D1 OTU domain containing 7B - HPRD，Biogrid 11463333
otud7b 塞尚|ZA20D1 OTU domain containing 7B - HPRD 9928991
PAICS ADE2 | ADE2H1 | AIRC | DKFZp781N1372 | MGC1343 | MGC5024 | PAIS 磷酸氨基氨基咪唑羧化酶，磷酸氨基氨基咪唑辅助辅助酰胺合成酶合成酶 Affinity Capture-MS BioGRID 17353931
PELI3 MGC35521 佩里诺同源物3（果蝇） - HPRD 12874243
PFAS fgams |fgarat |KIAA0361 |金银丝 phosphoribosylformylglycinamidine synthase Affinity Capture-MS BioGRID 17353931
PRKCZ PKC-Zeta |PKC2 protein kinase C, zeta - HPRD，Biogrid 10747026
PSMA4 HC9 | HsT17706 | MGC111191 | MGC12467 | MGC24813 | PSC9 蛋白酶体（Prosome，宏观）亚基，Alpha型，4 - HPRD 14743216
PSMB5 LMPX | MB1 | MGC104214 | X proteasome (prosome, macropain) subunit, beta type, 5 Affinity Capture-MS BioGRID 14743216
PSMC1 MGC24583 | MGC8541 | P26S4 | S4 | p56 蛋白酶体（Prosome，大蛋白）26S亚基，ATPase，1 Affinity Capture-MS BioGRID 14743216
PSMC2 MGC3004 |MSS1 |NBLA10058 |S7 蛋白酶体（Prosome，大蛋白）26S亚基，ATPase，2 Affinity Capture-MS BioGRID 14743216
PSMC3 MGC8487 | TBP1 蛋白酶体（Prosome，大蛋白）26S亚基，ATPase，3 Affinity Capture-MS BioGRID 14743216
PSMD1 MGC133040 |MGC133041 |P112 |rpn2 |S1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 - HPRD，Biogrid 14743216
PSMD12 MGC75406 | Rpn5 | p55 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，12 - HPRD，Biogrid 14743216
PSMD13 HSPC027 | Rpn9 | S11 | p40.5 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，13 Affinity Capture-MS BioGRID 14743216
PSMD3 P58 | RPN3 | S3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 - HPRD，Biogrid 14743216
PSMD4 AF | AF-1 | ASF | MCB1 | Rpn10 | S5A | pUB-R5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 - HPRD 14743216
PSMD7 MOV34 | P40 | Rpn8 | S12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Affinity Capture-MS BioGRID 14743216
PSMD8 hip6 |hypf |MGC1660 |nin1p |RPN12 |S14 |p31 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 - HPRD 14743216
RIPK2 card3 |Cardiak |CCK |gig30 |里克|RIP2 receptor-interacting serine-threonine kinase 2 - HPRD，Biogrid 9642260
RNF126 FLJ20552 | MGC1022 | MGC14317 ring finger protein 126 - HPRD 14743216
SIGIRR MGC110992 |tir8 单个免疫球蛋白和收费夹管1受体（TIR）结构域 - HPRD，Biogrid 12925853
SPOP tef2 speckle-type POZ protein - HPRD，Biogrid 11279055
SQSTM1 A170 | OSIL | PDB3 | zip2 | p60 | p62| p62B 隔离1 - HPRD，Biogrid 10747026|11244088
SRC ASV |src1 |C-SRC |P60-SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) - HPRD，Biogrid 10635328
Stradb ALS2CR2 |Cals-21 |Ilpip |ilpipa |MGC102916 |Papk |Pro1038 STE20-related kinase adaptor beta - HPRD，Biogrid 12048196
Syk dkfzp313n1010 |FLJ25043 |FLJ37489 spleen tyrosine kinase - HPRD，Biogrid 11418661
TARS MGC9344 | ThrRS Threonyl-tRNA合成酶 Affinity Capture-MS BioGRID 17353931
税务1BP1 CALCOCO3 | T6BP | TXBP151 Tax1 (human T-cell leukemia virus type I) binding protein 1 - HPRD，Biogrid 10920205
TICAM1 MGC35334 | PRVTIRB | TICAM-1 | TRIF toll-like receptor adaptor molecule 1 TRIF interacts with TRAF6. BIND 14530355
TICAM1 MGC35334 | PRVTIRB | TICAM-1 | TRIF toll-like receptor adaptor molecule 1 TRIF的未指定同工型与TRAF6相互作用。这种相互作用是根据未指定物种的TRIF与未指定物种的TRAF之间的相互作用进行建模的。 BIND 15474016
TICAM2 MGC129876 | MGC129877 | TICAM-2 | TIRAP3 | TIRP | TRAM Toll样受体适配器分子2 - HPRD 12721283
TICAM2 MGC129876 | MGC129877 | TICAM-2 | TIRAP3 | TIRP | TRAM Toll样受体适配器分子2 TIRP与TRAF6交互。这种交互是莫deled on a demonstrated interaction between human TIRP and TRAF6 from an unspecified species. BIND 12721283
TIFA MGC20791 | T2BP | T6BP | TIFAA 与叉头相关结构域的TRAF相互作用蛋白 - HPRD，Biogrid 12566447
TJP2 MGC26306 | X104 | ZO-2 | ZO2 紧密连接蛋白2(带occludens 2) Affinity Capture-MS BioGRID 17353931
TMEM189-UBE2V1 CROC-1B | Kua-UEV | UBE2V1 tmem189-ube2v1读取笔录 - HPRD，Biogrid 11057907
tnfaip3 A20 | MGC104522 | MGC138687 | MGC138688 | OTUD7C | TNFA1P2 肿瘤坏死因子，α诱导的蛋白3 - HPRD，Biogrid 9928991
TNFRSF11A CD265 |feo |loh18cr1 |ODFR |Ofe |OPTB7 |Osts |PDB2 |等级|Trancer tumor necrosis factor receptor superfamily, member 11a, NFKB activator Affinity Capture-Western
Reconstituted Complex		 BioGRID 9685412|9852070
|10025951|10075662
|11809792
TNFRSF11A CD265 |feo |loh18cr1 |ODFR |Ofe |OPTB7 |Osts |PDB2 |等级|Trancer tumor necrosis factor receptor superfamily, member 11a, NFKB activator - HPRD 9685412|10025951
|10075662|10635328
TNFRSF13B CD267 |cvid |FLJ39942 |MGC133214 |MGC39952 |塔西|TNFRSF14B 肿瘤坏死因子受体超家族，成员13b - HPRD，Biogrid 10880535
TNFRSF19 TAJ | TAJ-alpha | TRADE | TROY 肿瘤坏死因子受体超家族，成员19 - HPRD，Biogrid 12060722
TNFSF11 CD254 | ODF | OPGL | OPTB2 | RANKL | TRANCE | hRANKL2 | sOdf tumor necrosis factor (ligand) superfamily, member 11 - HPRD 10635328
TRAF2 MGC:45012 | TRAP | TRAP3 TNF受体相关因子2 Two-hybrid BioGRID 16189514
TRAF6 MGC：3310 |RNF85 TNF受体相关因子6 TRAF6与自身相互作用并形成低聚物。 BIND 15125833
TRIM37 KIAA0898 | MUL | POB1 | TEF3 tripartite motif-containing 37 - HPRD，Biogrid 11279055
TTRAP AD022 | EAP2 | MGC111021 | MGC9099 | dJ30M3.3 TRAF and TNF receptor associated protein - HPRD，Biogrid 10764746
TUBA3C tuba2 |BA408E5.3 微管蛋白，α3C - HPRD 14743216
TUBB2B DKFZp566F223 | FLJ98847 | MGC8685 | TUBB-PARALOG | bA506K6.1 tubulin, beta 2B - HPRD 14743216
UBB FLJ25987 | MGC8385 ubiquitin B TRAF6 interacts with Ub. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and Ub from an unspecified source. BIND 15125833
USP7 hausp |tef1 泛素特异性肽酶7（疱疹病毒相关） - HPRD，Biogrid 11279055
VARS G7A | VARS1 | VARS2 valyl-tRNA synthetase Affinity Capture-MS BioGRID 17353931
VCP IBMPFD |MGC131997 |MGC148092 |MGC8560 |tera |P97 valosin-containing protein Affinity Capture-MS BioGRID 17353931
VDAC1 MGC111064 | PORIN | PORIN-31-HL voltage-dependent anion channel 1 Affinity Capture-MS BioGRID 17353931
XIAP API3 | BIRC4 | ILP1 | MIHA | XLP2 X连锁凋亡的抑制剂 - HPRD，Biogrid 12048196
ZFAND5 ZA20D2 | ZFAND5A | ZNF216 锌指AN1型域5 Affinity Capture-Western BioGRID 14754897
ZFAND5 ZA20D2 | ZFAND5A | ZNF216 锌指AN1型域5 ZNF216 interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human ZNF216 and TRAF6 from an unspecified species. BIND 14754897
ZNF675 FLJ36350 |tbzf |蒂兹 zinc finger protein 675 - HPRD，Biogrid 11751921
ZRANB1 DKFZp762P2216 | TRABID zinc finger, RAN-binding domain containing 1 - HPRD，Biogrid 11463333


Section V. Pathway annotation

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG泛素介导的蛋白水解 138 98 All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 62 47 All SZGR 2.0 genes in this pathway
kegg钻机我喜欢受体信号通路 71 51 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
Kegg Leishmania感染 72 56 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 84 67 All SZGR 2.0 genes in this pathway
BIOCARTA RELA PATHWAY 16 12 All SZGR 2.0 genes in this pathway
Biocarta Rankl途径 14 13 All SZGR 2.0 genes in this pathway
BIOCARTA CD40 PATHWAY 15 13 All SZGR 2.0 genes in this pathway
Biocarta NFKB途径 23 19 All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY 33 29 All SZGR 2.0 genes in this pathway
BIOCARTA TALL1 PATHWAY 15 15 All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY 37 31 All SZGR 2.0 genes in this pathway
SIG CD40Pathwaymap 34 28 All SZGR 2.0 genes in this pathway
ST P38 MAPK途径 37 28 All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY 40 30 All SZGR 2.0 genes in this pathway
PID BCR 5 Pathway 65 50 All SZGR 2.0 genes in this pathway
PID P38 MKK3 6 Pathway 26 21 All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 66 51 All SZGR 2.0 genes in this pathway
PID NFKAPPAB CANONICAL PATHWAY 23 20 All SZGR 2.0 genes in this pathway
PID CD40途径 31 26 All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 31 25 All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 53 42 All SZGR 2.0 genes in this pathway
PID IL1途径 34 28 All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY 69 51 All SZGR 2.0 genes in this pathway
NGF的Reactome信号传导 217 167 All SZGR 2.0 genes in this pathway
Reactome Trif介导的TLR3信号传导 74 54 All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 54 46 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM TCR SIGNALING 37 32 All SZGR 2.0 genes in this pathway
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES 12 8 All SZGR 2.0 genes in this pathway
REACTOME REGULATED PROTEOLYSIS OF P75NTR 10 9 All SZGR 2.0 genes in this pathway
Reactome P75NTR信号通过NFKB 14 10 All SZGR 2.0 genes in this pathway
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 15 10 All SZGR 2.0 genes in this pathway
REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL 11 8 All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 60 43 All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 81 61 All SZGR 2.0 genes in this pathway
Reactome Tak1通过磷酸化和激活IKKS复合物激活NFKB 23 17 All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 50 37 All SZGR 2.0 genes in this pathway
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 16 9 All SZGR 2.0 genes in this pathway
Reactome激活的TA​​K1介导P38 MAPK激活 18 12 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 39 30 All SZGR 2.0 genes in this pathway
REACTOME IRAK1 RECRUITS IKK COMPLEX 10 8 All SZGR 2.0 genes in this pathway
Reactome Traf6介导的IRF7激活 30 26 All SZGR 2.0 genes in this pathway
Reactome Traf6介导的NFKB激活 21 17 All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 77 57 All SZGR 2.0 genes in this pathway
Reactome Traf6介导的IRF7激活IN TLR7 8 OR 9 SIGNALING 10 9 All SZGR 2.0 genes in this pathway
Reactome NFKB和MAP激酶激活由TLR4信号传导介导 72 53 All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 14 7 All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 73 57 All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 83 63 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 93 69 All SZGR 2.0 genes in this pathway
Reactome免疫系统 933 616 All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 118 84 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
Reactome Nod1 2信号通路 30 22 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 46 33 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276 165 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341 197 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781年 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
SNIJDERS AMPLIFIED IN HEAD AND NECK TUMORS 37 27 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156 106 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 110 78 All SZGR 2.0 genes in this pathway
通过ELK3和HIF1A的总缺氧 142 104 All SZGR 2.0 genes in this pathway
buytaert光动力疗法压力 811 508 All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE DN 11 9 All SZGR 2.0 genes in this pathway
BYSTRYKH造血干细胞QTL Trans 882 572 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0 107 72 All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK 75 47 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR UP 111 68 All SZGR 2.0 genes in this pathway
Lein Cerebellum标记 85 47 All SZGR 2.0 genes in this pathway
Kyng DNA受伽马辐射损伤 81 59 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226 164 All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM LOW RISK UP 22 15 All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK UP 10 7 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN 113 76 All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP 83 63 All SZGR 2.0 genes in this pathway
Zwang 1类由EGF瞬时诱导 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family 目标位置 mirna id miRNA seq
UTR start UTR end Match method
mir-146 473 480 1A,m8 hsa-miR-146a UGAGAACUGAAUUCCAUGGGUU
hsa-miR-146b脑 UGAGAACUGAAUUCCAUAGGCU