基因页：TRPM2
Summary？
| 基因 | 7226 |
| 象征 | TRPM2 |
| 同义词 | EREG1 | knp3 | ltrpc2 | ltrpc-2 | nudt9h | nudt9l1 | trpc7 |
| Description | transient receptor potential cation channel subfamily M member 2 |
| Reference | MIM：603749|HGNC：HGNC：12339|ENSEMBL：ENSG00000142185|HPRD：04777|Vega:OTTHUMG00000040840 |
| 基因类型 | 蛋白质编码 |
| 地图位置 | 21q22.3 |
| Pascal P值 | 0.565 |
| 胎儿β | -2.924 |
| DMG | 1(# studies) |
| 主持人 | 尾状基底神经节 小脑半球 小脑 皮质 Frontal Cortex BA9 伏隔核基底神经节 Putamen basal ganglia 元 |
Gene in Data Sources
| 基因集名称 | 基因组方法 | Description | 信息 |
|---|---|---|---|
| 简历：PGCNP | 全基因组协会研究 | GWAS | |
| DMG：Wockner_2014 | 全基因组DNA甲基化分析 | 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 | 1 |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | 点击显示详细信息 |
Section I. Genetics and epigenetics annotation
差异甲基化基因
差异甲基化基因| 探测 | 染色体 | 位置 | 最近的基因 | p（dis） | Beta (dis) | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| cg24355182 | 21 | 45842649 | TRPM2 | 4.682E-4 | 0.418 | 0.046 | DMG：Wockner_2014 |
EQTL注释
| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | PVALUE | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS62220412 | 21 | 45759486 | TRPM2 | ENSG00000142185.12 | 2.389E-7 | 0 | -10560 | gtex_brain_putamen_basal |
| RS62220413 | 21 | 45759510 | TRPM2 | ENSG00000142185.12 | 1.485E-6 | 0 | -10536 | gtex_brain_putamen_basal |
| RS55926438 | 21 | 45764222 | TRPM2 | ENSG00000142185.12 | 2.625E-7 | 0 | -5824 | gtex_brain_putamen_basal |
| RS62220416 | 21 | 45766262 | TRPM2 | ENSG00000142185.12 | 6.746E-7 | 0 | -3784 | gtex_brain_putamen_basal |
| RS2096860 | 21 | 45768598 | TRPM2 | ENSG00000142185.12 | 4.842e-8 | 0 | -1448 | gtex_brain_putamen_basal |
| RS56306722 | 21 | 45770681 | TRPM2 | ENSG00000142185.12 | 1.023E-8 | 0 | 635 | gtex_brain_putamen_basal |
| RS9975366 | 21 | 45773265 | TRPM2 | ENSG00000142185.12 | 1.754E-7 | 0 | 3219 | gtex_brain_putamen_basal |
| RS4818910 | 21 | 45776701 | TRPM2 | ENSG00000142185.12 | 2.479E-9 | 0 | 6655 | gtex_brain_putamen_basal |
| RS4818911 | 21 | 45776955 | TRPM2 | ENSG00000142185.12 | 2.475E-9 | 0 | 6909 | gtex_brain_putamen_basal |
| RS11908957 | 21 | 45777144 | TRPM2 | ENSG00000142185.12 | 2.481E-9 | 0 | 7098 | gtex_brain_putamen_basal |
| RS11908983 | 21 | 45777229 | TRPM2 | ENSG00000142185.12 | 2.486E-9 | 0 | 7183 | gtex_brain_putamen_basal |
| rs11702323 | 21 | 45777270 | TRPM2 | ENSG00000142185.12 | 1.856E-10 | 0 | 7224 | gtex_brain_putamen_basal |
| RS11700418 | 21 | 45777446 | TRPM2 | ENSG00000142185.12 | 2.487E-9 | 0 | 7400 | gtex_brain_putamen_basal |
| RS11702292 | 21 | 45777553 | TRPM2 | ENSG00000142185.12 | 2.489E-9 | 0 | 7507 | gtex_brain_putamen_basal |
| RS13313851 | 21 | 45777750 | TRPM2 | ENSG00000142185.12 | 2.489E-9 | 0 | 7704 | gtex_brain_putamen_basal |
| RS55712486 | 21 | 45777764 | TRPM2 | ENSG00000142185.12 | 7.179e-11 | 0 | 7718 | gtex_brain_putamen_basal |
| RS28688635 | 21 | 45777915 | TRPM2 | ENSG00000142185.12 | 2.489E-9 | 0 | 7869 | gtex_brain_putamen_basal |
| RS28709583 | 21 | 45777931 | TRPM2 | ENSG00000142185.12 | 2.489E-9 | 0 | 7885 | gtex_brain_putamen_basal |
| rs28532655 | 21 | 45777937 | TRPM2 | ENSG00000142185.12 | 2.489E-9 | 0 | 7891 | gtex_brain_putamen_basal |
| RS55671108 | 21 | 45778194 | TRPM2 | ENSG00000142185.12 | 2.589E-9 | 0 | 8148 | gtex_brain_putamen_basal |
| RS139826939 | 21 | 45778262 | TRPM2 | ENSG00000142185.12 | 2.614E-9 | 0 | 8216 | gtex_brain_putamen_basal |
| RS2838553 | 21 | 45778294 | TRPM2 | ENSG00000142185.12 | 2.106E-9 | 0 | 8248 | gtex_brain_putamen_basal |
| rs9984977 | 21 | 45778353 | TRPM2 | ENSG00000142185.12 | 2.647E-9 | 0 | 8307 | gtex_brain_putamen_basal |
| RS9977290 | 21 | 45778416 | TRPM2 | ENSG00000142185.12 | 2.677E-9 | 0 | 8370 | gtex_brain_putamen_basal |
| RS9974187 | 21 | 45778702 | TRPM2 | ENSG00000142185.12 | 2.783E-9 | 0 | 8656 | gtex_brain_putamen_basal |
| RS9974189 | 21 | 45778715 | TRPM2 | ENSG00000142185.12 | 2.797E-9 | 0 | 8669 | gtex_brain_putamen_basal |
| rs9974813 | 21 | 45778744 | TRPM2 | ENSG00000142185.12 | 2.803E-9 | 0 | 8698 | gtex_brain_putamen_basal |
| RS9975269 | 21 | 45778847 | TRPM2 | ENSG00000142185.12 | 2.847E-9 | 0 | 8801 | gtex_brain_putamen_basal |
| RS12626312 | 21 | 45778900 | TRPM2 | ENSG00000142185.12 | 2.868E-9 | 0 | 8854 | gtex_brain_putamen_basal |
| RS12626316 | 21 | 45778938 | TRPM2 | ENSG00000142185.12 | 2.885e-9 | 0 | 8892 | gtex_brain_putamen_basal |
| RS200368699 | 21 | 45778959 | TRPM2 | ENSG00000142185.12 | 2.27E-9 | 0 | 8913 | gtex_brain_putamen_basal |
| RS12626318 | 21 | 45778960 | TRPM2 | ENSG00000142185.12 | 3.472E-9 | 0 | 8914 | gtex_brain_putamen_basal |
| RS4818713 | 21 | 45779058 | TRPM2 | ENSG00000142185.12 | 1.027E-10 | 0 | 9012 | gtex_brain_putamen_basal |
| RS4818912 | 21 | 45779170 | TRPM2 | ENSG00000142185.12 | 2.988e-9 | 0 | 9124 | gtex_brain_putamen_basal |
| RS4818913 | 21 | 45779329 | TRPM2 | ENSG00000142185.12 | 3.065e-9 | 0 | 9283 | gtex_brain_putamen_basal |
| RS28615158 | 21 | 45779763 | TRPM2 | ENSG00000142185.12 | 8.231E-9 | 0 | 9717 | gtex_brain_putamen_basal |
| RS28472722 | 21 | 45779774 | TRPM2 | ENSG00000142185.12 | 8.299E-9 | 0 | 9728 | gtex_brain_putamen_basal |
| RS28636732 | 21 | 45780262 | TRPM2 | ENSG00000142185.12 | 3.261E-9 | 0 | 10216 | gtex_brain_putamen_basal |
| RS9980508 | 21 | 45780655 | TRPM2 | ENSG00000142185.12 | 3.853E-9 | 0 | 10609 | gtex_brain_putamen_basal |
| rs73231283 | 21 | 45780669 | TRPM2 | ENSG00000142185.12 | 9.638E-12 | 0 | 10623 | gtex_brain_putamen_basal |
| RS4818714 | 21 | 45781295 | TRPM2 | ENSG00000142185.12 | 4.309E-9 | 0 | 11249 | gtex_brain_putamen_basal |
| RS4818715 | 21 | 45781644 | TRPM2 | ENSG00000142185.12 | 4.659E-9 | 0 | 11598 | gtex_brain_putamen_basal |
| RS4818716 | 21 | 45781735 | TRPM2 | ENSG00000142185.12 | 7.198e-10 | 0 | 11689 | gtex_brain_putamen_basal |
| RS4818915 | 21 | 45782407 | TRPM2 | ENSG00000142185.12 | 7.203E-11 | 0 | 12361 | gtex_brain_putamen_basal |
| rs4169 | 21 | 45782474 | TRPM2 | ENSG00000142185.12 | 5.679E-9 | 0 | 12428 | gtex_brain_putamen_basal |
| RS151176888 | 21 | 45783372 | TRPM2 | ENSG00000142185.12 | 1.039E-10 | 0 | 13326 | gtex_brain_putamen_basal |
| RS2276252 | 21 | 45784271 | TRPM2 | ENSG00000142185.12 | 7.217e-11 | 0 | 14225 | gtex_brain_putamen_basal |
| RS2838554 | 21 | 45784632 | TRPM2 | ENSG00000142185.12 | 7.217e-11 | 0 | 14586 | gtex_brain_putamen_basal |
| RS11908814 | 21 | 45784900 | TRPM2 | ENSG00000142185.12 | 3.163E-8 | 0 | 14854 | gtex_brain_putamen_basal |
| rs111406792 | 21 | 45785066 | TRPM2 | ENSG00000142185.12 | 9.591E-12 | 0 | 15020 | gtex_brain_putamen_basal |
| RS2838555 | 21 | 45785478 | TRPM2 | ENSG00000142185.12 | 1.317E-8 | 0 | 15432 | gtex_brain_putamen_basal |
| rs45457102 | 21 | 45786068 | TRPM2 | ENSG00000142185.12 | 7.227e-11 | 0 | 16022 | gtex_brain_putamen_basal |
| RS762426 | 21 | 45787250 | TRPM2 | ENSG00000142185.12 | 4.144e-8 | 0 | 17204 | gtex_brain_putamen_basal |
| RS9982831 | 21 | 45788034 | TRPM2 | ENSG00000142185.12 | 4.102E-8 | 0 | 17988 | gtex_brain_putamen_basal |
| rs45552731 | 21 | 45789352 | TRPM2 | ENSG00000142185.12 | 1.809E-8 | 0 | 19306 | gtex_brain_putamen_basal |
| RS45480794 | 21 | 45789363 | TRPM2 | ENSG00000142185.12 | 1.198E-6 | 0 | 19317年 | gtex_brain_putamen_basal |
| RS45621438 | 21 | 45790238 | TRPM2 | ENSG00000142185.12 | 7.767e-12 | 0 | 20192 | gtex_brain_putamen_basal |
| RS62218764 | 21 | 45791063 | TRPM2 | ENSG00000142185.12 | 1.514E-10 | 0 | 21017 | gtex_brain_putamen_basal |
| RS7277517 | 21 | 45792279 | TRPM2 | ENSG00000142185.12 | 1.259E-9 | 0 | 22233 | gtex_brain_putamen_basal |
| RS62218765 | 21 | 45793331 | TRPM2 | ENSG00000142185.12 | 3.826e-10 | 0 | 23285 | gtex_brain_putamen_basal |
| RS7278527 | 21 | 45793962 | TRPM2 | ENSG00000142185.12 | 4.787E-9 | 0 | 23916 | gtex_brain_putamen_basal |
| RS11088949 | 21 | 45794731 | TRPM2 | ENSG00000142185.12 | 7.496E-12 | 0 | 24685 | gtex_brain_putamen_basal |
| rs12627182 | 21 | 45794867 | TRPM2 | ENSG00000142185.12 | 1.494E-10 | 0 | 24821 | gtex_brain_putamen_basal |
| RS45590835 | 21 | 45795148 | TRPM2 | ENSG00000142185.12 | 7.475E-12 | 0 | 25102 | gtex_brain_putamen_basal |
| RS2838556 | 21 | 45799164 | TRPM2 | ENSG00000142185.12 | 5.175E-8 | 0 | 29118 | gtex_brain_putamen_basal |
| RS4818917 | 21 | 45799280 | TRPM2 | ENSG00000142185.12 | 2.067E-9 | 0 | 29234 | gtex_brain_putamen_basal |
| rs11911248 | 21 | 45803097 | TRPM2 | ENSG00000142185.12 | 4.838e-9 | 0 | 33051 | gtex_brain_putamen_basal |
| rs11911332 | 21 | 45803612 | TRPM2 | ENSG00000142185.12 | 6.697e-12 | 0 | 33566 | gtex_brain_putamen_basal |
| RS62218767 | 21 | 45804596 | TRPM2 | ENSG00000142185.12 | 7.975e-13 | 0 | 34550 | gtex_brain_putamen_basal |
| RS2226686 | 21 | 45805392 | TRPM2 | ENSG00000142185.12 | 5.032e-9 | 0 | 35346 | gtex_brain_putamen_basal |
| RS56195574 | 21 | 45806160 | TRPM2 | ENSG00000142185.12 | 7.941E-13 | 0 | 36114 | gtex_brain_putamen_basal |
| RS62218769 | 21 | 45807376 | TRPM2 | ENSG00000142185.12 | 6.569E-12 | 0 | 37330 | gtex_brain_putamen_basal |
| RS28752243 | 21 | 45807821 | TRPM2 | ENSG00000142185.12 | 9.461E-9 | 0 | 37775 | gtex_brain_putamen_basal |
| RS1556314 | 21 | 45811343 | TRPM2 | ENSG00000142185.12 | 1.024E-8 | 0 | 41297 | gtex_brain_putamen_basal |
| RS2838557 | 21 | 45812703 | TRPM2 | ENSG00000142185.12 | 6.4e-9 | 0 | 42657 | gtex_brain_putamen_basal |
| RS11378494 | 21 | 45813170 | TRPM2 | ENSG00000142185.12 | 1.104E-8 | 0 | 43124 | gtex_brain_putamen_basal |
| RS1011557 | 21 | 45822606 | TRPM2 | ENSG00000142185.12 | 5.423e-7 | 0 | 52560 | gtex_brain_putamen_basal |
| RS1785440 | 21 | 45826803 | TRPM2 | ENSG00000142185.12 | 7.276E-7 | 0 | 56757 | gtex_brain_putamen_basal |
| rs1785467 | 21 | 45838632 | TRPM2 | ENSG00000142185.12 | 8.549E-7 | 0 | 68586 | gtex_brain_putamen_basal |
第二节。转录组注释
一般基因表达（GTEX）
Devlopment期间的基因表达（BrainCloud）
Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。
时间变化的基因表达（brainspan）
Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
No co-expressed genes in brain regions
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0005509 | calcium ion binding | IEA | - | |
| 去：0005262 | calcium channel activity | TAS | 9806837 | |
| 去：0005272 | 钠通道活性 | IEA | - | |
| 去：0004553 | 水解酶活性，水解O-糖基化合物 | IEA | - | |
| GO：0016787 | 水解酶活性 | IEA | - | |
| 去：0005216 | ion channel activity | IEA | - | |
| GO:0047631 | ADP-核糖二磷酸酶活性 | IEA | - | |
| GO：0031402 | 钠离子结合 | IEA | - | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0005975 | 碳水化合物代谢过程 | IEA | - | |
| 去：0006816 | 钙离子传输 | TAS | 9806837 | |
| 去：0006814 | 钠离子运输 | IEA | - | |
| 去：0006811 | 离子运输 | IEA | - | |
| 蜂窝组件 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0016020 | membrane | IEA | - | |
| GO：0016021 | 膜不可或缺 | IEA | - | |
| 去：0005887 | integral to plasma membrane | TAS | 9806837 |
Section V. Pathway annotation
| 路径名 | 路径大小 | # SZGR 2.0 genes in pathway | 信息 |
|---|---|---|---|
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| 棕色髓样细胞的发育 | 165 | 100 | All SZGR 2.0 genes in this pathway |
| Xu GH1自分泌目标 | 268 | 157 | All SZGR 2.0 genes in this pathway |
| Acevedo肝癌与H3K9me3 UP | 141 | 75 | All SZGR 2.0 genes in this pathway |
| 级结肠癌 | 871 | 505 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 LCP WITH H3K27ME3 | 29 | 11 | All SZGR 2.0 genes in this pathway |
| Mikkelsen MEF LCP带有H3K27ME3 | 70 | 35 | All SZGR 2.0 genes in this pathway |
| VERHAAK GLIOBLASTOMA MESENCHYMAL | 216 | 130 | All SZGR 2.0 genes in this pathway |
| Bruins通过TP53组C的UVC响应 | 92 | 60 | All SZGR 2.0 genes in this pathway |
| SERVITJA ISLET HNF1A TARGETS DN | 109 | 71 | All SZGR 2.0 genes in this pathway |