Gene Page:C5

Summary?
GeneID 727
Symbol C5
Synonyms C5D|C5a|C5b|CPAMD4|ECLZB
Description complement component 5
Reference MIM:120900|HGNC:HGNC:1331|Ensembl:ENSG00000106804|HPRD:00405|Vega:OTTHUMG00000020579
Gene type protein-coding
Map location 9q33-q34
Pascal p-value 0.003
Sherlock p-value 0.268
Fetal beta -0.019
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2245504 chr1 69704079 C5 727 0.19 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005102 receptor binding TAS Neurotransmitter (GO term level: 4) 9590258|10820279
GO:0004866 endopeptidase inhibitor activity IEA -
GO:0008009 chemokine activity TAS 10820279
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0000187 activation of MAPK activity TAS 7649993
GO:0007186 G-protein coupled receptor protein signaling pathway TAS 8898085
GO:0006950 response to stress TAS 9590258
GO:0019835 cytolysis IEA -
GO:0006957 complement activation, alternative pathway IEA -
GO:0006958 complement activation, classical pathway IEA -
GO:0006956 complement activation IEA -
GO:0006954 inflammatory response IEA -
GO:0006954 inflammatory response TAS 8759757
GO:0006935 chemotaxis TAS 10820279
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region EXP 3052276
GO:0005576 extracellular region IEA -
GO:0005579 membrane attack complex IEA -
GO:0005615 extracellular space TAS 9218605

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG COMPLEMENT AND COAGULATION CASCADES 69 49 All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES 35 28 All SZGR 2.0 genes in this pathway
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 140 100 All SZGR 2.0 genes in this pathway
BIOCARTA GRANULOCYTES PATHWAY 14 9 All SZGR 2.0 genes in this pathway
BIOCARTA LAIR PATHWAY 17 12 All SZGR 2.0 genes in this pathway
BIOCARTA CLASSIC PATHWAY 14 11 All SZGR 2.0 genes in this pathway
BIOCARTA COMP PATHWAY 19 15 All SZGR 2.0 genes in this pathway
BIOCARTA LECTIN PATHWAY 12 10 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 108 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME COMPLEMENT CASCADE 32 22 All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS DN 123 78 All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR 62 33 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203 134 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING DN 35 24 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 DN 66 38 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236 139 All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244 154 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY DN 48 33 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS UP 45 28 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL DN 127 75 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN 113 76 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K27ME3 206 108 All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222 141 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397 206 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194 133 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157 105 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway