Gene Page:TYK2
概括?
| 基因 | 7297 |
| Symbol | TYK2 |
| Synonyms | IMD35|JTK1 |
| Description | 酪氨酸激酶2 |
| Reference | MIM:176941|HGNC:HGNC:12440|Ensembl:ENSG00000105397|HPRD:01490|Vega:OTTHUMG00000166373 |
| Gene type | protein-coding |
| Map location | 19p13.2 |
| Pascal p-value | 0.316 |
| Sherlock p-value | 0.59 |
| Fetal beta | -0.193 |
| DMG | 1 (# studies) |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg18856252 | 19 | 10491173 | TYK2 | 5.1E-9 | -0.012 | 2.89E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | Affinity Capture-Western | BioGRID | 8780698 |
| CRKL | - | V-CRK肉瘤病毒CT10癌基因同源物（Avian）类似 | - | HPRD,BioGRID | 9374471 |
| ELP2 | FLJ10879 | SHINC-2 | STATIP1 | StIP | elongation protein 2 homolog (S. cerevisiae) | Affinity Capture-Western | BioGRID | 10954736 |
| Fyn | MGC45350 | SLK | SYN | Fynoncogene related to SRC, FGR, YES | - | HPRD,BioGRID | 9196040 |
| GHR | GHBP | growth hormone receptor | - | HPRD,BioGRID | 10502458 |
| GNB2L1 | Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | RACK-1 interacts with Tyk2. | BIND | 12960323 |
| GNB2L1 | Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 12960323 |
| IFNAR1 | AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRC | interferon (alpha, beta and omega) receptor 1 | - | HPRD,BioGRID | 9733772 |
| IFNAR2 | IFN-R | IFN-alpha-REC | IFNABR | IFNARB | interferon (alpha, beta and omega) receptor 2 | IFNR-beta-L interacts with Tyk2. | BIND | 12960323 |
| IL12RB1 | CD212 | IL-12R-BETA1 | IL12RB | MGC34454 | interleukin 12 receptor, beta 1 | IL12RB1的未指定同工型与TYK2相互作用。 | BIND | 9038232 |
| IL13RA1 | CD213A1 | IL-13Ra | NR4 | interleukin 13 receptor, alpha 1 | - | HPRD,BioGRID | 10409622 |
| IL6ST | CD130 | CDw130 | GP130 | GP130-RAPS | IL6R-beta | interleukin 6 signal transducer (gp130, oncostatin M receptor) | - | HPRD,BioGRID | 9388212 |
| IRS1 | HIRS-1 | insulin receptor substrate 1 | - | HPRD,BioGRID | 8550573 |
| IRS2 | - | insulin receptor substrate 2 | - | HPRD,BioGRID | 8550573 |
| JAK1 | jak1a |jak1b |JTK3 | Janus kinase 1 (a protein tyrosine kinase) | - | HPRD,BioGRID | 7589562 |
| JAKMIP1 | FLJ31564 |gababrbp |jamip1 |马林鱼1 | Janus激酶和微管相互作用蛋白1 | Jamip1 interacts with Tyk2. | BIND | 15277531 |
| LYN | FLJ26625 | JTK8 | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | - | HPRD,BioGRID | 9633884 |
| PLAUR | CD87 | UPAR | URKR | plasminogen activator, urokinase receptor | Affinity Capture-Western | BioGRID | 9417082 |
| PRMT5 | HRMT1L5 | IBP72 | JBP1 | SKB1 | SKB1Hs | protein arginine methyltransferase 5 | - | HPRD,BioGRID | 10531356 |
| PTPN1 | PTP1B | protein tyrosine phosphatase, non-receptor type 1 | in vivo | BioGRID | 11694501 |
| PTPN6 | HCP |HCPH |HPTP1C |PTP-1C |SH-PTP1 |SHP-1 |SHP-1L |SHP1 | protein tyrosine phosphatase, non-receptor type 6 | - | HPRD,BioGRID | 7629131|8780698 |
| STAM2 | DKFZp564C047 | Hbp | STAM2A | STAM2B | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | - | HPRD,BioGRID | 10899310 |
| STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | Biochemical Activity | BioGRID | 12960323 |
| TYK2 | JTK1 | 酪氨酸激酶2 | Affinity Capture-Western | BioGRID | 7589562 |
| VAV1 | VAV | VAV 1鸟嘌呤核苷酸交换因子 | - | HPRD,BioGRID | 10673353 |
| XRCC5 | FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIV | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Affinity Capture-Western | BioGRID | 10673353 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG JAK STAT SIGNALING PATHWAY | 155 | 105 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA IL6 PATHWAY | 22 | 16 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA IL12 PATHWAY | 23 | 17 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA IL22BP PATHWAY | 16 | 12 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA NO2IL12 PATHWAY | 17 | 14 | 该途径中的所有SZGR 2.0基因 |
| ST TYPE I INTERFERON PATHWAY | 9 | 8 | 该途径中的所有SZGR 2.0基因 |
| ST INTERLEUKIN 4 PATHWAY | 26 | 18 | 该途径中的所有SZGR 2.0基因 |
| PID IL27 PATHWAY | 26 | 20 | 该途径中的所有SZGR 2.0基因 |
| PID PTP1B PATHWAY | 52 | 40 | 该途径中的所有SZGR 2.0基因 |
| PID IL12 2PATHWAY | 63 | 54 | 该途径中的所有SZGR 2.0基因 |
| PID IL6 7 PATHWAY | 47 | 40 | 该途径中的所有SZGR 2.0基因 |
| PID IL23 PATHWAY | 37 | 30 | 该途径中的所有SZGR 2.0基因 |
| REACTOME SIGNALING BY ILS | 107 | 86 | 该途径中的所有SZGR 2.0基因 |
| REACTOME INTERFERON ALPHA BETA SIGNALING | 64 | 50 | 该途径中的所有SZGR 2.0基因 |
| IFNA信号的反应组调节 | 24 | 22 | 该途径中的所有SZGR 2.0基因 |
| REACTOME INTERFERON SIGNALING | 159 | 116 | 该途径中的所有SZGR 2.0基因 |
| REACTOME IL 6 SIGNALING | 11 | 9 | 该途径中的所有SZGR 2.0基因 |
| REACTOME IMMUNE SYSTEM | 933 | 616 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | 该途径中的所有SZGR 2.0基因 |
| BARRIER CANCER RELAPSE NORMAL SAMPLE DN | 31 | 19 | 该途径中的所有SZGR 2.0基因 |
| SCHLOSSER SERUM RESPONSE UP | 134 | 93 | 该途径中的所有SZGR 2.0基因 |
| DACOSTA UV RESPONSE VIA ERCC3 UP | 309 | 199 | 该途径中的所有SZGR 2.0基因 |
| INGRAM SHH TARGETS DN | 64 | 41 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH MYC MAX TARGETS | 775 | 494 | 该途径中的所有SZGR 2.0基因 |
| PENG GLUTAMINE DEPRIVATION UP | 38 | 25 | 该途径中的所有SZGR 2.0基因 |
| THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE UP | 1691年 | 1088 | 该途径中的所有SZGR 2.0基因 |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN | 287 | 208 | 该途径中的所有SZGR 2.0基因 |
| HELLER HDAC TARGETS UP | 317 | 208 | 该途径中的所有SZGR 2.0基因 |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | 该途径中的所有SZGR 2.0基因 |
| DING LUNG CANCER BY MUTATION RATE | 20 | 18 | 该途径中的所有SZGR 2.0基因 |
| DANG BOUND BY MYC | 1103 | 714 | 该途径中的所有SZGR 2.0基因 |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | 该途径中的所有SZGR 2.0基因 |
| Delacroix Rarg Bound MEF | 367 | 231 | 该途径中的所有SZGR 2.0基因 |
| Delacroix RAR目标 | 48 | 33 | 该途径中的所有SZGR 2.0基因 |