Gene Page:UBE2B

概括?
基因 7320
象征 UBE2B
Synonyms E2-17kDa|HHR6B|HR6B|RAD6B|UBC2
Description 泛素的jugating enzyme E2 B
Reference MIM:179095|HGNC:HGNC:12473|Ensembl:ENSG00000119048|HPRD:01533|Vega:OTTHUMG00000129120
Gene type protein-coding
Map location 5Q31.1
Pascal p-value 0.223
Sherlock p-value 0.074
DMG 1 (# studies)
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_I Genome scan meta-analysis Psr: 0.0032
Expression Meta-analysis of gene expression Pvalue: 1.559

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
CG00588727 5 133707840 UBE2B 1.31E-9 -0.008 1.35E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs11682393 chr2 47804496 UBE2B 7320 0.08 trans
rs13125675 chr4 40938622 UBE2B 7320 0.13 trans
rs2369618 chrX 6252204 UBE2B 7320 0.11 trans
RS10218335 chrX 6350730 UBE2B 7320 0.02 trans
rs16984151 chrX 6354595 UBE2B 7320 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -
去：0004842 ubiquitin-protein ligase activity IEA -
GO:0016874 ligase activity IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0006511 ubiquitin-dependent protein catabolic process TAS 1559696
GO:0006301 postreplication repair TAS 1559696
GO:0007288 sperm axoneme assembly IEA -
GO:0051246 regulation of protein metabolic process IEA -
GO:0043687 翻译后蛋白质修饰 IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000785 chromatin IEA -
GO:0005634 nucleus IEA -
GO:0005886 plasma membrane IEA -

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 138 98 该途径中的所有SZGR 2.0基因
REACTOME IMMUNE SYSTEM 933 616 该途径中的所有SZGR 2.0基因
REACTOME适应性免疫系统 539 350 该途径中的所有SZGR 2.0基因
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 该途径中的所有SZGR 2.0基因
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212 129 该途径中的所有SZGR 2.0基因
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 该途径中的所有SZGR 2.0基因
OSMAN BLADDER CANCER DN 406 230 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 该途径中的所有SZGR 2.0基因
AMUNDSON RESPONSE TO ARSENITE 217 143 该途径中的所有SZGR 2.0基因
NUYTTEN EZH2 TARGETS DN 1024 594 该途径中的所有SZGR 2.0基因
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 该途径中的所有SZGR 2.0基因
洛佩兹MBD目标 957 597 该途径中的所有SZGR 2.0基因
KAUFFMANN DNA REPAIR GENES 230 137 该途径中的所有SZGR 2.0基因
KAUFFMANN DNA REPLICATION GENES 147 87 该途径中的所有SZGR 2.0基因
OKUMURA INFLAMMATORY RESPONSE LPS 183 115 该途径中的所有SZGR 2.0基因
ZHAN MULTIPLE MYELOMA CD1 AND CD2 DN 51 32 该途径中的所有SZGR 2.0基因
KUMAR TARGETS OF MLL AF9 FUSION 405 264 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN 1237 837 该途径中的所有SZGR 2.0基因
WANG CISPLATIN RESPONSE AND XPC DN 228 146 该途径中的所有SZGR 2.0基因
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163 113 该途径中的所有SZGR 2.0基因
由Foxp3绑定的Marson未刺激 1229 713 该途径中的所有SZGR 2.0基因
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 该途径中的所有SZGR 2.0基因
MITSIADES RESPONSE TO APLIDIN UP 439 257 该途径中的所有SZGR 2.0基因
Bonome卵巢癌的生存次优秀 510 309 该途径中的所有SZGR 2.0基因
ZHANG BREAST CANCER PROGENITORS UP 425 253 该途径中的所有SZGR 2.0基因
MATZUK SPERMATOCYTE 72 55 该途径中的所有SZGR 2.0基因
MATZUK SPERMATID DIFFERENTIATION 37 26 该途径中的所有SZGR 2.0基因
MOOTHA PGC 420 269 该途径中的所有SZGR 2.0基因
HUNSBERGER EXERCISE REGULATED GENES 31 26 该途径中的所有SZGR 2.0基因
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE 101 76 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 该途径中的所有SZGR 2.0基因
米利假足型haptotaxis dn 668 419 该途径中的所有SZGR 2.0基因
肌肉中的罗马胰岛素靶标 442 263 该途径中的所有SZGR 2.0基因
CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP 85 50 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 1HR UP 61 44 该途径中的所有SZGR 2.0基因
CHICAS RB1 TARGETS SENESCENT 572 352 该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS DN 1972 1213 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE LATE 1137 655 该途径中的所有SZGR 2.0基因
RAO BOUND BY SALL4 ISOFORM B 517 302 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

mirna家族 Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 319 325 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 319 325 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-181 593 600 1A,m8 HSA-MIR-181Abrain aacauucaacgcugucggugagu
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-186 333 340 1A,m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429 1092 1098 m8 HSA-MIR-200B UAAUACUGCCUGGUAAUGAUGAC
HSA-MIR-200C UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
mir-377 183 189 1A hsa-miR-377 aucacacaaaggaacuuuuugu
miR-410 375 381 1A hsa-miR-410 aauauaacacagauggcugu
miR-505 1170 1176 1A hsa-miR-505 GUCAACACUUGCUGGUUUCCUC
miR-93.hd/291-3p/294/295/302/372/373/520 360 367 1A,m8 hsa-miR-93brain AAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU