Gene Page:UBE2N

Summary？
基因 7334
象征 UBE2N
Synonyms HEL-S-71 | UBC13 | Ubchben;ubc13 | ubch-ben | ubch13
Description 泛素结合酶E2 N
Reference MIM：603679|HGNC：HGNC：12492|HPRD:04725|
基因类型 蛋白质编码
Map location 12Q22
pascal p-value 0.003
Sherlock p-value 0.156
胎儿β -0.221
DMG 2(# studies)
主持人 元
Support RNA和蛋白质合成
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
DMG：JAFFE_2016 全基因组DNA甲基化分析 该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。 2
DMG：Vaneijk_2014 全基因组DNA甲基化分析 该数据集包括432个差异甲基化的CpG位点，对应于精神分裂症患者（n = 260）和未受影响的对照（n = 250）之间的391个独特的转录本。 2
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
表达 元-analysis of gene expression p价值：1.57
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息

Section I. Genetics and epigenetics annotation

@不同的米ethylated gene

probe 染色体 位置 最近的基因 p（dis） Beta (dis) fdr（dis） 学习
CG14790421 12 93834936 UBE2N 5.74E-9 -0.012 3.13E-6 DMG：JAFFE_2016
CG04797323 12 93966978 UBE2N 0.007 5.293 DMG：Vaneijk_2014


第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005515 蛋白质结合 IPI 11473255
GO:0004842 泛素 - 蛋白连接酶活性 IEA -
GO：0016874 ligase activity IEA -
去：0043130 ubiquitin binding IDA 16122702
生物过程 去学期 证据 神经关键字 PubMed ID
GO：0000724 double-strand break repair via homologous recombination IMP 17349954
去：0000729 DNA双链断裂处理 IMP 17349954
去：0006508 proteolysis TAS 8902611
去：0006511 ubiquitin-dependent protein catabolic process IEA -
去：0006301 后置式修复 IMP 17349954
去：0051092 NF-kappab转录因子活性的正调控 IMP 14695475
GO:0033182 组蛋白泛素化的调节 IMP 17349954
GO:0050852 T cell receptor signaling pathway IMP 15125833
GO:0031058 positive regulation of histone modification IMP 17349954
GO：0051246 regulation of protein metabolic process IEA -
GO：0043123 I-kappab激酶/NF-kappab级联的积极调节 IMP 16129784
GO:0045739 DNA修复的阳性调节 IMP 16129784
GO:0043687 post-translational protein modification IEA -
GO：0051443 泛素 - 蛋白连接酶活性的阳性调节 IMP 17349954
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005634 nucleus IDA 16129784
去：0005737 cytoplasm TAS 16130169
GO:0031372 UBC13-MMS2 complex IDA 16129784

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG泛素介导的蛋白水解 138 98 All SZGR 2.0 genes in this pathway
PID ATM路径 34 25 All SZGR 2.0 genes in this pathway
pID IL1 PATHWAY 34 28 All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 66 45 All SZGR 2.0 genes in this pathway
Reactome TCR信号传导 54 46 All SZGR 2.0 genes in this pathway
Reactome下游TCR信号传导 37 32 All SZGR 2.0 genes in this pathway
ILS的Reactome信号传导 107 86 All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 39 30 All SZGR 2.0 genes in this pathway
Reactome Irak1招募IKK综合体 10 8 All SZGR 2.0 genes in this pathway
Reactome Traf6在TLR7 8或9激活上介导的NFKB和MAP激酶的诱导 77 57 All SZGR 2.0 genes in this pathway
Reactome Traf6介导的IRF7激活TLR7 8或9信号传导 10 9 All SZGR 2.0 genes in this pathway
Reactome干扰素信号传导 159 116 All SZGR 2.0 genes in this pathway
Reactome myd88 mal级联反应于质膜发起 83 63 All SZGR 2.0 genes in this pathway
Reactome先天免疫系统 279 178 All SZGR 2.0 genes in this pathway
Reactome激活的TLR4信号传导 93 69 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
Reactome收费受体级联 118 84 All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
REACTOME NOD1 2信号通路 30 22 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
Reactome I类MHC介导的抗原加工表现 251 156 All SZGR 2.0 genes in this pathway
Reactome抗原加工泛素化蛋白酶体降解 212 129 All SZGR 2.0 genes in this pathway
反应组核苷酸结合结构域富含受体NLR信号通路富含亮氨酸重复途径 46 33 All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央 285 181 All SZGR 2.0 genes in this pathway
sotiriou乳腺癌1级vs 3 151 84 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN 485 334 All SZGR 2.0 genes in this pathway
WAKASUGI HAVE ZNF143 BINDING SITES 58 33 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络 779 480 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
带有E盒的WEI MYCN目标 795 478 All SZGR 2.0 genes in this pathway
Kauffmann DNA修复基因 230 137 All SZGR 2.0 genes in this pathway
彭亮氨酸剥夺 142 93 All SZGR 2.0 genes in this pathway
pENG LEUCINE DEPRIVATION DN 187 122 All SZGR 2.0 genes in this pathway
彭葡萄糖剥夺DN 169 112 All SZGR 2.0 genes in this pathway
pENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者 555 346 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
Mahajan对IL1A DN的反应 76 57 All SZGR 2.0 genes in this pathway
外邦紫外线响应集群D5 39 26 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312 203 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
由FOXP3绑定的Marson刺激 1022 619 All SZGR 2.0 genes in this pathway
Kyng DNA损坏4NQO或伽马辐射 15 13 All SZGR 2.0 genes in this pathway
Kyng DNA损坏 226 164 All SZGR 2.0 genes in this pathway
Massarweh tamoxifen抗性 578 341 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上 863 514 All SZGR 2.0 genes in this pathway
级结肠癌 871 505 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应 342 220 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
Sakai慢性肝炎与肝癌 83 63 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
Kyng Werner综合征和正常老化DN 225 124 All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应14 143 86 All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 75 47 All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up 548 370 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-128 291 298 1A，M8 hsa-miR-128a ucacagugaaccggucuuuu
hsa-miR-128b ucacagugaaccggucuuc
miR-134 1021 1027 1a HSA-MIR-134brain ugugacuggugaccagaggg
miR-139 495 501 1a HSA-MIR-139brain ucuacagugcacgugucu
mir-205 299 305 M8 hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
mir-219 734 740 M8 hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-22 440 446 1a hsa-miR-22brain Aagcugccaguugaagaacugu
miR-27 292 299 1A，M8 HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain UUCACAGUGGCUAAGUUCUGC
miR-31 986 993 1A，M8 hsa-miR-31 Aggcaagaugcuggcauagcug
miR-495 671 677 1a HSA-MIR-495brain Aaacaaacauggugcacuuuuu