SZGR2 - Beplay体育中心

Summary?

基因	7341
Symbol	SUMO1
同义词	DAP1\|GMP1\|OFC10\|PIC1\|SENP2\|SMT3\|SMT3C\|SMT3H3\|UBL1
描述	小型泛素样修饰符1
参考	MIM：601912\|HGNC：HGNC：12502\|Ensembl:ENSG00000116030\|HPRD:03554\|Vega:OTTHUMG00000132839
基因type	protein-coding
地图位置	2q33
Pascal P值	0.257
Sherlock P值	0.665
Fetal beta	0.48
DMG	1（＃研究）
eGene	迈尔斯的顺式和跨性别

基因in Data Sources

基因set name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。	1

第一节遗传学和表观遗传学注释

差异甲基化基因

探测	Chromosome	Position	最近的基因	P (dis)	beta（dis）	FDR (dis)	Study
CG02592124	2	203103479	SUMO1	2.47E-10	-0.011	6.18E-7	DMG:Jaffe_2016

EQTL注释

SNP ID	Chromosome	Position	eGene	基因Entrez ID	qvalue	eQTL type
rs823066	chr1	205771172	SUMO1	7341	0.12	trans
rs9882137	chr3	29494146	SUMO1	7341	0.07	trans
rs4491879	chr3	189373908	SUMO1	7341	0.11	trans
RS4505678	chr3	189374356	SUMO1	7341	0.08	trans
rs13175086	chr5	174691428	SUMO1	7341	0.15	trans
rs16894557	chr6	28999825	SUMO1	7341	0.1	trans
RS1999514	CHR13	84147878	SUMO1	7341	0.16	trans
rs917836	CHR18	20053367	SUMO1	7341	0.16	trans
rs1503026	CHR18	70842605	SUMO1	7341	0.01	trans
rs12326929	CHR18	70864592	SUMO1	7341	0.01	trans
RS12327665	CHR19	39622639	SUMO1	7341	0.05	trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
SLC25A11	0.91	0.92
C19orf62	0.89	0.87
PSMD8	0.89	0.86
MRPL4	0.88	0.88
WDR45	0.88	0.87
ANKRD39	0.88	0.85
MRPL38	0.88	0.87
APEH	0.88	0.85
TMEM9	0.88	0.86
Stoml2	0.87	0.89

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
AF347015.18	-0.59	-0.48
AC010300.1	-0.55	-0.60
MT-ATP8	-0.54	-0.41
AF347015.26	-0.53	-0.39
AF347015.8	-0.53	-0.37
AF347015.2	-0.50	-0.33
AF347015.15	-0.49	-0.35
C10orf108	-0.49	-0.45
AC100783.1	-0.48	-0.41
AF347015.21	-0.48	-0.33

第四节。蛋白质蛋白相互作用注释

Interactors	Aliases B	Official full name B	Experimental	资源	PubMed ID
C11orf65	MGC33948	chromosome 11 open reading frame 65	Two-hybrid	BioGRID	16189514
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8，与凋亡相关的半胱氨酸肽酶	CASP8（caspase-8）与SUMO1相互作用。	BIND	15782135
CBX4	NBP16 \|PC2 \|HPC2	Chromobox同源物4（PC类同源物，果蝇）	Pc2 interacts with SUMO1.	BIND	15592428
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40molecule, TNF receptor superfamily member 5	Two-hybrid	BioGRID	8906799
CHD3	Mi-2a \|mi2-alpha \|ZFH	染色体群酶DNA结合蛋白3	SUMO-1与CHD3相互作用。	BIND	14609633
CHD3	Mi-2a \|mi2-alpha \|ZFH	染色体群酶DNA结合蛋白3	-	HPRD	14609633
CHD3	Mi-2a \|mi2-alpha \|ZFH	染色体群酶DNA结合蛋白3	Two-hybrid	BioGRID	10961991
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	死亡域相关蛋白	Daxx interacts with sentrin.	BIND	11112409
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	死亡域相关蛋白	-	HPRD，Biogrid	11112409
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	死亡域相关蛋白	DAXX与SUMO1的未指定同工型相互作用。	BIND	11948183
DNMT3B	ICF \| M.HsaIIIB	DNA (cytosine-5-)-methyltransferase 3 beta	Dnmt3b interacts with SUMO-1.	BIND	11735126
DNMT3B	ICF \| M.HsaIIIB	DNA (cytosine-5-)-methyltransferase 3 beta	-	HPRD，Biogrid	11735126
fadd	Gig3 \|MGC8528 \|Mort1	Fas (TNFRSF6)-associated via death domain	Two-hybrid	BioGRID	8906799
fas	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	FAS（TNF受体超家族，成员6）	Reconstituted Complex Two-hybrid	BioGRID	8906799\|11112409
fas	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	FAS（TNF受体超家族，成员6）	FAS与Sentrin互动。	BIND	11112409
fas	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	FAS（TNF受体超家族，成员6）	-	HPRD	8906799\|9740801
fasLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	-	HPRD，Biogrid	8906799
HDAC9	DKFZP779K1053 \|HD7 \|HDAC \|HDAC7 \|HDAC7B \|HDAC9B \|HDAC9FL \|HDRP \|KIAA0744 \|mitr	组蛋白脱乙酰基酶9	-	HPRD	12590135
HIPK2	DKFZp686K02111 \| FLJ23711 \| PRO0593	homeodomain interacting protein kinase 2	SUMO-1 interacts with HIPK2.	BIND	14609633
HIPK2	DKFZp686K02111 \| FLJ23711 \| PRO0593	homeodomain interacting protein kinase 2	-	HPRD，Biogrid	14609633
HIPK3	dyrk6 \|Fist3 \|pky \|Yak1	homeodomain interacting protein kinase 3	Two-hybrid	BioGRID	10961991
HTT	高清\| IT15	亨廷顿	HD is covalently attached to SUMO-1 via lysine residues.	BIND	15064418
MDM2	HDMX \|MGC71221 \|HDM2	MDM2 p53结合蛋白同源物（小鼠）	-	HPRD	10892746
MITF	MI \| WS2A \| bHLHe32	microphthalmia-associated transcription factor	-	HPRD，Biogrid	10694430
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD	12193561
PIAS1	DDXBP1 \| GBP \| GU/RH-II \| MGC141878 \| MGC141879 \| ZMIZ3	活化统计的蛋白质抑制剂，1	SUMO-1 interacts with PIAS1.	BIND	14609633
PIAS1	DDXBP1 \| GBP \| GU/RH-II \| MGC141878 \| MGC141879 \| ZMIZ3	活化统计的蛋白质抑制剂，1	-	HPRD，Biogrid	11583632
PIAS2	MGC102682 \| MIZ1 \| PIASX \| PIASX-ALPHA \| PIASX-BETA \| SIZ2 \| ZMIZ4 \| miz	活化统计的蛋白质抑制剂2	SUMO-1与piasxbeta相互作用。	BIND	14609633
PIAS2	MGC102682 \| MIZ1 \| PIASX \| PIASX-ALPHA \| PIASX-BETA \| SIZ2 \| ZMIZ4 \| miz	活化统计的蛋白质抑制剂2	Two-hybrid	BioGRID	14609633
PML	MYL \| PP8675 \| RNF71 \| TRIM19	Promyelocytic白血病	-	HPRD	8806687\|11080164
PML	MYL \| PP8675 \| RNF71 \| TRIM19	Promyelocytic白血病	Affinity Capture-Western in vitro 体内 Two-hybrid	BioGRID	8806687\|9452416 \|11948183
PPM1J	DKFZp434P1514 \| FLJ35951 \| MGC19531 \| MGC90149 \| PP2CZ \| PP2Czeta \| PPP2CZ	protein phosphatase 1J (PP2C domain containing)	-	HPRD	12633878
RAD51	BRCC5 \| HRAD51 \| HsRad51 \| HsT16930 \| RAD51A \| RECA	RAD51同源物（RECA同源物，大肠杆菌）（S. cerevisiae）	-	HPRD，Biogrid	8812453\|9891849
RAD52	-	RAD52 homolog (S. cerevisiae)	Two-hybrid	BioGRID	8812453
RANBP2	NUP358 \| TRP1 \| TRP2	RAN binding protein 2	Reconstituted Complex	BioGRID	12192048
RANBP2	NUP358 \| TRP1 \| TRP2	RAN binding protein 2	SUMO-1与RANBP2相互作用。	BIND	15608651
RANGAP1	Fug1 \| KIAA1835 \| MGC20266 \| SD	Ran GTPase activating protein 1	-	HPRD	9019411
RANGAP1	Fug1 \| KIAA1835 \| MGC20266 \| SD	Ran GTPase activating protein 1	Rangap1与SUMO-1相互作用并共价修改。	BIND	9920803
RANGAP1	Fug1 \| KIAA1835 \| MGC20266 \| SD	Ran GTPase activating protein 1	Reconstituted Complex	BioGRID	12924945
SAE1	AOS1 \|FLJ3091 \|HSPC140 \|SUA1	SUMO1 activating enzyme subunit 1	Reconstituted Complex	BioGRID	12924945
SAE1	AOS1 \|FLJ3091 \|HSPC140 \|SUA1	SUMO1 activating enzyme subunit 1	-	HPRD	10187858
SALL1	hsal1 \|TBS \|ZNF794	类似sal的1（果蝇）	-	HPRD，Biogrid	12200128
SALL1	hsal1 \|TBS \|ZNF794	类似sal的1（果蝇）	SALL1 interacts with SUMO-1.	BIND	12200128
SENP2	AXAM2 \| DKFZp762A2316 \| KIAA1331 \| SMT3IP2	SUMO1/sentrin/SMT3 specific peptidase 2	-	HPRD	11997515
SENP2	AXAM2 \| DKFZp762A2316 \| KIAA1331 \| SMT3IP2	SUMO1/sentrin/SMT3 specific peptidase 2	Biochemical Activity	BioGRID	12192048
SENP6	FLJ11355 \| FLJ11887 \| KIAA0389 \| KIAA0797 \| SSP1 \| SUSP1	SUMO1/sentrin specific peptidase 6	-	HPRD	10799485
SLC2A1	DYT17 \| DYT18 \| GLUT \| GLUT1 \| MGC141895 \| MGC141896 \| PED	溶质载体家族2（促进葡萄糖转运蛋白），成员1	-	HPRD	10655495
Smad4	DPC4 \|jip \|madh4	SMAD family member 4	smad4被固定。	BIND	15592428
SP100	DKFZp686E07254 \| FLJ00340 \| FLJ34579	SP100核抗原	Two-hybrid	BioGRID	16189514
SREBF2	SREBP2 \| bHLHd2	固醇调节元件结合转录因子2	-	HPRD	12615929
stab2	DKFZP434E0321 \|Feel-2 \|Fele-2 \|跌倒\|FLEL-2 \|fex2 \|野兔\|Stab-2	stabilin 2	Biochemical Activity	BioGRID	14701874
SUMO1	DAP-1 \|GMP1 \|OFC10 \|pic1 \|senp2 \|SMT3 \|SMT3C \|SMT3H3 \|Sumo-1 \|UBL1	MIF的SMT3抑制器两个3同源物1（S. cerevisiae）	Two-hybrid	BioGRID	10961991\|11112409
SUMO1	DAP-1 \|GMP1 \|OFC10 \|pic1 \|senp2 \|SMT3 \|SMT3C \|SMT3H3 \|Sumo-1 \|UBL1	MIF的SMT3抑制器两个3同源物1（S. cerevisiae）	Sentrin与Sentrin互动以形成同型二聚体。	BIND	11112409
隔离	-	thymine-DNA glycosylase	-	HPRD，Biogrid	11889051
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	肿瘤坏死因子受体超家族，成员1a	Reconstituted Complex Two-hybrid	BioGRID	8906799\|10187798
TOE1	FLJ13949	target of EGR1, member 1 (nuclear)	Two-hybrid	BioGRID	16169070
TOP1	TOPI	拓扑异构酶（DNA）I	-	HPRD，Biogrid	11709553
top2a	TOP2 \| TP2A	拓扑异构酶（DNA）II alpha 170kDa	-	HPRD，Biogrid	10862613\|12832072
top2b	TOPIIB \| top2beta	拓扑异构酶（DNA）II beta 180kDa	-	HPRD，Biogrid	10862613
纹身	lun \|p53bp3 \|rp31 \|TP53BPL	topoisomerase I binding, arginine/serine-rich	-	HPRD	11842245
纹身	lun \|p53bp3 \|rp31 \|TP53BPL	topoisomerase I binding, arginine/serine-rich	Two-hybrid	BioGRID	14516784
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Two-hybrid	BioGRID	10961991
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53与SUMO-1相互作用。这种相互作用是建立在人类和SUMO-1之间的p53之间的相互作用的模型，未指定的物种。	BIND	10788439
TP73	p73	tumor protein p73	Two-hybrid	BioGRID	10961991
TTRAP	AD022 \| EAP2 \| MGC111021 \| MGC9099 \| dJ30M3.3	TRAF and TNF receptor associated protein	SUMO-1与TTRAP相互作用。	BIND	14609633
TTRAP	AD022 \| EAP2 \| MGC111021 \| MGC9099 \| dJ30M3.3	TRAF and TNF receptor associated protein	Two-hybrid	BioGRID	14609633
UBA2	arx \|FLJ13058 \|HRIHFB2115 \|SAE2	泛素样修饰剂激活酶2	SAE2和SUMO-1的未指定同工型硫酯键。这种相互作用是根据未指定物种的SAE2与来自未指定物种的SUMO-1之间的相互作用进行建模的。	BIND	15546615
UBA2	arx \|FLJ13058 \|HRIHFB2115 \|SAE2	泛素样修饰剂激活酶2	-	HPRD，Biogrid	10217437
ube2i	C358B7.1 \|P18 \|UBC9	泛素结合酶E2I（UBC9同源物，酵母）	-	HPRD，Biogrid	12924945
ube2i	C358B7.1 \|P18 \|UBC9	泛素结合酶E2I（UBC9同源物，酵母）	Ubc9 interacts with SUMO1.	BIND	15592428
ube2i	C358B7.1 \|P18 \|UBC9	泛素结合酶E2I（UBC9同源物，酵母）	hUbc9 interacts with SUMO-1.	BIND	9920803

V.途径注释

Pathway name	Pathway size	＃szgr 2.0基因	Info
Biocarta PML途径	17	12	All SZGR 2.0 genes in this pathway
Biocarta Parkin Pathway	13	8	All SZGR 2.0 genes in this pathway
PID HDAC Classii途径	34	27	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
PID RANBP2途径	11	11	All SZGR 2.0 genes in this pathway
IFNG信号的Reactome调节	14	10	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON GAMMA SIGNALING	63	48	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
Reactome免疫系统	933	616	All SZGR 2.0 genes in this pathway
免疫系统中的反应组细胞因子信号传导	270	204	All SZGR 2.0 genes in this pathway
威尔科克斯对孕酮的反应	152	90	All SZGR 2.0 genes in this pathway
casorelli急性临时细胞白血病DN	663	425	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
Choi ATL慢性与急性DN	18	10	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
tien肠益生菌24小时	557	331	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
OUELLET卵巢癌侵入性与LMP UP	117	85	All SZGR 2.0 genes in this pathway
Schlosser血清反应DN	712	443	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
考夫曼黑色素瘤复发	61	25	All SZGR 2.0 genes in this pathway
里克曼转移	344	180	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN	517	309	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN	200	112	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤亚组	30	20	All SZGR 2.0 genes in this pathway
kaab失败的心房DN	141	99	All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn	1237	837	All SZGR 2.0 genes in this pathway
江缺氧癌	83	52	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE	101	76	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
黄胚胎干细胞核心	335	193	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10	69	38	All SZGR 2.0 genes in this pathway
中村脂肪形成晚期	104	67	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
金双相情感障碍少突胶质细胞密度相关	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN	1972年	1213	All SZGR 2.0 genes in this pathway
Zwang仅通过第一egf脉冲瞬时向上	1839年	928	All SZGR 2.0 genes in this pathway

基因页：SUMO1