Gene Page:UBP1

Summary?
GeneID 7342
Symbol UBP1
Synonyms LBP-1B|LBP-1a|LBP1A|LBP1B
Description upstream binding protein 1 (LBP-1a)
Reference MIM:609784|HGNC:HGNC:12507|Ensembl:ENSG00000153560|HPRD:10291|Vega:OTTHUMG00000130749
Gene type protein-coding
Map location 3p22.3
Pascal p-value 0.002
Sherlock p-value 0.395
eGene Cerebellar Hemisphere
Cerebellum
Frontal Cortex BA9

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.006

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ATP5A1 0.94 0.93
COPS3 0.92 0.88
DRG1 0.91 0.86
PMPCB 0.91 0.87
CIAPIN1 0.91 0.88
PSMA1 0.91 0.87
FH 0.90 0.90
C1QBP 0.90 0.86
RAN 0.90 0.91
HSPA8 0.90 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.2 -0.72 -0.67
AF347015.8 -0.71 -0.66
MT-CO2 -0.71 -0.64
AF347015.26 -0.70 -0.67
MT-CYB -0.70 -0.65
AF347015.33 -0.68 -0.65
AF347015.15 -0.68 -0.64
AF347015.31 -0.68 -0.63
AF347015.18 -0.67 -0.70
AF347015.21 -0.67 -0.63

Section III. Gene Ontology annotation

Molecular function 去后m Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity TAS 8114710
GO:0003714 transcription corepressor activity TAS 8114710
GO:0016566 特定的转录抑制因子活动 TAS 8114710
Biological process 去后m Evidence Neuro keywords PubMed ID
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8114710
GO:0016481 negative regulation of transcription TAS 8114710
GO:0019079 viral genome replication TAS 8114710
Cellular component 去后m Evidence Neuro keywords PubMed ID
GO:0005634 nucleus TAS 8114710

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 116 71 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE DN 77 49 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 147 87 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING DN 45 31 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN 103 67 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
SUZUKI CTCFL TARGETS UP 12 5 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-138 1912 1919 1A,m8 hsa-miR-138brain AGCUGGUGUUGUGAAUC
miR-181 340 347 1A,m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-219 1082 1088 1A hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-34/449 171 178 1A,m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-365 360 366 m8 hsa-miR-365 UAAUGCCCCUAAAAAUCCUUAU
miR-377 52 59 1A,m8 hsa-miR-377 AUCACACAAAGGCAACUUUUGU
miR-494 103 110 1A,m8 hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU