Gene Page:USF2

Summary?
GeneID 7392
Symbol USF2
Synonyms FIP|bHLHb12
Description upstream transcription factor 2, c-fos interacting
Reference MIM:600390|HGNC:HGNC:12594|Ensembl:ENSG00000105698|HPRD:02668|Vega:OTTHUMG00000183182
Gene type protein-coding
Map location 19q13
Pascal p-value 0.122
Sherlock p-value 0.489
Fetal beta -0.229
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
USF2 chr19 35760545 G A NM_003367
NM_207291		 .
.		 silent
silent		 Schizophrenia DNM:Fromer_2014

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg14558639 19 35760677 USF2 3.13E-4 -0.317 0.04 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BIRC5 API4 | EPR-1 baculoviral IAP repeat-containing 5 Affinity Capture-MS BioGRID 17353931
BRCA1 BRCAI | BRCC1 | IRIS | PSCP | RNF53 breast cancer 1, early onset - HPRD,BioGRID 14502648
EP300 KAT3B | p300 E1A binding protein p300 - HPRD,BioGRID 10434034
FOS AP-1 | C-FOS v-fos FBJ murine osteosarcoma viral oncogene homolog - HPRD 1589769
FUS CHOP | FUS-CHOP | FUS1 | TLS | TLS/CHOP | hnRNP-P2 fusion (involved in t(12;16) in malignant liposarcoma) Affinity Capture-MS BioGRID 17353931
HSPA4L APG-1 | Osp94 heat shock 70kDa protein 4-like Affinity Capture-MS BioGRID 17353931
IGF2R CD222 | CIMPR | M6P-R | MPR1 | MPRI insulin-like growth factor 2 receptor An unspecified isoform of USF2 interacts with IGF2R promoter. BIND 12857727
MAF MGC71685 | c-MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) - HPRD,BioGRID 9070273
NPM1 B23 | MGC104254 | NPM nucleophosmin (nucleolar phosphoprotein B23, numatrin) Affinity Capture-MS BioGRID 17353931
PPARGC1A LEM6 | PGC-1(alpha) | PGC-1v | PGC1 | PGC1A | PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha - HPRD 12611894
PPRC1 KIAA0595 | MGC74642 | PRC | RP11-302K17.6 peroxisome proliferator-activated receptor gamma, coactivator-related 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 12611894
PTP4A2 HH13 | HH7-2 | HU-PP-1 | OV-1 | PRL-2 | PRL2 | PTP4A | PTPCAAX2 | ptp-IV1a | ptp-IV1b protein tyrosine phosphatase type IVA, member 2 Affinity Capture-MS BioGRID 17353931
S100A8 60B8AG | CAGA | CFAG | CGLA | CP-10 | L1Ag | MA387 | MIF | MRP8 | NIF | P8 S100 calcium binding protein A8 Affinity Capture-MS BioGRID 17353931
S100A9 60B8AG | CAGB | CFAG | CGLB | L1AG | LIAG | MAC387 | MIF | MRP14 | NIF | P14 S100 calcium binding protein A9 Affinity Capture-MS BioGRID 17353931
SERPINB3 HsT1196 | SCC | SCCA-1 | SCCA-PD | SCCA1 | T4-A serpin peptidase inhibitor, clade B (ovalbumin), member 3 Affinity Capture-MS BioGRID 17353931
SERPINB4 LEUPIN | PI11 | SCCA-2 | SCCA1 | SCCA2 serpin peptidase inhibitor, clade B (ovalbumin), member 4 Affinity Capture-MS BioGRID 17353931
USF1 FCHL | FCHL1 | HYPLIP1 | MLTF | MLTFI | UEF | bHLHb11 upstream transcription factor 1 - HPRD 8576131|9053857
USF1 FCHL | FCHL1 | HYPLIP1 | MLTF | MLTFI | UEF | bHLHb11 upstream transcription factor 1 Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		 BioGRID 8576131|17353931
USF2 FIP | bHLHb12 upstream transcription factor 2, c-fos interacting - HPRD 8576131|9070273
USF2 FIP | bHLHb12 upstream transcription factor 2, c-fos interacting Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		 BioGRID 8576131|17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID FRA PATHWAY 37 28 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS UP 33 20 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA 164 118 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 142 93 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203 130 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP 87 67 All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP 81 52 All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION DN 54 30 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
MOREIRA RESPONSE TO TSA UP 28 23 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN 50 36 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 69 48 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317 190 All SZGR 2.0 genes in this pathway
CHANGOLKAR H2AFY TARGETS DN 40 26 All SZGR 2.0 genes in this pathway