Gene Page:UTRN

概括?
基因 7402
象征 UTRN
Synonyms DMDL | DRP | DRP1
Description utrophin
Reference MIM:128240|HGNC:HGNC:12635|ENSEMBL：ENSG00000152818|HPRD:00547|Vega:OTTHUMG00000015746
Gene type protein-coding
Map location 6q24
Pascal p-value 0.282
Fetal beta -0.172
eGene Myers' cis & trans
Support COMPOSITESET

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM：Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance患有精神分裂症keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1
Network 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 0.0156

第一节遗传学和表观遗传学注释

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type 筛 CG46 Trait Study
UTRN chr6 145073047 C T NM_007124 p.2772R>C 错过 精神分裂症 DNM：Fromer_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
RS7738467 chr6 145457783 UTRN 7402 0.15 cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003779 actin binding IEA -
GO:0005509 钙离子结合 IEA -
GO:0005515 protein binding 新闻学会 8576247
GO:0005198 structural molecule activity IEA -
GO:0008270 zinc ion binding IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0007517 muscle development TAS 9288751
GO:0006936 muscle contraction TAS 9288751
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0005856 cytoskeleton TAS 8977119
GO:0005624 membrane fraction TAS 1426262
GO:0005737 细胞质 IEA -
GO:0005886 plasma membrane TAS 8977119
GO:0030054 细胞连接 IEA -

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA AGR PATHWAY 36 31 该途径中的所有SZGR 2.0基因
THUM SYSTOLIC HEART FAILURE UP 423 283 该途径中的所有SZGR 2.0基因
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN 50 36 该途径中的所有SZGR 2.0基因
RODRIGUES DCC TARGETS DN 121 84 该途径中的所有SZGR 2.0基因
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE DN 54 38 该途径中的所有SZGR 2.0基因
SENESE HDAC1 TARGETS DN 260 143 该途径中的所有SZGR 2.0基因
SENESE HDAC3 TARGETS DN 536 332 该途径中的所有SZGR 2.0基因
GOZGIT ESR1 TARGETS DN 781 465 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE EPIDERMIS DN 508 354 该途径中的所有SZGR 2.0基因
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153 100 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 该途径中的所有SZGR 2.0基因
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 该途径中的所有SZGR 2.0基因
MCBRYAN PUBERTAL BREAST 6 7WK DN 79 54 该途径中的所有SZGR 2.0基因
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 该途径中的所有SZGR 2.0基因
PAX3 FOXO1融合的Ebauer目标 207 128 该途径中的所有SZGR 2.0基因
EBAUER MYOGENIC TARGETS OF PAX3 FOXO1 FUSION 50 26 该途径中的所有SZGR 2.0基因
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 该途径中的所有SZGR 2.0基因
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 该途径中的所有SZGR 2.0基因
LE EGR2 TARGETS DN 108 84 该途径中的所有SZGR 2.0基因
伊万诺娃造血干细胞长期 302 191 该途径中的所有SZGR 2.0基因
Lian Lipa目标6m 74 47 该途径中的所有SZGR 2.0基因
CHUANG OXIDATIVE STRESS RESPONSE DN 11 9 该途径中的所有SZGR 2.0基因
LIAN LIPA TARGETS 3M 59 36 该途径中的所有SZGR 2.0基因
GENTILE UV LOW DOSE DN 67 46 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 该途径中的所有SZGR 2.0基因
DURCHDEWALD SKIN CARCINOGENESIS DN 264 168 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性5 482 296 该途径中的所有SZGR 2.0基因
ZHENG BOUND BY FOXP3 491 310 该途径中的所有SZGR 2.0基因
Zheng Foxp3 t淋巴细胞DN中的靶标 37 29 该途径中的所有SZGR 2.0基因
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 该途径中的所有SZGR 2.0基因
CCND1和CDK4的Molenaar靶标 67 48 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 该途径中的所有SZGR 2.0基因
CAIRO HEPATOBLASTOMA UP 207 143 该途径中的所有SZGR 2.0基因
CHICAS RB1 TARGETS CONFLUENT 567 365 该途径中的所有SZGR 2.0基因
Dutertre雌二醇反应6小时DN 91 56 该途径中的所有SZGR 2.0基因
GABRIELY MIR21 TARGETS 289 187 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 1600 1607 1A,m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain agagguaguagguugcauagu
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-1/206 400 406 m8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
HSA-MIR-206SZ Uggaauguaaggaagugugugg
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-142-3p 1863 1870 1A,m8 hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA
miR-153 223 230 1A,m8 hsa-miR-153 Uugcauagucacaaaaguga
miR-381 286 292 1A hsa-miR-381 uauacaagggcaagcucucugu
miR-410 1569年 1575 1A hsa-miR-410 aauauaacacagauggcugu
miR-448 224 230 1A HSA-MIR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-9 160 166 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA