Gene Page:VEGFB

Summary?
GeneID 7423
Symbol VEGFB
Synonyms VEGFL|VRF
Description vascular endothelial growth factor B
Reference MIM:601398|HGNC:HGNC:12681|HPRD:03237|
Gene type protein-coding
Map location 11q13
Pascal p-value 0.013
Fetal beta -0.57
DMG 1 (# studies)
eGene Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg05492845 11 64002298 VEGFB 6.11E-6 -0.275 0.011 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1027497 chr4 125640906 VEGFB 7423 0.1 trans
rs17008527 chr4 125656445 VEGFB 7423 0.1 trans
rs6879593 chr5 75253310 VEGFB 7423 0.03 trans
rs11142564 chr9 73365108 VEGFB 7423 0.11 trans
rs16940174 chr15 58686337 VEGFB 7423 0.18 trans
rs5979195 chrX 9835238 VEGFB 7423 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),圣2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TPP1 0.86 0.86
ABHD15 0.84 0.83
TPCN1 0.81 0.82
HEPACAM 0.81 0.77
IL17D 0.81 0.80
LRP10 0.81 0.82
RETSAT 0.81 0.82
NACC2 0.80 0.85
MOCS1 0.80 0.82
TIMP3 0.80 0.84
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FRG1 -0.54 -0.62
C11orf57 -0.49 -0.58
POLB -0.48 -0.54
CYP2R1 -0.48 -0.55
AC026786.2 -0.48 -0.54
NDUFAF2 -0.48 -0.59
EXOSC8 -0.47 -0.56
STMN1 -0.47 -0.46
MED19 -0.46 -0.49
RBMX2 -0.46 -0.51

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
KEGG MTOR SIGNALING PATHWAY 52 40 All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 70 60 All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 70 56 All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER 42 33 All SZGR 2.0 genes in this pathway
PID VEGF VEGFR PATHWAY 10 6 All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY 26 23 All SZGR 2.0 genes in this pathway
REACTOME VEGF LIGAND RECEPTOR INTERACTIONS 10 6 All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 89 56 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 133 78 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
AGARWAL AKT PATHWAY TARGETS 10 9 All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS 29 20 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE DN 64 45 All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE UP 38 23 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS UP 49 40 All SZGR 2.0 genes in this pathway
LEIN MEDULLA MARKERS 81 48 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242 168 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 138 92 All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP 71 49 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D DN 49 34 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP 70 49 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178 108 All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 105 75 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL IL3RA 9 6 All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING UP 59 44 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
KANG AR TARGETS DN 19 12 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP 140 94 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321 200 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway