SZGR2 - Beplay体育中心

Summary?

基因	7428
Symbol	VHL
同义词	HRCA1\|RCA1\|VHL1\|pVHL
描述	von Hippel-Lindau肿瘤抑制剂
参考	MIM：608537\|HGNC:HGNC:12687\|HPRD：01905\|
基因type	protein-coding
地图位置	3P25.3
Pascal P值	0.169
Sherlock P值	0.878
Fetal beta	1.691
eGene	迈尔斯的顺式和反式元

基因in Data Sources

基因set name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS
PMID:cooccur	高通量文献搜索	系统搜索PubMed的基因co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	高通量文献搜索	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
网络	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.1204

Section I. Genetics and epigenetics annotation

EQTL注释

SNP ID	Chromosome	Position	eGene	基因Entrez ID	PVALUE	qvalue	TSS distance	eQTL type
RS10497672		0	VHL	7428		0.17		trans
RS11230726	Chr11	61275103	VHL	7428		0.13		trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
AC009041.1	0.70	0.53
TRIM17	0.69	0.79
AC009041.3	0.66	0.50
CORT	0.65	0.73
NPAS2	0.65	0.73
TTC22	0.65	0.69
TNK1	0.64	0.24
ANKRD55	0.63	0.77
FHOD1	0.63	0.54
APITD1	0.63	0.73

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
HEBP2	-0.36	-0.61
CSRP2	-0.32	-0.48
METRNL	-0.31	-0.47
COTL1	-0.31	-0.25
SNX7	-0.31	-0.26
RNF182	-0.31	-0.37
CBS	-0.30	-0.32
NEUROD6	-0.30	-0.17
SLA	-0.30	-0.11
klhl1	-0.30	-0.10

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
去：0008134	transcription factor binding	助教		7660122
生物过程	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	助教		7660122
GO:0000902	cell morphogenesis	NAS		12169691
去：0001525	angiogenesis	IEA		-
GO:0006508	蛋白水解	助教		10353251
GO:0006511	泛素依赖性蛋白质分解代谢过程	IEA		-
GO:0006950	response to stress	NAS		12169691
去：0008285	细胞增殖的阴性调节	助教		7660130
GO:0006916	anti-apoptosis	NAS		12169691
GO:0016567	蛋白质泛素化	IMP		12169691
GO:0050821	蛋白质稳定	NAS		12169691
去：0030163	蛋白质分解代谢过程	IEA		-
去：0030198	细胞外基质组织	IEA		-
GO：0045786	negative regulation of cell cycle	IEA		-
GO:0043534	blood vessel endothelial cell migration	IEA		-
GO:0045597	positive regulation of cell differentiation	NAS		12169691
GO:0045449	regulation of transcription	IMP		15824735
细胞分量	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	助教		7604013
GO:0005634	核	助教		7604013
GO:0005737	cytoplasm	IEA		-
GO:0005739	线粒体	NAS		12169691
GO:0005783	endoplasmic reticulum	NAS		12169691
去：0016020	膜	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
aprt	amp \|DKFZP686D13177 \|MGC125856 \|MGC125857 \|MGC129961	腺嘌呤磷脂基转移酶	Affinity Capture-MS	BioGRID	17353931
ATXN2	atx2 \|FLJ46772 \|sca2 \|TNRC13	ataxin 2	Affinity Capture-MS	BioGRID	17353931
CAB39	CGI-66 \| FLJ22682 \| MO25	钙结合蛋白39	Affinity Capture-MS	BioGRID	17353931
CCDC59	BR22 \|DKFZP686K1021 \|FLJ10294 \|HSPC128 \|TAP26	coiled-coil domain containing 59	Affinity Capture-MS	BioGRID	17353931
CCDC82	FLJ23518 \|HSPC048	包含82	Affinity Capture-MS	BioGRID	17353931
CDK2	p33（CDK2）	细胞周期蛋白依赖性激酶2	Affinity Capture-MS	BioGRID	17353931
CDO1	-	半胱氨酸二氧酶，I型	Affinity Capture-MS	BioGRID	17353931
CHMP2B	chmp2.5 \|DKFZP564O123 \|DMT1 \|VPS2-2 \|VPS2B	chromatin modifying protein 2B	Affinity Capture-MS	BioGRID	17353931
据	HCNTF	ciliary neurotrophic factor	Affinity Capture-MS	BioGRID	17353931
CSTB	CST6 \|EPM1 \|PME \|STFB	cystatin B (stefin B)	Affinity Capture-MS	BioGRID	17353931
CSTF3	CSTF-77 \|MGC117398 \|MGC43001 \|MGC75122	切割刺激因子，3'Pre-RNA，亚基3，77KDA	Affinity Capture-MS	BioGRID	17353931
CUL2	MGC131970	cullin 2	Affinity Capture-MS Affinity Capture-Western Reconstituted Complex	BioGRID	10587522\|11384984 \|17353931
CUL5	VACM-1 \| VACM1	cullin 5	Reconstituted Complex	BioGRID	11384984
EPAS1	ecyt4 \|hif2a \|HLF \|mop2 \|PASD2	内皮PAS域蛋白1	The von Hippel-Lindau tumor suppressor protein (pVHL) interacts with Hypoxia inducible factor-2-alpha (HIF-2 alpha)	BIND	10823831
FLNA	ABP-280 \|ABPX \|DKFZP434P031 \|fln \|fln1 \|FMD \|MNS \|NHBP \|OPD \|OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	The von Hippel-Lindau tumor suppressor protein (pVHL) interacts with FLNA .	BIND	12169691
FLNA	ABP-280 \|ABPX \|DKFZP434P031 \|fln \|fln1 \|FMD \|MNS \|NHBP \|OPD \|OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD，Biogrid	8674032\|12169691
FN1	CIG \|DKFZP686F10164 \|DKFZP686H0342 \|DKFZP686I1370 \|DKFZP686O13149 \|ed-b \|Finc \|fn \|fnz \|gfnd \| GFND2 \| LETS \| MSF	fibronectin 1	pVHL交互with fibronectin 1	BIND	10823831
FN1	CIG \|DKFZP686F10164 \|DKFZP686H0342 \|DKFZP686I1370 \|DKFZP686O13149 \|ed-b \|Finc \|fn \|fnz \|gfnd \| GFND2 \| LETS \| MSF	fibronectin 1	-	HPRD，Biogrid	9651579
FSCN1	FLJ38511 \| SNL \| p55	FASTIN同源物1，肌动蛋白捆绑蛋白（purvuratus strongylocentrotus）	Affinity Capture-MS	BioGRID	17353931
有1	有	透明质酸合酶1	Affinity Capture-MS	BioGRID	17353931
HDAC1	DKFZP686H12203 \|gon-10 \|HD1 \|RPD3 \|RPD3L1	组蛋白脱乙酰基酶1	Reconstituted Complex	BioGRID	11641274
HDAC2	RPD3 \|YAF1	组蛋白脱乙酰基酶2	Reconstituted Complex	BioGRID	11641274
HDAC3	HD3 \| RPD3 \| RPD3-2	组蛋白脱乙酰基酶3	Reconstituted Complex	BioGRID	11641274
HIF1A	HIF-1Alpha \|HIF1 \|hif1-alpha \|mop1 \|PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Hydroxylated HIF-1 alpha interacts with VHL. This interaction was modeled on a demonstrated interaction between human hydroxylated HIF-1 alpha and an unspecified isoform of VHL from an unspecified species.	BIND	15721254
HIF1A	HIF-1Alpha \|HIF1 \|hif1-alpha \|mop1 \|PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	The von Hippel-Lindau tumor suppressor protein (pVHL) interacts with Hypoxia inducible factor-alpha (HIF-1 alpha)	BIND	10823831
HIF1A	HIF-1Alpha \|HIF1 \|hif1-alpha \|mop1 \|PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	-	HPRD	11504942
HIF1A	HIF-1Alpha \|HIF1 \|hif1-alpha \|mop1 \|PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	HIF1A (HIF-1alpha) interacts with VHL.	BIND	15750626
HIF1A	HIF-1Alpha \|HIF1 \|hif1-alpha \|mop1 \|PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	-	HPRD，Biogrid	10944113
HIF1AN	DKFZP762F1811 \|fih1 \|FLJ20615 \|FLJ22027	低氧诱导因子1，α亚基抑制剂	Reconstituted Complex	BioGRID	11641274
HIF3A	HIF-3A \|HIF-3A2 \|HIF-3A4 \|IPA \|MOP7 \|Pasd7 \|Bhlhe17	hypoxia inducible factor 3, alpha subunit	-	HPRD	12538644
Hist1H2BC	H2B.1 \|H2B/L \|H2BFL \|MGC104246 \|DJ221C16.3	histone cluster 1, H2bc	Affinity Capture-MS	BioGRID	17353931
HNRNPA2B1	DKFZP779B0244 \|FLJ22720 \|hnrnpa2 \|HNRNPB1 \|HNRPA2 \|HNRPA2B1 \|HNRPB1 \|RNPA2 \|SNRPB1	异质核核糖核蛋白A2/B1	-	HPRD，Biogrid	11517223
IARS	FLJ20736 \| IARS1 \| ILRS \| PRO0785	isoleucyl-tRNA synthetase	Affinity Capture-MS	BioGRID	17353931
impdh2	impd2 \|impdh-ii	IMP（肌苷一磷酸）脱氢酶2	Affinity Capture-MS	BioGRID	17353931
JMJD1C	DKFZP761F0118 \|FLJ14374 \|KIAA1380 \|RP11-10C13.2 \|Trip8	jumonji domain containing 1C	Affinity Capture-MS	BioGRID	17353931
KNTC1	FLJ36151 \| KIAA0166 \| ROD	动力学相关1	Affinity Capture-MS	BioGRID	17353931
MCC	DKFZP762O1615 \|FLJ38893 \|FLJ46755 \|MCC1	mutated in colorectal cancers	Affinity Capture-MS	BioGRID	17353931
MOBKL3	2C4D \| CGI-95 \| MGC12264 \| MOB1 \| MOB3 \| PREI3	MOB1，MPS一个粘合激酶激活剂样3（酵母）	Affinity Capture-MS	BioGRID	17353931
MRCL3	MLCB \|MRLC3	myosin regulatory light chain MRCL3	Affinity Capture-MS	BioGRID	17353931
nedd8	FLJ43224 \|MGC104393 \|MGC125896 \|MGC125897 \|NEDD-8	neural precursor cell expressed, developmentally down-regulated 8	Affinity Capture-MS	BioGRID	17353931
PAPSS2	atpsk2 \|SK2	3'-磷酸腺苷5'-磷脂合酶2	Affinity Capture-MS	BioGRID	17353931
PCMT1	-	蛋白质-L-异天冬氨酸（D-天冬氨酸）O-甲基转移酶	Affinity Capture-MS	BioGRID	17353931
PFAS	FGAMS \| FGARAT \| KIAA0361 \| PURL	phosphoribosylformylglycinamidine synthase	Affinity Capture-MS	BioGRID	17353931
PHF17	FLJ22479 \| JADE1 \| KIAA1807	PhD手指蛋白17	The von Hippel-Lindau tumor suppressor protein (pVHL) interacts with Jade-1	BIND	12169691
PHF17	FLJ22479 \| JADE1 \| KIAA1807	PhD手指蛋白17	-	HPRD，Biogrid	12169691
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Affinity Capture-MS	BioGRID	17353931
PKD1L3	-	多囊肾脏疾病1类样3	Affinity Capture-MS	BioGRID	17353931
PPIB	CYP-S1 \|CYPB \|MGC14109 \|MGC2224 \|scylp	peptidylprolyl isomerase B (cyclophilin B)	Affinity Capture-MS	BioGRID	17353931
PSMB1	FLJ25321 \|HC5 \|KIAA1838 \|PMSB1 \|PSC5	proteasome (prosome, macropain) subunit, beta type, 1	Affinity Capture-MS	BioGRID	17353931
PSMB3	HC10-II \| MGC4147	proteasome (prosome, macropain) subunit, beta type, 3	Affinity Capture-MS	BioGRID	17353931
PSMC3	MGC8487 \| TBP1	蛋白酶体（Prosome，大蛋白）26S亚基，ATPase，3	-	HPRD，Biogrid	14556007
PSMD13	HSPC027 \| Rpn9 \| S11 \| p40.5	蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，13	Affinity Capture-MS	BioGRID	17353931
RAB1B	-	RAB1B, member RAS oncogene family	Affinity Capture-MS	BioGRID	17353931
rasgrp1	CALDAG-GEFI \| CALDAG-GEFII \| MGC129998 \| MGC129999 \| RASGRP \| V \| hRasGRP1	Ras鸟甘释放蛋白1（钙和DAG调节）	Affinity Capture-MS	BioGRID	17353931
RBX1	BA554C12.1 \| MGC13357 \| MGC1481 \| RNF75 \| ROC1	ring-box 1	Affinity Capture-MS	BioGRID	17353931
Rhoc	arh9 \|ARHC \|H9 \|MGC1448 \|MGC61427 \|RHOH9	RAS同源基因家族，成员C	Affinity Capture-MS	BioGRID	17353931
RNF139	HRCA1 \| MGC31961 \| RCA1 \| TRC8	ring finger protein 139	-	HPRD	12032852
RPA3	repa3	replication protein A3, 14kDa	Affinity Capture-MS	BioGRID	17353931
RPS9	-	核糖体蛋白S9	Affinity Capture-MS	BioGRID	17353931
STK16	FLJ39635 \| KRCT \| MPSK \| PKL12 \| TSF1	serine/threonine kinase 16	Affinity Capture-MS	BioGRID	17353931
tagln2	HA1756 \| KIAA0120	transgelin 2	Affinity Capture-MS	BioGRID	17353931
TARS	MGC9344 \| ThrRS	Threonyl-tRNA合成酶	Affinity Capture-MS	BioGRID	17353931
TCEB1	SIII	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	Affinity Capture-MS Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	8674032\|10587522 \|11739384\|12004076 \|17353931
TCEB1	SIII	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	-	HPRD	7660130\|10449727 \|12004076
TCEB2	ELOB \| SIII	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	Affinity Capture-MS Affinity Capture-Western Co-crystal Structure Reconstituted Complex	BioGRID	10587522\|12004076 \|17353931
TGFB1I1	ARA55 \|HIC-5 \|Hic5 \|TSC-5	transforming growth factor beta 1 induced transcript 1	Affinity Capture-MS	BioGRID	17353931
TPT1	FLJ27337 \|HRF \|TCTP \|P02	tumor protein, translationally-controlled 1	Affinity Capture-MS	BioGRID	17353931
Trim28	FLJ29029 \|kap1 \|RNF96 \|TF1B \|tif1b	tripartite motif-containing 28	Reconstituted Complex	BioGRID	12682018
TXN	DKFZp686B1993 \| MGC61975 \| TRX \| TRX1	thioredoxin	Affinity Capture-MS	BioGRID	17353931
USP33	KIAA1097 \| MGC16868 \| VDU1	泛素特异性肽酶33	pVHL交互with VDU1-type II.	BIND	11739384
USP33	KIAA1097 \| MGC16868 \| VDU1	泛素特异性肽酶33	-	HPRD，Biogrid	11739384
VBP1	PFD3 \|pfdn3 \|VBP-1	von Hippel-Lindau binding protein 1	Affinity Capture-Western Two-hybrid	BioGRID	8674032\|12169691
VBP1	PFD3 \|pfdn3 \|VBP-1	von Hippel-Lindau binding protein 1	The von Hippel-Lindau tumor suppressor protein (pVHL) interacts with VBP1.	BIND	12169691
ZNF197	D3S1363E \|P18 \|Vhlak \|ZKSCAN9 \|Znf166 \|ZNF20	锌指蛋白197	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12682018

Section V. Pathway annotation

Pathway name	Pathway size	＃szgr 2.0基因	Info
KEGG泛素介导的蛋白水解	138	98	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA	70	60	All SZGR 2.0 genes in this pathway
BIOCARTA HIF PATHWAY	15	12	All SZGR 2.0 genes in this pathway
BIOCARTA VEGF PATHWAY	29	18	All SZGR 2.0 genes in this pathway
PID HIF2PATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID HIF1A PATHWAY	19	12	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	25	17	All SZGR 2.0 genes in this pathway
反应组氧依赖性脯氨酸羟基诱导因子α的羟基化	18	12	All SZGR 2.0 genes in this pathway
Reactome免疫系统	933	616	All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统	539	350	All SZGR 2.0 genes in this pathway
Reactome I类MHC介导的抗原加工表现	251	156	All SZGR 2.0 genes in this pathway
Reactome抗原加工泛素化蛋白酶体降解	212	129	All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS UP	31	23	All SZGR 2.0 genes in this pathway
Darwiche皮肤肿瘤启动子DN	185	115	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN	165	107	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP	147	101	All SZGR 2.0 genes in this pathway
darwiche鳞状细胞癌	146	104	All SZGR 2.0 genes in this pathway
lastowska神经母细胞瘤副本编号dn	800	473	All SZGR 2.0 genes in this pathway
Rashi对电离辐射5的响应5	147	89	All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP	81	57	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH VS LOW UP	6	6	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN	110	78	All SZGR 2.0 genes in this pathway
通过ELK3和HIF1A的总缺氧	142	104	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
里克曼转移	344	180	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
DORSAM HOXA9靶向DN	32	22	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS DN	31	25	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
QI HYPOXIA	140	96	All SZGR 2.0 genes in this pathway

基因页：VHL