Gene Page:WEE1
Summary?
| GeneID | 7465 |
| Symbol | WEE1 |
| Synonyms | WEE1A|WEE1hu |
| Description | WEE1 G2 checkpoint kinase |
| Reference | MIM:193525|HGNC:HGNC:12761|Ensembl:ENSG00000166483|HPRD:01907|Vega:OTTHUMG00000165863 |
| Gene type | protein-coding |
| Map location | 11p15.4 |
| Pascal p-value | 0.916 |
| Fetal beta | 3.654 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | 系统的海rch in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Expression | Meta-analysis of gene expression | Pvalue: 1.388 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FKBP15 | 0.90 | 0.90 |
| KIAA0562 | 0.87 | 0.88 |
| BMS1 | 0.87 | 0.86 |
| FUBP3 | 0.87 | 0.85 |
| SUPT6H | 0.86 | 0.86 |
| SPAG9 | 0.85 | 0.86 |
| USP36 | 0.85 | 0.88 |
| RFC1 | 0.84 | 0.84 |
| TXLNA | 0.84 | 0.85 |
| CTTN | 0.84 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.68 | -0.69 |
| C1orf54 | -0.66 | -0.67 |
| AF347015.31 | -0.66 | -0.64 |
| MT-CO2 | -0.63 | -0.62 |
| IFI27 | -0.63 | -0.60 |
| CLEC2B | -0.62 | -0.66 |
| HIGD1B | -0.61 | -0.61 |
| CXCL14 | -0.61 | -0.59 |
| ENHO | -0.61 | -0.60 |
| VAMP5 | -0.60 | -0.59 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0000287 | magnesium ion binding | IEA | - | |
| GO:0005515 | protein binding | 新闻学会 | 15070733 | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0004674 | protein serine/threonine kinase activity | IEA | - | |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IEA | - | |
| GO:0016740 | transferase activity | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0006468 | protein amino acid phosphorylation | IEA | - | |
| GO:0007049 | cell cycle | IEA | - | |
| GO:0007067 | mitosis | IEA | - | |
| GO:0051301 | cell division | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | TAS | 8348613 | |
| GO:0005654 | nucleoplasm | EXP | 1384126|1396589 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BTRC | BETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCP | beta-transducin repeat containing | Wee1A interacts with an unspecified isoform of beta-TrCP1. | BIND | 15070733 |
| CDC2 | CDC28A | CDK1 | DKFZp686L20222 | MGC111195 | cell division cycle 2, G1 to S and G2 to M | WEE1 phosphorylates CDC2. | BIND | 15735702 |
| CDCA3 | GRCC8 | MGC2577 | TOME-1 | cell division cycle associated 3 | - | HPRD,BioGRID | 12679038 |
| CRK | CRKII | v-crk sarcoma virus CT10 oncogene homolog (avian) | - | HPRD,BioGRID | 11839808 |
| FBXW11 | BTRC2 | BTRCP2 | FBW1B | FBXW1B | Fbw11 | Hos | KIAA0696 | F-box and WD repeat domain containing 11 | Wee1A interacts with an unspecified isoform of beta-TrCP2. | BIND | 15070733 |
| KLF2 | LKLF | Kruppel-like factor 2 (lung) | KLF2 SP1 / CPBP图案的交互the WEE1 promoter. | BIND | 15735666 |
| PIN1 | DOD | UBL5 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Affinity Capture-Western Far Western |
BioGRID | 9499405 |
| PLK1 | PLK | STPK13 | polo-like kinase 1 (Drosophila) | Wee1A interacts with and is phophorylated by Plk1. This interaction was modeled on a demonstrated interaction between human Wee1A and mouse Plk1. | BIND | 15070733 |
| SFN | YWHAS | stratifin | Affinity Capture-MS | BioGRID | 15778465 |
| SKP2 | FBL1 | FBXL1 | FLB1 | MGC1366 | S-phase kinase-associated protein 2 (p45) | Wee1A interacts with an unspecified isoform of SKP2. | BIND | 15070733 |
| YWHAB | GW128 | HS1 | KCIP-1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | - | HPRD,BioGRID | 10775038 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CELL CYCLE | 128 | 84 | 所有SZGR 2.0基因this pathway |
| BIOCARTA G2 PATHWAY | 24 | 20 | 所有SZGR 2.0基因this pathway |
| BIOCARTA RB PATHWAY | 13 | 11 | 所有SZGR 2.0基因this pathway |
| SA G2 AND M PHASES | 8 | 7 | 所有SZGR 2.0基因this pathway |
| PID PLK1 PATHWAY | 46 | 25 | 所有SZGR 2.0基因this pathway |
| REACTOME CELL CYCLE | 421 | 253 | 所有SZGR 2.0基因this pathway |
| REACTOME CELL CYCLE MITOTIC | 325 | 185 | 所有SZGR 2.0基因this pathway |
| REACTOME CELL CYCLE CHECKPOINTS | 124 | 70 | 所有SZGR 2.0基因this pathway |
| REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | 65 | 40 | 所有SZGR 2.0基因this pathway |
| REACTOME G1 S TRANSITION | 112 | 63 | 所有SZGR 2.0基因this pathway |
| REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | 15 | 8 | 所有SZGR 2.0基因this pathway |
| REACTOME MITOTIC G1 G1 S PHASES | 137 | 79 | 所有SZGR 2.0基因this pathway |
| REACTOME MITOTIC G2 G2 M PHASES | 81 | 50 | 所有SZGR 2.0基因this pathway |
| REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | 132 | 101 | 所有SZGR 2.0基因this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | 所有SZGR 2.0基因this pathway |
| REACTOME G2 M CHECKPOINTS | 45 | 23 | 所有SZGR 2.0基因this pathway |
| REACTOME G2 M DNA DAMAGE CHECKPOINT | 12 | 8 | 所有SZGR 2.0基因this pathway |
| REACTOME S PHASE | 109 | 66 | 所有SZGR 2.0基因this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | 所有SZGR 2.0基因this pathway |
| BORCZUK MALIGNANT MESOTHELIOMA UP | 305 | 185 | 所有SZGR 2.0基因this pathway |
| WANG LMO4 TARGETS UP | 372 | 227 | 所有SZGR 2.0基因this pathway |
| SLEBOS HEAD AND NECK CANCER WITH HPV UP | 84 | 43 | 所有SZGR 2.0基因this pathway |
| SENESE HDAC3 TARGETS UP | 501 | 327 | 所有SZGR 2.0基因this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | 所有SZGR 2.0基因this pathway |
| NAGASHIMA NRG1 SIGNALING UP | 176 | 123 | 所有SZGR 2.0基因this pathway |
| COLDREN GEFITINIB RESISTANCE DN | 230 | 115 | 所有SZGR 2.0基因this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 48HR UP | 128 | 95 | 所有SZGR 2.0基因this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 96HR UP | 117 | 84 | 所有SZGR 2.0基因this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | 所有SZGR 2.0基因this pathway |
| LANDIS ERBB2 BREAST TUMORS 324 UP | 150 | 93 | 所有SZGR 2.0基因this pathway |
| MCBRYAN PUBERTAL BREAST 4 5WK DN | 196 | 131 | 所有SZGR 2.0基因this pathway |
| MCBRYAN PUBERTAL BREAST 5 6WK UP | 116 | 68 | 所有SZGR 2.0基因this pathway |
| MCBRYAN PUBERTAL TGFB1 TARGETS UP | 169 | 127 | 所有SZGR 2.0基因this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | 所有SZGR 2.0基因this pathway |
| NEBEN AML WITH FLT3 OR NRAS DN | 12 | 6 | 所有SZGR 2.0基因this pathway |
| MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | 所有SZGR 2.0基因this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM6 | 46 | 32 | 所有SZGR 2.0基因this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 所有SZGR 2.0基因this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | 所有SZGR 2.0基因this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | 所有SZGR 2.0基因this pathway |
| BENPORATH NANOG TARGETS | 988 | 594 | 所有SZGR 2.0基因this pathway |
| BENPORATH OCT4 TARGETS | 290 | 172 | 所有SZGR 2.0基因this pathway |
| BENPORATH MYC TARGETS WITH EBOX | 230 | 156 | 所有SZGR 2.0基因this pathway |
| AMIT SERUM RESPONSE 40 MCF10A | 32 | 21 | 所有SZGR 2.0基因this pathway |
| GOTTWEIN TARGETS OF KSHV MIR K12 11 | 63 | 45 | 所有SZGR 2.0基因this pathway |
| MAGRANGEAS MULTIPLE MYELOMA IGG VS IGA UP | 22 | 12 | 所有SZGR 2.0基因this pathway |
| PENG GLUCOSE DEPRIVATION DN | 169 | 112 | 所有SZGR 2.0基因this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | 546 | 351 | 所有SZGR 2.0基因this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP | 555 | 346 | 所有SZGR 2.0基因this pathway |
| HESS TARGETS OF HOXA9 AND MEIS1 UP | 65 | 44 | 所有SZGR 2.0基因this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | 所有SZGR 2.0基因this pathway |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | 所有SZGR 2.0基因this pathway |
| DAZARD RESPONSE TO UV SCC DN | 123 | 86 | 所有SZGR 2.0基因this pathway |
| ZHU CMV 8 HR DN | 53 | 40 | 所有SZGR 2.0基因this pathway |
| ZHU CMV 24 HR DN | 91 | 64 | 所有SZGR 2.0基因this pathway |
| GENTILE UV HIGH DOSE DN | 312 | 203 | 所有SZGR 2.0基因this pathway |
| BURTON ADIPOGENESIS PEAK AT 2HR | 51 | 36 | 所有SZGR 2.0基因this pathway |
| ZHU CMV ALL DN | 128 | 93 | 所有SZGR 2.0基因this pathway |
| BURTON ADIPOGENESIS 1 | 33 | 24 | 所有SZGR 2.0基因this pathway |
| GENTILE UV RESPONSE CLUSTER D1 | 18 | 13 | 所有SZGR 2.0基因this pathway |
| DAZARD RESPONSE TO UV NHEK DN | 318 | 220 | 所有SZGR 2.0基因this pathway |
| BROWNE HCMV INFECTION 6HR DN | 160 | 101 | 所有SZGR 2.0基因this pathway |
| MARTINEZ RESPONSE TO TRABECTEDIN DN | 271 | 175 | 所有SZGR 2.0基因this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | 所有SZGR 2.0基因this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | 所有SZGR 2.0基因this pathway |
| AMUNDSON GAMMA RADIATION RESPONSE | 40 | 25 | 所有SZGR 2.0基因this pathway |
| MARTINEZ RB1 TARGETS UP | 673 | 430 | 所有SZGR 2.0基因this pathway |
| MARTINEZ TP53 TARGETS UP | 602 | 364 | 所有SZGR 2.0基因this pathway |
| MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | 所有SZGR 2.0基因this pathway |
| MITSIADES RESPONSE TO APLIDIN DN | 249 | 165 | 所有SZGR 2.0基因this pathway |
| TOYOTA TARGETS OF MIR34B AND MIR34C | 463 | 262 | 所有SZGR 2.0基因this pathway |
| ZHANG BREAST CANCER PROGENITORS UP | 425 | 253 | 所有SZGR 2.0基因this pathway |
| BONCI TARGETS OF MIR15A AND MIR16 1 | 91 | 75 | 所有SZGR 2.0基因this pathway |
| ALONSO METASTASIS UP | 198 | 128 | 所有SZGR 2.0基因this pathway |
| MUELLER PLURINET | 299 | 189 | 所有SZGR 2.0基因this pathway |
| JIANG TIP30 TARGETS UP | 46 | 28 | 所有SZGR 2.0基因this pathway |
| FRASOR RESPONSE TO SERM OR FULVESTRANT DN | 50 | 29 | 所有SZGR 2.0基因this pathway |
| GOLDRATH ANTIGEN RESPONSE | 346 | 192 | 所有SZGR 2.0基因this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | 所有SZGR 2.0基因this pathway |
| ZHANG TLX TARGETS 60HR DN | 277 | 166 | 所有SZGR 2.0基因this pathway |
| CROONQUIST IL6 DEPRIVATION DN | 98 | 69 | 所有SZGR 2.0基因this pathway |
| CROONQUIST NRAS SIGNALING DN | 72 | 47 | 所有SZGR 2.0基因this pathway |
| YAMASHITA LIVER CANCER STEM CELL UP | 47 | 38 | 所有SZGR 2.0基因this pathway |
| YAGI AML WITH INV 16 TRANSLOCATION | 422 | 277 | 所有SZGR 2.0基因this pathway |
| WONG EMBRYONIC STEM CELL CORE | 335 | 193 | 所有SZGR 2.0基因this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | 所有SZGR 2.0基因this pathway |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | 所有SZGR 2.0基因this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | 所有SZGR 2.0基因this pathway |
| CARD MIR302A TARGETS | 77 | 62 | 所有SZGR 2.0基因this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | 所有SZGR 2.0基因this pathway |
| JOHNSTONE PARVB TARGETS 2 DN | 336 | 211 | 所有SZGR 2.0基因this pathway |
| LINSLEY MIR16 TARGETS | 206 | 127 | 所有SZGR 2.0基因this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | 所有SZGR 2.0基因this pathway |
| FEVR CTNNB1 TARGETS DN | 553 | 343 | 所有SZGR 2.0基因this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | 所有SZGR 2.0基因this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION UP | 570 | 339 | 所有SZGR 2.0基因this pathway |
| SERVITJA LIVER HNF1A TARGETS UP | 135 | 96 | 所有SZGR 2.0基因this pathway |
| DELACROIX RAR BOUND ES | 462 | 273 | 所有SZGR 2.0基因this pathway |
| RAO BOUND BY SALL4 | 227 | 149 | 所有SZGR 2.0基因this pathway |
| ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF | 222 | 159 | 所有SZGR 2.0基因this pathway |
Section VI. microRNA annotation
| miRNA family | Target position | miRNA ID | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-128 | 252 | 258 | m8 | hsa-miR-128a | UCACAGUGAACCGGUCUCUUUU |
| hsa-miR-128b | UCACAGUGAACCGGUCUCUUUC | ||||
| hsa-miR-128a | UCACAGUGAACCGGUCUCUUUU | ||||
| hsa-miR-128b | UCACAGUGAACCGGUCUCUUUC | ||||
| miR-130/301 | 1085 | 1091 | m8 | hsa-miR-130abrain | CAGUGCAAUGUUAAAAGGGCAU |
| hsa-miR-301 | CAGUGCAAUAGUAUUGUCAAAGC | ||||
| hsa-miR-130bbrain | CAGUGCAAUGAUGAAAGGGCAU | ||||
| hsa-miR-454-3p | UAGUGCAAUAUUGCUUAUAGGGUUU | ||||
| miR-15/16/195/424/497 | 265 | 271 | m8 | hsa-miR-15abrain | UAGCAGCACAUAAUGGUUUGUG |
| hsa-miR-16brain | UAGCAGCACGUAAAUAUUGGCG | ||||
| hsa-miR-15bbrain | UAGCAGCACAUCAUGGUUUACA | ||||
| hsa-miR-195SZ | UAGCAGCACAGAAAUAUUGGC | ||||
| hsa-miR-424 | CAGCAGCAAUUCAUGUUUUGAA | ||||
| hsa-miR-497 | CAGCAGCACACUGUGGUUUGU | ||||
| hsa-miR-15abrain | UAGCAGCACAUAAUGGUUUGUG | ||||
| hsa-miR-16brain | UAGCAGCACGUAAAUAUUGGCG | ||||
| hsa-miR-15bbrain | UAGCAGCACAUCAUGGUUUACA | ||||
| hsa-miR-195SZ | UAGCAGCACAGAAAUAUUGGC | ||||
| hsa-miR-424 | CAGCAGCAAUUCAUGUUUUGAA | ||||
| hsa-miR-497 | CAGCAGCACACUGUGGUUUGU | ||||
| miR-155 | 581 | 588 | 1A,m8 | hsa-miR-155 | UUAAUGCUAAUCGUGAUAGGGG |
| miR-17-5p/20/93.mr/106/519.d | 480 | 486 | m8 | hsa-miR-17-5p | CAAAGUGCUUACAGUGCAGGUAGU |
| hsa-miR-20abrain | UAAAGUGCUUAUAGUGCAGGUAG | ||||
| hsa-miR-106a | AAAAGUGCUUACAGUGCAGGUAGC | ||||
| hsa-miR-106bSZ | UAAAGUGCUGACAGUGCAGAU | ||||
| hsa-miR-20bSZ | CAAAGUGCUCAUAGUGCAGGUAG | ||||
| hsa-miR-519d | CAAAGUGCCUCCCUUUAGAGUGU | ||||
| miR-19 | 1084 | 1090 | m8 | hsa-miR-19a | UGUGCAAAUCUAUGCAAAACUGA |
| hsa-miR-19b | UGUGCAAAUCCAUGCAAAACUGA | ||||
| miR-204/211 | 369 | 375 | m8 | hsa-miR-204brain | UUCCCUUUGUCAUCCUAUGCCU |
| hsa-miR-211 | UUCCCUUUGUCAUCCUUCGCCU | ||||
| miR-219 | 589 | 595 | 1A | hsa-miR-219brain | UGAUUGUCCAAACGCAAUUCU |
| miR-23 | 629 | 635 | 1A | hsa-miR-23abrain | AUCACAUUGCCAGGGAUUUCC |
| hsa-miR-23bbrain | AUCACAUUGCCAGGGAUUACC | ||||
| miR-27 | 29 | 35 | m8 | hsa-miR-27abrain | UUCACAGUGGCUAAGUUCCGC |
| hsa-miR-27bbrain | UUCACAGUGGCUAAGUUCUGC | ||||
| miR-381 | 461 | 468 | 1A,m8 | hsa-miR-381 | UAUACAAGGGCAAGCUCUCUGU |
| miR-503 | 545 | 551 | 1A | hsa-miR-503 | UAGCAGCGGGAACAGUUCUGCAG |
| miR-93.hd/291-3p/294/295/302/372/373/520 | 479 | 485 | m8 | hsa-miR-93brain | AAAGUGCUGUUCGUGCAGGUAG |
| hsa-miR-302a | UAAGUGCUUCCAUGUUUUGGUGA | ||||
| hsa-miR-302b | UAAGUGCUUCCAUGUUUUAGUAG | ||||
| hsa-miR-302c | UAAGUGCUUCCAUGUUUCAGUGG | ||||
| hsa-miR-302d | UAAGUGCUUCCAUGUUUGAGUGU | ||||
| hsa-miR-372 | AAAGUGCUGCGACAUUUGAGCGU | ||||
| hsa-miR-373 | GAAGUGCUUCGAUUUUGGGGUGU | ||||
| hsa-miR-520e | AAAGUGCUUCCUUUUUGAGGG | ||||
| hsa-miR-520a | AAAGUGCUUCCCUUUGGACUGU | ||||
| hsa-miR-520b | AAAGUGCUUCCUUUUAGAGGG | ||||
| hsa-miR-520c | AAAGUGCUUCCUUUUAGAGGGUU | ||||
| hsa-miR-520d | AAAGUGCUUCUCUUUGGUGGGUU | ||||
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.