Gene Page:WNT1

Summary?
GeneID 7471
Symbol WNT1
Synonyms BMND16|INT1|OI15
Description wingless-type MMTV integration site family member 1
Reference MIM:164820|HGNC:HGNC:12774|HPRD:01276|
Gene type protein-coding
Map location 12q13
Pascal p-value 0.285
eGene Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的搜索页ubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 4

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10506284 chr12 49752650 WNT1 7471 0.02 cis
rs12030788 chr1 66768128 WNT1 7471 0.07 trans
rs725667 chr1 68488649 WNT1 7471 0.02 trans
rs11807500 chr1 68503525 WNT1 7471 0 trans
rs11808365 chr1 68507122 WNT1 7471 0.02 trans
rs12086539 chr1 68507537 WNT1 7471 0.02 trans
rs11801053 chr1 68512170 WNT1 7471 0.05 trans
rs17091285 chr1 71957915 WNT1 7471 0.06 trans
rs6663174 chr1 82004206 WNT1 7471 0.15 trans
rs12033254 chr1 165654868 WNT1 7471 0.11 trans
rs16843346 chr1 198543026 WNT1 7471 0.01 trans
rs1080976 chr1 198545551 WNT1 7471 0.1 trans
rs16843417 chr1 198568664 WNT1 7471 0.04 trans
rs16843424 chr1 198572758 WNT1 7471 0.14 trans
rs16843476 chr1 198591076 WNT1 7471 0.13 trans
rs16843670 chr1 198650005 WNT1 7471 5.147的军医 trans
rs10925947 chr1 235701552 WNT1 7471 0.06 trans
rs636167 chr1 237402264 WNT1 7471 0.08 trans
rs1876946 chr1 245459606 WNT1 7471 0.05 trans
rs17490288 chr2 36902427 WNT1 7471 0.13 trans
rs2014805 chr2 175165192 WNT1 7471 0 trans
rs17394437 chr2 176801863 WNT1 7471 0.14 trans
rs4674479 chr2 220806451 WNT1 7471 0.1 trans
rs7586700 chr2 237769742 WNT1 7471 0.09 trans
rs7574988 chr2 237770124 WNT1 7471 0.09 trans
rs9831161 chr3 43768017 WNT1 7471 0.17 trans
rs17075993 chr3 43800880 WNT1 7471 0.04 trans
rs1014141 chr3 43810759 WNT1 7471 0 trans
rs7615639 chr3 43852564 WNT1 7471 0.01 trans
rs4234437 chr3 43863375 WNT1 7471 0.2 trans
rs9809244 chr3 62078922 WNT1 7471 0.15 trans
rs17044826 chr3 66620522 WNT1 7471 0.03 trans
rs17072034 chr4 182594793 WNT1 7471 0.02 trans
rs16881626 chr5 8901096 WNT1 7471 0.09 trans
rs16881658 chr5 8909712 WNT1 7471 0.04 trans
rs2962730 chr5 8946017 WNT1 7471 0.13 trans
rs2962729 chr5 8946323 WNT1 7471 0.08 trans
rs1478417 chr5 122277035 WNT1 7471 0.04 trans
rs1368303 chr5 147672388 WNT1 7471 0.15 trans
rs9450829 chr6 88624436 WNT1 7471 0.04 trans
rs6935871 chr6 109107049 WNT1 7471 0.01 trans
rs887719 chr7 21184272 WNT1 7471 0 trans
rs320082 chr7 29105404 WNT1 7471 1.885E-10 trans
rs317720 chr7 29110633 WNT1 7471 3.381E-9 trans
rs317714 chr7 29115553 WNT1 7471 5.579E-9 trans
rs317724 chr7 29120565 WNT1 7471 3.381E-9 trans
rs10487032 chr7 88343822 WNT1 7471 0.18 trans
rs2294031 chr8 1812077 WNT1 7471 0.1 trans
rs7830307 chr8 36560734 WNT1 7471 0.03 trans
rs7837675 chr8 36615251 WNT1 7471 0.01 trans
rs1981322 chr8 36630228 WNT1 7471 0.01 trans
rs16923894 chr8 59700319 WNT1 7471 0.08 trans
rs16899109 chr8 102243951 WNT1 7471 0.19 trans
rs16886605 chr8 115894398 WNT1 7471 0.02 trans
rs1494750 chr8 116094224 WNT1 7471 0.1 trans
rs1831517 chr9 2513405 WNT1 7471 0.13 trans
rs7046585 chr9 8681939 WNT1 7471 0.15 trans
rs7868778 chr9 133811342 WNT1 7471 0.08 trans
rs4607971 chr10 19407890 WNT1 7471 0.03 trans
rs11203077 chr10 91097084 WNT1 7471 2.067E-6 trans
rs16933545 chr11 7918293 WNT1 7471 0.05 trans
rs10834670 chr11 25404015 WNT1 7471 0.01 trans
rs10834671 chr11 25404269 WNT1 7471 0.01 trans
rs2514177 chr11 57808227 WNT1 7471 0.19 trans
rs2122803 chr11 57811883 WNT1 7471 0.19 trans
rs2443424 chr11 57846310 WNT1 7471 0.19 trans
rs2443436 chr11 57859737 WNT1 7471 0.1 trans
rs17152341 chr11 57872189 WNT1 7471 0.19 trans
rs11229262 chr11 57905460 WNT1 7471 0.19 trans
rs10791832 chr11 65683917 WNT1 7471 0.01 trans
rs17119713 chr11 116338674 WNT1 7471 0.14 trans
rs11221223 chr11 128123258 WNT1 7471 0.04 trans
rs12310284 chr12 28738932 WNT1 7471 0.17 trans
rs11052230 chr12 32931283 WNT1 7471 0.04 trans
rs11176643 chr12 67629785 WNT1 7471 2.839E-6 trans
rs17764482 chr12 82483756 WNT1 7471 0.06 trans
rs7963156 chr12 97472647 WNT1 7471 0.18 trans
rs17026331 chr12 97478907 WNT1 7471 0 trans
rs11066476 chr12 113465366 WNT1 7471 0 trans
rs12312224 chr12 129771735 WNT1 7471 0.16 trans
rs17069275 chr13 47573172 WNT1 7471 0.16 trans
rs7322001 chr13 94895345 WNT1 7471 0.14 trans
rs17793815 chr14 22794531 WNT1 7471 0.04 trans
rs11158850 chr14 70757171 WNT1 7471 0.04 trans
rs8010077 chr14 75242784 WNT1 7471 0.16 trans
rs1862127 chr14 78407295 WNT1 7471 0.11 trans
rs17120009 chr14 84924155 WNT1 7471 0.06 trans
rs3790050 chr14 94421666 WNT1 7471 0.18 trans
rs11635209 chr15 32333996 WNT1 7471 0.12 trans
rs8043232 chr15 41282370 WNT1 7471 0.03 trans
rs4468583 chr15 41328652 WNT1 7471 0.03 trans
rs2412599 chr15 41347970 WNT1 7471 0.03 trans
rs16971463 chr15 41370625 WNT1 7471 0.01 trans
rs518137 chr15 41381512 WNT1 7471 0.01 trans
rs11072201 chr15 70857175 WNT1 7471 0.01 trans
rs17781350 chr15 71108134 WNT1 7471 0 trans
rs7200513 chr16 17219474 WNT1 7471 0.15 trans
rs3829495 chr16 17221986 WNT1 7471 0.04 trans
rs16949485 chr16 79104374 WNT1 7471 0.15 trans
rs12452652 chr17 72235560 WNT1 7471 1.811E-8 trans
rs17188689 chr18 23359136 WNT1 7471 0.01 trans
rs10513931 chr18 61569462 WNT1 7471 0.06 trans
rs2469009 chr18 70713334 WNT1 7471 0.1 trans
rs17087020 chr18 70828793 WNT1 7471 0.09 trans
rs1893731 chr18 70954644 WNT1 7471 0.16 trans
rs17056775 chr18 72988809 WNT1 7471 0 trans
rs321929 chr19 52835463 WNT1 7471 0.14 trans
rs10485563 chr20 16813100 WNT1 7471 0.02 trans
rs1523533 chr20 51329866 WNT1 7471 0.03 trans
rs2689370 chr20 51335422 WNT1 7471 0.11 trans
rs2745070 chr20 51337694 WNT1 7471 0.11 trans
rs402866 chr21 28531675 WNT1 7471 0.15 trans
rs5992705 chr22 17914003 WNT1 7471 0.11 trans
rs13057846 chr22 26291756 WNT1 7471 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DHX15 0.95 0.97
GPBP1 0.95 0.96
PRPF4B 0.95 0.97
PAPOLA 0.95 0.96
SUZ12 0.95 0.97
MSH2 0.95 0.95
YME1L1 0.94 0.95
NUP133 0.94 0.97
METTL14 0.94 0.94
UHRF2 0.94 0.96
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.75 -0.88
FXYD1 -0.75 -0.87
AF347015.31 -0.74 -0.86
AF347015.33 -0.73 -0.85
IFI27 -0.73 -0.86
AF347015.27 -0.72 -0.84
MT-CYB -0.72 -0.84
AF347015.8 -0.72 -0.86
HLA-F -0.70 -0.77
HIGD1B -0.70 -0.84

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005102 receptor binding NAS Neurotransmitter (GO term level: 4) 15592430
GO:0004871 signal transducer activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007417 central nervous system development TAS Brain (GO term level: 6) 2202907
GO:0022004 midbrain-hindbrain boundary maturation during brain development IEA Brain (GO term level: 12) -
GO:0048664 neuron fate determination IEA neuron (GO term level: 10) -
GO:0001708 cell fate specification TAS 15592430
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway IEA -
GO:0007163 establishment or maintenance of cell polarity TAS 15592430
GO:0007275 multicellular organismal development IEA -
GO:0016477 cell migration TAS 15592430
GO:0030154 cell differentiation TAS 15592430
GO:0042472 inner ear morphogenesis IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
GO:0005578 proteinaceous extracellular matrix IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
KEGG HEDGEHOG SIGNALING PATHWAY 56 42 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG BASAL CELL CARCINOMA 55 44 All SZGR 2.0 genes in this pathway
BIOCARTA ALK PATHWAY 37 29 All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY 27 26 All SZGR 2.0 genes in this pathway
BIOCARTA PITX2 PATHWAY 15 15 All SZGR 2.0 genes in this pathway
BIOCARTA PS1 PATHWAY 14 14 All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY 26 24 All SZGR 2.0 genes in this pathway
WNT SIGNALING 89 71 All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY 46 39 All SZGR 2.0 genes in this pathway
PID WNT SIGNALING PATHWAY 28 23 All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 84 61 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 88 58 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 72 53 All SZGR 2.0 genes in this pathway
THEODOROU MAMMARY TUMORIGENESIS 31 24 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 6 11 9 All SZGR 2.0 genes in this pathway
NADLER HYPERGLYCEMIA AT OBESITY 58 35 All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 97 72 All SZGR 2.0 genes in this pathway
DE YY1 TARGETS UP 20 14 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS WITH HCP H3K27ME3 102 76 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 227 233 m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-130/301 260 266 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-140 168 174 m8 hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-148/152 261 267 m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-19 685 691 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-34/449 263 269 m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC