Gene Page:WNT5A

Summary？
基因 7474
象征 WNT5A
Synonyms hwnt5a
Description 无翼型MMTV集成站点家庭成员5A
Reference MIM：164975|HGNC：HGNC：12784|ENSEMBL：ENSG00000114251|HPRD：01293|Vega：Otthumg00000158361
基因类型 蛋白质编码
Map location 3P21-P14
Pascal p-value 0.495
DMG 1 (# studies)
主持人 Cerebellar Hemisphere

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
DMG：JAFFE_2016 全基因组DNA甲基化分析 该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。 2
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息
go_annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
CG09615965 3 55522618 WNT5A 1.05E-8 -0.009 4.51E-6 DMG：JAFFE_2016
CG15757271 3 55521789 WNT5A 9.26e-8 -0.007 2.11E-5 DMG：JAFFE_2016


第二节。转录组注释

一般基因表达（GTEX）

Not available

时间变化的基因表达（brainspan）

Footnote:
SC:分皮质区域;SM:感觉运动区域s; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
POLD1 0.87 0.72
C7orf27 0.85 0.81
APBA3 0.85 0.82
RECQL4 0.85 0.72
MUTYH 0.84 0.73
H2AFX 0.84 0.70
Haus5 0.83 0.68
TCF3 0.83 0.67
ZNF219 0.83 0.67
KIF22 0.83 0.73
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
AF347015.27 -0.51 -0.59
AF347015.31 -0.47 -0.55
AF347015.8 -0.46 -0.56
MT-CO2 -0.45 -0.54
AF347015.21 -0.45 -0.61
C5orf53 -0.45 -0.50
AF347015.33 -0.45 -0.53
mt-cyb -0.45 -0.54
MT-ATP8 -0.43 -0.61
AF347015.15 -0.42 -0.53

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005102 receptor binding TAS 神经递质（GO期限：4） 8288227|10491302
GO:0004871 信号传感器活性 TAS 8288227|10491302
生物过程 去学期 证据 神经关键字 PubMed ID
去：0007267 细胞细胞信号传导 TAS 8288227
去：0007254 JNK cascade IEA -
去：0007223 Wnt受体信号通路，钙调节途径 IEA -
GO:0007165 信号转导 TAS 10491302
去：0009653 解剖结构形态发生 TAS 9054360
去：0009790 胚胎发展 IEA -
去：0030326 embryonic limb morphogenesis IEA -
GO：0030324 肺发展 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005576 细胞外区域 IEA -
去：0005578 proteinaceous extracellular matrix IEA -
去：0005615 细胞外空间 TAS 10491302
去：0005625 soluble fraction TAS 10491302

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
kegg刺猬信号通路 56 42 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
癌症中的KEGG途径 328 259 All SZGR 2.0 genes in this pathway
KEGG BASAL CELL CARCINOMA 55 44 All SZGR 2.0 genes in this pathway
wnt信令 89 71 All SZGR 2.0 genes in this pathway
pid wnt非规范途径 32 26 All SZGR 2.0 genes in this pathway
pid wnt信号通路 28 23 All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 63 52 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 88 58 All SZGR 2.0 genes in this pathway
Reactome GPCR配体结合 408 246 All SZGR 2.0 genes in this pathway
Chemnitz对前列腺素E2 DN的反应 391 222 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
周的炎症反应生活 485 293 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158 103 All SZGR 2.0 genes in this pathway
Jaeger转移DN 258 141 All SZGR 2.0 genes in this pathway
Mullighan NPM1突变签名1向上 276 165 All SZGR 2.0 genes in this pathway
Mullighan NPM1签名3 341 197 All SZGR 2.0 genes in this pathway
Senese HDAC1和HDAC2靶向DN 232 139 All SZGR 2.0 genes in this pathway
Senese HDAC2靶向DN 133 77 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
Wamunyokoli卵巢癌LMP DN 199 124 All SZGR 2.0 genes in this pathway
kokkinakis蛋氨酸剥夺48小时 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN 485 334 All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡 1781 1082 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS B DN 8 5 All SZGR 2.0 genes in this pathway
McBryan Pubertal TGFB1靶向 169 127 All SZGR 2.0 genes in this pathway
埃尔南德斯有丝分裂逮捕Docetaxel 1 Up 36 18 All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM DN 25 18 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3公共DN 483 336 All SZGR 2.0 genes in this pathway
TSUNODA CISPLATIN RESISTANCE DN 51 38 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN 514 319 All SZGR 2.0 genes in this pathway
王HCP前列腺癌 111 69 All SZGR 2.0 genes in this pathway
Gruetzmann胰腺癌 358 245 All SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN 637 377 All SZGR 2.0 genes in this pathway
WU细胞迁移 184 114 All SZGR 2.0 genes in this pathway
Shin B细胞淋巴瘤簇3 28 23 All SZGR 2.0 genes in this pathway
Onder CDH1目标2向上 256 159 All SZGR 2.0 genes in this pathway
ZHANG TARGETS OF EWSR1 FLI1 FUSION 88 68 All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 89 61 All SZGR 2.0 genes in this pathway
NOUZOVA METHYLATED IN APL 68 39 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR DN 86 62 All SZGR 2.0 genes in this pathway
郑对砷DN的反应 18 15 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 113 71 All SZGR 2.0 genes in this pathway
Bild E2F3致癌特征 246 153 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
哈里斯脑癌祖细胞 44 23 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO 38 24 All SZGR 2.0 genes in this pathway
Kyng DNA损坏 226 164 All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 97 72 All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向DN 591 366 All SZGR 2.0 genes in this pathway
Cheng由雌二醇印记 110 68 All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存次优秀 510 309 All SZGR 2.0 genes in this pathway
Boquest干细胞向上 260 174 All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜 425 298 All SZGR 2.0 genes in this pathway
TGFB1和WNT3A的LABBE目标 111 70 All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记 165 118 All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP 71 49 All SZGR 2.0 genes in this pathway
Hinata NFKB靶向角质形成细胞 91 63 All SZGR 2.0 genes in this pathway
Han Satb1靶向DN 442 275 All SZGR 2.0 genes in this pathway
4EBP1和4EBP2的COLINA目标 356 214 All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 134 83 All SZGR 2.0 genes in this pathway
Gyorffy Mitoxantrone抗性 57 35 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN 115 73 All SZGR 2.0 genes in this pathway
Gabriely miR21靶标 289 187 All SZGR 2.0 genes in this pathway
Bruins通过TP53组A的UVC响应 898 516 All SZGR 2.0 genes in this pathway
Steger脂肪形成DN 25 15 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
Plasari TGFB1通过NFIC 1HR DN信号传导 106 77 All SZGR 2.0 genes in this pathway
通过p38完成的phong TNF响应 227 151 All SZGR 2.0 genes in this pathway
lim乳腺腔内成熟 116 65 All SZGR 2.0 genes in this pathway
NABA分泌因素 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-186 2771 2777 M8 HSA-MIR-186 caaagaauuuugggcuu
HSA-MIR-186 caaagaauuuugggcuu
miR-26 1350 1357 1A，M8 HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ UUCAAGUAAUUCAGGAUAGGUU
mir-369-3p 169 175 1a hsa-miR-369-3p aauauacaugguugaucuuu
miR-374 169 176 1A，M8 HSA-MIR-374 uuauaauacaAccugauaagug
miR-375 2671 2677 1a HSA-MIR-375 UUUGUUCGUUCGGCUCGCGUGA
miR-381 2501 2508 1A，M8 HSA-MIR-381 uauacaagggcaagcucucugu
HSA-MIR-381 uauacaagggcaagcucucugu
HSA-MIR-381 uauacaagggcaagcucucugu
miR-493-5p 2396 2402 M8 HSA-MIR-493-5p uuguacaugguaggcuuucauu