Gene Page:WRN

Summary?
GeneID 7486
Symbol WRN
Synonyms RECQ3|RECQL2|RECQL3
Description Werner syndrome RecQ like helicase
Reference MIM:604611|HGNC:HGNC:12791|Ensembl:ENSG00000165392|HPRD:05212|Vega:OTTHUMG00000163894
Gene type protein-coding
Map location 8p12
Pascal p-value 0.022
Fetal beta 0.947
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.00057
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.03086

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
WRN chr8 31004622 C T NM_000553 p.1146S>L missense Schizophrenia DNM:Fromer_2014

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg10709021 8 30890108 PURG;WRN 1.583E-4 0.432 0.032 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RAB6A 0.93 0.91
ITFG1 0.92 0.92
ARMCX3 0.92 0.90
CLTC 0.92 0.93
C5orf22 0.91 0.92
USP14 0.91 0.89
VPS41 0.91 0.88
PNMA2 0.91 0.89
SRPK2 0.91 0.91
NCKAP1 0.90 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.65 -0.52
AF347015.2 -0.65 -0.53
MT-CO2 -0.64 -0.54
EIF4EBP3 -0.63 -0.65
AF347015.8 -0.63 -0.53
HIGD1B -0.63 -0.54
FXYD1 -0.62 -0.55
AF347015.31 -0.61 -0.53
AF347015.26 -0.61 -0.49
MT-CYB -0.60 -0.51

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000403 Y-form DNA binding IDA 17715146
GO:0000405 bubble DNA binding IDA 11433031
GO:0003677 DNA binding IDA 9288107
GO:0004003 ATP-dependent DNA helicase activity IDA 9288107
GO:0005524 ATP binding IEA -
GO:0016787 hydrolase activity IEA -
GO:0008408 3'-5' exonuclease activity IDA 10783163|12181313
GO:0009378 four-way junction helicase activity IDA 11433031
去:0016887 ATPase activity IDA 10373438|10871376
GO:0042803 protein homodimerization activity IDA 10783163
GO:0032403 protein complex binding IDA 10783163
GO:0043138 3'-5' DNA helicase activity IDA 17715146
GO:0051880 G-quadruplex DNA binding IDA 11433031
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0000723 telomere maintenance IMP 18212065
GO:0000731 DNA synthesis during DNA repair IDA 17563354
GO:0001302 replicative cell aging IEA -
GO:0006310 DNA recombination IEA -
GO:0006284 base-excision repair IDA 17611195
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process IEA -
GO:0010225 response to UV-C IDA 17563354
GO:0010259 multicellular organismal aging IMP 16673358
GO:0006979 response to oxidative stress IDA 17611195
GO:0042981 regulation of apoptosis IGI 9681877
GO:0051345 positive regulation of hydrolase activity IDA 17611195
GO:0031297 replication fork processing IDA 17115688
GO:0031297 replication fork processing IMP 12882351
GO:0040009 regulation of growth rate IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005813 centrosome IDA 17498979
GO:0005622 intracellular IEA -
GO:0005634 nucleus IEA -
GO:0005654 nucleoplasm IDA 11420665|12944467
GO:0005730 nucleolus IDA 9618508|12181313
GO:0032389 MutLalpha complex IDA 17715146

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ATM AT1 | ATA |C | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1 ataxia telangiectasia mutated Protein-peptide BioGRID 10608806
ATR FRP1 | MEC1 | SCKL | SCKL1 ataxia telangiectasia and Rad3 related Protein-peptide BioGRID 10608806
BLM BS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3 Bloom syndrome BLM interacts with WRN. BIND 11919194
BLM BS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3 Bloom syndrome - HPRD,BioGRID 11919194
CDKN2A ARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) p14 interacts with WRN. BIND 15355988
FEN1 FEN-1 | MF1 | RAD2 flap structure-specific endonuclease 1 - HPRD 12356323
FEN1 FEN-1 | MF1 | RAD2 flap structure-specific endonuclease 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 11598021|14688284
MDC1 DKFZp781A0122 | KIAA0170 | MGC166888 | NFBD1 中介的DNA损伤检查点1 Protein-peptide BioGRID 14578343
PARP1 ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1 poly (ADP-ribose) polymerase 1 WRN interacts with PARP1. BIND 14734561
PCNA MGC8367 proliferating cell nuclear antigen - HPRD,BioGRID 10871373|12633936
POLR1C RPA39 | RPA40 | RPA5 | RPAC1 polymerase (RNA) I polypeptide C, 30kDa - HPRD,BioGRID 11971179
PRKDC DNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350 protein kinase, DNA-activated, catalytic polypeptide - HPRD,BioGRID 11889123
RAD52 - RAD52 homolog (S. cerevisiae) WRN interacts with RAD52. BIND 12750383
RDM1 MGC33977 | RAD52B RAD52 motif 1 - HPRD 12750383
TERF2 TRBF2 | TRF2 telomeric repeat binding factor 2 - HPRD,BioGRID 12181313
TERF2 TRBF2 | TRF2 telomeric repeat binding factor 2 Wrn interacts with TRF2. BIND 12181313
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 WRN interacts with p53. BIND 12080066
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 - HPRD,BioGRID 11427532|12080066
WRNIP1 FLJ22526 | RP11-420G6.2 | WHIP | bA420G6.2 Werner helicase interacting protein 1 - HPRD,BioGRID 11301316
XRCC5 FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIV X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) - HPRD,BioGRID 12177300
XRCC6 CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAA X-ray repair complementing defective repair in Chinese hamster cells 6 WRN interacts with G22P1 (Ku70) as part of a complex. BIND 14734561
XRCC6 CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAA X-ray repair complementing defective repair in Chinese hamster cells 6 - HPRD,BioGRID 12177300


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID TELOMERASE PATHWAY 68 48 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
MARKS ACETYLATED NON HISTONE PROTEINS 15 9 All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 9 8 6 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 81 57 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 81 51 All SZGR 2.0 genes in this pathway
COLLIS PRKDC SUBSTRATES 20 15 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230 137 All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN 64 47 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN 79 45 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242 146 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway