SZGR2 - Beplay体育中心

Summary?

GeneID	7514
Symbol	XPO1
Synonyms	CRM1\|emb\|exp1
Description	exportin 1
Reference	MIM:602559\|HGNC:HGNC:12825\|Ensembl:ENSG00000082898\|HPRD:03975\|Vega:OTTHUMG00000152316
Gene type	protein-coding
Map location	2p15
Pascal p-value	0.081
Sherlock p-value	0.136
Fetal beta	0.821
DMG	1 (# studies)
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg09455096	2	61765470	XPO1	1.45E-9	-0.008	1.39E-6	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs1872418	chr3	3888893	XPO1	7514		0.11		trans
rs9921236	chr16	88117014	XPO1	7514		0.15		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
			Crm1 interacts with U3 snoRNA	BIND	15574333
ADAR	ADAR1 \| DRADA \| DSH \| DSRAD \| G1P1 \| IFI-4 \| IFI4 \| K88dsRBP \| p136	adenosine deaminase, RNA-specific	-	HPRD,BioGRID	11604520
AHR	-	aryl hydrocarbon receptor	-	HPRD	12065584
ANP32A	C15orf1 \| I1PP2A \| LANP \| MAPM \| MGC119787 \| MGC150373 \| PHAP1 \| PHAPI \| PP32	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	Affinity Capture-Western	BioGRID	11565755
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	Affinity Capture-Western Reconstituted Complex	BioGRID	12070164
ARNT	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	Affinity Capture-Western	BioGRID	12065584
BECN1	ATG6 \| VPS30 \| beclin1	beclin 1, autophagy related	-	HPRD	11309306
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	Reconstituted Complex	BioGRID	12529437
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	p27Kip1 interacts with CRM1.	BIND	11889117
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	-	HPRD,BioGRID	11889117\|12529437
CIITA	C2TA \| CIITAIV \| MHC2TA \| NLRA	class II, major histocompatibility complex, transactivator	-	HPRD,BioGRID	12517958
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	-	HPRD,BioGRID	11839808
DDX3X	DBX \| DDX14 \| DDX3 \| HLP2	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	DDX3 interacts with CRM1.	BIND	15507209
E2F5	E2F-5	p130-binding E2F转录因子5日	-	HPRD	12089160
EIF5A	A \| EIF-5A \| EIF5A1 \| MGC104255 \| MGC99547 \| uORF	eukaryotic translation initiation factor 5A	-	HPRD,BioGRID	10381392
ELAVL1	ELAV1 \| HUR \| Hua \| MelG	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	-	HPRD,BioGRID	11565755
ERF	PE-2 \| PE2	Ets2 repressor factor	-	HPRD	14729966
FOXO4	AFX \| AFX1 \| MGC120490 \| MLLT7	forkhead box O4	-	HPRD,BioGRID	11313479
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	-	HPRD,BioGRID	11779848
KIF17	KIAA1405 \| KIF17B \| KIF3X	kinesin family member 17	-	HPRD,BioGRID	12493914
NF2	ACN \| BANF \| SCH	neurofibromin 2 (merlin)	-	HPRD,BioGRID	12217955
NMD3	CGI-07 \| FLJ21053	NMD3 homolog (S. cerevisiae)	-	HPRD,BioGRID	12724356
NPM1	B23 \| MGC104254 \| NPM	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	An unspecified isoform of NPM1 (NPM) interacts with XPO1 (CRM1).	BIND	16041368
NUP153	HNUP153 \| N153	nucleoporin 153kDa	-	HPRD,BioGRID	10202161
NUP214	CAIN \| CAN \| D9S46E \| MGC104525 \| N214	nucleoporin 214kDa	-	HPRD	11551912
NUP214	CAIN \| CAN \| D9S46E \| MGC104525 \| N214	nucleoporin 214kDa	Affinity Capture-Western	BioGRID	11425870
NUP50	MGC39961 \| NPAP60 \| NPAP60L	nucleoporin 50kDa	-	HPRD,BioGRID	10891499
NUP62	DKFZp547L134 \| FLJ20822 \| FLJ43869 \| IBSN \| MGC841 \| SNDI \| p62	nucleoporin 62kDa	-	HPRD,BioGRID	10330396
NUPL2	CG1 \| NLP-1 \| NLP_1 \| hCG1	nucleoporin like 2	NUPL2 (NLP-1) interacts with XPO1 (CRM-1).	BIND	10358091
NXF3	-	nuclear RNA export factor 3	-	HPRD,BioGRID	11545741
NXT1	MTR2 \| P15	NTF2-like export factor 1	-	HPRD,BioGRID	11149927
ORC1L	HSORC1 \| ORC1 \| PARC1	origin recognition complex, subunit 1-like (yeast)	-	HPRD	11716535
PHAX	FLJ13193 \| RNUXA	磷酸化适配器RNA出口	-	HPRD	10786834
RAN	ARA24 \| Gsp1 \| TC4	RAN, member RAS oncogene family	-	HPRD,BioGRID	9323133
RANBP1	HTF9A \| MGC88701	RAN binding protein 1	Reconstituted Complex	BioGRID	10601307\|10779340
RANBP2	NUP358 \| TRP1 \| TRP2	RAN binding protein 2	-	HPRD	10601307
RANBP3	DKFZp586I1520	RAN binding protein 3	-	HPRD,BioGRID	11425870
RCC1	CHC1 \| RCC1-I	regulator of chromosome condensation 1	-	HPRD,BioGRID	11932251
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	Affinity Capture-Western	BioGRID	16895915
SMAD1	BSP1 \| JV4-1 \| JV41 \| MADH1 \| MADR1	SMAD全家ly member 1	-	HPRD	12519765
SMARCB1	BAF47 \| INI1 \| RDT \| SNF5 \| SNF5L1 \| Sfh1p \| Snr1 \| hSNFS	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	-	HPRD,BioGRID	11782423
SMURF1	KIAA1625	SMAD specific E3 ubiquitin protein ligase 1	-	HPRD	12519765
SNUPN	KPNBL \| RNUT1 \| Snurportin1	snurportin 1	-	HPRD,BioGRID	10209022
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD	9205132
TNFSF12-TNFSF13	TWE-PRIL	TNFSF12-TNFSF13 readthrough transcript	-	HPRD	11565755
TNFSF13	APRIL \| CD256 \| TALL2 \| TRDL-1 \| UNQ383/PRO715 \| ligand	tumor necrosis factor (ligand) superfamily, member 13	Affinity Capture-Western	BioGRID	11565755
TOP2A	TOP2 \| TP2A	topoisomerase (DNA) II alpha 170kDa	-	HPRD	12821127
TOP2B	TOPIIB \| top2beta	topoisomerase (DNA) II beta 180kDa	-	HPRD	12821127

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA PTC1 PATHWAY	11	6	All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID NFKAPPAB CANONICAL PATHWAY	23	20	All SZGR 2.0 genes in this pathway
PID ILK PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID RANBP2 PATHWAY	11	11	All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY	48	35	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	23	13	All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	26	16	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	15	8	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES	172	98	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES	81	50	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	50	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE	203	72	All SZGR 2.0 genes in this pathway
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	27	19	All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION	207	122	All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE	125	69	All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS	132	81	All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE	104	61	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE	87	51	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	63	42	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP	269	146	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW UP	32	25	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN	199	124	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL	116	62	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
MANN RESPONSE TO AMIFOSTINE DN	10	5	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK	117	72	All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS	88	60	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP	236	139	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN	81	51	All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN	76	52	All SZGR 2.0 genes in this pathway
YAGI AML RELAPSE PROGNOSIS	35	24	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
CROMER METASTASIS UP	79	46	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS DN	48	26	All SZGR 2.0 genes in this pathway
YAGI AML SURVIVAL	129	87	All SZGR 2.0 genes in this pathway
KAMMINGA EZH2 TARGETS	41	26	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D4	55	37	All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP	206	118	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C2	54	39	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
GEISS RESPONSE TO DSRNA UP	38	29	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 7	51	34	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6	153	112	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 8HR	39	31	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP	294	199	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP	163	102	All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP	70	49	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN	185	116	All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2	356	214	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP	188	121	All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP	162	86	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
BOUDOUKHA BOUND BY IGF2BP2	111	59	All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE	45	33	All SZGR 2.0 genes in this pathway

Gene Page:XPO1