基因Page:YWHAB

Summary?
基因ID 7529
象征 YWHAB
同义词 GW128 | HEL-S-1 | HS1 | KCIP-1 | YWHAA
描述 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
参考 MIM：601289|HGNC:HGNC:12849|Ensembl:ENSG00000166913|HPRD:03184|Vega:OTTHUMG00000032549
基因类型 protein-coding
Map location 20q13.1
Pascal P值 0.011
Sherlock p-value 0.807
Fetal beta -0.55
DMG 1 (# studies)
eGene Caudate basal ganglia
Cerebellum
皮质
Hypothalamus
伏隔核基底神经节
梭子基底神经节
Support 细胞内信号转导
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS
G2Cdb.human_clathrin
G2Cdb.human_mGluR5
g2cdb.human_synaptosom
G2Cdb.humanPSD
G2Cdb.humanPSP
COMPOSITESET

基因in Data Sources
基因set name 基因组方法 描述 Info
简历：PGCNP Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0065

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome 位置 Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg15324310 20 43514360 YWHAB 1.23E-5 -0.455 0.014 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome 位置 eGene 基因Entrez ID pvalue qvalue TSS distance eQTL type
rs3838037 20 43525483 YWHAB ENSG00000166913.8 1.14082E-8 0 11166 gtex_brain_putamen_basal

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Not available

Devlopment期间的基因表达（BrainCloud）

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

基因expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
基因 皮尔逊的相关性 斯皮尔曼的相关性
FRS2 0.93 0.95
ZNF451 0.93 0.94
SOCS4 0.92 0.93
MIB1 0.92 0.93
KLHL24 0.92 0.93
GABPA 0.92 0.92
KLHL28 0.92 0.93
CEP97 0.91 0.94
ZNF148 0.91 0.90
CREB1 0.90 0.91
前10个负共表达基因
基因 皮尔逊的相关性 斯皮尔曼的相关性
IFI27 -0.61 -0.70
MT-CO2 -0.61 -0.69
FXYD1 -0.61 -0.70
AF347015.21 -0.59 -0.69
CXCL14 -0.59 -0.69
AF347015.31 -0.59 -0.67
HIGD1B -0.58 -0.67
AF347015.8 -0.57 -0.66
CSAG1 -0.57 -0.63
AC018755.7 -0.57 -0.61

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004497 单加氧酶活性 IEA -
GO:0019904 protein domain specific binding IEA -
GO:0019904 protein domain specific binding IPI 11984006
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007265 Ras protein signal transduction 经验 11520933
GO:0008633 activation of pro-apoptotic gene products 经验 15231831
GO:0006605 protein targeting IEA -
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
去：0005813 centrosome IDA 18029348
去：0005829 cytosol 经验 9069260|10195903|12657644
GO:0005634 核 IDA 18029348
GO:0005737 细胞质 IDA 12963375
GO:0048471 细胞质的核周区 IDA 12963375
GO:0042470 melanosome IEA -

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b Experimental 资源 PubMed ID
AKAP13 AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31 | LBC | PROTO-LB | PROTO-LBC | c-lbc A kinase (PRKA) anchor protein 13 Affinity Capture-MS BioGRID 17353931
坏的 BBC2 |BCl2L8 BCL2-associated agonist of cell death - HPRD,BioGRID 9369453
BID FP497 | MGC15319 | MGC42355 BH3 interacting domain death agonist - HPRD 12871587
BRAF B-RAF1 | BRAF1 | FLJ95109 | MGC126806 | MGC138284 | RAFB1 v-raf murine sarcoma viral oncogene homolog B1 BRAF (B-Raf) interacts with an unspecified isoform of YWHAB (14-3-3-beta). BIND 12620389
BRAF B-RAF1 | BRAF1 | FLJ95109 | MGC126806 | MGC138284 | RAFB1 v-raf murine sarcoma viral oncogene homolog B1 B-RAF与14-3-3-β相互作用。 BIND 12620389
BRAF B-RAF1 | BRAF1 | FLJ95109 | MGC126806 | MGC138284 | RAFB1 v-raf murine sarcoma viral oncogene homolog B1 - HPRD,BioGRID 10931830
CBL C-CBL |CBL2 |RNF55 Cas-Br-M (murine) ecotropic retroviral transforming sequence c-Cbl interacts with 14-3-3-beta. BIND 9367879
CBL C-CBL |CBL2 |RNF55 Cas-Br-M (murine) ecotropic retroviral transforming sequence Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 9367879
CDC25A CDC25A2 cell division cycle 25 homolog A (S. pombe) - HPRD,BioGRID 7644510
CDC25A CDC25A2 cell division cycle 25 homolog A (S. pombe) 14-3-3-beta interacts with cdc25A. BIND 7644510
CDC25B - 细胞分裂周期25同源物B（S. pombe） 14-3-3-beta interacts with cdc25B. BIND 7644510
CDC25B - 细胞分裂周期25同源物B（S. pombe） - HPRD,BioGRID 7644510|10713667
CDC25C CDC25 细胞分裂周期25同源C（S。Pombe） - HPRD 12937170
cdc2l1 CDC2L2 | CDK11 | CDK11-p110 | CDK11-p46 | CDK11-p58 | CLK-1 | FLJ59152 | PK58 | p58 | p58CDC2L1 | p58CLK-1 细胞分裂周期2样1（pitslre蛋白） CDK11-P110与14-3-3-beta相互作用。 BIND 15883043
CGN DKFZP779N1112 |FLJ39281 |KIAA1319 cingulin Affinity Capture-MS BioGRID 17353931
CRTC2 RP11-422P24.6 |torc2 CREB regulated transcription coactivator 2 TORC2与14-3-3-beta相互作用。 BIND 15454081
CSNK2A1 CK2A1 | CKII casein kinase 2, alpha 1 polypeptide Affinity Capture-MS BioGRID 17353931
DAPK1 DAPK |DKFZP781I035 死亡相关蛋白激酶1 - HPRD 12911633
DENND4A FLJ33949 | IRLB | KIAA0476 | MYCPBP Denn/MADD域中包含4A Affinity Capture-MS BioGRID 17353931
EDC3 FLJ21128 |FLJ31777 |LSM16 |yjdc |YJEFN2 mRNA的增强子Decapting 3同源物（S. cerevisiae） Affinity Capture-MS BioGRID 17353931
EPB41L3 4.1B | DAL-1 | DAL1 | FLJ37633 | KIAA0987 红细胞膜蛋白条带4.1样3 - HPRD,BioGRID 11996670
FAM82A2 FAM82C |FLJ10579 |RMD3 |HRMD-3 |PTPIP51 family with sequence similarity 82, member A2 Affinity Capture-MS BioGRID 17353931
FOXK1 FLJ14977 | FOXK1L forkhead box K1 Affinity Capture-MS BioGRID 17353931
FRYL DKFZP686E205 |FLJ16177 |KIAA0826 FRY-like Affinity Capture-MS BioGRID 17353931
HDAC4 HA6116 | HD4 | HDAC-A | HDACA | KIAA0288 组蛋白脱乙酰基酶4 Affinity Capture-Western BioGRID 10869435
HDAC5 FLJ90614 | HD5 | NY-CO-9 组蛋白脱乙酰基酶5 - HPRD,BioGRID 10869435
IGF1R CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 胰岛素样生长因子1受体 - HPRD,BioGRID 9581554
IGF1R CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 胰岛素样生长因子1受体 IGFIR interacts with 14-3-3-beta isoform. This interaction was modelled on a demonstrated interaction between human IGFIR and mouse 14-3-3-beta. BIND 9581554
IRS1 HIRS-1 胰岛素受体底物1 - HPRD,BioGRID 9422753
IRS2 - 胰岛素受体底物2 Affinity Capture-MS BioGRID 17353931
ITGB1 CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB 整合素，β1（纤连蛋白受体，β多肽，抗原CD29包括MDF2，MSK12） - HPRD,BioGRID 11313964
KCNK3 K2p3.1 | OAT1 | TASK | TASK-1 | TBAK1 钾通道，亚家族K，成员3 Affinity Capture-Western
Protein-peptide		 BioGRID 12437930
KIF1C KIAA0706 | LTXS1 动机家庭成员1C - HPRD 10559254
KIF23 CHO1 | KNSL5 | MKLP-1 | MKLP1 动机家庭成员23 Affinity Capture-MS BioGRID 17353931
KIF5B Kinh |KNS |KNS1 |UKHC 动机家庭成员5B Affinity Capture-MS BioGRID 17353931
KLC1 KLC | KNS2 | KNS2A | MGC15245 动力素轻链1 Affinity Capture-MS BioGRID 17353931
KRT18 CYK18 |K18 角蛋白18 - HPRD 9524113
LARP1 KIAA0731 | LARP | MGC19556 la核糖核蛋白域家族，成员1 Affinity Capture-MS BioGRID 17353931
LYST CHS | CHS1 lysosomal trafficking regulator - HPRD,BioGRID 11984006
MAPK7 BMK1 | ERK4 | ERK5 | PRKM7 mitogen-activated protein kinase 7 - HPRD,BioGRID 14679215
mapt ddpac |FLJ31424 |FTDP-17 |maptl |MGC138549 |MSTD |mtbt1 |mtbt2 |ppnd |tau microtubule-associated protein tau - HPRD,BioGRID 10840038
标记3 CTAK1 | KP78 | PAR1A 地图/微管亲和调节激酶3 Affinity Capture-MS BioGRID 17353931
MLLT4 AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3 髓样/淋巴样或混合细胞白血病（果蝇Trithorax同源物）；易位为4 Affinity Capture-MS BioGRID 17353931
mlxip KIAA0867 | MIR | MONDOA | bHLHe36 MLX相互作用蛋白 - HPRD,BioGRID 12446771
MPRIP KIAA0864 |m-rip |Rhoip3 |P116RIP 肌球蛋白磷酸酶Rho相互作用蛋白 Affinity Capture-MS BioGRID 17353931
NCKAP1 FLJ11291 |Hem2 |KIAA0587 |MGC8981 |NAP1 |NAP125 NCK-associated protein 1 Affinity Capture-MS BioGRID 17353931
OSBPL3 DKFZp667P1518 | KIAA0704 | MGC21526 | ORP-3 | ORP3 | OSBP3 氧蛋白质结合蛋白样3 Affinity Capture-MS BioGRID 17353931
PARD3 ASIP | Baz | Bazooka | FLJ21015 | PAR3 | PAR3alpha | PARD3A | SE2-5L16 | SE2-5LT1 | SE2-5T2 par-3 partitioning defective 3 homolog (C. elegans) Affinity Capture-MS BioGRID 17353931
PDCL2 GCPHLP phosducin-like 2 - HPRD 12424248
pde3b HcGIP1 | cGIPDE1 phosphodiesterase 3B, cGMP-inhibited - HPRD 12453887
PI4KB PI4K-BETA | PI4KIIIbeta | PI4Kbeta | PIK4CB | pi4K92 磷脂酰肌醇4-激酶，催化，β - HPRD 15324660
PI4KB PI4K-BETA | PI4KIIIbeta | PI4Kbeta | PIK4CB | pi4K92 磷脂酰肌醇4-激酶，催化，β Affinity Capture-MS BioGRID 17353931
PRKCZ PKC-Zeta |PKC2 蛋白激酶C，Zeta - HPRD,BioGRID 10620507
PRPF6 ANT-1 | C20orf14 | TOM | U5-102K | hPrp6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) Two-hybrid BioGRID 10848612
PTPN3 DKFZp686N0569 | PTPH1 蛋白质酪氨酸磷酸酶，非受体3型 - HPRD,BioGRID 9341175
RABGEF1 FLJ32302 | RABEX5 | rabex-5 Rab鸟嘌呤核苷酸交换因子（GEF）1 Affinity Capture-MS BioGRID 17353931
RACGAP1 HSCYK-4 |ID-GAP |mgcracgap RAC GTPase激活蛋白1 Affinity Capture-MS BioGRID 17353931
RAF1 CRAF | NS5 | Raf-1 | c-Raf V-RAF-1鼠白血病病毒癌基因同源1 C-RAF与14-3-3-beta相互作用。 BIND 12620389
RAF1 CRAF | NS5 | Raf-1 | c-Raf V-RAF-1鼠白血病病毒癌基因同源1 - HPRD 8702721|12360521
RAF1 CRAF | NS5 | Raf-1 | c-Raf V-RAF-1鼠白血病病毒癌基因同源1 RAF1 (C-Raf) interacts with YWHAB (14-3-3-beta). BIND 12620389
RAF1 CRAF | NS5 | Raf-1 | c-Raf V-RAF-1鼠白血病病毒癌基因同源1 Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 8702721|10620507
|10848612|12360521
|12620389
RAI14 DKFZp564G013 | KIAA1334 | NORPEG | RAI13 视黄酸诱导14 Affinity Capture-MS BioGRID 17353931
RASGRF1 CDC25 | CDC25L | GNRP | GRF1 | GRF55 | H-GRF55 | PP13187 Ras protein-specific guanine nucleotide-releasing factor 1 Reconstituted Complex BioGRID 9543386
RGS3 C2PA |FLJ20370 |FLJ31516 |FLJ90496 |PDZ-RGS3 |rgp3 G蛋白信号传导的调节剂3 Affinity Capture-Western BioGRID 10862767
RIN1 - Ras和Rab Interactor 1 - HPRD 9144171|11784866
RPS6KA1 HU-1 | MAPKAPK1A | RSK | RSK1 核糖体蛋白S6激酶，90KDA，多肽1 - HPRD,BioGRID 12618428
SAMD4B FLJ10211 |MGC99832 |SMGB 含4B的无菌α基序域 Affinity Capture-MS BioGRID 17353931
SLC4A7 DKFZp686H168 | NBC2 | NBC3 | SBC2 | SLC4A6 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Affinity Capture-MS BioGRID 17353931
SNCA MGC110988 | NACP | PARK1 | PARK4 | PD1 synuclein, alpha (non A4 component of amyloid precursor) - HPRD 10407019
SRC ASV |src1 |C-SRC |P60-SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) - HPRD 8702721
SRM2 300-kd |CWF21 |DKFZP686O15166 |FLJ21926 |FLJ22250 |KIAA0324 |MGC40295 |SRL300 |SRM300 丝氨酸/精氨酸重复矩阵2 Affinity Capture-MS BioGRID 17353931
TESK1 - 睾丸特异性激酶1 - HPRD,BioGRID 11555644
TESK2 - 睾丸特异性激酶2 - HPRD,BioGRID 11555644
TJP2 MGC26306 | X104 | ZO-2 | ZO2 tight junction protein 2 (zona occludens 2) Affinity Capture-MS BioGRID 17353931
TNFAIP3 A20 | MGC104522 | MGC138687 | MGC138688 | OTUD7C | TNFA1P2 肿瘤坏死因子，α诱导的蛋白3 - HPRD,BioGRID 8702721
TSC1 KIAA0243 | LAM | MGC86987 | TSC 结节硬化症1 Hamartin与14-3-3-β相互作用。这种相互作用是建立在人宅甲和小鼠14-3-3-β同工型之间的相互作用的模型。 BIND 12176984
TSC2 FLJ43106 | LAM | TSC4 结节硬化2 - HPRD 12438239|12468542
TSC2 FLJ43106 | LAM | TSC4 结节硬化2 The tumor suppressor protein tuberin interacts with 14-3-3-beta isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-beta isoform. BIND 12176984
UCP2 BMIQ4 |SLC25A8 |UCPH uncoupling protein 2 (mitochondrial, proton carrier) - HPRD,BioGRID 10785390
UCP2 BMIQ4 |SLC25A8 |UCPH uncoupling protein 2 (mitochondrial, proton carrier) UCP2 interacts with 14.3.3-beta. BIND 10785390
UCP3 SLC25A9 uncoupling protein 3 (mitochondrial, proton carrier) UCP3 interacts with 14.3.3-beta. BIND 10785390
UCP3 SLC25A9 uncoupling protein 3 (mitochondrial, proton carrier) - HPRD,BioGRID 10785390
USP8 FLJ34456 |humorf8 |KIAA0055 |MGC129718 |Ubpy 泛素特异性肽酶8 Affinity Capture-MS BioGRID 17353931
wee1 DKFZP686I18166 |FLJ16446 |wee1a |wee1hu wee1homolog (S. pombe) - HPRD,BioGRID 10775038
YWHAB GW128 | HS1 | KCIP-1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide - HPRD 12453887
ZFP36 G0S24 | GOS24 | NUP475 | RNF162A | TIS11 | TTP 锌指蛋白36，C3H类型，同源物（小鼠） - HPRD,BioGRID 11886850


Section V. Pathway annotation

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG CELL CYCLE 128 84 All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 114 79 All SZGR 2.0 genes in this pathway
KEGG神经营养蛋白信号传导途径 126 103 All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY 42 35 All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 67 54 All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES 51 41 All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY 37 29 All SZGR 2.0 genes in this pathway
PID HDAC Classii途径 34 27 All SZGR 2.0 genes in this pathway
PID ATR PATHWAY 39 25 All SZGR 2.0 genes in this pathway
PID ATM PATHWAY 34 25 All SZGR 2.0 genes in this pathway
PID LKB1途径 47 37 All SZGR 2.0 genes in this pathway
PID NFAT 3 Pathway 54 47 All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 69 55 All SZGR 2.0 genes in this pathway
PID FOXO途径 49 43 All SZGR 2.0 genes in this pathway
PID ERBB1下游途径 105 78 All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129 103 All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY 21 19 All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 80 60 All SZGR 2.0 genes in this pathway
PID A6B1 A6B4整合素途径 46 35 All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY 26 24 All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY 35 30 All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY 36 31 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT 78 59 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 90 67 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
ERBB2信号中的Reactome GRB2事件 22 20 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 109 80 All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING 20 17 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY HIPPO 22 15 All SZGR 2.0 genes in this pathway
Reactome胰岛素受体信号传导级联 87 64 All SZGR 2.0 genes in this pathway
REACTOME ARMS MEDIATED ACTIVATION 17 17 All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS 19 18 All SZGR 2.0 genes in this pathway
Reactome对RAS的信号传导 27 23 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS 36 30 All SZGR 2.0 genes in this pathway
FGFR在疾病中的反应组信号传导 127 88 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 15 14 All SZGR 2.0 genes in this pathway
Reactome胃胃CREB信号传导途径通过PKC和MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN EGFR SIGNALING 15 13 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
PDGF的Reactome信号传导 122 93 All SZGR 2.0 genes in this pathway
Reactome下游信号转导 95 76 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 64 49 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE 36 27 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
Reactome的下游信号传导激活的FGFR 100 74 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
REACTOME RAP1 SIGNALLING 17 12 All SZGR 2.0 genes in this pathway
BRF1对mRNA的反应组不稳定 17 9 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 50 All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP 17 7 All SZGR 2.0 genes in this pathway
REACTOME IL 2 SIGNALING 41 34 All SZGR 2.0 genes in this pathway
胰岛素受体的反应组信号传导 108 72 All SZGR 2.0 genes in this pathway
REACTOME SOS MEDIATED SIGNALLING 14 13 All SZGR 2.0 genes in this pathway
反应组凋亡 148 94 All SZGR 2.0 genes in this pathway
Reactome RAF MAP激酶级联 10 10 All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED SIGNALLING 15 12 All SZGR 2.0 genes in this pathway
Reactome免疫系统 933 616 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 17 12 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 112 80 All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 30 21 All SZGR 2.0 genes in this pathway
REACTOME SHC RELATED EVENTS 17 13 All SZGR 2.0 genes in this pathway
WIKMAN ASBESTOS LUNG CANCER UP 17 11 All SZGR 2.0 genes in this pathway
ginestier乳腺癌20q13扩增 119 66 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341 197 All SZGR 2.0 genes in this pathway
CREIGHTON AKT1 SIGNALING VIA MTOR DN 23 16 All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 142 96 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162 104 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180 110 All SZGR 2.0 genes in this pathway
darwiche鳞状细胞癌 146 104 All SZGR 2.0 genes in this pathway
Scheidereit IKK目标 18 15 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR UP 25 17 All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5 26 21 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 20Q12 Q13 AMPLICON 149 76 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN 49 29 All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX DN 80 49 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
Ramalho Stemness 206 118 All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203 135 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 132 93 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425 253 All SZGR 2.0 genes in this pathway
Beier神经胶质瘤干细胞DN 66 42 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175 103 All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN 102 65 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
wakabayashi脂肪生成PPARG RXRA绑定8D 882 506 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 mirna id miRNA seq
UTR start UTR end Match method
miR-128 273 280 1a,m8 HSA-MIR-128A ucacagugaaccggucuuuu
HSA-MIR-128B ucacagugaaccggucuuc
miR-148/152 1667年 1674年 1a,m8 HSA-MIR-148A UCAGUGCACUACAGAACUUUGU
hsa-miR-152脑 UCAGUGCAUGACAGAACUUGGG
HSA-MIR-148B ucagugcaucacacaacuuugu
miR-200bc/429 1841年 1847年 M8 hsa-miR-200b uaauacugccugguaaugaugac
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-214 1640年 1646年 1a hsa-miR-214脑 acagcaggcacagacaggcag
miR-218 1888年 1894年 M8 hsa-miR-218脑 UUGUGCUUGAUCUAACCAUGU
miR-27 274 280 M8 hsa-miR-27a脑 UUCACAGUGGCUAAGUUCCGC
hsa-miR-27b脑 UUCACAGUGGCUAAGUUCUGC
miR-361 363 369 M8 hsa-miR-361脑 UUAUCAGAAUCUCCAGGGGUAC
mir-488 1804年 1810 M8 hsa-miR-488 CCCAGAUAAUGGCACUCUCAA