Gene Page:YWHAE

Summary?
GeneID 7531
Symbol YWHAE
Synonyms 14-3-3E|HEL2|KCIP-1|MDCR|MDS
Description tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Reference MIM:605066|HGNC:HGNC:12851|Ensembl:ENSG00000108953|HPRD:05457|Vega:OTTHUMG00000134316
Gene type protein-coding
Map location 17p13.3
Pascal p-value 1.016E-4
Sherlock p-value 0.241
Fetal beta 0.345
Support INTRACELLULAR SIGNAL TRANSDUCTION
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 2 Link to SZGene
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.539

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ZNF131 0.94 0.95
DDX20 0.92 0.93
ZNF615 0.92 0.93
ZNF280D 0.92 0.93
ZNF567 0.91 0.92
TOPORS 0.91 0.92
WDR43 0.91 0.92
PHF20L1 0.91 0.92
ZNF175 0.91 0.91
C10orf137 0.91 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.77 -0.86
AF347015.31 -0.77 -0.85
FXYD1 -0.76 -0.86
AF347015.33 -0.75 -0.83
AF347015.27 -0.75 -0.84
IFI27 -0.75 -0.85
MT-CYB -0.74 -0.83
AF347015.8 -0.74 -0.85
HIGD1B -0.74 -0.86
AIFM3 -0.73 -0.79

Section III. Gene Ontology annotation

分子功能 去的术语 Evidence Neuro keywords PubMed ID
GO:0019904 protein domain specific binding IEA -
GO:0019899 enzyme binding 新闻学会 10788521
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007242 intracellular signaling cascade TAS 7644510
GO:0006605 protein targeting IEA -
GO:0044419 interspecies interaction between organisms IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IEA -
GO:0005739 mitochondrion IEA -
GO:0042470 melanosome IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ARHGEF2 DKFZp547L106 | DKFZp547P1516 | GEF | GEF-H1 | GEFH1 | KIAA0651 | LFP40 | P40 rho/rac guanine nucleotide exchange factor (GEF) 2 - HPRD 14970201
BAD BBC2 | BCL2L8 BCL2-associated agonist of cell death - HPRD,BioGRID 9369453
BIRC3 AIP1 | API2 | CIAP2 | HAIP1 | HIAP1 | MALT2 | MIHC | RNF49 baculoviral IAP repeat-containing 3 The cIAP-2 promoter interacts with 14-3-3-epsilon. BIND 15494311
CALM1 CALML2 | CAMI | DD132 | PHKD calmodulin 1 (phosphorylase kinase, delta) - HPRD 10088721
CDC25A CDC25A2 细胞分裂周期25同族体A (S. pombe) - HPRD,BioGRID 7644510
CDC25A CDC25A2 细胞分裂周期25同族体A (S. pombe) - HPRD 7644510|14559997
CDC25A CDC25A2 细胞分裂周期25同族体A (S. pombe) 14-3-3-epsilon interacts with cdc25A. BIND 7644510
CDC25B - 细胞分裂周期25同族体B (S. pombe) - HPRD,BioGRID 7644510|10713667
CDC25B - 细胞分裂周期25同族体B (S. pombe) 14-3-3-epsilon interacts with cdc25B. BIND 7644510
CDC25C CDC25 细胞分裂周期25同族体C (S. pombe) Affinity Capture-Western BioGRID 10330186
CDC2L1 CDC2L2 | CDK11 | CDK11-p110 | CDK11-p46 | CDK11-p58 | CLK-1 | FLJ59152 | PK58 | p58 | p58CDC2L1 | p58CLK-1 cell division cycle 2-like 1 (PITSLRE proteins) CDK11-p110 interacts with 14-3-3-epsilon. BIND 15883043
CDKN1B CDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) - HPRD 12042314
GPRIN2 GRIN2 | KIAA0514 | MGC15171 G protein regulated inducer of neurite outgrowth 2 Two-hybrid BioGRID 16189514
GRAP2 GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38 GRB2-related adaptor protein 2 Two-hybrid BioGRID 16189514
HDAC4 HA6116 | HD4 | HDAC-A | HDACA | KIAA0288 histone deacetylase 4 Affinity Capture-Western
Reconstituted Complex		 BioGRID 10869435|11504882
HDAC4 HA6116 | HD4 | HDAC-A | HDACA | KIAA0288 histone deacetylase 4 - HPRD 11486037
HDAC5 FLJ90614 | HD5 | NY-CO-9 histone deacetylase 5 - HPRD,BioGRID 10869435
IGF1R CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 insulin-like growth factor 1 receptor - HPRD,BioGRID 9111084
IGF1R CD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216 insulin-like growth factor 1 receptor IGFIR interacts with 14-3-3-epsilon isoform. This interaction is modeled on a demonstrated interaction between human IGFIR and mouse 14-3-3-epsilon isoform BIND 9111084
IRS1 HIRS-1 insulin receptor substrate 1 IRS-1 interacts with 14-3-3-epsilon isoform. This interaction was modeled on a demonstrated interaction between human IRS-1 and mouse 14-3-3-epsilon isoform. BIND 9111084
IRS1 HIRS-1 insulin receptor substrate 1 - HPRD,BioGRID 9111084|9312143
IRS2 - insulin receptor substrate 2 - HPRD,BioGRID 9312143
KCNH2 ERG1 | HERG | HERG1 | Kv11.1 | LQT2 | SQT1 potassium voltage-gated channel, subfamily H (eag-related), member 2 - HPRD,BioGRID 11953308
KIF1C KIAA0706 | LTXS1 kinesin family member 1C - HPRD 10559254
KRT18 CYK18 | K18 keratin 18 - HPRD 9524113
MAP3K1 MAPKKK1 | MEKK | MEKK1 mitogen-activated protein kinase kinase kinase 1 Reconstituted Complex BioGRID 9452471
MAP3K10 MLK2 | MST mitogen-activated protein kinase kinase kinase 10 - HPRD,BioGRID 9427749
MAP3K2 MEKK2 | MEKK2B mitogen-activated protein kinase kinase kinase 2 - HPRD,BioGRID 9452471
MAP3K3 MAPKKK3 | MEKK3 mitogen-activated protein kinase kinase kinase 3 - HPRD,BioGRID 9452471
MAP3K7IP2 FLJ21885 | KIAA0733 | TAB2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2 - HPRD 14743216
MAPK7 BMK1 | ERK4 | ERK5 | PRKM7 mitogen-activated protein kinase 7 Two-hybrid BioGRID 14679215
NCOR2 CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 nuclear receptor co-repressor 2 14-3-3-epsilon interacts with SMRT. BIND 15494311
NDEL1 DKFZp451M0318 | EOPA | MITAP1 | NUDEL nudE nuclear distribution gene E homolog (A. nidulans)-like 1 - HPRD,BioGRID 12796778
NGFRAP1 BEX3 | Bex | DXS6984E | HGR74 | NADE nerve growth factor receptor (TNFRSF16) associated protein 1 - HPRD,BioGRID 11278287
PAPOLA MGC5378 | PAP poly(A) polymerase alpha - HPRD 14517258
PCTK1 FLJ16665 | PCTAIRE | PCTAIRE1 | PCTGAIRE PCTAIRE protein kinase 1 - HPRD 12154078
RAF1 CRAF | NS5 | Raf-1 | c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 - HPRD,BioGRID 7644510
RAF1 CRAF | NS5 | Raf-1 | c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 14-3-3-epsilon interacts with Raf-1. BIND 7644510
RASGRF1 CDC25 | CDC25L | GNRP | GRF1 | GRF55 | H-GRF55 | PP13187 Ras protein-specific guanine nucleotide-releasing factor 1 - HPRD 11533041
REM1 GD:REM | GES | MGC48669 | REM RAS (RAD and GEM)-like GTP-binding 1 - HPRD,BioGRID 10441394
RGNEF DKFZp686P12164 | FLJ21817 | KIAA1998 Rho-guanine nucleotide exchange factor - HPRD 11533041
RGS3 C2PA | FLJ20370 | FLJ31516 | FLJ90496 | PDZ-RGS3 | RGP3 regulator of G-protein signaling 3 - HPRD 11985497
RIN1 - Ras and Rab interactor 1 - HPRD 9144171|11784866
SNCA MGC110988 | NACP | PARK1 | PARK4 | PD1 synuclein, alpha (non A4 component of amyloid precursor) - HPRD 10407019
SORBS2 ARGBP2 | FLJ93447 | KIAA0777 | PRO0618 sorbin and SH3 domain containing 2 Two-hybrid BioGRID 16189514
SRC ASV | SRC1 | c-SRC | p60-Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) - HPRD 8702721
SYN2 SYNII | SYNIIa | SYNIIb synapsin II Two-hybrid BioGRID 10358015
TGFB1 CED | DPD1 | TGFB | TGFbeta 转化生长因子β1 - HPRD,BioGRID 11172812
TNFAIP3 A20 | MGC104522 | MGC138687 | MGC138688 | OTUD7C | TNFA1P2 肿瘤坏死factor, alpha-induced protein 3 - HPRD,BioGRID 8702721
TOP2A TOP2 | TP2A topoisomerase (DNA) II alpha 170kDa - HPRD,BioGRID 10788521
TSC1 KIAA0243 | LAM | MGC86987 | TSC tuberous sclerosis 1 Hamartin interacts with 14-3-3-epsilon. BIND 12176984
TSC2 FLJ43106 | LAM | TSC4 tuberous sclerosis 2 - HPRD 12438239
TSC2 FLJ43106 | LAM | TSC4 tuberous sclerosis 2 Tumor suppressor protein tuberin interacts with 14-3-3-epsilon isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-epsilon isoform. BIND 12176984
WWTR1 DKFZp586I1419 | TAZ WW domain containing transcription regulator 1 - HPRD 11118213


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL CYCLE 128 84 All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 114 79 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY 42 35 All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 67 54 All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES 51 41 All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY 37 29 All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY 34 27 All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY 47 37 All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY 68 48 All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 54 47 All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 69 55 All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY 30 23 All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 49 43 All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY 69 51 All SZGR 2.0 genes in this pathway
PID LIS1 PATHWAY 28 22 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129 103 All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY 21 19 All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 80 60 All SZGR 2.0 genes in this pathway
PID A6B1A6B4 INTEGRIN PATHWAY 46 35 All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY 26 24 All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY 35 30 All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY 36 31 All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY 55 38 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY HIPPO 22 15 All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 60 43 All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 81 61 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 66 43 All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 59 38 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 81 50 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP 55 34 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214 134 All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP 98 58 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES UP 19 15 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 108 74 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP 108 66 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX2 DN 7 6 All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5 26 21 All SZGR 2.0 genes in this pathway
ZUCCHI METASTASIS DN 44 29 All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS 53 35 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN 141 99 All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153 120 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
WU HBX TARGETS 1 DN 23 14 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
WU HBX TARGETS 2 UP 23 13 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM 66 47 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 132 93 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN 79 45 All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447 277 All SZGR 2.0 genes in this pathway
SPIRA SMOKERS LUNG CANCER UP 38 24 All SZGR 2.0 genes in this pathway
HAHTOLA CTCL CUTANEOUS 26 19 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP 72 53 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP 140 94 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 UP 87 52 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-155 266 272 m8 hsa-miR-155 UUAAUGCUAAUCGUGAUAGGGG
miR-186 227 233 1A hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-26 777 783 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-30-3p 560 566 1A hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
miR-31 608 614 m8 hsa-miR-31 AGGCAAGAUGCUGGCAUAGCUG
miR-320 216 222 m8 hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-490 636 642 1A hsa-miR-490 CAACCUGGAGGACUCCAUGCUG