SZGR2 - Beplay体育中心

Summary?

基因ID	7534
象征	YWHAZ
同义词	14-3-3-zeta\|HEL-S-3\|HEL-S-93\|HEL4\|KCIP-1\|YWHAD
描述	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
参考	MIM：601288\|HGNC:HGNC:12855\|Ensembl:ENSG00000164924\|HPRD：03183\|Vega：Otthumg00000134291
基因类型	protein-coding
Map location	8Q23.1
Pascal P值	0.031
Sherlock p-value	0.209
Fetal beta	0.924
DMG	1 (# studies)
eGene	Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere 小脑皮质 Frontal Cortex BA9 伏隔核基底神经节
Support	细胞内信号转导 G2Cdb.human_mGluR5 G2Cdb.human_mitochondria G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP COMPOSITESET 潜在的突触基因

基因in Data Sources

基因集名称	基因组方法	描述	Info
简历：PGCNP	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	2
DNM:Fromer_2014	整个外显子组测序分析	This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccur	高通量文献搜索	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Association	组合的优势比方法（Sun等。2008），协会研究	1	Link to SZGene
文学	高通量文献搜索	与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症	点击to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 11.6823

Section I. Genetics and epigenetics annotation

DNM表

基因	染色体	位置	Ref	Alt	成绩单	AA更改	突变类型	筛选	CG46	特征	Study
YWHAZ	CHR8	101937218	T	C	NM_001135699 NM_001135700 NM_001135701 NM_001135702 NM_003406 NM_145690	p.115k> r p.115k> r p.115k> r p.115k> r p.115k> r p.115k> r	missense missense missense missense missense missense			Schizophrenia	DNM:Fromer_2014

Differentially methylated gene

Probe	染色体	位置	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
CG06776824	8	101962949	YWHAZ	1.84E-5	0.873	0.016	DMG:Wockner_2014
cg06692871	8	101964133	YWHAZ	5.67E-5	-0.524	0.022	DMG:Wockner_2014

eQTL annotation

SNP ID	染色体	位置	eGene	基因Entrez ID	pvalue	qvalue	TSS distance	eQTL type
RS3105460	8	101937374	YWHAZ	ENSG00000164924.13	1.093E-6	0.01	28242	gtex_brain_ba24
RS34699406	8	101946380	YWHAZ	ENSG00000164924.13	1.095E-6	0.01	19236	gtex_brain_ba24
rs3134353	8	101947453	YWHAZ	ENSG00000164924.13	1.093E-6	0.01	18163	gtex_brain_ba24
RS1470764	8	101950038	YWHAZ	ENSG00000164924.13	1.093E-6	0.01	15578	gtex_brain_ba24
rs3134358	8	101958433	YWHAZ	ENSG00000164924.13	1.138E-6	0.01	7183	gtex_brain_ba24
RS983583	8	101961910	YWHAZ	ENSG00000164924.13	1.155E-6	0.01	3706	gtex_brain_ba24
rs71506350	8	101962901	YWHAZ	ENSG00000164924.13	1.057E-6	0.01	2715	gtex_brain_ba24
RS3100052	8	101967139	YWHAZ	ENSG00000164924.13	1.194E-6	0.01	-1523	gtex_brain_ba24
RS7817485	8	101969528	YWHAZ	ENSG00000164924.13	1.279E-6	0.01	-3912	gtex_brain_ba24
rs4734500	8	101970119	YWHAZ	ENSG00000164924.13	8.091E-7	0.01	-4503	gtex_brain_ba24
rs2386921	8	101975378	YWHAZ	ENSG00000164924.13	4.478E-7	0.01	-9762	gtex_brain_ba24
rs2386922	8	101975479	YWHAZ	ENSG00000164924.13	2.485E-7	0.01	-9863	gtex_brain_ba24
rs2923781	8	101976510	YWHAZ	ENSG00000164924.13	7.683E-7	0.01	-10894	gtex_brain_ba24
RS57408636	8	101980444	YWHAZ	ENSG00000164924.13	3.22E-7	0.01	-14828	gtex_brain_ba24

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008134	转录因子结合	IPI		16114898
GO:0019904	protein domain specific binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
去：0007165	signal transduction	TAS		16130169
去：0006916	抗凋亡	TAS		16130169
细胞分量	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	细胞质	TAS		16130169
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	Experimental	资源	PubMed ID
AANAT	aa-nat \|sn	芳基烷基胺N-乙酰转移酶	-	HPRD,BioGRID	11336675
AANAT	aa-nat \|sn	芳基烷基胺N-乙酰转移酶	AANAT interacts with 14-3-3-zeta isoform. This interaction was modeled on a demonstrated interaction between sheep AANAT and human 14-3-3-zeta.	绑定	8024705\|11336675 \|11427721
ADAM22	mdc2 \|MGC149832	ADAM metallopeptidase domain 22	-	HPRD	12589811
adra2a	ADRA2 \| ADRA2R \| ADRAR \| ALPHA2AAR \| ZNF32	肾上腺素，α-2A-，受体	-	HPRD	10224112
ADRA2B	ADRA2L1 \| ADRA2RL1 \| ADRARL1 \| ALPHA2BAR	adrenergic, alpha-2B-, receptor	-	HPRD	10224112
ADRA2C	ADRA2L2 \| ADRA2RL2 \| ADRARL2 \| ALPHA2CAR	adrenergic, alpha-2C-, receptor	-	HPRD	10224112
AKT1	akt \|MGC99656 \|PKB \|pkb-alpha \|Prkba \|RAC \|Rac-Alpha	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	11956222
AKT1	akt \|MGC99656 \|PKB \|pkb-alpha \|Prkba \|RAC \|Rac-Alpha	v-akt murine thymoma viral oncogene homolog 1	Akt与MAPKAPK2相同的残基与14-3-3 ZETA的磷酸化相互作用和磷酸化。	绑定	11956222
ARHGEF2	DKFZp547L106 \| DKFZp547P1516 \| GEF \| GEF-H1 \| GEFH1 \| KIAA0651 \| LFP40 \| P40	rho/rac guanine nucleotide exchange factor (GEF) 2	-	HPRD	14970201
坏的	BBC2 \|BCl2L8	BCL2-associated agonist of cell death	-	HPRD,BioGRID	11410287
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	-	HPRD,BioGRID	10026197
BCR	全部\|BCR-ABL1 \|BCR1 \|CML \|D22S11 \|D22S662 \|FLJ16453 \|phl	breakpoint cluster region	-	HPRD	7939633
布拉夫	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	Affinity Capture-MS	BioGRID	17353931
布拉夫	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	-	HPRD	8668348
BSPRY	FLJ20150	B-box and SPRY domain containing	-	HPRD	12615066
C22orf9	-	染色体22开放阅读框9	Affinity Capture-MS	BioGRID	17353931
CBL	C-CBL \|CBL2 \|RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Two-hybrid	BioGRID	9367879
CBL	C-CBL \|CBL2 \|RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	C-CBL与14-3-3-zeta相互作用。	绑定	9367879
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	-	HPRD,BioGRID	11912208
CDC25B	-	细胞分裂周期25同源物B（S. pombe）	-	HPRD,BioGRID	10713667
CDC25B	-	细胞分裂周期25同源物B（S. pombe）	14-3-3-Zeta与磷酸化的CDC25B相互作用。	绑定	15629715
CDC25C	CDC25	细胞分裂周期25同源C（S。Pombe）	-	HPRD,BioGRID	10864927
clic4	clic4L \| DKFZp566G223 \| FLJ38640 \| H1 \| MTCLIC \| huH1 \| p64H1	氯化物内通道4	-	HPRD	11563969
CSF2RB	CD131 \| CDw131 \| IL3RB \| IL5RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	-	HPRD,BioGRID	8278375\|10477722
DFFA	DFF-45 \|DFF1 \|ICAD	DNA fragmentation factor, 45kDa, alpha polypeptide	Affinity Capture-MS	BioGRID	17353931
EDC3	FLJ21128 \|FLJ31777 \|LSM16 \|yjdc \|YJEFN2	mRNA的增强子Decapting 3同源物（S. cerevisiae）	Affinity Capture-MS	BioGRID	17353931
EGFR	ERBB \|ERBB1 \|her1 \|PIG61 \|梅纳	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	EGFR interacts with 14-3-3-zeta.	绑定	15225635
EPB41L3	4.1B \| DAL-1 \| DAL1 \| FLJ37633 \| KIAA0987	红细胞膜蛋白条带4.1样3	Affinity Capture-MS	BioGRID	17353931
FOXO1	FKH1 \| FKHR \| FOXO1A	叉子盒O1	-	HPRD,BioGRID	11237865
FOXO3	AF6Q21 \|DKFZP781A0677 \|fkhrl1 \|fkhrl1p2 \|FOXO2 \|foxo3a \|MGC12739 \|MGC31925	叉子盒O3	-	HPRD,BioGRID	10102273
GP1BA	BSS \|CD42B \|CD42B-Alpha \|GP1B \|MGC34595	糖蛋白IB（血小板），α多肽	-	HPRD,BioGRID	8631758\|9454760 \|10627461 \| 9454760
GP1BB	CD42c	glycoprotein Ib (platelet), beta polypeptide	-	HPRD	8034572\|10627461
GP1BB	CD42c	glycoprotein Ib (platelet), beta polypeptide	in vitro 体内 Two-hybrid	BioGRID	8034572\|9454760 \|10627461
HDAC4	HA6116 \|HD4 \|HDAC-A \|hdaca \|KIAA0288	组蛋白脱乙酰基酶4	Reconstituted Complex	BioGRID	11504882
HDAC4	HA6116 \|HD4 \|HDAC-A \|hdaca \|KIAA0288	组蛋白脱乙酰基酶4	-	HPRD	11486037
HMGN1	FLJ27265 \|FLJ31471 \|HMG14 \|MGC104230 \|MGC117425	high-mobility group nucleosome binding domain 1	-	HPRD,BioGRID	12215538
hnrnpl	FLJ35509 \|hnrpl \|p/okcl.14 \|HNRNP-L	异质核核糖核蛋白L	Affinity Capture-MS	BioGRID	17353931
IGF1R	CD221 \|igfir \|JTK13 \|MGC142170 \|MGC142172 \|MGC18216	insulin-like growth factor 1 receptor	-	HPRD	9581554
IGF1R	CD221 \|igfir \|JTK13 \|MGC142170 \|MGC142172 \|MGC18216	insulin-like growth factor 1 receptor	IGFIR interacts with 14-3-3-zeta isoform.	绑定	9581554
IL9R	CD129	interleukin 9 receptor	-	HPRD,BioGRID	10642536
inpp5a	5ptase \|DKFZP434A1721 \|MGC116947 \|MGC116949	inositol polyphosphate-5-phosphatase, 40kDa	-	HPRD,BioGRID	9398266
IRS1	HIRS-1	胰岛素受体底物1	-	HPRD,BioGRID	9312143
IRS2	-	胰岛素受体底物2	-	HPRD,BioGRID	9312143
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	16169070
KIF1C	KIAA0706 \| LTXS1	动机家庭成员1C	-	HPRD	10559254
KIF5B	Kinh \|KNS \|KNS1 \|UKHC	动机家庭成员5B	Affinity Capture-MS	BioGRID	17353931
KLC1	KLC \| KNS2 \| KNS2A \| MGC15245	动力素轻链1	Affinity Capture-MS	BioGRID	17353931
KLC4	knsl8 \|MGC111777 \|BA387M24.3	动力素轻链4	Affinity Capture-MS	BioGRID	17353931
KRT18	CYK18 \|K18	角蛋白18	-	HPRD	9524113\|11917136
LARP1	KIAA0731 \| LARP \| MGC19556	la核糖核蛋白域家族，成员1	Affinity Capture-MS	BioGRID	17353931
limk1	肢体	LIM domain kinase 1	-	HPRD,BioGRID	12323073
莱斯特	CHS \| CHS1	lysosomal trafficking regulator	Reconstituted Complex	BioGRID	11984006
MAP3K2	mekk2 \|mekk2b	mitogen-activated protein kinase kinase kinase 2	-	HPRD	9452471
MAP3K3	MAPKKK3 \|mekk3	mitogen-activated protein kinase kinase kinase 3	-	HPRD	9452471
MAP3K5	Ask1 \|MAPKKK5 \|mekk5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	10411906\|11336675
MAPKAPK2	MK2	mitogen-activated protein kinase-activated protein kinase 2	MAPKAPK2与14-3-3-zeta相互作用并磷酸化。	绑定	12861023
mapt	ddpac \|FLJ31424 \|FTDP-17 \|maptl \|MGC138549 \|MSTD \|mtbt1 \|mtbt2 \|ppnd \|tau	microtubule-associated protein tau	Tau interacts with 14-3-3-zeta.	绑定	12176984
mapt	ddpac \|FLJ31424 \|FTDP-17 \|maptl \|MGC138549 \|MSTD \|mtbt1 \|mtbt2 \|ppnd \|tau	microtubule-associated protein tau	-	HPRD,BioGRID	10840038
MLF1	-	myeloid leukemia factor 1	-	HPRD	12176995
NADK	FLJ13052 \|FLJ37724 \|DJ283E3.1	NAD激酶	Affinity Capture-MS	BioGRID	17353931
NCKAP1	FLJ11291 \|Hem2 \|KIAA0587 \|MGC8981 \|NAP1 \|NAP125	NCK-associated protein 1	Affinity Capture-MS	BioGRID	17353931
NFATC2	KIAA0611 \|NFAT1 \|NFATP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	-	HPRD,BioGRID	10611249
NFATC4	NF-ATC4 \|NFAT3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	-	HPRD,BioGRID	10611249
NOLC1	KIAA0035 \| NOPP130 \| NOPP140 \| NS5ATP13 \| P130	nucleolar and coiled-body phosphoprotein 1	Affinity Capture-MS	BioGRID	17353931
PABPC4	App-1 \|App1 \|FLJ43938 \|PABP4 \|ipabp	保利(A)结合蛋白、胞质4(诱导form)	Affinity Capture-MS	BioGRID	17353931
PAK4	-	p21 protein (Cdc42/Rac)-activated kinase 4	Affinity Capture-MS	BioGRID	17353931
PCTK1	FLJ16665 \|Pctaire \|pctaire1 \|Pctgaire	PCTAIRE protein kinase 1	-	HPRD,BioGRID	9197417
PDC	MEKA \| PHD \| PhLOP \| PhLP	phosducin	-	HPRD	11287646\|11331285
PFKFB2	DKFZp781D2217 \| MGC138308 \| MGC138310 \| PFK-2/FBPase-2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	-	HPRD	12853467
prkca	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	蛋白激酶C，α	-	HPRD,BioGRID	11950841
prkcd	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	蛋白激酶C,三角洲	Affinity Capture-Western	BioGRID	11950841
prkce	MGC125656 \| MGC125657\| PKCE \| nPKC-epsilon	蛋白激酶C，Epsilon	Affinity Capture-Western	BioGRID	11950841
prkci	DXS1179E \|MGC26534 \|PKCI \|npkc-iota	protein kinase C, iota	Reconstituted Complex	BioGRID	12893243
Prkcz	PKC-Zeta \|PKC2	蛋白激酶C，Zeta	Biochemical Activity Reconstituted Complex	BioGRID	10620507\|12893243
PRKD1	PKC-MU \| PKCM \| PKD \| PRKCM	protein kinase D1	Reconstituted Complex	BioGRID	12893243
PTPN13	DKFZp686J1497 \| FAP-1 \| PNP1 \| PTP-BAS \| PTP-BL \| PTP1E \| PTPL1 \| PTPLE	蛋白酪氨酸磷酸酶，非受体13型（APO-1/CD95（FAS）相关磷酸酶）	-	HPRD	9305890
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	V-RAF-1鼠白血病病毒癌基因同源1	Raf-1 interacts with 14-3-3 zeta. This interaction was modelled on a demonstrated interaction between human Raf-1 and murine 14-3-3-zeta.	绑定	7559537
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	V-RAF-1鼠白血病病毒癌基因同源1	Affinity Capture-Western Reconstituted Complex	BioGRID	7628630\|9261098 \|10620507\|10887173
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	V-RAF-1鼠白血病病毒癌基因同源1	-	HPRD	7628630\|7939632
RAI14	DKFZp564G013 \| KIAA1334 \| NORPEG \| RAI13	视黄酸诱导14	Affinity Capture-MS	BioGRID	17353931
ralgps2	FLJ10244 \| FLJ25604 \| KIAA0351 \| dJ595C2.1	带有pH结构域和SH3结合基序2的RAL GEF 2	Affinity Capture-MS	BioGRID	17353931
REM1	GD：rem \|Ges \|MGC48669 \|REM	RAS (RAD and GEM)-like GTP-binding 1	-	HPRD,BioGRID	10441394
RGS3	C2PA \|FLJ20370 \|FLJ31516 \|FLJ90496 \|PDZ-RGS3 \|rgp3	G蛋白信号传导的调节剂3	-	HPRD,BioGRID	11985497
RIN1	-	Ras和Rab Interactor 1	-	HPRD	9144171
RPL31	MGC88191	核糖体蛋白L31	Affinity Capture-MS	BioGRID	17353931
RRAD	rad \|rad1 \|REM3	Ras-related associated with diabetes	Affinity Capture-Western	BioGRID	10441394
SAMD4B	FLJ10211 \|MGC99832 \|SMGB	含4B的无菌α基序域	Affinity Capture-MS	BioGRID	17353931
SF3B1	PRP10 \| PRPF10 \| SAP155 \| SF3b155	剪接因子3B，亚基1，155KDA	Affinity Capture-MS	BioGRID	17353931
SFRS10	DKFZp686F18120 \| Htra2-beta \| SRFS10 \| TRA2-BETA \| TRA2B \| TRAN2B	splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)	Affinity Capture-MS	BioGRID	17353931
SSH1	FLJ38102 \| KIAA1298 \| SSH-1	slingshot homolog 1 (Drosophila)	SSH-1S interacts with 14-3-3-zeta.	绑定	15660133
SSH1	FLJ38102 \| KIAA1298 \| SSH-1	slingshot homolog 1 (Drosophila)	SSH-1L与14-3-3-Zeta相互作用。	绑定	15660133
SSH2	KIAA1725 \| MGC78588 \| SSH-2	slingshot homolog 2 (Drosophila)	SSH-2S与14-3-3-Zeta相互作用。	绑定	15660133
SSH3	FLJ10928 \| FLJ20515 \| SSH-3	slingshot homolog 3 (Drosophila)	SSH-3S interacts with 14-3-3-zeta.	绑定	15660133
SYN2	Synii \|Syriia \|Syniib	synapsin II	Two-hybrid	BioGRID	10358015
Tert	EST2 \|TCS1 \|TP2 \|trt \|hest2	端粒酶逆转录酶	Two-hybrid	BioGRID	10835362
TH	tyh	酪氨酸羟化酶	-	HPRD	11359875
TJP2	MGC26306 \| X104 \| ZO-2 \| ZO2	紧密连接蛋白2（Zona occludens 2）	Affinity Capture-MS	BioGRID	17353931
TNFAIP3	A20 \|MGC104522 \|MGC138687 \|MGC138688 \|otud7c \|TNFA1P2	肿瘤坏死因子，α诱导的蛋白3	-	HPRD,BioGRID	9299557
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	肿瘤蛋白p53	-	HPRD,BioGRID	9620776
TPH1	MGC119994 \|TPH \|TPRH	色氨酸羟化酶1	-	HPRD,BioGRID	8101440
TSC1	KIAA0243 \|林\|MGC86987 \|TSC	结节硬化症1	-	HPRD,BioGRID	12176984
TSC2	FLJ43106 \| LAM \| TSC4	结节硬化2	-	HPRD	12176984\|12438239 \|12468542
TSC2	FLJ43106 \| LAM \| TSC4	结节硬化2	-	HPRD,BioGRID	12176984
TSC2	FLJ43106 \| LAM \| TSC4	结节硬化2	肿瘤抑制蛋白结核素与14-3-3-ZETA同工型相互作用。	绑定	11533041\|12176984
UCP2	BMIQ4 \|SLC25A8 \|UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	UCP2 interacts with 14.3.3-zeta.	绑定	10785390
UCP2	BMIQ4 \|SLC25A8 \|UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	-	HPRD,BioGRID	10785390
UCP3	SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	UCP3 interacts with 14.3.3-zeta.	绑定	10785390
UCP3	SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	-	HPRD,BioGRID	10785390
USP8	FLJ34456 \|humorf8 \|KIAA0055 \|MGC129718 \|Ubpy	泛素特异性肽酶8	Affinity Capture-MS	BioGRID	17353931
vim	FLJ36605	波形蛋白	-	HPRD,BioGRID	10887173
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X射线修复补充中国仓鼠细胞中有缺陷的修复6	Two-hybrid	BioGRID	16169070
YWHAZ	KCIP-1 \|MGC111427 \|MGC126532 \|MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Affinity Capture-Western Reconstituted Complex	BioGRID	10887173
YWHAZ	KCIP-1 \|MGC111427 \|MGC126532 \|MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	-	HPRD	11336675
YWHAZ	KCIP-1 \|MGC111427 \|MGC126532 \|MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	14-3-3zeta homodimerizes.	绑定	12861023

Section V. Pathway annotation

路径名	Pathway size	＃szgr 2.0基因	Info
kegg细胞周期	128	84	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG神经营养蛋白信号传导途径	126	103	All SZGR 2.0 genes in this pathway
KEGG致病性大肠杆菌感染	59	36	All SZGR 2.0 genes in this pathway
Biocarta Chrebp2途径	42	35	All SZGR 2.0 genes in this pathway
SIG PIP3在心脏肌周期中发出信号	67	54	All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	51	41	All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	37	29	All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY	37	31	All SZGR 2.0 genes in this pathway
PID ATR PATHWAY	39	25	All SZGR 2.0 genes in this pathway
PID LKB1途径	47	37	All SZGR 2.0 genes in this pathway
PID NFAT 3 Pathway	54	47	All SZGR 2.0 genes in this pathway
PID MTOR 4 Pathway	69	55	All SZGR 2.0 genes in this pathway
PID IGF1途径	30	23	All SZGR 2.0 genes in this pathway
PID FOXO途径	49	43	All SZGR 2.0 genes in this pathway
PID ERBB1下游途径	105	78	All SZGR 2.0 genes in this pathway
PID IL3途径	27	19	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY	46	35	All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY	26	24	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY	36	31	All SZGR 2.0 genes in this pathway
PID整合素A4B1途径	33	24	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
ILS的Reactome信号传导	107	86	All SZGR 2.0 genes in this pathway
Reactome IL 3 5和GM CSF信号传导	43	34	All SZGR 2.0 genes in this pathway
Reactome Rap1信号传导	17	12	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	50	All SZGR 2.0 genes in this pathway
KSRP对mRNA的反应组不稳定	17	9	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
Reactome免疫系统	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
Reactome血小板激活信号传导和聚集	208	138	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
弗雷索莫昔芬反应	51	36	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
Borczuk恶性间皮瘤	305	185	All SZGR 2.0 genes in this pathway
Senese HDAC1靶向	457	269	All SZGR 2.0 genes in this pathway
Senese HDAC3靶向	501	327	All SZGR 2.0 genes in this pathway
罗德里格甲状腺癌的分化不佳	633	376	All SZGR 2.0 genes in this pathway
甲状腺癌的甲状腺癌间变性	722	443	All SZGR 2.0 genes in this pathway
hahtola兄弟姐妹Fungoides皮肤	177	113	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡	1781	1082	All SZGR 2.0 genes in this pathway
Graessmann对MC和阿霉素DN的反应	770	415	All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶标C向上	170	114	All SZGR 2.0 genes in this pathway
OUELLET卵巢癌侵入性与LMP UP	117	85	All SZGR 2.0 genes in this pathway
LUI甲状腺癌PAX8 PPARG DN	45	29	All SZGR 2.0 genes in this pathway
李肺癌	41	30	All SZGR 2.0 genes in this pathway
Lindgren膀胱癌簇2B	392	251	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲DN	584	395	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT DN	45	33	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5	26	21	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON	132	82	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP	151	100	All SZGR 2.0 genes in this pathway
MLL CBP融合的王目标	44	26	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
kaab失败的心房DN	141	99	All SZGR 2.0 genes in this pathway
lu衰老的脑dn	153	120	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
JI对FSH DN的响应	58	43	All SZGR 2.0 genes in this pathway
dazard对UV SCC的反应	123	75	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL	311	205	All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN	434	302	All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN	264	168	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE	77	50	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN	315	197	All SZGR 2.0 genes in this pathway
Smid乳腺癌基础	648	398	All SZGR 2.0 genes in this pathway
Mir34b和Mir34C的丰田目标	463	262	All SZGR 2.0 genes in this pathway
王肿瘤的侵入性DN	210	128	All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN	366	257	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
Yamashita肝癌干细胞向上	47	38	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
Gutierrez多发性骨髓瘤	35	24	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN	553	343	All SZGR 2.0 genes in this pathway
Smad2或Smad3的Koinuma目标	824	528	All SZGR 2.0 genes in this pathway
ikeda mir1靶向	53	39	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
GUILLAUMOND KLF10 TARGETS UP	51	39	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	目标位置			mirna id	miRNA seq
mirna家族	UTR start	UTR end	Match method	mirna id	miRNA seq
mir-1/206	590	597	1A，M8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	aggaauguucuuugcc
miR-149	172	178	M8	hsa-miR-149^脑	UCUGGCUCCGUGUCUUCACUCC
miR-155	1353	1360	1A，M8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-193	296	302	M8	HSA-MIR-193A	Aacuggccuacaaagucccag
miR-193	296	302	M8	HSA-MIR-193B	aacuggcccucaaagucccgcuuu
mir-214	613	619	M8	hsa-miR-214^脑	acagcaggcacagacaggcag
mir-30-5p	85	91	M8	hsa-miR-30a-5p	uguaaaacauccuccugagaag
				HSA-MIR-30C^脑	uguaaacauccuacucucucucucagc
				HSA-MIR-30D^SZ	uguaaacauccccgacuggaag
				HSA-MIR-30B^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-328	294	300	M8	HSA-MIR-328^脑	CUGGCCCUCUCUGCCCUUCCGU
miR-34b	334	341	1A，M8	HSA-MIR-34B	UAGGCAGUGUCAUUAGCUGAUUG
miR-433-3p	916	922	1a	hsa-miR-433^脑	AUCAUGAUGGGCUCCUCGGUGU
mir-451	582	588	M8	hsa-miR-451^脑	AAACCGUUACCAUUACUGAGUUU
miR-544	577	583	1a	HSA-MIR-544	auucugcauuuuuuagcaagu
miR-93.hd/291-3p/294/295/302/372/373/520	426	433	1A，M8	hsa-miR-93^脑	AAAGUGCUGUUCGUGCAGGUAG
				HSA-MIR-302A	UAAGUGCUUCCAUGUUUUGGUGA
				HSA-MIR-302B	UAAGUGCUUCCAUGUUUUAGUAG
				HSA-MIR-302C	UAAGUGCUUCCAUGUUUCAGUGG
				HSA-MIR-302D	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				HSA-MIR-520E	Aaagugcuuuuuugaggg
				HSA-MIR-520A	AAAGUGCUUCCCUUUGGACUGU
				HSA-MIR-520B	AAAGUGCUUCCUUUUAGAGGG
				HSA-MIR-520C	AAAGUGCUUCCUUUUAGAGGGUU
				HSA-MIR-520D	AAAGUGCUUCUCUUUGGUGGGUU

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击这里to see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击这里to see the list of brain related miRNAs.

基因Page:YWHAZ