SZGR2 - Beplay体育中心

Summary？

基因	7535
象征	ZAP70
Synonyms	SRK\|STCD\|STD\|TZK\|ZAP-70
Description	zeta chain of T cell receptor associated protein kinase 70kDa
Reference	MIM：176947\|HGNC:HGNC:12858\|Ensembl：ENSG00000115085\|HPRD：01495\|Vega：Otthumg00000153060
基因类型	蛋白质编码
Map location	2Q12
Pascal p-value	0.012
主持人	Caudate basal ganglia Cerebellar Hemisphere 小脑 Frontal Cortex BA9 伏隔核基底神经节 Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	PSR：0.0004
go_annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS16869851	CHR4	20690056	ZAP70	7535		0.19		反式

第二节。转录组注释

一般基因表达（GTEX）

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0000166	nucleotide binding	IEA		-
GO:0001784	磷酸酪氨酸结合	IEA		-
去：0005515	蛋白质结合	IPI		7528772\|11891219\|12359715 \|12646565
去：0005524	ATP binding	nas		1423621
GO:0004715	非膜跨度蛋白酪氨酸激酶活性	IEA		-
GO：0016740	转移酶活性	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
GO:0007243	蛋白激酶级联反应	nas		1423621
去：0006955	免疫反应	IDA		1423621
GO：0018108	peptidyl-tyrosine phosphorylation	IEA		-
GO:0050852	T cell receptor signaling pathway	IEA		-
GO:0043366	beta选择	IEA		-
GO:0050850	钙介导的信号传导的阳性调节	IEA		-
GO：0045060	-胸腺T细胞election	IEA		-
GO：0045059	阳性胸腺T细胞选择	IDA		7630421
GO:0046638	positive regulation of alpha-beta T cell differentiation	IEA		-
GO:0046641	α-βT细胞增殖的阳性调节	IEA		-
GO:0046777	protein amino acid autophosphorylation	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0042101	T细胞受体复合物	IDA	突触（GO期限：8）	8176201
GO:0005829	细胞质	经验		11048639\|17652306
GO:0005829	细胞质	IEA		-
去：0005634	nucleus	IDA		18029348
去：0005730	nucleolus	IDA		18029348
去：0005737	cytoplasm	TAS		12359715

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
ABL1	ABL \|JTK7 \|BCR/ABL \|c-abl \|P150 \|V-ABL	C-ABL癌基因1，受体酪氨酸激酶	-	HPRD,BioGRID	7760813
ACP1	haap \|MGC111030 \|MGC3499	acid phosphatase 1, soluble	-	HPRD,BioGRID	11976341
CBL	C-CBL \| CBL2 \| RNF55	CAS-BR-M（鼠）生态逆转录病毒转化序列	亲和力捕获 - 韦斯特恩共晶结构	Biogrid	8798643\|10078535
CBLB	DKFZp686J10223 \| DKFZp779A0729 \| DKFZp779F1443 \| FLJ36865 \| FLJ41152 \| Nbla00127 \| RNF56	CAS-BR-M（鼠）生态逆转录病毒转化序列b	-	HPRD,BioGRID	10074432
CD247	CD3-Zeta \|CD3H \|CD3Q \|CD3Z \|T3z \|TCRZ	CD247molecule	-	HPRD	8366117
CD3E	FLJ18683 \|T3e \|TCRE	CD3E分子，Epsilon（CD3-TCR复合物）	重构的复合物	Biogrid	7761456
CD3E	FLJ18683 \|T3e \|TCRE	CD3E分子，Epsilon（CD3-TCR复合物）	-	HPRD	11855827
CD5	leu1 \|T1	CD5分子	-	HPRD,BioGRID	9378960
CRK	crkii	v-crk sarcoma virus CT10 oncogene homolog (avian)	-	HPRD,BioGRID	10419455
CRK	crkii	v-crk sarcoma virus CT10 oncogene homolog (avian)	ZAP-70interacts with Crk-I.	绑定	10419455
CRK	crkii	v-crk sarcoma virus CT10 oncogene homolog (avian)	ZAP-70与CRK-II相互作用。	绑定	10419455
CRKL	-	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	ZAP-70interacts with CrkL. This interaction was modeled on a demonstrated interaction between human ZAP-70 and CrkL from an unspecified species.	绑定	10419455
DBNL	ABP1 \|HIP-55 \|SH3P7	像德雷布林一样	-	HPRD,BioGRID	14557276
FCGR3A	CD16 \|CD16A \|FCG3 \|FCGR3 \|fcgriii \|FCR-10 \|fcriii \|fcriiia \|IGFR3	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	-	HPRD	7819147
FCRL3	FCRH3 \|ifgp3 \|irta3 \|SPAP2	FC受体样3	重构的复合物	Biogrid	12051764
Fyn	MGC45350 \| SLK \| SYN	Fyn Oncogene与SRC，FGR，是的	-	HPRD,BioGRID	7760813
GAB2	KIAA0571	GRB2-associated binding protein 2	-	HPRD,BioGRID	11572860
GRB2	灰烬\|EGFRBP-GRB2 \|Grb3-3 \|MST084 \|MSTP084	生长因子受体结合蛋白2	亲和力捕获 - 韦斯特恩	Biogrid	7629168
拉特	拉特1 \| pp36	激活T细胞的接头	生化活动	Biogrid	11368773\|12186560
LCK	yt16 \|p56lck \|pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD,BioGRID	10318843
LCP2	SLP-76 \|SLP76	淋巴细胞胞质蛋白2（含有76KDA的白细胞蛋白的SH2结构域）	生化活动	Biogrid	9047237
NFAM1	CNAIP \| FLJ40652 \| bK126B4.4	NFAT用ITAM基序1激活蛋白1	-	HPRD	15143214
PAG1	CBP \|FLJ37858 \|MGC138364 \|PAG	与糖磷脂微域1相关的磷蛋白1	-	HPRD,BioGRID	10790433
PLCG1	PLC-II \|PLC1 \|PLC148 \|Plcgamma1	磷脂酶C，伽马1	-	HPRD,BioGRID	7629168
PTK2B	Cadtk \|cakb \|fadk2 \|fak2 \|frnk \|PKB \|PTK \|pyk2 \|筏	PTK2B protein tyrosine kinase 2 beta	-	HPRD	10867021
PTPN6	HCP \| HCPH \| HPTP1C \| PTP-1C \| SH-PTP1 \| SHP-1 \| SHP-1L \| SHP1	蛋白质酪氨酸磷酸酶，非受体6型	-	HPRD,BioGRID	8638162\|10458769
ptprc	B220 \|CD45 \|CD45R \|GP180 \|LCA \|ly5 \|T200	蛋白酪氨酸磷酸酶，受体类型，C	-	HPRD,BioGRID	7737297
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	Ras P21蛋白激活剂（GTPase激活蛋白）1	-	HPRD,BioGRID	7760813
SH3BP2	3BP2 \|CRBM \|CRPM \|FLJ42079 \|RES4-23	SH3膜结合蛋白2	-	HPRD	11390470
SH3BP2	3BP2 \|CRBM \|CRPM \|FLJ42079 \|RES4-23	SH3膜结合蛋白2	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	9846481
SHB	RP11-3J10.8 \| bA3J10.2	SRC同源性2含有衔接蛋白B的结构域	-	HPRD,BioGRID	12084069
SHC1	FLJ26504 \| SHC \| SHCA	SHC（SRC同源性2结构域）转化蛋白1	-	HPRD,BioGRID	8761298\|9685404
坐1	MGC125908 \|MGC125909 \|MGC125910 \|RP11-331F9.5 \|坐	signaling threshold regulating transmembrane adaptor 1	-	HPRD,BioGRID	10209036
SLA	Sla1 \|拍击	类似于SRC的适应器	-	HPRD,BioGRID	10449770
Sla2	C20orf156 \| FLJ21992 \| MGC49845 \| SLAP-2 \| SLAP2	类似于SRC的适应器2	-	HPRD,BioGRID	11891219
SLAMF6	卡利\|卡利布\|Ly108 \|MGC104953 \|NTB-A \|ntba \|SF2000	大满贯家庭成员6	-	HPRD	8756661
SOS1	GF1 \|GGF1 \|gingf \|HGF \|NS4	七个无同胞1的儿子（果蝇）	-	HPRD	7629168
tuba4a	FLJ30169 \|H2-Alpha \|tuba1	tubulin, alpha 4a	-	HPRD	8530437
VAV1	VAV	VAV 1鸟嘌呤核苷酸交换因子	-	HPRD,BioGRID	7798261
ZAP70	FLJ17670 \|FLJ17679 \|SRK \|std \|tzk \|ZAP-70	Zeta链（TCR）相关蛋白激酶70KDA	ZAP70自磷酸化。	绑定	15735648

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg天然杀伤细胞介导的细胞毒性	137	92	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG初级免疫缺陷	35	28	All SZGR 2.0 genes in this pathway
Biocarta CSK途径	24	20	All SZGR 2.0 genes in this pathway
Biocarta TCRA途径	13	10	All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY	49	37	All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION	45	33	All SZGR 2.0 genes in this pathway
PID TCR途径	66	51	All SZGR 2.0 genes in this pathway
PID CD8 TCR途径	53	42	All SZGR 2.0 genes in this pathway
PID PI3KCI途径	49	40	All SZGR 2.0 genes in this pathway
Reactome TCR信号传导	54	46	All SZGR 2.0 genes in this pathway
ZAP 70向免疫突触的Reactome易位	14	14	All SZGR 2.0 genes in this pathway
Reactome生成第二信使分子	27	25	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统	539	350	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN	267	178	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR DN	129	84	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN	209	122	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN	226	132	All SZGR 2.0 genes in this pathway
阿霉素的Graessmann凋亡	1142	669	All SZGR 2.0 genes in this pathway
Perez TP53目标	1174	695	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 1	45	27	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 4	61	34	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
Pujana BRCA2 PCC网络	423	265	All SZGR 2.0 genes in this pathway
里克曼转移DN	261	155	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN	366	238	All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70	67	33	All SZGR 2.0 genes in this pathway
NPM1突变DN的Verhaak AML	246	180	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
Ramalho茎DN	74	55	All SZGR 2.0 genes in this pathway
VARELA ZMPSTE24 TARGETS DN	38	18	All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK	75	47	All SZGR 2.0 genes in this pathway
Zheng由Foxp3绑定	491	310	All SZGR 2.0 genes in this pathway
由FOXP3绑定的Marson刺激	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
Marson Foxp3目标刺激了	29	19	All SZGR 2.0 genes in this pathway
MARSON FOXP3 CORE DIRECT TARGETS	19	14	All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCER KINOME GREEN	16	14	All SZGR 2.0 genes in this pathway
华莱士前列腺癌竞赛	299	167	All SZGR 2.0 genes in this pathway
肝癌DN中的阿塞维多甲基化	940	425	All SZGR 2.0 genes in this pathway
SMID乳腺癌腔B DN	564	326	All SZGR 2.0 genes in this pathway
Smid乳腺癌正常	476	285	All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP	259	185	All SZGR 2.0 genes in this pathway
CUI葡萄糖剥夺	60	44	All SZGR 2.0 genes in this pathway
Vilimas Notch1靶向	52	41	All SZGR 2.0 genes in this pathway
Han Satb1靶向DN	442	275	All SZGR 2.0 genes in this pathway
MARSON FOXP3目标DN	54	38	All SZGR 2.0 genes in this pathway
KASLER HDAC7目标1	194	133	All SZGR 2.0 genes in this pathway

Gene Page:ZAP70