Gene Page:SF1

概括?
GeneID 7536
Symbol SF1
Synonyms BBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162
Description splicing factor 1
参考 MIM:601516|HGNC:HGNC:12950|ENSEMBL：ENSG00000168066|HPRD:03306|Vega:OTTHUMG00000066833
Gene type protein-coding
Map location 11q13
Pascal p-value 0.422
Fetal beta 0.893
DMG 1（＃研究）
eGene 迈尔斯的顺式和跨性别
Meta

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur 高通量文献搜索 Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 高通量文献搜索 与精神分裂症Co-occurance keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
CG04619046 11 64541730 SF1 2.476E-4 -0.604 0.037 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6576747 chr1 85530213 SF1 7536 0.19 trans
rs17025528 chr1 216043152 SF1 7536 0.1 trans
rs12997903 chr2 1952083 SF1 7536 0.08 trans
rs6733654 chr2 1963270 SF1 7536 0.04 trans
rs891877 chr2 2043348 SF1 7536 0.03 trans
rs1395163 chr3 31028951 SF1 7536 0 trans
rs17029291 chr3 32402138 SF1 7536 1.254E-4 trans
rs6446109 chr3 60076988 SF1 7536 0.07 trans
RS624496 chr3 120506736 SF1 7536 0.02 trans
rs16870339 chr5 2705169 SF1 7536 0.01 trans
rs4617108 chr7 49423831 SF1 7536 0.13 trans
RS17160578 chr7 85672108 SF1 7536 0.13 trans
rs722970 chr7 85803264 SF1 7536 0.07 trans
rs17324099 chr7 85856288 SF1 7536 0.13 trans
snp_a-1904613 0 SF1 7536 0.02 trans
rs1831517 chr9 2513405 SF1 7536 0.07 trans
rs7864672 chr9 31068069 SF1 7536 0.03 trans
rs11259374 chr10 14917473 SF1 7536 0.08 trans
rs4607971 chr10 19407890 SF1 7536 0.04 trans
rs12569493 chr10 74886042 SF1 7536 0.07 trans
RS16930362 chr10 74890320 SF1 7536 0.11 trans
rs909288 chr10 124257417 SF1 7536 0.12 trans
rs11021829 chr11 11416216 SF1 7536 0.15 trans
rs17133022 chr11 98980829 SF1 7536 0.17 trans
rs9554597 chr13 100117238 SF1 7536 0.17 trans
rs10145685 chr14 22794892 SF1 7536 0.02 trans
rs17793827 chr14 22797560 SF1 7536 0.01 trans
rs10136383 chr14 22801078 SF1 7536 0.01 trans
rs2455956 chr14 43524686 SF1 7536 0.04 trans
rs2254834 chr14 43596184 SF1 7536 0.01 trans
rs1954396 chr14 43601835 SF1 7536 1.31E-4 trans
rs9925128 chr16 79102822 SF1 7536 0.11 trans
rs1761450 chr19 54818034 SF1 7536 0.03 trans
rs16996418 chr20 9778936 SF1 7536 0.04 trans
rs16996420 chr20 9780867 SF1 7536 0.01 trans
rs12157904 chr22 37982011 SF1 7536 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CHD4 0.92 0.92
CRKRS 0.91 0.93
ZNF264 0.91 0.93
LIG3 0.91 0.90
ZNF740 0.91 0.90
KDM3B 0.91 0.92
CYTSA 0.90 0.92
GCN1L1 0.90 0.90
KPNB1 0.90 0.92
ZXDC 0.90 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.72 -0.83
FXYD1 -0.70 -0.81
IFI27 -0.70 -0.81
MT-CO2 -0.69 -0.81
AF347015.27 -0.68 -0.79
higd1b -0.68 -0.81
AF347015.33 -0.67 -0.77
AF347015.21 -0.67 -0.85
S100B -0.66 -0.75
CXCL14 -0.66 -0.79

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 资源 PubMed ID
BCL2 Bcl-2 B-cell CLL/lymphoma 2 - HPRD,BioGRID 8668206
DDX17 DKFZp761H2016 | P72 | RH70 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 两个杂交 BioGRID 16189514
EWSR1 EWS Ewing sarcoma breakpoint region 1 - HPRD,BioGRID 9660765
FUS CHOP | FUS-CHOP | FUS1 | TLS | TLS/CHOP | hnRNP-P2 fusion (involved in t(12;16) in malignant liposarcoma) - HPRD,BioGRID 9660765
PLSCR1 MMTRA1B 磷脂cramblase 1 两个杂交 BioGRID 16189514
PRPF40A FBP-11 |FBP11 |flaf1 |FLJ20585 |fnbp3 |hip10 |hypa |NY-REN-6 PRP40前MRNA处理因子40同源物A（酿酒酵母） - HPRD 15456888
RBPMS HERMES RNA binding protein with multiple splicing 两个杂交 BioGRID 16189514
TAF15 Npl3 | RBP56 | TAF2N | TAFII68 | hTAFII68 TAF15 RNA聚合酶II，TATA盒结合蛋白（TBP）相关因子，68KDA - HPRD,BioGRID 9660765
TCERG1 CA150 | MGC133200 | TAF2S transcription elongation regulator 1 - HPRD,BioGRID 11604498
TRIM23 ard1 |arfd1 |RNF46 tripartite motif-containing 23 两个杂交 BioGRID 16189514
U2AF2 U2AF65 U2 small nuclear RNA auxiliary factor 2 - HPRD,BioGRID 9150140|9512519
U2AF2 U2AF65 U2 small nuclear RNA auxiliary factor 2 U2AF65 interacts with an unspecified isoform of SF1 (mBBP). BIND 9512519
WWP2 AIP2 | WWp2-like WW domain containing E3 ubiquitin protein ligase 2 两个杂交 BioGRID 16189514


V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198 110 该途径中的所有SZGR 2.0基因
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177 110 该途径中的所有SZGR 2.0基因
BORCZUK MALIGNANT MESOTHELIOMA DN 104 59 该途径中的所有SZGR 2.0基因
BASAKI YBX1 TARGETS DN 384 230 该途径中的所有SZGR 2.0基因
Ginestier乳腺癌Znf217扩增DN 335 193 该途径中的所有SZGR 2.0基因
Ginestier乳腺癌20Q13扩增DN 180 101 该途径中的所有SZGR 2.0基因
KIM WT1 TARGETS UP 214 155 该途径中的所有SZGR 2.0基因
WOOD EBV EBNA1 TARGETS UP 110 71 该途径中的所有SZGR 2.0基因
JAZAG TGFB1 SIGNALING VIA SMAD4 DN 66 38 该途径中的所有SZGR 2.0基因
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK 1652 1023 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 该途径中的所有SZGR 2.0基因
BROCKE APOPTOSIS REVERSED BY IL6 144 98 该途径中的所有SZGR 2.0基因
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151 100 该途径中的所有SZGR 2.0基因
彭谷氨酰胺剥夺DN 337 230 该途径中的所有SZGR 2.0基因
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 36 24 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302 191 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 12HR UP 111 68 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 24HR UP 148 96 该途径中的所有SZGR 2.0基因
由Foxp3绑定的Marson未刺激 1229 713 该途径中的所有SZGR 2.0基因
WALLACE PROSTATE CANCER RACE UP 299 167 该途径中的所有SZGR 2.0基因
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 该途径中的所有SZGR 2.0基因
Matzuk男性繁殖Sertoli 28 23 该途径中的所有SZGR 2.0基因
WEST ADRENOCORTICAL TUMOR DN 546 362 该途径中的所有SZGR 2.0基因
MOOTHA PGC 420 269 该途径中的所有SZGR 2.0基因
HSIAO HOUSEKEEPING GENES 389 245 该途径中的所有SZGR 2.0基因
肌肉中的罗马胰岛素靶标 442 263 该途径中的所有SZGR 2.0基因
Yagi AML与T 9 11易位 130 87 该途径中的所有SZGR 2.0基因
Yagi AML与11q23重新排列 351 238 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 该途径中的所有SZGR 2.0基因
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR 152 88 该途径中的所有SZGR 2.0基因
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 该途径中的所有SZGR 2.0基因