概括?
基因ID 757
Symbol TMEM50B
同义词 C21orf4|HCVP7TP3
描述 transmembrane protein 50B
参考 HGNC:HGNC:1280|ENSEMBL:ENSG00000142188|HPRD:10747|Vega:OTTHUMG00000065286
基因type protein-coding
地图位置 21q22.11
Pascal P值 0.005
Fetal beta 0.027
DMG 1(#研究)
eGene 前扣带回皮层BA24
尾状基底神经节
小脑半球
Cerebellum
Cortex
额叶皮质BA9
Hippocampus
下丘脑
Nucleus accumbens basal ganglia
梭子基底神经节
Meta

数据源中的基因
基因set name 基因组方法 描述 Info
简历:PGCNP Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1

第一节遗传学和表观遗传学注释

@Differentially methylated gene

探测 Chromosome Position Nearest gene P (dis) beta(dis) FDR (dis) Study
cg17356733 21 34774627 TMEM50B 0.003 2.944 DMG:vanEijk_2014

@eQTL annotation

SNP ID Chromosome Position eGene 基因Entrez ID PVALUE qvalue TSS distance eQTL type
rs13050246 21 34841869 TMEM50B ENSG00000142188.12 1.429E-6 0.03 10449 gtex_brain_ba24
rs78293890 21 34859401 TMEM50B ENSG00000142188.12 2.59E-6 0.03 -7083 gtex_brain_ba24
RS9808685 21 34785672 TMEM50B ENSG00000142188.12 3.062E-6 0 66646 gtex_brain_putamen_basal
RS2834210 21 34786574 TMEM50B ENSG00000142188.12 3.062E-6 0 65744 gtex_brain_putamen_basal
rs7283850 21 34789549 TMEM50B ENSG00000142188.12 1.16E-7 0 62769 gtex_brain_putamen_basal
rs7277808 21 34789695 TMEM50B ENSG00000142188.12 3.048e-6 0 62623 gtex_brain_putamen_basal
RS2834214 21 34793706 TMEM50B ENSG00000142188.12 3.052E-6 0 58612 gtex_brain_putamen_basal
RS71326949 21 34794982 TMEM50B ENSG00000142188.12 2.44e-7 0 57336 gtex_brain_putamen_basal
RS17885944 21 34796199 TMEM50B ENSG00000142188.12 9.381E-8 0 56119 gtex_brain_putamen_basal
RS2834215 21 34796886 TMEM50B ENSG00000142188.12 3.026E-6 0 55432 gtex_brain_putamen_basal
rs17882848 21 34797183 TMEM50B ENSG00000142188.12 2.243E-6 0 55135 gtex_brain_putamen_basal
rs11910627 21 34799350 TMEM50B ENSG00000142188.12 1.164E-7 0 52968 gtex_brain_putamen_basal
rs139258193 21 34800146 TMEM50B ENSG00000142188.12 2.245E-8 0 52172 gtex_brain_putamen_basal
rs67816861 21 34800150 TMEM50B ENSG00000142188.12 1.036E-6 0 52168 gtex_brain_putamen_basal
rs8130924 21 34800872 TMEM50B ENSG00000142188.12 1.132E-7 0 51446 gtex_brain_putamen_basal
RS8132006 21 34802841 TMEM50B ENSG00000142188.12 1.053E-7 0 49477 gtex_brain_putamen_basal
rs8132535 21 34802946 TMEM50B ENSG00000142188.12 3.957E-8 0 49372 gtex_brain_putamen_basal
rs1532 21 34804966 TMEM50B ENSG00000142188.12 1.046E-7 0 47352 gtex_brain_putamen_basal
rs17882822 21 34806091 TMEM50B ENSG00000142188.12 1.618E-8 0 46227 gtex_brain_putamen_basal
RS2284554 21 34806218 TMEM50B ENSG00000142188.12 1.618E-8 0 46100 gtex_brain_putamen_basal
RS2284555 21 34806288 TMEM50B ENSG00000142188.12 1.622E-8 0 46030 gtex_brain_putamen_basal
RS2284556 21 34806305 TMEM50B ENSG00000142188.12 1.384E-8 0 46013 gtex_brain_putamen_basal
rs2409493 21 34808289 TMEM50B ENSG00000142188.12 1.955E-8 0 44029 gtex_brain_putamen_basal
rs2409494 21 34808408 TMEM50B ENSG00000142188.12 2.024E-8 0 43910 gtex_brain_putamen_basal
RS2040120 21 34809049 TMEM50B ENSG00000142188.12 4.139E-8 0 43269 gtex_brain_putamen_basal
rs1059293 21 34809693 TMEM50B ENSG00000142188.12 2.89E-8 0 42625 gtex_brain_putamen_basal
rs8131980 21 34810007 TMEM50B ENSG00000142188.12 1.245E-7 0 42311 gtex_brain_putamen_basal
rs4816452 21 34810330 TMEM50B ENSG00000142188.12 2.89E-8 0 41988 gtex_brain_putamen_basal
rs4816453 21 34811357 TMEM50B ENSG00000142188.12 2.89E-8 0 40961 gtex_brain_putamen_basal
rs6517171 21 34811711 TMEM50B ENSG00000142188.12 9.491E-8 0 40607 gtex_brain_putamen_basal
rs6517172 21 34811835 TMEM50B ENSG00000142188.12 5.619E-8 0 40483 gtex_brain_putamen_basal
rs4817567 21 34813316 TMEM50B ENSG00000142188.12 2.89E-8 0 39002 gtex_brain_putamen_basal
rs4817568 21 34813400 TMEM50B ENSG00000142188.12 2.89E-8 0 38918 gtex_brain_putamen_basal
rs6517173 21 34813562 TMEM50B ENSG00000142188.12 2.89E-8 0 38756 gtex_brain_putamen_basal
RS71702114 21 34814327 TMEM50B ENSG00000142188.12 2.048E-8 0 37991 gtex_brain_putamen_basal
rs1972256 21 34815111 TMEM50B ENSG00000142188.12 2.89E-8 0 37207 gtex_brain_putamen_basal
rs4816455 21 34815794 TMEM50B ENSG00000142188.12 2.89E-8 0 36524 gtex_brain_putamen_basal
rs7276112 21 34816479 TMEM50B ENSG00000142188.12 3.422E-8 0 35839 gtex_brain_putamen_basal
RS9981203 21 34816988 TMEM50B ENSG00000142188.12 1.232E-7 0 35330 gtex_brain_putamen_basal
rs68082076 21 34818296 TMEM50B ENSG00000142188.12 2.89E-8 0 34022 gtex_brain_putamen_basal
rs9976619 21 34818692 TMEM50B ENSG00000142188.12 1.35E-7 0 33626 gtex_brain_putamen_basal
rs9976414 21 34819131 TMEM50B ENSG00000142188.12 2.89E-8 0 33187 gtex_brain_putamen_basal
rs9976356 21 34819201 TMEM50B ENSG00000142188.12 9.064E-8 0 33117 gtex_brain_putamen_basal
RS7282496 21 34819582 TMEM50B ENSG00000142188.12 2.89E-8 0 32736 gtex_brain_putamen_basal
rs11088253 21 34820317 TMEM50B ENSG00000142188.12 2.89E-8 0 32001 gtex_brain_putamen_basal
rs8133486 21 34820803 TMEM50B ENSG00000142188.12 1.037E-7 0 31515 gtex_brain_putamen_basal
RS8134200 21 34821131 TMEM50B ENSG00000142188.12 1.944E-8 0 31187 gtex_brain_putamen_basal
RS2834216 21 34821372 TMEM50B ENSG00000142188.12 4.897E-8 0 30946 gtex_brain_putamen_basal
RS1044218 21 34821570 TMEM50B ENSG00000142188.12 1.944E-8 0 30748 gtex_brain_putamen_basal
RS1044213 21 34821691 TMEM50B ENSG00000142188.12 1.944E-8 0 30627 gtex_brain_putamen_basal
RS2834217 21 34822150 TMEM50B ENSG00000142188.12 1.121E-8 0 30168 gtex_brain_putamen_basal
RS2834218 21 34822452 TMEM50B ENSG00000142188.12 4.897E-8 0 29866 gtex_brain_putamen_basal
rs71322211 21 34822493 TMEM50B ENSG00000142188.12 4.897E-8 0 29825 gtex_brain_putamen_basal
RS60665114 21 34822508 TMEM50B ENSG00000142188.12 8.831E-8 0 29810 gtex_brain_putamen_basal
rs11088254 21 34822582 TMEM50B ENSG00000142188.12 4.897E-8 0 29736 gtex_brain_putamen_basal
RS9983740 21 34822629 TMEM50B ENSG00000142188.12 1.034E-6 0 29689 gtex_brain_putamen_basal
RS3183852 21 34822636 TMEM50B ENSG00000142188.12 2.155E-8 0 29682 gtex_brain_putamen_basal
rs2834220 21 34823252 TMEM50B ENSG00000142188.12 2.89E-8 0 29066 gtex_brain_putamen_basal
rs4817571 21 34823663 TMEM50B ENSG00000142188.12 1.944E-8 0 28655 gtex_brain_putamen_basal
rs61422135 21 34824151 TMEM50B ENSG00000142188.12 1.944E-8 0 28167 gtex_brain_putamen_basal
rs928739 21 34824203 TMEM50B ENSG00000142188.12 1.944E-8 0 28115 gtex_brain_putamen_basal
rs2834221 21 34824478 TMEM50B ENSG00000142188.12 1.944E-8 0 27840 gtex_brain_putamen_basal
rs2834222 21 34824771 TMEM50B ENSG00000142188.12 2.89E-8 0 27547 gtex_brain_putamen_basal
rs2834223 21 34825147 TMEM50B ENSG00000142188.12 1.944E-8 0 27171 gtex_brain_putamen_basal
rs2834224 21 34825318 TMEM50B ENSG00000142188.12 1.944E-8 0 27000 gtex_brain_putamen_basal
RS4481072 21 34825466 TMEM50B ENSG00000142188.12 1.944E-8 0 26852 gtex_brain_putamen_basal
rs4300927 21 34825721 TMEM50B ENSG00000142188.12 1.944E-8 0 26597 gtex_brain_putamen_basal
rs2834225 21 34825875 TMEM50B ENSG00000142188.12 1.944E-8 0 26443 gtex_brain_putamen_basal
rs9305529 21 34826700 TMEM50B ENSG00000142188.12 8.437E-8 0 25618 gtex_brain_putamen_basal
rs10154248 21 34827112 TMEM50B ENSG00000142188.12 1.944E-8 0 25206 gtex_brain_putamen_basal
RS9974084 21 34827421 TMEM50B ENSG00000142188.12 4.897E-8 0 24897 gtex_brain_putamen_basal
rs3787705 21 34828637 TMEM50B ENSG00000142188.12 1.953E-8 0 23681 gtex_brain_putamen_basal
rs58525092 21 34829287 TMEM50B ENSG00000142188.12 1.953E-8 0 23031 gtex_brain_putamen_basal
RS56884576 21 34829419 TMEM50B ENSG00000142188.12 1.524E-7 0 22899 gtex_brain_putamen_basal
rs2850024 21 34830968 TMEM50B ENSG00000142188.12 1.944E-8 0 21350 gtex_brain_putamen_basal
rs2834227 21 34832170 TMEM50B ENSG00000142188.12 1.944E-8 0 20148 gtex_brain_putamen_basal
RS201068471 21 34832984 TMEM50B ENSG00000142188.12 1.948E-8 0 19334 gtex_brain_putamen_basal
rs2245573 21 34832985 TMEM50B ENSG00000142188.12 1.944E-8 0 19333 gtex_brain_putamen_basal
rs2248340 21 34833123 TMEM50B ENSG00000142188.12 1.944E-8 0 19195 gtex_brain_putamen_basal
rs2248355 21 34833329 TMEM50B ENSG00000142188.12 4.895E-8 0 18989 gtex_brain_putamen_basal
rs2834229 21 34834727 TMEM50B ENSG00000142188.12 1.944E-8 0 17591 gtex_brain_putamen_basal
rs13049122 21 34834957 TMEM50B ENSG00000142188.12 1.944E-8 0 17361 gtex_brain_putamen_basal
RS7283459 21 34835594 TMEM50B ENSG00000142188.12 1.944E-8 0 16724 gtex_brain_putamen_basal
rs7278056 21 34835774 TMEM50B ENSG00000142188.12 1.944E-8 0 16544 gtex_brain_putamen_basal
rs13046185 21 34836091 TMEM50B ENSG00000142188.12 4.895E-8 0 16227 gtex_brain_putamen_basal
rs2834230 21 34836319 TMEM50B ENSG00000142188.12 1.944E-8 0 15999 gtex_brain_putamen_basal
RS2186280 21 34837144 TMEM50B ENSG00000142188.12 1.902E-8 0 15174 gtex_brain_putamen_basal
rs2248820 21 34837623 TMEM50B ENSG00000142188.12 1.944E-8 0 14695 gtex_brain_putamen_basal
rs68149965 21 34838167 TMEM50B ENSG00000142188.12 1.944E-8 0 14151 gtex_brain_putamen_basal
rs2471841 21 34838339 TMEM50B ENSG00000142188.12 1.953E-8 0 13979 gtex_brain_putamen_basal
rs2850028 21 34838589 TMEM50B ENSG00000142188.12 1.944E-8 0 13729 gtex_brain_putamen_basal
rs743334 21 34839533 TMEM50B ENSG00000142188.12 1.944E-8 0 12785 gtex_brain_putamen_basal
rs13049278 21 34839756 TMEM50B ENSG00000142188.12 4.895E-8 0 12562 gtex_brain_putamen_basal
rs71322215 21 34840448 TMEM50B ENSG00000142188.12 2.572E-7 0 11870 gtex_brain_putamen_basal
rs5843608 21 34840554 TMEM50B ENSG00000142188.12 3.073E-8 0 11764 gtex_brain_putamen_basal
rs13050246 21 34841869 TMEM50B ENSG00000142188.12 5.577E-9 0 10449 gtex_brain_putamen_basal
rs13051161 21 34842311 TMEM50B ENSG00000142188.12 1.944E-8 0 10007 gtex_brain_putamen_basal
rs13047270 21 34842725 TMEM50B ENSG00000142188.12 1.947E-8 0 9593 gtex_brain_putamen_basal
rs13047446 21 34843014 TMEM50B ENSG00000142188.12 1.939E-8 0 9304 gtex_brain_putamen_basal
rs13047352 21 34843055 TMEM50B ENSG00000142188.12 1.939E-8 0 9263 gtex_brain_putamen_basal
RS13051901 21 34844457 TMEM50B ENSG00000142188.12 3.893E-9 0 7861 gtex_brain_putamen_basal
RS35330441 21 34844874 TMEM50B ENSG00000142188.12 5.487E-8 0 7444 gtex_brain_putamen_basal
rs71322217 21 34845466 TMEM50B ENSG00000142188.12 1.176E-7 0 6852 gtex_brain_putamen_basal
rs7277751 21 34845614 TMEM50B ENSG00000142188.12 6.222E-8 0 6704 gtex_brain_putamen_basal
RS7277905 21 34845708 TMEM50B ENSG00000142188.12 2.366E-8 0 6610 gtex_brain_putamen_basal
rs146886032 21 34846540 TMEM50B ENSG00000142188.12 4.883E-8 0 5778 gtex_brain_putamen_basal
rs13049439 21 34846997 TMEM50B ENSG00000142188.12 1.776E-6 0 5321 gtex_brain_putamen_basal
rs2843974 21 34848517 TMEM50B ENSG00000142188.12 4.883E-8 0 3801 gtex_brain_putamen_basal
rs2843722 21 34848995 TMEM50B ENSG00000142188.12 1.939E-8 0 3323 gtex_brain_putamen_basal
rs2734727 21 34850004 TMEM50B ENSG00000142188.12 5.138E-7 0 2314 gtex_brain_putamen_basal
rs2211688 21 34850744 TMEM50B ENSG00000142188.12 1.545e-7 0 1574 gtex_brain_putamen_basal
rs6517175 21 34857840 TMEM50B ENSG00000142188.12 9.307E-7 0 -5522 gtex_brain_putamen_basal
rs78293890 21 34859401 TMEM50B ENSG00000142188.12 9.964E-7 0 -7083 gtex_brain_putamen_basal

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Not available

基因expression during devlopment (BrainCloud)

脚注:
总共绘制了269个时间点,n = 38个胎儿样品(x = 1:38)。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

脚注:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因 皮尔逊的相关性 Spearman's Correlation
IQGAP2 0.79 0.34
PDPN 0.73 0.54
AC093251.1 0.71 0.30
TNC 0.70 0.27
CDO1 0.68 0.43
palld 0.67 0.49
MRC2 0.66 0.44
PLCE1 0.66 0.42
PLS3 0.66 0.35
ZHX2 0.66 0.39
前10个负共表达基因
基因 皮尔逊的相关性 Spearman's Correlation
MT-CO2 -0.23 -0.20
AF347015.31 -0.23 -0.21
AF347015.8 -0.23 -0.22
MT-CYB -0.23 -0.22
AF347015.27 -0.22 -0.21
AF347015.2 -0.22 -0.19
AF347015.33 -0.22 -0.21
AF347015.21 -0.22 -0.23
AF347015.15 -0.21 -0.20
AF347015.26 -0.21 -0.18

V.途径注释

Pathway name Pathway size #szgr 2.0基因 Info
thum收缩性心力衰竭 423 283 该途径中的所有SZGR 2.0基因
WANG LMO4 TARGETS UP 372 227 该途径中的所有SZGR 2.0基因
Gargalovic对氧化磷脂黄色DN的反应 23 15 该途径中的所有SZGR 2.0基因
Gargalovic对氧化磷脂的反应蓝色DN 61 35 该途径中的所有SZGR 2.0基因
ELVIDGE HYPOXIA DN 146 94 该途径中的所有SZGR 2.0基因
Bidus转移DN 161 93 该途径中的所有SZGR 2.0基因
MAYBURD RESPONSE TO L663536 DN 56 32 该途径中的所有SZGR 2.0基因
多德鼻咽癌 1821 933 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE EPIDERMIS DN 508 354 该途径中的所有SZGR 2.0基因
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 81 57 该途径中的所有SZGR 2.0基因
TERAMOTO OPN TARGETS CLUSTER 1 13 10 该途径中的所有SZGR 2.0基因
Tomlins转移DN 20 16 该途径中的所有SZGR 2.0基因
MORI PRE BI LYMPHOCYTE DN 77 49 该途径中的所有SZGR 2.0基因
MORI IMMATURE B LYMPHOCYTE UP 53 35 该途径中的所有SZGR 2.0基因
LEE TARGETS OF PTCH1 AND SUFU DN 83 69 该途径中的所有SZGR 2.0基因
Sansom APC目标DN 366 238 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 该途径中的所有SZGR 2.0基因
MCCLUNG COCAINE REWARD 5D 79 62 该途径中的所有SZGR 2.0基因
道格拉斯BMI1靶向 566 371 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性5 482 296 该途径中的所有SZGR 2.0基因
促进耐受巨噬细胞DN 409 268 该途径中的所有SZGR 2.0基因
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 该途径中的所有SZGR 2.0基因
GRADE COLON CANCER UP 871 505 该途径中的所有SZGR 2.0基因
ALONSO METASTASIS UP 198 128 该途径中的所有SZGR 2.0基因
甜肺癌克拉斯 491 316 该途径中的所有SZGR 2.0基因
张TLX目标60小时 293 203 该途径中的所有SZGR 2.0基因
开罗肝脏开发 166 105 该途径中的所有SZGR 2.0基因
Pilon KLF1靶向DN 1972年 1213 该途径中的所有SZGR 2.0基因
FORTSCHEGGER PHF8 TARGETS DN 784 464 该途径中的所有SZGR 2.0基因
PHONG TNF RESPONSE NOT VIA P38 337 236 该途径中的所有SZGR 2.0基因