Gene Page:ZNF189
Summary?
GeneID | 7743 |
Symbol | ZNF189 |
Synonyms | - |
Description | zinc finger protein 189 |
Reference | MIM: 603132|HGNC:HGNC:12980|Ensembl:ENSG00000136870|HPRD:11930|Vega:OTTHUMG00000020383 |
Gene type | protein-coding |
Map location | 9q22-q31 |
Pascal p-value | 0.859 |
Sherlock p-value | 0.001 |
Fetal beta | 0.247 |
eGene | Cerebellar Hemisphere 小脑 Hippocampus Myers' cis & trans |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs504023 | chr9 | 104178110 | ZNF189 | 7743 | 0.14 | cis | ||
rs682 | chr9 | 104187019 | ZNF189 | 7743 | 0.05 | cis | ||
rs2070396 | chr21 | 30878751 | ZNF189 | 7743 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
![Not available](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/ZNF189_DE_GTEx.png)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
DCAF7 | 0.94 | 0.95 |
ZXDB | 0.94 | 0.94 |
YTHDF2 | 0.93 | 0.93 |
SUFU | 0.93 | 0.93 |
GTF3C4 | 0.93 | 0.95 |
MEX3C | 0.93 | 0.95 |
ZNF317 | 0.93 | 0.94 |
USP10 | 0.93 | 0.94 |
RRP1B | 0.93 | 0.95 |
ADNP2 | 0.93 | 0.95 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.31 | -0.70 | -0.86 |
MT-CO2 | -0.70 | -0.88 |
FXYD1 | -0.70 | -0.86 |
C5orf53 | -0.69 | -0.75 |
AF347015.27 | -0.69 | -0.84 |
AF347015.33 | -0.69 | -0.84 |
S100B | -0.69 | -0.81 |
AIFM3 | -0.68 | -0.73 |
MT-CYB | -0.67 | -0.84 |
AF347015.8 | -0.67 | -0.86 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
THUM SYSTOLIC HEART FAILURE DN | 244 | 147 | All SZGR 2.0 genes in this pathway |
MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | All SZGR 2.0 genes in this pathway |
CHEN LVAD SUPPORT OF FAILING HEART UP | 103 | 69 | All SZGR 2.0 genes in this pathway |
CAIRO HEPATOBLASTOMA UP | 207 | 143 | All SZGR 2.0 genes in this pathway |
RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |
VANOEVELEN MYOGENESIS SIN3A TARGETS | 220 | 133 | All SZGR 2.0 genes in this pathway |
ZWANG CLASS 2 TRANSIENTLY INDUCED BY EGF | 51 | 29 | All SZGR 2.0 genes in this pathway |