Gene Page:LRP8
Summary？
| 基因 | 7804 |
| 象征 | LRP8 |
| Synonyms | apoer2 | HSZ75190 | LRP-8 | MCI1 |
| Description | LDL受体相关蛋白8 |
| Reference | MIM：602600|HGNC:HGNC:6700|Ensembl：ENSG00000157193|HPRD：04002|Vega:OTTHUMG00000008924 |
| 基因类型 | 蛋白质编码 |
| Map location | 134 |
| Pascal p-value | 0.003 |
| Sherlock p-value | 0.141 |
| 胎儿β | 1.255 |
| DMG | 1(# studies) |
| 主持人 | Cerebellar Hemisphere 元 |
| Support | CompositeSet Darnell FMRP目标 潜在的突触基因 |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | 精神分裂症的GWASDB记录 | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG：Wockner_2014 | 全基因组DNA甲基化分析 | 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 | 1 |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | 点击显示详细信息 |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | PPI网络中最短路径的贡献：3.9483 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | 染色体 | 位置 | Nearest gene | p（dis） | Beta (dis) | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| cg24107728 | 1 | 53760337 | LRP8 | 5.321E-4 | 0.589 | 0.048 | DMG：Wockner_2014 |
第二节。转录组注释
一般基因表达（GTEX）
Devlopment期间的基因表达（BrainCloud）
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
No co-expressed genes in brain regions
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0004888 | 跨膜受体活性 | TAS | 8626535 | |
| 去：0030229 | very-low-density lipoprotein receptor activity | IDA | 8626535 | |
| GO：0030227 | 载脂蛋白ereceptor activity | IDA | 8626535 | |
| GO：0030227 | 载脂蛋白ereceptor activity | TAS | 11152697 | |
| 去：0005509 | calcium ion binding | IEA | - | |
| GO:0008034 | 脂蛋白结合 | 我知道了 | 11152697 | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0006508 | proteolysis | nas | 11152697 | |
| GO:0007165 | 信号转导 | TAS | 10380922 | |
| 去：0006629 | 脂质代谢过程 | nas | 11152697 | |
| 去：0006897 | 内吞作用 | IDA | 8626535 | |
| : 0019221 | 细胞因子介导的信号通路 | nas | 11152697 | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0005576 | 细胞外区域 | IEA | - | |
| GO：0016021 | 膜不可或缺 | 我知道了 | 11152697 | |
| GO:0005901 | 小屋 | IDA | 11369809 | |
| 去：0005886 | plasma membrane | nas | 10380922 |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| ANAPC10 | APC10 | DKFZp564L0562 | DOC1 | anaphase promoting complex subunit 10 | Two-hybrid | Biogrid | 10827173 |
| APBA2 | D15S1518E |HST16821 |lin-10 |MGC99508 |MGC：14091 |mint2 |x11l | amyloid beta (A4) precursor protein-binding, family A, member 2 | Two-hybrid | Biogrid | 10827173 |
| APOE | ad2 |LPG |MGC1571 |载蛋白 | 载脂蛋白e | - | HPRD,BioGRID | 12167620|12950167 |
| APOH | B2G1 |BG | apolipoprotein H (beta-2-glycoprotein I) | - | HPRD,BioGRID | 12807892 |
| 克鲁 | AAG4 |apoj |克利|kub1 |MGC24903 |SGP-2 |SGP2 |SP-40 |TRPM-2 |TRPM2 | 簇蛋白 | - | HPRD | 12824284 |
| DAB1 | - | 残疾同源1（果蝇） | - | HPRD | 10380922 |
| DAB1 | - | 残疾同源1（果蝇） | Two-hybrid | Biogrid | 10827173 |
| DLG4 | FLJ97752 | FLJ98574 | PSD95 | SAP90 | 圆盘，大型同源物4（果蝇） | Two-hybrid | Biogrid | 10827173 |
| GIPC1 | C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2 | GIPC PDZ domain containing family, member 1 | Two-hybrid | Biogrid | 10827173 |
| ITGB1BP1 | DKFZp686K08158 | ICAP-1A | ICAP-1B | ICAP-1alpha | ICAP1 | ICAP1A | ICAP1B | integrin beta 1 binding protein 1 | Two-hybrid | Biogrid | 10827173 |
| LRPAP1 | A2MRAP | A2RAP | HBP44 | MGC138272 | MRAP | RAP | 低密度脂蛋白受体相关蛋白相关蛋白1 | - | HPRD,BioGRID | 12899622 |
| MAPK8IP1 | IB1 | JIP-1 | JIP1 | PRKM8IP | 有丝分裂原激活的蛋白激酶8相互作用蛋白1 | Two-hybrid | Biogrid | 10827173 |
| MAPK8IP2 | IB2 |JIP2 |prkm8ipl | 有丝分裂原激活的蛋白激酶8相互作用蛋白2 | Two-hybrid | Biogrid | 10827173 |
| nos1ap | 6330408P19Rik | CAPON | MGC138500 | 一氧化氮合酶1（神经元）衔接蛋白 | Two-hybrid | Biogrid | 10827173 |
| RELN | Pro1598 |RL | reelin | - | HPRD,BioGRID | 10571240|12167620 |12670700|12899622 |
| SCN3A | KIAA1356 |NAC3 |NAV1.3 | 钠通道，电压门控，III型，α亚基 | Two-hybrid | Biogrid | 10827173 |
| SNX17 | KIAA0064 | 排序Nexin 17 | - | HPRD,BioGRID | 12169628 |
| synj2bp | arip2 |FLJ11271 |FLJ41973 |OMP25 | synaptojanin 2 binding protein | Two-hybrid | Biogrid | 10827173 |
Section V. Pathway annotation
第六节。microRNA注释
| mirna家族 | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| mir-130/301 | 238 | 245 | 1A，M8 | hsa-miR-130abrain | cagugcaauguaaaaggggau |
| hsa-miR-301 | cagugcaauaugucaaagc | ||||
| hsa-miR-130bbrain | Cagugcaaugaagggauggau | ||||
| hsa-miR-454-3p | UAGUGCAAUAUUGCUUAUAGGGUUU | ||||
| mir-148/152 | 1154 | 1160 | 1a | hsa-miR-148a | ucagugcacuacaacuuugu |
| HSA-MIR-152brain | UCAGUGCAUGACACUUGGG | ||||
| hsa-miR-148b | ucagugcaucacacaacuuugu | ||||
| mir-330 | 423 | 429 | M8 | hsa-miR-330brain | GCAAAGCACACGGCCUGCAGAGA |