Gene Page:CACNB4

Summary?
GeneID 785
Symbol CACNB4
Synonyms CAB4|CACNLB4|EA5|EIG9|EJM|EJM4|EJM6
Description calcium voltage-gated channel auxiliary subunit beta 4
Reference MIM:601949|HGNC:HGNC:1404|Ensembl:ENSG00000182389|HPRD:09057|Vega:OTTHUMG00000155091
Gene type protein-coding
Map location 2q23.3
Pascal p-value 0.058
Sherlock p-value 0.984
Fetal beta -1.242
DMG 1 (# studies)
eGene Myers' cis & trans
Support CANABINOID
DOPAMINE
EXCITABILITY
METABOTROPIC GLUTAMATE RECEPTOR
SEROTONIN
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.02395

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg05105477 2 152906698 CACNB4 2.2E-5 0.606 0.017 DMG:Wockner_2014
cg22159341 2 152893963 CACNB4 4.786E-4 0.7 0.046 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 CACNB4 785 0 cis
rs12463708 chr2 149073943 CACNB4 785 0.09 trans
rs16829545 chr2 151977407 CACNB4 785 0.17 trans
rs6813178 chr4 71575238 CACNB4 785 0.11 trans
rs6032295 chr20 44178138 CACNB4 785 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13- 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005509 calcium ion binding IEA -
GO:0005515 protein binding 新闻学会 16525042
GO:0005244 voltage-gated ion channel activity IEA -
GO:0005245 voltage-gated calcium channel activity IDA 16525042
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006816 calcium ion transport IEA -
GO:0006811 ion transport IEA -
GO:0051925 regulation of calcium ion transport via voltage-gated calcium channel IDA 11880487
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 8825650
GO:0009898 internal side of plasma membrane TAS 16385006
GO:0005891 voltage-gated calcium channel complex IDA 16525042

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG CARDIAC MUSCLE CONTRACTION 80 51 All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC 76 59 All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY 92 68 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME NCAM1 INTERACTIONS 39 27 All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 64 49 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
DN CHEBOTAEV GR目标 120 73 All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS UP 82 58 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES UP 27 19 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-129-5p 614 620 1A hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-132/212 736 742 1A hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain UAACAGUCUACAGCCAUGGUCG
miR-151 168 175 1A,m8 hsa-miR-151brain ACUAGACUGAAGCUCCUUGAGG
miR-182 611 617 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-183 38 44 1A hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-299-5p 360 366 1A hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-338 509 515 1A hsa-miR-338brain UCCAGCAUCAGUGAUUUUGUUGA
miR-455 294 301 1A,m8 hsa-miR-455 UAUGUGCCUUUGGACUACAUCG
miR-96 610 617 1A,m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC