Gene Page:BRPF1
Summary?
| GeneID | 7862 |
| Symbol | BRPF1 |
| Synonyms | BR140 |
| Description | bromodomain and PHD finger containing 1 |
| Reference | MIM:602410|HGNC:HGNC:14255|Ensembl:ENSG00000156983|HPRD:03875|Vega:OTTHUMG00000097033 |
| Gene type | protein-coding |
| Map location | 3p26-p25 |
| Pascal p-value | 0.312 |
| Sherlock p-value | 0.376 |
| TADA p-value | 0.004 |
| Fetal beta | 0.899 |
| eGene | Myers' cis & trans |
| Support | CompositeSet Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| 认为:Xu_2012 | Whole Exome Sequencing analysis | 新创4基因的突变identified by exome sequencing of 795 samples in this study |
Section I. Genetics and epigenetics annotation
认为table
认为table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRPF1 | chr3 | 9786813 | T | C | NM_001003694 NM_004634 |
. . |
silent silent |
Schizophrenia | 认为:Fromer_2014 | ||
| BRPF1 | chr3 | 9786691 | G | N | NM_001003694 NM_001003694 NM_004634 NM_004634 |
. . . . |
intronic splice-acceptor-in2 intronic splice-acceptor-in2 |
Schizophrenia | 认为:Xu_2012 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | BRPF1 | 7862 | 0.02 | trans | ||
| rs16955618 | chr15 | 29937543 | BRPF1 | 7862 | 0.02 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 2B | 392 | 251 | All SZGR 2.0 genes in this pathway |
| INGRAM SHH TARGETS DN | 64 | 41 | All SZGR 2.0 genes in this pathway |
| MORI SMALL PRE BII LYMPHOCYTE DN | 76 | 52 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| FRASOR RESPONSE TO SERM OR FULVESTRANT DN | 50 | 29 | All SZGR 2.0 genes in this pathway |
| NAKAYAMA FGF2 TARGETS | 29 | 17 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |