Gene Page:PVRIG
Summary?
| GeneID | 79037 |
| Symbol | PVRIG |
| Synonyms | C7orf15 |
| Description | poliovirus receptor related immunoglobulin domain containing |
| Reference | HGNC:HGNC:32190|Ensembl:ENSG00000213413|Vega:OTTHUMG00000156798 |
| Gene type | protein-coding |
| Map location | 7q22.1 |
| Pascal p-value | 0.129 |
| Fetal beta | 0.059 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DMG:vanEijk_2014 | Genome-wide DNA methylation analysis | This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg13650156 | 7 | 99970502 | PVRIG | 5.23E-6 | 5.117 | DMG:vanEijk_2014 | |
| cg10681065 | 7 | 100239172 | PVRIG | 1.264E-4 | 4.919 | DMG:vanEijk_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TP53I11 | 0.95 | 0.93 |
| EML1 | 0.94 | 0.94 |
| TMEM108 | 0.94 | 0.92 |
| GPR12 | 0.93 | 0.95 |
| BCL9 | 0.93 | 0.94 |
| BCORL1 | 0.93 | 0.95 |
| FOXG1B | 0.93 | 0.91 |
| DAB1 | 0.93 | 0.90 |
| AFF3 | 0.92 | 0.94 |
| MFHAS1 | 0.92 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SERPINB6 | -0.68 | -0.77 |
| C5orf53 | -0.66 | -0.80 |
| AIFM3 | -0.65 | -0.79 |
| HEPN1 | -0.65 | -0.78 |
| S100B | -0.64 | -0.87 |
| TSC22D4 | -0.63 | -0.79 |
| AF347015.31 | -0.63 | -0.90 |
| ALDOC | -0.63 | -0.71 |
| HLA-F | -0.63 | -0.75 |
| HSD17B14 | -0.63 | -0.79 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| JAATINEN HEMATOPOIETIC STEM CELL DN | 226 | 132 | All SZGR 2.0 genes in this pathway |
| HADDAD B LYMPHOCYTE PROGENITOR | 293 | 193 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER RACE UP | 299 | 167 | All SZGR 2.0 genes in this pathway |
| 乳腺癌萧述三腔的DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
| LEE DIFFERENTIATING T LYMPHOCYTE | 200 | 115 | All SZGR 2.0 genes in this pathway |
| SMIRNOV RESPONSE TO IR 6HR DN | 114 | 69 | All SZGR 2.0 genes in this pathway |
| ZWANG DOWN BY 2ND EGF PULSE | 293 | 119 | All SZGR 2.0 genes in this pathway |