Gene Page:DHRS11
概括?
| GeneID | 79154 |
| Symbol | DHRS11 |
| Synonyms | ARPG836|SDR24C1|spDHRS11 |
| Description | 特别提款权脱氢酶/还原酶(家庭)成员11 |
| Reference | MIM:616159|HGNC:HGNC:28639|Ensembl:ENSG00000278535|HPRD:08331|Vega：Otthumg00000188442 |
| Gene type | protein-coding |
| Map location | 17q12 |
| Pascal p-value | 0.005 |
| Sherlock p-value | 0.406 |
| Fetal beta | -0.863 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellum Cortex Frontal Cortex BA9 Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CNV:YES | Copy number variation studies | Manual curation | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs201641174 | 17 | 34838297 | DHRS11 | ENSG00000108272.9 | 3.262E-6 | 0 | -109931 | gtex_brain_ba24 |
| rs726311 | 17 | 34838547 | DHRS11 | ENSG00000108272.9 | 1.325E-6 | 0 | -109681 | gtex_brain_ba24 |
| rs34713024 | 17 | 34840664 | DHRS11 | ENSG00000108272.9 | 9.982E-8 | 0 | -107564 | gtex_brain_ba24 |
| rs12150387 | 17 | 34841669 | DHRS11 | ENSG00000108272.9 | 1.423E-6 | 0 | -106559 | gtex_brain_ba24 |
| rs4796225 | 17 | 34843839 | DHRS11 | ENSG00000108272.9 | 2.68E-6 | 0 | -104389 | gtex_brain_ba24 |
| rs75381777 | 17 | 34844505 | DHRS11 | ENSG00000108272.9 | 8.725E-8 | 0 | -103723 | gtex_brain_ba24 |
| rs34675748 | 17 | 34844756 | DHRS11 | ENSG00000108272.9 | 8.735E-8 | 0 | -103472 | gtex_brain_ba24 |
| rs62070707 | 17 | 34849050 | DHRS11 | ENSG00000108272.9 | 2.666E-6 | 0 | -99178 | gtex_brain_ba24 |
| rs79931608 | 17 | 34849051 | DHRS11 | ENSG00000108272.9 | 2.666E-6 | 0 | -99177 | gtex_brain_ba24 |
| rs62070708 | 17 | 34849052 | DHRS11 | ENSG00000108272.9 | 2.666E-6 | 0 | -99176 | gtex_brain_ba24 |
| RS12948803 | 17 | 34853103 | DHRS11 | ENSG00000108272.9 | 8.824E-8 | 0 | -95125 | gtex_brain_ba24 |
| rs2306590 | 17 | 34854280 | DHRS11 | ENSG00000108272.9 | 8.832E-8 | 0 | -93948 | gtex_brain_ba24 |
| rs17560870 | 17 | 34865131 | DHRS11 | ENSG00000108272.9 | 8.854E-8 | 0 | -83097 | gtex_brain_ba24 |
| rs7224434 | 17 | 34876866 | DHRS11 | ENSG00000108272.9 | 1.094E-7 | 0 | -71362 | gtex_brain_ba24 |
| rs2411192 | 17 | 34882998 | DHRS11 | ENSG00000108272.9 | 8.44E-8 | 0 | -65230 | gtex_brain_ba24 |
| rs35989249 | 17 | 34884149 | DHRS11 | ENSG00000108272.9 | 1.794E-7 | 0 | -64079 | gtex_brain_ba24 |
| rs2291285 | 17 | 34890362 | DHRS11 | ENSG00000108272.9 | 1.267E-7 | 0 | -57866 | gtex_brain_ba24 |
| rs12952548 | 17 | 34898722 | DHRS11 | ENSG00000108272.9 | 8.854E-8 | 0 | -49506 | gtex_brain_ba24 |
| rs12941866 | 17 | 34900120 | DHRS11 | ENSG00000108272.9 | 2.031E-6 | 0 | -48108 | gtex_brain_ba24 |
| rs3736165 | 17 | 34900642 | DHRS11 | ENSG00000108272.9 | 8.89E-8 | 0 | -47586 | gtex_brain_ba24 |
| rs3736167 | 17 | 34900847 | DHRS11 | ENSG00000108272.9 | 6.458E-8 | 0 | -47381 | gtex_brain_ba24 |
| rs12601380 | 17 | 34904985 | DHRS11 | ENSG00000108272.9 | 2.927E-7 | 0 | -43243 | gtex_brain_ba24 |
| rs10584099 | 17 | 34908378 | DHRS11 | ENSG00000108272.9 | 2.181E-7 | 0 | -39850 | gtex_brain_ba24 |
| rs12951387 | 17 | 34913982 | DHRS11 | ENSG00000108272.9 | 2.554E-7 | 0 | -34246 | gtex_brain_ba24 |
| rs12150665 | 17 | 34914787 | DHRS11 | ENSG00000108272.9 | 2.554E-7 | 0 | -33441 | gtex_brain_ba24 |
| rs71950509 | 17 | 34915044 | DHRS11 | ENSG00000108272.9 | 2.241E-7 | 0 | -33184 | gtex_brain_ba24 |
| rs8068351 | 17 | 34916879 | DHRS11 | ENSG00000108272.9 | 2.552E-7 | 0 | -31349 | gtex_brain_ba24 |
| rs34966008 | 17 | 34919623 | DHRS11 | ENSG00000108272.9 | 2.554E-7 | 0 | -28605 | gtex_brain_ba24 |
| rs34874411 | 17 | 34919643 | DHRS11 | ENSG00000108272.9 | 2.554E-7 | 0 | -28585 | gtex_brain_ba24 |
| rs59720361 | 17 | 34929379 | DHRS11 | ENSG00000108272.9 | 2.554E-7 | 0 | -18849 | gtex_brain_ba24 |
| rs12952492 | 17 | 34932498 | DHRS11 | ENSG00000108272.9 | 4.391E-6 | 0 | -15730 | gtex_brain_ba24 |
| rs12939690 | 17 | 34937572 | DHRS11 | ENSG00000108272.9 | 2.554E-7 | 0 | -10656 | gtex_brain_ba24 |
| rs12949679 | 17 | 34938599 | DHRS11 | ENSG00000108272.9 | 2.554E-7 | 0 | -9629 | gtex_brain_ba24 |
| rs34758451 | 17 | 34941376 | DHRS11 | ENSG00000108272.9 | 2.551E-7 | 0 | -6852 | gtex_brain_ba24 |
| rs17619821 | 17 | 34944593 | DHRS11 | ENSG00000108272.9 | 2.554E-7 | 0 | -3635 | gtex_brain_ba24 |
| rs28647740 | 17 | 34945034 | DHRS11 | ENSG00000108272.9 | 9.492E-7 | 0 | -3194 | gtex_brain_ba24 |
| rs1005551 | 17 | 34949361 | DHRS11 | ENSG00000108272.9 | 2.554E-7 | 0 | 1133 | gtex_brain_ba24 |
| rs12937411 | 17 | 34950239 | DHRS11 | ENSG00000108272.9 | 2.48E-7 | 0 | 2011 | gtex_brain_ba24 |
| rs2285639 | 17 | 34951327 | DHRS11 | ENSG00000108272.9 | 2.375E-7 | 0 | 3099 | gtex_brain_ba24 |
| rs58447929 | 17 | 34956585 | DHRS11 | ENSG00000108272.9 | 2.206E-7 | 0 | 8357 | gtex_brain_ba24 |
| rs8078079 | 17 | 34959346 | DHRS11 | ENSG00000108272.9 | 1.72E-7 | 0 | 11118 | gtex_brain_ba24 |
| rs12936319 | 17 | 34959459 | DHRS11 | ENSG00000108272.9 | 1.72E-7 | 0 | 11231 | gtex_brain_ba24 |
| rs2078447 | 17 | 34959861 | DHRS11 | ENSG00000108272.9 | 1.896E-7 | 0 | 11633 | gtex_brain_ba24 |
| rs1075218 | 17 | 34960103 | DHRS11 | ENSG00000108272.9 | 8.247E-7 | 0 | 11875 | gtex_brain_ba24 |
| rs35712149 | 17 | 34960336 | DHRS11 | ENSG00000108272.9 | 3.179E-7 | 0 | 12108 | gtex_brain_ba24 |
| rs12941009 | 17 | 34961051 | DHRS11 | ENSG00000108272.9 | 2.641E-7 | 0 | 12823 | gtex_brain_ba24 |
| rs34713024 | 17 | 34840664 | DHRS11 | ENSG00000108272.9 | 6.552E-8 | 0 | -107564 | gtex_brain_putamen_basal |
| rs12150387 | 17 | 34841669 | DHRS11 | ENSG00000108272.9 | 1.606E-6 | 0 | -106559 | gtex_brain_putamen_basal |
| rs4796225 | 17 | 34843839 | DHRS11 | ENSG00000108272.9 | 8.081E-7 | 0 | -104389 | gtex_brain_putamen_basal |
| rs75381777 | 17 | 34844505 | DHRS11 | ENSG00000108272.9 | 6.626E-8 | 0 | -103723 | gtex_brain_putamen_basal |
| rs34675748 | 17 | 34844756 | DHRS11 | ENSG00000108272.9 | 6.626E-8 | 0 | -103472 | gtex_brain_putamen_basal |
| rs62070707 | 17 | 34849050 | DHRS11 | ENSG00000108272.9 | 1.981E-6 | 0 | -99178 | gtex_brain_putamen_basal |
| rs79931608 | 17 | 34849051 | DHRS11 | ENSG00000108272.9 | 1.978E-6 | 0 | -99177 | gtex_brain_putamen_basal |
| rs62070708 | 17 | 34849052 | DHRS11 | ENSG00000108272.9 | 1.981E-6 | 0 | -99176 | gtex_brain_putamen_basal |
| RS12948803 | 17 | 34853103 | DHRS11 | ENSG00000108272.9 | 6.626E-8 | 0 | -95125 | gtex_brain_putamen_basal |
| rs2306590 | 17 | 34854280 | DHRS11 | ENSG00000108272.9 | 6.626E-8 | 0 | -93948 | gtex_brain_putamen_basal |
| rs17560870 | 17 | 34865131 | DHRS11 | ENSG00000108272.9 | 6.626E-8 | 0 | -83097 | gtex_brain_putamen_basal |
| rs7224434 | 17 | 34876866 | DHRS11 | ENSG00000108272.9 | 1.326E-7 | 0 | -71362 | gtex_brain_putamen_basal |
| rs2411192 | 17 | 34882998 | DHRS11 | ENSG00000108272.9 | 3.538E-7 | 0 | -65230 | gtex_brain_putamen_basal |
| rs35989249 | 17 | 34884149 | DHRS11 | ENSG00000108272.9 | 2.324E-7 | 0 | -64079 | gtex_brain_putamen_basal |
| rs2291285 | 17 | 34890362 | DHRS11 | ENSG00000108272.9 | 1.417E-7 | 0 | -57866 | gtex_brain_putamen_basal |
| rs12952548 | 17 | 34898722 | DHRS11 | ENSG00000108272.9 | 6.626E-8 | 0 | -49506 | gtex_brain_putamen_basal |
| rs12941866 | 17 | 34900120 | DHRS11 | ENSG00000108272.9 | 8.771E-7 | 0 | -48108 | gtex_brain_putamen_basal |
| rs3736165 | 17 | 34900642 | DHRS11 | ENSG00000108272.9 | 6.626E-8 | 0 | -47586 | gtex_brain_putamen_basal |
| rs3736167 | 17 | 34900847 | DHRS11 | ENSG00000108272.9 | 1.445E-7 | 0 | -47381 | gtex_brain_putamen_basal |
| rs12601380 | 17 | 34904985 | DHRS11 | ENSG00000108272.9 | 5.137E-9 | 0 | -43243 | gtex_brain_putamen_basal |
| rs201257631 | 17 | 34905449 | DHRS11 | ENSG00000108272.9 | 3.028E-7 | 0 | -42779 | gtex_brain_putamen_basal |
| rs145940493 | 17 | 34905455 | DHRS11 | ENSG00000108272.9 | 2.961E-7 | 0 | -42773 | gtex_brain_putamen_basal |
| rs8078390 | 17 | 34908219 | DHRS11 | ENSG00000108272.9 | 2.952E-7 | 0 | -40009 | gtex_brain_putamen_basal |
| rs10584099 | 17 | 34908378 | DHRS11 | ENSG00000108272.9 | 2.502E-8 | 0 | -39850 | gtex_brain_putamen_basal |
| rs35915570 | 17 | 34910357 | DHRS11 | ENSG00000108272.9 | 1.24E-7 | 0 | -37871 | gtex_brain_putamen_basal |
| rs35751000 | 17 | 34913528 | DHRS11 | ENSG00000108272.9 | 7.326E-8 | 0 | -34700 | gtex_brain_putamen_basal |
| rs12951387 | 17 | 34913982 | DHRS11 | ENSG00000108272.9 | 2.231E-8 | 0 | -34246 | gtex_brain_putamen_basal |
| rs28573110 | 17 | 34914365 | DHRS11 | ENSG00000108272.9 | 1.833E-6 | 0 | -33863 | gtex_brain_putamen_basal |
| rs12150665 | 17 | 34914787 | DHRS11 | ENSG00000108272.9 | 2.231E-8 | 0 | -33441 | gtex_brain_putamen_basal |
| rs71950509 | 17 | 34915044 | DHRS11 | ENSG00000108272.9 | 2.394E-6 | 0 | -33184 | gtex_brain_putamen_basal |
| rs8068351 | 17 | 34916879 | DHRS11 | ENSG00000108272.9 | 2.241E-8 | 0 | -31349 | gtex_brain_putamen_basal |
| rs7217095 | 17 | 34918092 | DHRS11 | ENSG00000108272.9 | 2.952E-7 | 0 | -30136 | gtex_brain_putamen_basal |
| rs34966008 | 17 | 34919623 | DHRS11 | ENSG00000108272.9 | 2.231E-8 | 0 | -28605 | gtex_brain_putamen_basal |
| rs34874411 | 17 | 34919643 | DHRS11 | ENSG00000108272.9 | 2.231E-8 | 0 | -28585 | gtex_brain_putamen_basal |
| rs57705647 | 17 | 34924538 | DHRS11 | ENSG00000108272.9 | 2.705E-7 | 0 | -23690 | gtex_brain_putamen_basal |
| rs7223633 | 17 | 34928562 | DHRS11 | ENSG00000108272.9 | 3.753E-6 | 0 | -19666 | gtex_brain_putamen_basal |
| rs34327767 | 17 | 34929002 | DHRS11 | ENSG00000108272.9 | 2.708E-7 | 0 | -19226 | gtex_brain_putamen_basal |
| rs59720361 | 17 | 34929379 | DHRS11 | ENSG00000108272.9 | 1.569E-8 | 0 | -18849 | gtex_brain_putamen_basal |
| rs12952492 | 17 | 34932498 | DHRS11 | ENSG00000108272.9 | 1.252E-7 | 0 | -15730 | gtex_brain_putamen_basal |
| rs2074103 | 17 | 34935878 | DHRS11 | ENSG00000108272.9 | 2.708E-7 | 0 | -12350 | gtex_brain_putamen_basal |
| rs12939690 | 17 | 34937572 | DHRS11 | ENSG00000108272.9 | 1.232E-7 | 0 | -10656 | gtex_brain_putamen_basal |
| rs12949068 | 17 | 34938437 | DHRS11 | ENSG00000108272.9 | 3.556E-7 | 0 | -9791 | gtex_brain_putamen_basal |
| rs12949679 | 17 | 34938599 | DHRS11 | ENSG00000108272.9 | 2.231E-8 | 0 | -9629 | gtex_brain_putamen_basal |
| rs34758451 | 17 | 34941376 | DHRS11 | ENSG00000108272.9 | 2.226E-8 | 0 | -6852 | gtex_brain_putamen_basal |
| rs1106908 | 17 | 34942595 | DHRS11 | ENSG00000108272.9 | 2.708E-7 | 0 | -5633 | gtex_brain_putamen_basal |
| rs1106907 | 17 | 34942870 | DHRS11 | ENSG00000108272.9 | 2.708E-7 | 0 | -5358 | gtex_brain_putamen_basal |
| rs3744593 | 17 | 34943719 | DHRS11 | ENSG00000108272.9 | 2.34E-6 | 0 | -4509 | gtex_brain_putamen_basal |
| rs17619821 | 17 | 34944593 | DHRS11 | ENSG00000108272.9 | 2.231E-8 | 0 | -3635 | gtex_brain_putamen_basal |
| rs202054291 | 17 | 34945033 | DHRS11 | ENSG00000108272.9 | 3.898E-7 | 0 | -3195 | gtex_brain_putamen_basal |
| rs28647740 | 17 | 34945034 | DHRS11 | ENSG00000108272.9 | 7.437E-8 | 0 | -3194 | gtex_brain_putamen_basal |
| rs12603276 | 17 | 34946547 | DHRS11 | ENSG00000108272.9 | 3.753E-6 | 0 | -1681 | gtex_brain_putamen_basal |
| rs1005551 | 17 | 34949361 | DHRS11 | ENSG00000108272.9 | 1.232E-7 | 0 | 1133 | gtex_brain_putamen_basal |
| rs1005552 | 17 | 34949598 | DHRS11 | ENSG00000108272.9 | 2.34E-6 | 0 | 1370 | gtex_brain_putamen_basal |
| rs12937411 | 17 | 34950239 | DHRS11 | ENSG00000108272.9 | 1.237E-7 | 0 | 2011 | gtex_brain_putamen_basal |
| rs35230968 | 17 | 34950837 | DHRS11 | ENSG00000108272.9 | 2.361E-6 | 0 | 2609 | gtex_brain_putamen_basal |
| rs2285639 | 17 | 34951327 | DHRS11 | ENSG00000108272.9 | 1.25E-7 | 0 | 3099 | gtex_brain_putamen_basal |
| RS35258073 | 17 | 34952789 | DHRS11 | ENSG00000108272.9 | 2.398E-6 | 0 | 4561 | gtex_brain_putamen_basal |
| rs8069331 | 17 | 34952964 | DHRS11 | ENSG00000108272.9 | 2.402E-6 | 0 | 4736 | gtex_brain_putamen_basal |
| rs58447929 | 17 | 34956585 | DHRS11 | ENSG00000108272.9 | 1.264E-7 | 0 | 8357 | gtex_brain_putamen_basal |
| rs8078079 | 17 | 34959346 | DHRS11 | ENSG00000108272.9 | 1.232E-7 | 0 | 11118 | gtex_brain_putamen_basal |
| rs12936319 | 17 | 34959459 | DHRS11 | ENSG00000108272.9 | 1.232E-7 | 0 | 11231 | gtex_brain_putamen_basal |
| rs2078447 | 17 | 34959861 | DHRS11 | ENSG00000108272.9 | 1.262E-7 | 0 | 11633 | gtex_brain_putamen_basal |
| rs1075218 | 17 | 34960103 | DHRS11 | ENSG00000108272.9 | 2.317E-8 | 0 | 11875 | gtex_brain_putamen_basal |
| rs35712149 | 17 | 34960336 | DHRS11 | ENSG00000108272.9 | 1.317E-7 | 0 | 12108 | gtex_brain_putamen_basal |
| rs12941009 | 17 | 34961051 | DHRS11 | ENSG00000108272.9 | 1.443E-7 | 0 | 12823 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| BASAKI YBX1 TARGETS UP | 290 | 177 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER ADVANCED VS EARLY DN | 138 | 70 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| SABATES COLORECTAL ADENOMA DN | 291 | 176 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| SANA TNF SIGNALING DN | 90 | 57 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS UP | 388 | 234 | All SZGR 2.0 genes in this pathway |
| ALONSO METASTASIS UP | 198 | 128 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS | 535 | 325 | All SZGR 2.0 genes in this pathway |
| LI INDUCED T TO NATURAL KILLER UP | 307 | 182 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |