Gene Page:IRX1

Summary?
GeneID 79192
Symbol IRX1
Synonyms IRX-5|IRXA1
Description iroquois homeobox 1
Reference MIM:606197|HGNC:HGNC:14358|Ensembl:ENSG00000170549|HPRD:16203|Vega:OTTHUMG00000161632
Gene type protein-coding
Map location 5p15.3
Pascal p-value 0.014
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:McCarthy_2014 Whole Exome Sequencing analysis Whole exome sequencing of 57 trios with sporadic or familial schizophrenia.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
IRX1 chr5 3601122 C G NM_024337 p.P471A missense SNV C P Schizophrenia DNM:McCarthy_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16827839 chr2 150987417 IRX1 79192 0.12 trans
rs16829545 chr2 151977407 IRX1 79192 0.02 trans
rs7584986 chr2 184111432 IRX1 79192 0.01 trans
rs1981925 chr4 34348578 IRX1 79192 0.01 trans
rs10491487 chr5 80323367 IRX1 79192 0.02 trans
rs7713523 chr5 97248325 IRX1 79192 0.15 trans
rs2268637 chr6 39050917 IRX1 79192 0.16 trans
rs17160028 chr7 31292738 IRX1 79192 0.16 trans
rs1976192 chr9 117074359 IRX1 79192 0.01 trans
rs17410931 chr10 98912175 IRX1 79192 0.05 trans
rs10500981 chr11 24543474 IRX1 79192 0.19 trans
rs17129612 chr11 96658135 IRX1 79192 0.18 trans
rs11044062 chr12 8371319 IRX1 79192 0.18 trans
rs11106191 chr12 78060911 IRX1 79192 0.11 trans
rs2145444 chr14 52005406 IRX1 79192 0.16 trans
rs16955618 chr15 29937543 IRX1 79192 1.214E-5 trans
rs12599961 chr16 8443409 IRX1 79192 0.19 trans
rs16944856 chr17 11394566 IRX1 79192 0.08 trans
rs1541352 chr17 13265560 IRX1 79192 0.09 trans
rs17070739 chr18 60819382 IRX1 79192 0.14 trans
rs7268640 chr20 47150267 IRX1 79192 0.02 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL DN 91 53 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271 175 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 110 78 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185 111 All SZGR 2.0 genes in this pathway
NOUZOVA METHYLATED IN APL 68 39 All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 97 72 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
GYORFFY MITOXANTRONE RESISTANCE 57 35 All SZGR 2.0 genes in this pathway
KORKOLA EMBRYONIC CARCINOMA VS SEMINOMA DN 25 14 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275 155 All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN 99 74 All SZGR 2.0 genes in this pathway