Gene Page:HSD17B8

Summary?
GeneID 7923
Symbol HSD17B8
Synonyms D6S2245E|FABG|FABGL|H2-KE6|HKE6|KE6|RING2|SDR30C1|dJ1033B10.9
Description hydroxysteroid (17-beta) dehydrogenase 8
Reference MIM:601417|HGNC:HGNC:3554|Ensembl:ENSG00000204228|HPRD:03248|Vega:OTTHUMG00000031117
Gene type protein-coding
Map location 6p21.3
Pascal p-value 4.567E-4
Sherlock p-value 0.158
eGene Cerebellar Hemisphere

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.033

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005488 binding IEA -
GO:0004303 estradiol 17-beta-dehydrogenase activity NAS -
GO:0016491 oxidoreductase activity IEA -
GO:0050327 testosterone 17-beta-dehydrogenase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006703 estrogen biosynthetic process NAS -
GO:0055114 oxidation reduction IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005575 cellular_component ND -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG STEROID HORMONE BIOSYNTHESIS 55 30 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC LEUKEMIA UP 368 234 All SZGR 2.0 genes in this pathway
AKL HTLV1 INFECTION UP 27 16 All SZGR 2.0 genes in this pathway
SCIBETTA KDM5B TARGETS DN 81 55 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261 153 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE UP 78 51 All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 145 91 All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING DN 68 44 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN 74 55 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP 123 75 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
ZHAN V1 LATE DIFFERENTIATION GENES UP 32 25 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-214 53 60 1A,m8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG