Gene Page:OR2H2
Summary?
| GeneID | 7932 |
| Symbol | OR2H2 |
| Synonyms | FAT11|OLFR2|OLFR42B|OR2H3|dJ271M21.2|hs6M1-12 |
| Description | olfactory receptor family 2 subfamily H member 2 |
| Reference | MIM:600578|HGNC:HGNC:8253|HPRD:08367| |
| Gene type | protein-coding |
| Map location | 6p21.3 |
| Pascal p-value | 1.633E-5 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7023147 | chr9 | 10077179 | OR2H2 | 7932 | 0.15 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C1orf103 | 0.92 | 0.93 |
| THUMPD3 | 0.91 | 0.91 |
| PLRG1 | 0.91 | 0.91 |
| USPL1 | 0.90 | 0.92 |
| LARS | 0.90 | 0.92 |
| TRMT5 | 0.90 | 0.90 |
| FASTKD2 | 0.90 | 0.90 |
| ZNF567 | 0.90 | 0.90 |
| OGFOD1 | 0.90 | 0.91 |
| PLAA | 0.90 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.76 | -0.80 |
| AF347015.31 | -0.75 | -0.79 |
| AF347015.33 | -0.74 | -0.78 |
| AF347015.8 | -0.73 | -0.79 |
| FXYD1 | -0.73 | -0.80 |
| MT-CYB | -0.73 | -0.77 |
| IFI27 | -0.73 | -0.81 |
| AF347015.27 | -0.72 | -0.76 |
| HIGD1B | -0.72 | -0.79 |
| AF347015.2 | -0.72 | -0.78 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0004984 | olfactory receptor activity | IEA | - | |
| GO:0004984 | olfactory receptor activity | TAS | 7665158 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | IEA | - | |
| GO:0007165 | signal transduction | IEA | - | |
| GO:0007618 | mating | TAS | 7665158 | |
| GO:0007608 | sensory perception of smell | IEA | - | |
| GO:0006952 | defense response | TAS | 7665158 | |
| GO:0050896 | response to stimulus | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG嗅觉传导 | 389 | 85 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| CROMER METASTASIS UP | 79 | 46 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI UP | 412 | 249 | All SZGR 2.0 genes in this pathway |