Gene Page:PGBD5

Summary?
GeneID 79605
Symbol PGBD5
Synonyms -
Description piggyBac transposable element derived 5
Reference MIM:616791|HGNC:HGNC:19405|Ensembl:ENSG00000177614|HPRD:10148|Vega:OTTHUMG00000037759
Gene type protein-coding
Map location 1q42.13
Sherlock p-value 0.141
Fetal beta -0.938
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Cerebellum
元
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg03347632 1 230457979 PGBD5 1.182E-4 0.608 0.029 DMG:Wockner_2014
cg04095826 1 230457906 PGBD5 1.771E-4 0.508 0.034 DMG:Wockner_2014
cg22875527 1 230492944 PGBD5 5.525E-4 0.587 0.049 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MRPL22 0.76 0.71
RPA3 0.75 0.66
MRPS14 0.74 0.73
NDUFA6 0.74 0.70
TRMT112 0.74 0.67
TOMM5 0.73 0.68
ACN9 0.73 0.70
MRPL13 0.73 0.67
NSL1 0.73 0.73
AK2 0.72 0.60
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.15 -0.35 -0.34
AF347015.26 -0.34 -0.31
AF347015.2 -0.33 -0.29
AF347015.18 -0.32 -0.27
AF347015.8 -0.32 -0.29
MT-CYB -0.32 -0.31
C9orf131 -0.30 -0.32
BAI1 -0.29 -0.25
AC100783.1 -0.29 -0.31
MT-ATP8 -0.29 -0.25

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 DN 48 28 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A DN 90 61 All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION DN 48 31 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 240 MCF10A 57 36 All SZGR 2.0 genes in this pathway
ROSS AML WITH PML RARA FUSION 77 62 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL 129 85 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway