Gene Page:FAT4

Summary?
GeneID 79633
Symbol FAT4
Synonyms CDHF14|CDHR11|FAT-J|FATJ|HKLLS2|NBLA00548|VMLDS2
Description FAT atypical cadherin 4
Reference MIM:612411|HGNC:HGNC:23109|Ensembl:ENSG00000196159|HPRD:07637|Vega:OTTHUMG00000133100
Gene type protein-coding
Map location 4q28.1
Pascal p-value 0.324
Fetal beta 0.71
eGene Myers' cis & trans
Support CompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
FAT4 chr4 126240143 A T NM_024582 p.859Q>H missense Schizophrenia DNM:Fromer_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9288980 chr3 112964991 FAT4 79633 0.16 trans
rs3995908 chr3 112998529 FAT4 79633 0.16 trans
rs7652801 chr3 113008605 FAT4 79633 0.16 trans
rs16889842 chr4 9872012 FAT4 79633 0.04 trans
rs313946 chr4 113975904 FAT4 79633 0.11 trans
rs657141 chr4 113981041 FAT4 79633 0.13 trans
rs2398707 chr7 2113428 FAT4 79633 0.19 trans
rs3778951 chr7 2125319 FAT4 79633 0.19 trans
rs3778957 chr7 2127710 FAT4 79633 0.19 trans
rs3823550 chr7 137346101 FAT4 79633 0.19 trans
rs7823144 chr8 38028194 FAT4 79633 0.18 trans
rs9551590 chr13 29589464 FAT4 79633 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DAVICIONI MOLECULAR ARMS VS ERMS DN 182 111 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170 114 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256 159 All SZGR 2.0 genes in this pathway
CLAUS PGR POSITIVE MENINGIOMA UP 10 7 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER POOR SURVIVAL UP 31 22 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
GYORFFY DOXORUBICIN RESISTANCE 56 34 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210 141 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN 106 77 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway