Gene Page:OGFOD2

年代ummary?
GeneID 79676
年代ymbol OGFOD2
年代ynonyms -
Description 2-oxoglutarate and iron dependent oxygenase domain containing 2
Reference HGNC:HGNC:25823|Ensembl:ENSG00000111325|HPRD:07829|Vega:OTTHUMG00000168778
Gene type protein-coding
Map location 12q24.31
Pascal p-value 1.27E-10
年代herlock p-value 0.066
Fetal beta -1.069
eGene Hypothalamus
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
LK:YES Genome-wide Association Study This data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013

年代ection I. Genetics and epigenetics annotation

@eQTL annotation

年代NP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4275659 chr12 123447927 OGFOD2 79676 0.01 cis
rs1106240 chr12 123626981 OGFOD2 79676 0.03 cis
rs1569068 chr12 123632275 OGFOD2 79676 0.02 cis
rs1727315 chr12 123638929 OGFOD2 79676 0.01 cis
rs1727313 chr12 123640852 OGFOD2 79676 0.03 cis
rs1716168 chr12 123651965 OGFOD2 79676 0.02 cis
rs2695478 chr12 123689520 OGFOD2 79676 0 cis
rs1609520 chr12 123735936 OGFOD2 79676 0.02 cis
rs10846489 chr12 123743926 OGFOD2 79676 0.03 cis
rs2695478 chr12 123689520 OGFOD2 79676 0.19 trans

年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
TMEM67 0.89 0.63
EFHC1 0.88 0.60
C3orf15 0.88 0.64
CCDC40 0.88 0.59
LRP2BP 0.88 0.37
CCDC146 0.88 0.66
DNAH6 0.87 0.61
TTC25 0.86 0.58
CCDC81 0.85 0.51
HYDIN 0.85 0.66
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
MT-CO2 -0.31 -0.46
AF347015.27 -0.31 -0.45
PTGDS -0.31 -0.38
AF347015.31 -0.31 -0.47
COX4I2 -0.30 -0.46
HLA-F -0.30 -0.37
AF347015.33 -0.30 -0.44
ALDH1A1 -0.30 -0.43
MT-CYB -0.30 -0.45
CA4 -0.30 -0.39

年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276 165 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341 197 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
DARWICHE皮肤肿瘤促进剂DN 185 115 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165 107 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180 110 All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181 107 All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS DN 52 34 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220 133 All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238 125 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway