Gene Page:ISOC2

Summary?
GeneID 79763
Symbol ISOC2
Synonyms -
Description isochorismatase domain containing 2
Reference MIM:612928|HGNC:HGNC:26278|Ensembl:ENSG00000063241|HPRD:08030|Vega:OTTHUMG00000180830
Gene type protein-coding
Map location 19q13.42
Pascal p-value 0.403
Sherlock p-value 0.975
Fetal beta -0.944
DMG 1 (# studies)
eGene 元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.05

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04504956 19 55963317 ISOC2 2.5E-8 -0.02 8.03E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CR381670.2 0.39 0.07
PAPOLB 0.38 0.21
DNAH8 0.36 0.14
RP11-413E6.1 0.36 0.08
XIRP1 0.35 0.10
RP1L1 0.33 0.29
CES3 0.32 0.29
FBXW12 0.31 0.26
NUP210L 0.30 0.13
C12orf54 0.30 0.15
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GNG11 -0.21 -0.28
IL32 -0.21 -0.26
CLEC3B -0.20 -0.23
AC131097.1 -0.19 -0.21
MRPL41 -0.19 -0.19
CLDN5 -0.19 -0.21
HIGD1B -0.18 -0.22
AF347015.21 -0.18 -0.29
BTBD17 -0.18 -0.21
METRN -0.17 -0.25

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003824 catalytic activity IEA -
GO:0005515 protein binding 新闻学会 15231747
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008152 metabolic process IEA -
GO:0031648 protein destabilization IMP 17658461
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 17658461
GO:0005737 cytoplasm IDA 17658461
GO:0005739 mitochondrion IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HOOI ST7 TARGETS UP 94 57 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN 161 93 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN 103 67 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295 155 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-33 166 172 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA