创e Page:NAA25
Summary?
| 创eID | 80018 |
| Symbol | NAA25 |
| Synonyms | C12orf30|MDM20|NAP1 |
| Description | N(alpha)-acetyltransferase 25, NatB auxiliary subunit |
| Reference | MIM:612755|HGNC:HGNC:25783|Ensembl:ENSG00000111300|HPRD:08578|Vega:OTTHUMG00000169638 |
| 创e type | protein-coding |
| Map location | 12q24.13 |
| Pascal p-value | 0.216 |
| Fetal beta | 0.466 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Putamen basal ganglia |
创e in Data Sources
| 创e set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | 创ome-wide Association Study | GWAS | |
| CV:PheWAS | Phenome-wide association studies (PheWAS) | 157 SNPs associated with schizophrenia | 1 |
| DMG:Wockner_2014 | 创ome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
CV:PheWAS
CV:PheWAS| SNP ID | Chromosome | Position | Allele | P | Function | 创e | Up/Down Distance |
|---|---|---|---|---|---|---|---|
| rs17696736 | 12 | 112486818 | null | 0.6809 | NAA25 | null |
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg18700744 | 12 | 112534559 | NAA25 | 3.967E-4 | -0.488 | 0.044 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | 创e Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs58376384 | 12 | 112287753 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 259073 | gtex_brain_putamen_basal |
| rs77211491 | 12 | 112322778 | NAA25 | ENSG00000111300.5 | 2.402E-6 | 0.01 | 224048 | gtex_brain_putamen_basal |
| rs16941724 | 12 | 112327057 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 219769 | gtex_brain_putamen_basal |
| rs77030808 | 12 | 112329028 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 217798 | gtex_brain_putamen_basal |
| rs12580246 | 12 | 112331317 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 215509 | gtex_brain_putamen_basal |
| rs75797656 | 12 | 112340341 | NAA25 | ENSG00000111300.5 | 2.408E-6 | 0.01 | 206485 | gtex_brain_putamen_basal |
| rs78729142 | 12 | 112357260 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 189566 | gtex_brain_putamen_basal |
| rs12580175 | 12 | 112364512 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 182314 | gtex_brain_putamen_basal |
| rs61012856 | 12 | 112365491 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 181335 | gtex_brain_putamen_basal |
| rs79976090 | 12 | 112366118 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 180708 | gtex_brain_putamen_basal |
| rs58742238 | 12 | 112366324 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 180502 | gtex_brain_putamen_basal |
| rs59131168 | 12 | 112368363 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 178463 | gtex_brain_putamen_basal |
| rs59836372 | 12 | 112369878 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 176948 | gtex_brain_putamen_basal |
| rs12582100 | 12 | 112378909 | NAA25 | ENSG00000111300.5 | 2.447 e-6 | 0.01 | 167917 | gtex_brain_putamen_basal |
| rs77809791 | 12 | 112380027 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 166799 | gtex_brain_putamen_basal |
| rs77204391 | 12 | 112391876 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 154950 | gtex_brain_putamen_basal |
| rs12578195 | 12 | 112393934 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 152892 | gtex_brain_putamen_basal |
| rs12579799 | 12 | 112397887 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 148939 | gtex_brain_putamen_basal |
| rs12423689 | 12 | 112403135 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 143691 | gtex_brain_putamen_basal |
| rs12423699 | 12 | 112403161 | NAA25 | ENSG00000111300.5 | 5.469E-6 | 0.01 | 143665 | gtex_brain_putamen_basal |
| rs12426312 | 12 | 112406749 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 140077 | gtex_brain_putamen_basal |
| rs80104974 | 12 | 112427796 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 119030 | gtex_brain_putamen_basal |
| rs78745958 | 12 | 112428171 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 118655 | gtex_brain_putamen_basal |
| rs57929857 | 12 | 112433556 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 113270 | gtex_brain_putamen_basal |
| rs60998439 | 12 | 112445969 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 100857 | gtex_brain_putamen_basal |
| rs79271898 | 12 | 112454619 | NAA25 | ENSG00000111300.5 | 2.916E-6 | 0.01 | 92207 | gtex_brain_putamen_basal |
| rs79761579 | 12 | 112458885 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 87941 | gtex_brain_putamen_basal |
| rs78831907 | 12 | 112474664 | NAA25 | ENSG00000111300.5 | 2.861E-6 | 0.01 | 72162 | gtex_brain_putamen_basal |
| rs74778442 | 12 | 112485072 | NAA25 | ENSG00000111300.5 | 5.469E-6 | 0.01 | 61754 | gtex_brain_putamen_basal |
| rs80190218 | 12 | 112500687 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 46139 | gtex_brain_putamen_basal |
| rs10219716 | 12 | 112503474 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 43352 | gtex_brain_putamen_basal |
| rs58886972 | 12 | 112509281 | NAA25 | ENSG00000111300.5 | 5.465E-6 | 0.01 | 37545 | gtex_brain_putamen_basal |
| rs77176084 | 12 | 112515312 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 31514 | gtex_brain_putamen_basal |
| rs74636821 | 12 | 112515912 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 30914 | gtex_brain_putamen_basal |
| rs78866396 | 12 | 112522346 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 24480 | gtex_brain_putamen_basal |
| rs12422941 | 12 | 112537738 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 9088 | gtex_brain_putamen_basal |
| rs79540372 | 12 | 112538713 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | 8113 | gtex_brain_putamen_basal |
| rs77710189 | 12 | 112557759 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -10933 | gtex_brain_putamen_basal |
| rs77288277 | 12 | 112582088 | NAA25 | ENSG00000111300.5 | 3.764E-6 | 0.01 | -35262 | gtex_brain_putamen_basal |
| rs60549974 | 12 | 112591821 | NAA25 | ENSG00000111300.5 | 1.898E-6 | 0.01 | -44995 | gtex_brain_putamen_basal |
| rs199972720 | 12 | 112593868 | NAA25 | ENSG00000111300.5 | 2.392E-6 | 0.01 | -47042 | gtex_brain_putamen_basal |
| rs12427185 | 12 | 112597274 | NAA25 | ENSG00000111300.5 | 2.025E-6 | 0.01 | -50448 | gtex_brain_putamen_basal |
| rs3519 | 12 | 112598321 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -51495 | gtex_brain_putamen_basal |
| rs3830633 | 12 | 112599935 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -53109 | gtex_brain_putamen_basal |
| rs2293432 | 12 | 112601808 | NAA25 | ENSG00000111300.5 | 2.242E-6 | 0.01 | -54982 | gtex_brain_putamen_basal |
| rs200400577 | 12 | 112608316 | NAA25 | ENSG00000111300.5 | 2.392E-6 | 0.01 | -61490 | gtex_brain_putamen_basal |
| rs12580428 | 12 | 112615377 | NAA25 | ENSG00000111300.5 | 1.287E-6 | 0.01 | -68551 | gtex_brain_putamen_basal |
| rs12579336 | 12 | 112615538 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -68712 | gtex_brain_putamen_basal |
| rs12423572 | 12 | 112615919 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -69093 | gtex_brain_putamen_basal |
| rs74187049 | 12 | 112617918 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -71092 | gtex_brain_putamen_basal |
| rs3741993 | 12 | 112621886 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -75060 | gtex_brain_putamen_basal |
| rs16941909 | 12 | 112626224 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -79398 | gtex_brain_putamen_basal |
| rs57866673 | 12 | 112633304 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -86478 | gtex_brain_putamen_basal |
| rs77522654 | 12 | 112635191 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -88365 | gtex_brain_putamen_basal |
| rs12423268 | 12 | 112641707 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -94881 | gtex_brain_putamen_basal |
| rs60082293 | 12 | 112661269 | NAA25 | ENSG00000111300.5 | 2.391E-6 | 0.01 | -114443 | gtex_brain_putamen_basal |
| rs12579851 | 12 | 112668755 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -121929 | gtex_brain_putamen_basal |
| rs12579123 | 12 | 112845843 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -299017 | gtex_brain_putamen_basal |
| rs78401045 | 12 | 112876736 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -329910 | gtex_brain_putamen_basal |
| rs11066308 | 12 | 112881996 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -335170 | gtex_brain_putamen_basal |
| rs12423190 | 12 | 112909340 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -362514 | gtex_brain_putamen_basal |
| rs60633068 | 12 | 112938755 | NAA25 | ENSG00000111300.5 | 2.389E-6 | 0.01 | -391929 | gtex_brain_putamen_basal |
| rs10850043 | 12 | 112957138 | NAA25 | ENSG00000111300.5 | 6.482E-6 | 0.01 | -410312 | gtex_brain_putamen_basal |
| rs10850045 | 12 | 112959096 | NAA25 | ENSG00000111300.5 | 6.476E-6 | 0.01 | -412270 | gtex_brain_putamen_basal |
| rs11066330 | 12 | 112960013 | NAA25 | ENSG00000111300.5 | 6.476E-6 | 0.01 | -413187 | gtex_brain_putamen_basal |
| rs2891397 | 12 | 112961447 | NAA25 | ENSG00000111300.5 | 6.476E-6 | 0.01 | -414621 | gtex_brain_putamen_basal |
| rs10850047 | 12 | 112964652 | NAA25 | ENSG00000111300.5 | 7.152E-6 | 0.01 | -417826 | gtex_brain_putamen_basal |
| rs5800948 | 12 | 112964757 | NAA25 | ENSG00000111300.5 | 6.476E-6 | 0.01 | -417931 | gtex_brain_putamen_basal |
| rs2383999 | 12 | 112964844 | NAA25 | ENSG00000111300.5 | 6.476E-6 | 0.01 | -418018 | gtex_brain_putamen_basal |
| rs10850048 | 12 | 112965801 | NAA25 | ENSG00000111300.5 | 1.229E-6 | 0.01 | -418975年 | gtex_brain_putamen_basal |
| rs11066344 | 12 | 112991832 | NAA25 | ENSG00000111300.5 | 7.695E-6 | 0.01 | -445006 | gtex_brain_putamen_basal |
| rs4767908 | 12 | 113000783 | NAA25 | ENSG00000111300.5 | 7.129E-6 | 0.01 | -453957 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
创eral gene expression (GTEx)
创e expression during devlopment (BrainCloud)
补充说明:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
创e expression of temporal and spatial changes (BrainSpan)
补充说明:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP | 285 | 181 | 所有SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP | 73 | 50 | 所有SZGR 2.0 genes in this pathway |
| HOOI ST7 TARGETS DN | 123 | 78 | 所有SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS UP | 372 | 227 | 所有SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY UP | 430 | 232 | 所有SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | 所有SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | 所有SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR | 681 | 420 | 所有SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | 所有SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | 所有SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | 所有SZGR 2.0 genes in this pathway |
| KARLSSON TGFB1 TARGETS UP | 127 | 78 | 所有SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | 所有SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | 所有SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | 所有SZGR 2.0 genes in this pathway |