SZGR2 - Beplay体育中心

Summary?

GeneID	801
象征	CALM1
Synonyms	CALML2\|CAMI\|CPVT4\|DD132\|LQT14\|PHKD\|caM
Description	钙调蛋白1（磷酸化酶激酶，三角洲）
Reference	MIM:114180\|HGNC:HGNC:1442\|Ensembl:ENSG00000198668\|HPRD:00241\|Vega:OTTHUMG00000171044
基因类型	protein-coding
Map location	14Q32.11
Pascal p-value	0.044
Sherlock p-value	0.768
Fetal beta	-0.689
DMG	2（＃研究）
Support	细胞内信号转导 SEROTONIN G2Cdb.human_mGluR5 G2Cdb.human_PocklingtonH1 G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
ADT:Sun_2012	Systematic Investigation of Antipsychotic Drugs and Their Targets	A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：JAFFE_2016	Genome-wide DNA methylation analysis	该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。	3
DMG：Vaneijk_2014	Genome-wide DNA methylation analysis	该数据集包括432个差异甲基化的CpG位点，对应于精神分裂症患者（n = 260）和未受影响的对照（n = 250）之间的391个独特的转录本。	3
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 14.7236

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	位置	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg20328328	14	90863801	CALM1	9.98E-9	-0.01	4.36E-6	DMG：JAFFE_2016
cg10173240	14	90849342	CALM1	3.41E-8	-0.021	1.02E-5	DMG：JAFFE_2016
cg12624641	14	90420569	CALM1	0.001	3.969		DMG：Vaneijk_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	皮尔逊的相关性	斯皮尔曼的相关性
CACYBP	0.88	0.93
ATP6V1D	0.84	0.89
SNX3	0.84	0.87
nkiras1	0.83	0.88
TCEAL7	0.83	0.92
NAT5	0.82	0.88
NDUFAF4	0.82	0.86
NDUFA5	0.81	0.85
TTC1	0.81	0.86
顺式1	0.81	0.86

前10个负共表达基因
Gene	皮尔逊的相关性	斯皮尔曼的相关性
SMTN	-0.50	-0.55
SLC27A1	-0.49	-0.50
FAM59B	-0.48	-0.50
RP4-697K14.1	-0.48	-0.55
PLXNB1	-0.48	-0.50
tenc1	-0.47	-0.47
NFKB2	-0.47	-0.51
AC010618.2	-0.47	-0.50
CDC42EP4	-0.46	-0.50
SEMA4B	-0.46	-0.46

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	Experimental	Source	PubMed ID
ADCYAP1R1	PAC1 \| PACAPR \| PACAPRI	腺苷酸环化酶激活多肽1（垂体）受体I型	钙调蛋白与PACPR相互作用。	BIND	15670850
ADD1	ADDA \| MGC3339 \| MGC44427	adducin 1 (alpha)	Phenotypic Suppression	BioGRID	8626479
ADD1	ADDA \| MGC3339 \| MGC44427	adducin 1 (alpha)	-	HPRD	8663089
ADD2	ADDB	adducin 2 (beta)	-	HPRD	7490111
AKAP9	AKAP350 \| AKAP450 \| CG-NAP \| HYPERION \| KIAA0803 \| MU-RMS-40.16A \| PRKA9 \| YOTIAO	A kinase (PRKA) anchor protein (yotiao) 9	Affinity Capture-Western Reconstituted Complex	BioGRID	12221128
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Affinity Capture-Western 共定位 Reconstituted Complex	BioGRID	14695896
ASCL2	ASH2 \| HASH2 \| MASH2 \| bHLHa45	achaete-scute complex homolog 2 (Drosophila)	-	HPRD	10757985
CABIN1	CAIN \| KIAA0330 \| PPP3IN	calcineurin binding protein 1	CALM1 (CaM) interacts with CABIN1. This interaction was modelled on a demonstrated interaction between CaM from an unspecified species and human CABIN1.	BIND	15902271
CALCR	CRT \| CTR \| CTR1	calcitonin receptor	Calmodulin interacts with CALTR.	BIND	15670850
CALD1	CDM \| H-CAD \| L-CAD \| MGC21352 \| NAG22	caldesmon 1	-	HPRD	11736632
CAMK2G	CAMK \|CAMK-II \|Camkg \|FLJ16043 \|MGC26678	calcium/calmodulin-dependent protein kinase II gamma	-	HPRD,BioGRID	10860555
CCNA2	CCN1 \| CCNA	cyclin A2	Reconstituted Complex	BioGRID	14695896
CCND1	bcl1 \|D11S287E \|prad1 \|U21B31	Cyclin D1	-	HPRD	9837900
CNN1	SMCC \| Sm-Calp	钙蛋白1，基本的平滑肌	-	HPRD,BioGRID	2161834\|2455687
CRHR1	CRF-R \|CRF1 \|CRFR1 \|CRH-R1H \|CRHR \|CRHR1F	corticotropin releasing hormone receptor 1	Calmodulin interacts with CRF1R.	BIND	15670850
EDF1	EDF-1 \| MBF1 \| MGC9058	endothelial differentiation-related factor 1	-	HPRD	10816571
EGFR	ERBB \|ERBB1 \|her1 \|PIG61 \|梅纳	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	EGFR与钙调蛋白互动	BIND	14960328
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	-	HPRD	11981030
ESR2	ER-BETA \| ESR-BETA \| ESRB \| ESTRB \| Erb \| NR3A2	estrogen receptor 2 (ER beta)	-	HPRD	11981030
ewsR1	ews	Ewing sarcoma breakpoint region 1	Reconstituted Complex	BioGRID	9341188
GAP43	B-50 \| PP46	生长蛋白43	GAP-43与CAM相互作用。	BIND	8872303
GLP1R	MGC138331	glucagon-like peptide 1 receptor	Calmodulin interacts with GLP1R.	BIND	15670850
GLP2R	-	glucagon-like peptide 2 receptor	Calmodulin interacts with GLP2R.	BIND	15670850
GRB7	-	生长因子受体结合蛋白7	GRB7与CAM相互作用。这种相互作用是根据大鼠和未指定物种的人类Grb7和CAM之间的相互作用进行建模的。	BIND	15806159
GRK1	GPRK1 \| RHOK \| RK	G protein-coupled receptor kinase 1	-	HPRD	9753452
GRK4	GPRK2L \| GPRK4 \| GRK4a \| IT11	G protein-coupled receptor kinase 4	Reconstituted Complex	BioGRID	9092566
GRK5	GPRK5	G protein-coupled receptor kinase 5	Reconstituted Complex	BioGRID	9092566
GRM5	GPRC1E \| MGLUR5 \| MGLUR5A \| MGLUR5B \| mGlu5	谷氨酸受体，代谢5	-	HPRD	11953448
GRM7	FLJ40498 \| GLUR7 \| GPRC1G \| MGLUR7 \| mGlu7	谷氨酸受体，代谢7	-	HPRD	10488094\|11953448
HSP90AA1	FLJ31884 \|HSP86 \|HSP89A \|HSP90A \|HSP90N \|HSPC1 \|HSPCA \|HSPCAL1 \|HSPCAL4 \|HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD	8486648
IQGAP1	HUMORFA01 \| KIAA0051 \| SAR1 \| p195	IQ motif containing GTPase activating protein 1	Reconstituted Complex	BioGRID	11734550\|12446675
IQGAP2	-	IQ motif containing GTPase activating protein 2	-	HPRD	8756646
KCNN2	KCa2.2 \| SK2 \| SKCA2 \| hSK2	钾中间/小电导钙激活通道，亚家族n，成员2	-	HPRD,BioGRID	11323678
KCNQ2	BFNC \| EBN \| EBN1 \| ENB1 \| HNSPC \| KCNA11 \| KV7.2 \| KVEBN1	钾电压门控通道，类似KQT的亚家族，成员2	-	HPRD	12032157
KCNQ5	KV7.5	钾电压门控通道，类似KQT的亚家族，成员5	-	HPRD	12032157
LYST	CHS \| CHS1	lysosomal trafficking regulator	-	HPRD	11984006
mapt	ddpac \|FLJ31424 \|FTDP-17 \|maptl \|MGC138549 \|MSTD \|mtbt1 \|mtbt2 \|ppnd \|tau	microtubule-associated protein tau	-	HPRD,BioGRID	2123288
MYF5	bHLHc2	肌源性因子5	-	HPRD	10757985
MYF6	MRF4 \| bHLHc4	肌原因子6（巨蛋白）	-	HPRD	10757985
MYLK	DKFZp686I10125 \| FLJ12216 \| KRP \| MLCK \| MLCK1 \| MLCK108 \| MLCK210 \| MSTP083 \| MYLK1 \| smMLCK	myosin light chain kinase	-	HPRD,BioGRID	7947686
MYO9B	CELIAC4 \| MYR5	myosin IXB	-	HPRD,BioGRID	9490638
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	-	HPRD	10757985
MYOG	myf4 \|肌蛋白\|BHLHC3	myogenin (myogenic factor 4)	-	HPRD	10757985
Neurod1	beta2 \|BHF-1 \|Neurod \|BHLHA3	神经源分化1	-	HPRD	10757985
OPRM1	KIAA0403 \| MOR \| MOR1 \| OPRM	opioid receptor, mu 1	-	HPRD,BioGRID	11457836
PCNT	肯mopd2 \|PCN \|PCNT2 \|PCNTB \|pctn2 \|SCKL4	pericentrin	Reconstituted Complex	BioGRID	10823944
PDE1A	HCAM1 \| HSPDE1A \| MGC26303	phosphodiesterase 1A, calmodulin-dependent	-	HPRD,BioGRID	12135876
phkg1	phkg	phosphorylase kinase, gamma 1 (muscle)	-	HPRD	2507540
PPEF1	PP7 \| PPEF \| PPP7C	protein phosphatase, EF-hand calcium binding domain 1	-	HPRD,BioGRID	12051765
PPEF2	-	protein phosphatase, EF-hand calcium binding domain 2	-	HPRD,BioGRID	12051765
PTH2R	PTHR2	parathyroid hormone 2 receptor	Calmodulin interacts with PTH2R.	BIND	15670850
Rab3b	-	Rab3b，Ras Oncogene家族成员	-	HPRD	11741295
RIT2	riba \|Rin \|ROC2	像RAS一样无CAAX 2	-	HPRD,BioGRID	8824319
RYR1	CCO \| MHS \| MHS1 \| RYDR \| RYR \| SKRR	ryanodine receptor 1 (skeletal)	-	HPRD	12509414
SCN4A	HYKPP \| HYPP \| NAC1A \| Na(V)1.4 \| Nav1.4 \| SkM1	sodium channel, voltage-gated, type IV, alpha subunit	Nav1.4 interacts with CaM. This interaction was modeled on a demonstrated interaction between rat Nav1.4 and human CaM.	BIND	15746172
SCTR	SR	Sectionin受体	Calmodulin interacts with SECRR.	BIND	15670850
SLC9A1	apnh \|FLJ42224 \|NHE1	溶质载体家族9（钠/氢交换器），成员1	Far Western	BioGRID	12809501
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD,BioGRID	12358748
SNTA1	SNT1 \| TACIP1 \| dJ1187J4.5	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	-	HPRD	9512352
SYT1	DKFZp781D2042 \| P65 \| SVP65 \| SYT	synaptotagmin I	Reconstituted Complex	BioGRID	8901523
TCF3	E2A \| ITF1 \| MGC129647 \| MGC129648 \| bHLHb21	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	-	HPRD,BioGRID	10757985
TCF4	E2-2 \| ITF2 \| MGC149723 \| MGC149724 \| PTHS \| SEF2 \| SEF2-1 \| SEF2-1A \| SEF2-1B \| bHLHb19	转录因子4	-	HPRD,BioGRID	10757985
TRPV1	DKFZP434K0220 \|VR1	瞬态受体电位阳离子通道，亚家族V，成员1	Affinity Capture-Western Reconstituted Complex	BioGRID	12808128
TTN	CMD1G \| CMH9 \| CMPD4 \| CONNECTIN \| DKFZp451N061 \| EOMFC \| FLJ26020 \| FLJ26409 \| FLJ32040 \| FLJ34413 \| FLJ39564 \| FLJ43066 \| HMERF \| LGMD2J \| TMD	titin	-	HPRD	11178895
VIPR1	FLJ41949 \| HVR1 \| II \| PACAP-R-2 \| RDC1 \| VAPC1 \| VIPR \| VIRG \| VPAC1 \| VPCAP1R	vasoactive intestinal peptide receptor 1	钙调蛋白与VIP1R相互作用。	BIND	15670850
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，epsilon多肽	-	HPRD	10088721

Section V. Pathway annotation

路径名	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CALCIUM SIGNALING PATHWAY	178	134	All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM	76	56	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION	115	81	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG神经营养蛋白信号传导途径	126	103	All SZGR 2.0 genes in this pathway
KEGG OLFACTORY TRANSDUCTION	389	85	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY	101	77	All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS	102	80	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
BIOCARTA NO1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY	36	28	All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY	37	28	All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY	45	35	All SZGR 2.0 genes in this pathway
BIOCARTA CACAM PATHWAY	16	11	All SZGR 2.0 genes in this pathway
BIOCARTA HDAC PATHWAY	32	25	All SZGR 2.0 genes in this pathway
BIOCARTA GCR PATHWAY	22	17	All SZGR 2.0 genes in this pathway
BIOCARTA CALCINEURIN PATHWAY	21	17	All SZGR 2.0 genes in this pathway
Biocarta ndkdynamin途径	21	15	All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY	41	30	All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY	39	29	All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
BIOCARTA VIP PATHWAY	29	26	All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY	56	45	All SZGR 2.0 genes in this pathway
BIOCARTA NOS1 PATHWAY	24	21	All SZGR 2.0 genes in this pathway
BIOCARTA CCR5 PATHWAY	20	16	All SZGR 2.0 genes in this pathway
BIOCARTA PGC1A PATHWAY	26	20	All SZGR 2.0 genes in this pathway
BIOCARTA MEF2D PATHWAY	23	16	All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY	49	37	All SZGR 2.0 genes in this pathway
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	18	10	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING	32	25	All SZGR 2.0 genes in this pathway
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	13	9	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	29	24	All SZGR 2.0 genes in this pathway
B细胞受体BCR的反应组信号传导	126	90	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME ENOS ACTIVATION AND REGULATION	20	14	All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	89	56	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME神经系统	279	221	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
Reactome阿片类药物信号传导	78	56	All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS	30	23	All SZGR 2.0 genes in this pathway
Reactome darpp 32事件	25	20	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS	43	32	All SZGR 2.0 genes in this pathway
PDGF的Reactome信号传导	122	93	All SZGR 2.0 genes in this pathway
Reactome下游信号转导	95	76	All SZGR 2.0 genes in this pathway
REACTOME MUSCLE CONTRACTION	48	24	All SZGR 2.0 genes in this pathway
Reactome RAS激活UOPN CA2通过NMDA受体Infux	17	15	All SZGR 2.0 genes in this pathway
REACTOME SMOOTH MUSCLE CONTRACTION	25	14	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	37	32	All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	27	23	All SZGR 2.0 genes in this pathway
反应组后NMDA受体激活事件	33	28	All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	15	14	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	54	40	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	31	23	All SZGR 2.0 genes in this pathway
REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	11	11	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES	247	154	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
反应组葡萄糖代谢	69	42	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
Reactome血小板激活信号传导和聚集	208	138	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES UP	82	51	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
μLLIGHAN MLL SIGNATURE 1 UP	380	236	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN	146	94	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG DN	59	40	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821年	933	All SZGR 2.0 genes in this pathway
甲状腺癌变性DN	537	339	All SZGR 2.0 genes in this pathway
hahtola兄弟姐妹Fungoides皮肤	177	113	All SZGR 2.0 genes in this pathway
hahtola兄弟姐妹fungoides CD4 DN	116	71	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN	64	39	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN	75	50	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
温曼对缺氧的适应	29	24	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
JOHANSSON BRAIN CANCER EARLY VS LATE DN	45	35	All SZGR 2.0 genes in this pathway
Tomlins前列腺癌DN	40	33	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER	214	139	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
里克曼肿瘤分化和管理不善的DN	382	224	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP	487	286	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN	169	102	All SZGR 2.0 genes in this pathway
公园HSC vs多功能祖先DN	18	12	All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN	41	28	All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION L1 G1 UP	25	15	All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN	169	112	All SZGR 2.0 genes in this pathway
弗莱赫纳活检肾脏移植被拒绝vs ok dn	546	351	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP	157	105	All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR	293	193	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
YAGI AML SURVIVAL	129	87	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN	49	29	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
CUI TCF21目标2 DN	830	547	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP	175	116	All SZGR 2.0 genes in this pathway
Browne HCMV感染8小时	105	73	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
阿塞维多肝癌DN	540	340	All SZGR 2.0 genes in this pathway
Bernard PPAPDC1B目标DN	58	39	All SZGR 2.0 genes in this pathway
黄达沙替尼抵抗DN	69	44	All SZGR 2.0 genes in this pathway
Fournier腺泡开发2	277	172	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17	181	101	All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 UP	49	35	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL	162	122	All SZGR 2.0 genes in this pathway
gregory合成致死与伊马替尼	145	83	All SZGR 2.0 genes in this pathway
THILLAINADESAN ZNF217 TARGETS UP	44	22	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP	281	183	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN	784	464	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN	146	88	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	目标位置			miRNA ID	miRNA seq
mirna家族	UTR开始	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	472	478	1a	hsa-let-7a^brain	ugagguaguaguauauaguu
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	ugagguaguagguuguaugguu
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	ugagguaggagguuauauagu
				hsa-let-7f^brain	ugagguagauuguauauaguu
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
mir-1/206	830	836	1a	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	aggaauguucuuugcc
mir-129-5p	67	74	1a,m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
mir-129-5p	67	74	1a,m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-133	3463	3470	1a,m8	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	3463	3470	1a,m8	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
mir-142-3p	1367	1373	M8	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-142-5p	2900	2906	1a	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-143	3542	3548	M8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-15/16/195/424/497	1228	1234	M8	hsa-miR-15a^brain	uagcagcacauaugguugug
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	Cagcagcaauucauguuuugaa
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-181	126	132	M8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	aacauucauugcugucggggg
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	aacauucauuguugucggggguggguu
miR-19	2824	2831	1a,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	2824	2831	1a,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-193	301	307	M8	HSA-MIR-193A	AACUGGCCUACAAAGUCCCAG
miR-193	301	307	M8	HSA-MIR-193B	aacuggcccucaaagucccgcuuu
miR-196	237	243	M8	HSA-MIR-196A	UAGGUAGUUUCAUGUUGUUGG
miR-196	237	243	M8	HSA-MIR-196B	UAGGUAGUUUCCUGUUGUUGG
miR-203.1	3526	3532	M8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-214	1230	1236	1a	hsa-miR-214^brain	acagcaggcacagacaggcag
miR-214	1230	1236	1a	hsa-miR-214^brain	acagcaggcacagacaggcag
mir-409-5p	1552	1558	1a	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-410	2611	2617	1a	hsa-miR-410	aauauaacacagauggcugu

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击hereto see the list of brain related miRNAs.

Gene Page:CALM1