Gene Page:SIKE1

概括?
基因 80143
Symbol SIKE1
Synonyms SIKE
Description suppressor of IKBKE 1
Reference MIM:611656|HGNC:HGNC:26119|Ensembl：ENSG00000052723|HPRD：07958|Vega:OTTHUMG00000012061
Gene type protein-coding
Map location 1p13.2
Pascal p-value 2.936E-4
eGene Anterior cingulate cortex BA24

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs577918359 1 115254238 SIKE1 ENSG00000052723.7 7.83169E-7 0.02 69068 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SHROOM4 0.80 0.72
TJP1 0.78 0.74
PDE8A 0.78 0.75
SLC12A2 0.78 0.73
GLDN 0.78 0.75
TMC7 0.77 0.73
DOCK5 0.77 0.64
AC022100.1 0.77 0.69
plekhh1 0.77 0.69
KIF13B 0.76 0.62
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RPL35 -0.51 -0.67
RPL27 -0.50 -0.67
RPL36 -0.49 -0.68
RPS9 -0.48 -0.65
FAU -0.48 -0.64
RPL18 -0.48 -0.66
RPL31 -0.48 -0.64
RPS20 -0.48 -0.67
RPL8 -0.47 -0.61
RPS3P3 -0.47 -0.64

Section III. Gene Ontology annotation

Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 细胞质 IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
FAM40A FLJ14743 |KIAA1761 |MGC148091 |RP4-773N10.1 family with sequence similarity 40, member A Affinity Capture-MS BioGRID 18782753
FAM40B - family with sequence similarity 40, member B Affinity Capture-MS BioGRID 18782753
FGFR1OP2 DKFZP564O1863 |HSPC123 FGFR1 oncogene partner 2 Affinity Capture-MS BioGRID 18782753
MOBKL3 2C4D | CGI-95 | MGC12264 | MOB1 | MOB3 | PREI3 MOB1, Mps One Binder kinase activator-like 3 (yeast) Affinity Capture-MS BioGRID 18782753
PDCD10 CCM3 | MGC1212 | MGC24477 | TFAR15 程序性细胞死亡10 Affinity Capture-MS BioGRID 18782753
PPP2CA PP2Ac | PP2CA | RP-C protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Affinity Capture-MS BioGRID 18782753
PPP2R1A MGC786 | PR65A protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform Affinity Capture-MS BioGRID 18782753
RP6-213H19.1 MASK | MST4 serine/threonine protein kinase MST4 Affinity Capture-MS BioGRID 18782753
SLMAP FLJ42206 | KIAA1601 | MGC138760 | MGC138761 | SLAP sarcolemma associated protein Affinity Capture-MS BioGRID 18782753
STK24 MST-3 | MST3 | MST3B | STE20 | STK3 丝氨酸/苏氨酸激酶24（Ste20同源物，酵母） Affinity Capture-MS BioGRID 18782753
STK25 DKFZp686J1430 | SOK1 | YSK1 serine/threonine kinase 25 (STE20 homolog, yeast) Affinity Capture-MS BioGRID 18782753
STRN MGC125642 | SG2NA striatin, calmodulin binding protein Affinity Capture-MS BioGRID 18782753
STRN3 SG2NA striatin, calmodulin binding protein 3 Affinity Capture-MS BioGRID 18782753
STRN4 FLJ35594 | ZIN | zinedin striatin, calmodulin binding protein 4 Affinity Capture-MS BioGRID 18782753
TRAF3IP3 DJ434O14.3 | FLJ44151 | MGC117354 | MGC163289 | T3JAM TRAF3 interacting protein 3 Affinity Capture-MS
Affinity Capture-Western		 BioGRID 18782753


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 71 51 该途径中的所有SZGR 2.0基因
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION 30 26 该途径中的所有SZGR 2.0基因
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 14 10 该途径中的所有SZGR 2.0基因
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 73 57 该途径中的所有SZGR 2.0基因
REACTOME INNATE IMMUNE SYSTEM 279 178 该途径中的所有SZGR 2.0基因
REACTOME IMMUNE SYSTEM 933 616 该途径中的所有SZGR 2.0基因
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
XU HGF TARGETS REPRESSED BY AKT1 DN 95 58 该途径中的所有SZGR 2.0基因
SHETH LIVER CANCER VS TXNIP LOSS PAM6 46 32 该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK 1652 1023 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
PUJANA CHEK2 PCC NETWORK 779 480 该途径中的所有SZGR 2.0基因
NUYTTEN NIPP1 TARGETS DN 848 527 该途径中的所有SZGR 2.0基因
LOPEZ MBD TARGETS 957 597 该途径中的所有SZGR 2.0基因
LANDEMAINE LUNG METASTASIS 21 12 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 20HR UP 240 152 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 16HR UP 225 139 该途径中的所有SZGR 2.0基因
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 该途径中的所有SZGR 2.0基因
KANG DOXORUBICIN RESISTANCE DN 19 8 该途径中的所有SZGR 2.0基因
JIANG HYPOXIA NORMAL 311 205 该途径中的所有SZGR 2.0基因
STEIN ESRRA TARGETS UP 388 234 该途径中的所有SZGR 2.0基因
LEE RECENT THYMIC EMIGRANT 227 128 该途径中的所有SZGR 2.0基因
STEIN ESRRA TARGETS 535 325 该途径中的所有SZGR 2.0基因
CHANDRAN METASTASIS UP 221 135 该途径中的所有SZGR 2.0基因
KARLSSON TGFB1 TARGETS DN 207 139 该途径中的所有SZGR 2.0基因
PHONG TNF RESPONSE VIA P38 COMPLETE 227 151 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-17-5p/20/93.mr/106/519.d 534 541 1A,m8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-29 519 526 1A,m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU