Gene Page:CUL5

概括?
基因 8065
象征 CUL5
Synonyms Vacm-1 | Vacm1
Description 卡林5
Reference MIM:601741|HGNC:HGNC:2556|Ensembl:ENSG00000166266|HPRD:03444|Vega:OTTHUMG00000166369
Gene type protein-coding
Map location 11q22.3
Pascal p-value 0.314
eGene Myers' cis & trans
Support G2Cdb.humanPSD
G2Cdb.humanPSP

数据源中的基因
Gene set name Method of gene set Description Info
CV：GWASDB Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis PSR：0.006
Network 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 0.0125

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7132043 chr12 80968399 CUL5 8065 0.1 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity TAS 9581826
GO:0005515 protein binding 新闻学会 12504025
去：0005262 calcium channel activity TAS 9581826
GO:0031625 ubiquitin protein ligase binding IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0000082 G1/S transition of mitotic cell cycle TAS 8681378
GO:0006511 ubiquitin-dependent protein catabolic process IEA -
GO:0007050 cell cycle arrest TAS 8681378
GO:0008285 negative regulation of cell proliferation TAS 8681378
GO:0008629 induction of apoptosis by intracellular signals TAS 9581826
GO:0044419 interspecies interaction between organisms IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005794 Golgi apparatus IDA 18029348
GO:0005829 cytosol 经验 14564014|15781449
GO:0005737 细胞质 IDA 18029348
GO:0031461 卡林环泛素连接酶复合物 IEA -

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 138 98 该途径中的所有SZGR 2.0基因
ERBB2的Reactome信号传导 101 78 该途径中的所有SZGR 2.0基因
REACTOME HIV INFECTION 207 122 该途径中的所有SZGR 2.0基因
REACTOME HOST INTERACTIONS OF HIV FACTORS 132 81 该途径中的所有SZGR 2.0基因
REACTOME IMMUNE SYSTEM 933 616 该途径中的所有SZGR 2.0基因
REACTOME适应性免疫系统 539 350 该途径中的所有SZGR 2.0基因
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 该途径中的所有SZGR 2.0基因
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212 129 该途径中的所有SZGR 2.0基因
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G 52 30 该途径中的所有SZGR 2.0基因
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 该途径中的所有SZGR 2.0基因
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 该途径中的所有SZGR 2.0基因
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320 184 该途径中的所有SZGR 2.0基因
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 该途径中的所有SZGR 2.0基因
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 该途径中的所有SZGR 2.0基因
LINDGREN BLADDER CANCER WITH LOH IN CHR9Q 116 71 该途径中的所有SZGR 2.0基因
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 108 74 该途径中的所有SZGR 2.0基因
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
NUYTTEN NIPP1 TARGETS DN 848 527 该途径中的所有SZGR 2.0基因
NUYTTEN EZH2 TARGETS DN 1024 594 该途径中的所有SZGR 2.0基因
BENPORATH MYC MAX TARGETS 775 494 该途径中的所有SZGR 2.0基因
GEORGES CELL CYCLE MIR192 TARGETS 62 46 该途径中的所有SZGR 2.0基因
GEORGES TARGETS OF MIR192 AND MIR215 893 528 该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS UP 424 268 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE UP 1691年 1088 该途径中的所有SZGR 2.0基因
LINDVALL IMMORTALIZED BY TERT DN 80 56 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS INTERMEDIATE PROGENITOR 149 84 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 该途径中的所有SZGR 2.0基因
DE YY1 TARGETS DN 92 64 该途径中的所有SZGR 2.0基因
ACEVEDO LIVER CANCER UP 973 570 该途径中的所有SZGR 2.0基因
WEST ADRENOCORTICAL TUMOR DN 546 362 该途径中的所有SZGR 2.0基因
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP 83 63 该途径中的所有SZGR 2.0基因
DANG BOUND BY MYC 1103 714 该途径中的所有SZGR 2.0基因
NIELSEN GIST 98 66 该途径中的所有SZGR 2.0基因
JOHNSTONE PARVB TARGETS 2 DN 336 211 该途径中的所有SZGR 2.0基因
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN 106 77 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 120 126 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 120 126 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-148/152 393 400 1A,m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-181 3212 3218 m8 hsa-miR-181abrain aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-182 1123 1130 1A,m8 hsa-miR-182 uuuggcaaugguagaacucaca
miR-186 2255 2261 1A hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-19 189 195 1A hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga
miR-217 3277 3284 1A,m8 hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
miR-299-5p 1923 1929 1A hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-31 1122 1128 1A hsa-miR-31 AGGCAAGAUGCUGGCAUAGCUG
miR-324-5p 3056 3062 m8 hsa-miR-324-5p CGCAUCCCCUAGGGCAUUGGUGU
miR-33 2023 2029 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
HSA-MIR-33B GUGCAUUGCUGUUGCAUUGCA
mir-370 643 649 1A hsa-miR-370brain GCCUGCUGGGGUGGAACCUGG
miR-381 3335 3341 1A hsa-miR-381 uauacaagggcaagcucucugu
miR-410 1148 1154 1A hsa-miR-410 aauauaacacagauggcugu
miR-433-3p 234 240 1A hsa-miR-433brain AUCAUGAUGGGCUCCUCGGUGU
mir-493-5p 1134 1140 m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
mir-96 1124 1130 1A hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC