Gene Page:ALX1

Summary?
GeneID 8092
Symbol ALX1
Synonyms CART1|FND3|HEL23
Description ALX同源框1
Reference MIM:601527|HGNC:HGNC:1494|Ensembl:ENSG00000180318|HPRD:03316|Vega:OTTHUMG00000169820
Gene type protein-coding
Map location 12q21.31
Pascal p-value 0.502
Fetal beta 0.173
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg07780095 12 85674296 ALX1 4.92E-5 -0.465 0.022 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity TAS 8756334
GO:0003714 transcription corepressor activity TAS 8756334
GO:0005515 protein binding 新闻学会 16189514
GO:0043565 sequence-specific DNA binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007420 brain development TAS Brain (GO term level: 7) 8673125
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 8756334
GO:0001502 cartilage condensation TAS 8756334
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0007275 multicellular organismal development TAS 8756334
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005794 Golgi apparatus IDA 18029348
GO:0005634 nucleus IEA -
GO:0005730 nucleolus IDA 18029348

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
NEWMAN ERCC6 TARGETS UP 26 18 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276 165 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341 197 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390 236 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K27ME3 79 59 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269 159 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 88 59 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR DN 37 20 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180 116 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP 169 105 All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289 188 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-192/215 103 109 1A hsa-miR-192 CUGACCUAUGAAUUGACAGCC
hsa-miR-215 AUGACCUAUGAAUUGACAGAC
miR-21 76 82 m8 hsa-miR-21brain UAGCUUAUCAGACUGAUGUUGA
hsa-miR-590 GAGCUUAUUCAUAAAAGUGCAG
miR-409-3p 41 47 m8 hsa-miR-409-3p CGAAUGUUGCUCGGUGAACCCCU
miR-539 50 57 1A,m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU