Gene Page:TMPRSS5

年代ummary?
GeneID 80975
年代ymbol TMPRSS5
年代ynonyms 年代PINESIN
Description transmembrane protease, serine 5
Reference MIM:606751|HGNC:HGNC:14908|Ensembl:ENSG00000166682|HPRD:05995|Vega:OTTHUMG00000168186
Gene type protein-coding
Map location 11q
Pascal p-value 0.15
Fetal beta -0.87
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.006
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

年代ection I. Genetics and epigenetics annotation

@CV:PGC128

年代NP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs2514218 chr11 113392994 TC 4.091E-10 intergenic DRD2,TMPRSS5 dist=46993;dist=165274

@eQTL annotation

年代NP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2885987 chr11 113602554 TMPRSS5 80975 0 cis
rs17115918 chr11 113613757 TMPRSS5 80975 0 cis
rs10789970 chr11 113773945 TMPRSS5 80975 0.16 cis
rs737518 chr2 2734669 TMPRSS5 80975 0.19 trans
rs264672 chr3 65880606 TMPRSS5 80975 1.213E-6 trans
rs1165892 chr3 103844929 TMPRSS5 80975 0.14 trans
rs12651357 chr4 53029658 TMPRSS5 80975 0.08 trans
rs9996479 chr4 53029771 TMPRSS5 80975 0.08 trans
rs4544841 chr5 95491996 TMPRSS5 80975 0.2 trans
rs17053975 chr9 90836064 TMPRSS5 80975 0.15 trans
rs11192251 chr10 83798240 TMPRSS5 80975 0.04 trans
rs11192252 chr10 83798258 TMPRSS5 80975 0.13 trans
rs7073610 chr10 102006624 TMPRSS5 80975 0.01 trans
rs2885987 chr11 113602554 TMPRSS5 80975 0.08 trans
rs17115918 chr11 113613757 TMPRSS5 80975 0.09 trans
rs17730330 chr12 92998513 TMPRSS5 80975 0.19 trans
rs17630491 chr13 41292492 TMPRSS5 80975 0.11 trans
rs3863293 11 113582504 TMPRSS5 ENSG00000166682.6 6.22E-7 0.01 -5409年 gtex_brain_ba24
rs4083004 11 113582634 TMPRSS5 ENSG00000166682.6 6.22E-7 0.01 -5539 gtex_brain_ba24
rs4471465 11 113583690 TMPRSS5 ENSG00000166682.6 1.203E-6 0.01 -6595 gtex_brain_ba24
rs12279366 11 113585256 TMPRSS5 ENSG00000166682.6 6.22E-7 0.01 -8161 gtex_brain_ba24
rs12273259 11 113585370 TMPRSS5 ENSG00000166682.6 6.22E-7 0.01 -8275 gtex_brain_ba24
rs12292853 11 113585782 TMPRSS5 ENSG00000166682.6 5.131E-7 0.01 -8687 gtex_brain_ba24
rs3914060 11 113586757 TMPRSS5 ENSG00000166682.6 6.22E-7 0.01 -9662 gtex_brain_ba24
rs4938050 11 113590031 TMPRSS5 ENSG00000166682.6 6.22E-7 0.01 -12936 gtex_brain_ba24
rs7114297 11 113591402 TMPRSS5 ENSG00000166682.6 6.22E-7 0.01 -14307 gtex_brain_ba24
rs75601171 11 113506551 TMPRSS5 ENSG00000166682.6 1.974E-6 0 70544 gtex_brain_putamen_basal
rs151155465 11 113519175 TMPRSS5 ENSG00000166682.6 4.317E-8 0 57920 gtex_brain_putamen_basal
rs12291314 11 113520200 TMPRSS5 ENSG00000166682.6 7.414E-8 0 56895 gtex_brain_putamen_basal
rs876378 11 113521593 TMPRSS5 ENSG00000166682.6 4.355E-8 0 55502 gtex_brain_putamen_basal
rs74939839 11 113533742 TMPRSS5 ENSG00000166682.6 4.317E-8 0 43353 gtex_brain_putamen_basal
rs11214704 11 113562750 TMPRSS5 ENSG00000166682.6 3.856E-8 0 14345 gtex_brain_putamen_basal
rs45503699 11 113566327 TMPRSS5 ENSG00000166682.6 7.447E-10 0 10768 gtex_brain_putamen_basal
rs72103801 11 113569927 TMPRSS5 ENSG00000166682.6 4.494E-9 0 7168 gtex_brain_putamen_basal
rs73568808 11 113570208 TMPRSS5 ENSG00000166682.6 2.744E-10 0 6887 gtex_brain_putamen_basal
rs3802854 11 113570852 TMPRSS5 ENSG00000166682.6 7.086E-11 0 6243 gtex_brain_putamen_basal
rs111627504 11 113573461 TMPRSS5 ENSG00000166682.6 5.529E-11 0 3634 gtex_brain_putamen_basal
rs2089653 11 113573837 TMPRSS5 ENSG00000166682.6 2.021E-9 0 3258 gtex_brain_putamen_basal
rs2089652 11 113573914 TMPRSS5 ENSG00000166682.6 5.395E-11 0 3181 gtex_brain_putamen_basal
rs4553400 11 113574703 TMPRSS5 ENSG00000166682.6 5.249E-11 0 2392 gtex_brain_putamen_basal
rs3902836 11 113574840 TMPRSS5 ENSG00000166682.6 5.233E-11 0 2255 gtex_brain_putamen_basal
rs3907855 11 113577533 TMPRSS5 ENSG00000166682.6 2.323E-10 0 -438 gtex_brain_putamen_basal
rs12285469 11 113581816 TMPRSS5 ENSG00000166682.6 2.327E-10 0 -4721 gtex_brain_putamen_basal
rs3863293 11 113582504 TMPRSS5 ENSG00000166682.6 1.158E-13 0 -5409年 gtex_brain_putamen_basal
rs4083004 11 113582634 TMPRSS5 ENSG00000166682.6 1.158E-13 0 -5539 gtex_brain_putamen_basal
rs4259857 11 113583491 TMPRSS5 ENSG00000166682.6 2.327E-10 0 -6396 gtex_brain_putamen_basal
rs4471465 11 113583690 TMPRSS5 ENSG00000166682.6 8.457 e-14 0 -6595 gtex_brain_putamen_basal
rs12279366 11 113585256 TMPRSS5 ENSG00000166682.6 1.158E-13 0 -8161 gtex_brain_putamen_basal
rs12273259 11 113585370 TMPRSS5 ENSG00000166682.6 3.576E-13 0 -8275 gtex_brain_putamen_basal
rs12292722 11 113585371 TMPRSS5 ENSG00000166682.6 1.023E-9 0 -8276 gtex_brain_putamen_basal
rs12292878 11 113585626 TMPRSS5 ENSG00000166682.6 2.327E-10 0 -8531 gtex_brain_putamen_basal
rs12292853 11 113585782 TMPRSS5 ENSG00000166682.6 1.034E-13 0 -8687 gtex_brain_putamen_basal
rs3914060 11 113586757 TMPRSS5 ENSG00000166682.6 1.158E-13 0 -9662 gtex_brain_putamen_basal
rs17115875 11 113587738 TMPRSS5 ENSG00000166682.6 2.327E-10 0 -10643 gtex_brain_putamen_basal
rs61345035 11 113587882 TMPRSS5 ENSG00000166682.6 2.327E-10 0 -10787 gtex_brain_putamen_basal
rs11214711 11 113588082 TMPRSS5 ENSG00000166682.6 2.327E-10 0 -10987 gtex_brain_putamen_basal
rs11195658 11 113588652 TMPRSS5 ENSG00000166682.6 2.327E-10 0 -11557 gtex_brain_putamen_basal
rs4938050 11 113590031 TMPRSS5 ENSG00000166682.6 1.158E-13 0 -12936 gtex_brain_putamen_basal
rs7114297 11 113591402 TMPRSS5 ENSG00000166682.6 1.158E-13 0 -14307 gtex_brain_putamen_basal
rs12577772 11 113591532 TMPRSS5 ENSG00000166682.6 1.578E-9 0 -14437 gtex_brain_putamen_basal
rs12295777 11 113592223 TMPRSS5 ENSG00000166682.6 2.307E-10 0 -15128 gtex_brain_putamen_basal
rs73551130 11 113592489 TMPRSS5 ENSG00000166682.6 2.294E-10 0 -15394 gtex_brain_putamen_basal
rs398045598 11 113616733 TMPRSS5 ENSG00000166682.6 2.365E-7 0 -39638 gtex_brain_putamen_basal

年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


年代ection III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004252 serine-type endopeptidase activity IEA glutamate (GO term level: 7) -
GO:0005044 scavenger receptor activity IEA -
GO:0008233 peptidase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006508 proteolysis IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -

年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway