SZGR2 - Beplay体育中心

Summary？

基因	811
象征	CALR
Synonyms	CRT \| HEL-S-99N \| RO \| SSA \| CC1QR
Description	calreticulin
Reference	MIM:109091\|HGNC：HGNC：1455\|Ensembl:ENSG00000179218\|HPRD：00169\|Vega：Otthumg00000180574
基因类型	蛋白质编码
Map location	19p13.13
Pascal p-value	0.041
Sherlock p-value	0.055
胎儿β	0.049
主持人	Myers' cis & trans
Support	INTRACELLULAR SIGNAL TRANSDUCTION

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
rs2140065	CHR1	241390757	CALR	811		0.06		反式

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SYNPO	0.95	0.95
PACSIN1	0.95	0.93
CAMTA2	0.95	0.87
MICAL2	0.93	0.84
MFSD4	0.92	0.92
DGKZ	0.92	0.88
extl1	0.92	0.92
C8orf46	0.91	0.89
KCNAB2	0.91	0.90
SLC17A7	0.91	0.72

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
BCL7C	-0.60	-0.71
traf4	-0.54	-0.67
tubb2b	-0.54	-0.63
KIAA1949	-0.54	-0.55
PDE9A	-0.53	-0.63
SH3BP2	-0.53	-0.63
SH2B2	-0.53	-0.63
DYNLT1	-0.53	-0.70
FADS2	-0.53	-0.53
PPP1R14B	-0.52	-0.69

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
APOB	FLDB	载脂蛋白B（包括AG（X）抗原）	-	HPRD,BioGRID	10513896\|12397072
应用程序	AAA \|Abeta \|abpp \|AD1 \|appi \|ctfgamma \|CVAP \|PN2	淀粉样β（A4）前体蛋白	-	HPRD,BioGRID	11378243
ar	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	雄激素受体	-	HPRD,BioGRID	8107809
B2M	-	β-2-微球蛋白	-	HPRD	8769474
CALR	CRT \| FLJ26680 \| RO \| SSA \| cC1qR	calreticulin	CRT interacts with itself to form a dimer.	绑定	15383281
CANX	CNX \| FLJ26570 \| IP90 \| P90	calnexin	亲和力捕获 - 韦斯特恩	Biogrid	10436013
CD1D	CD1A \|MGC34622 \|R3	CD1d molecule	-	HPRD,BioGRID	12239218
CD40	BP50 \|CDW40 \|MGC9013 \|tnfrsf5 \|P50	CD40分子，TNF受体超家族成员5	Affinity Capture-MS	Biogrid	17353931
CD93	C1QR1 \| C1qR(P) \| C1qRP \| CDw93 \| MXRA4 \| dJ737E23.1	CD93 molecule	-	HPRD	8062452
ELF3	EPR-1 \| ERT \| ESE-1 \| ESX	E74样因子3（ETS域转录因子，上皮特异性）	Affinity Capture-MS	Biogrid	17353931
EPB41	4.1r \|El1 \|他	红细胞膜蛋白条带4.1（椭圆细胞增多症1，rh-c-链接）	Affinity Capture-MS	Biogrid	17353931
F5	fvl \|PCCF	coagulation factor V (proaccelerin, labile factor)	亲和力捕获 - 韦斯特恩	Biogrid	9525969
F8	AHF \| DXS1253E \| F8B \| F8C \| FVIII \| HEMA	coagulation factor VIII, procoagulant component	-	HPRD	9525969
FBN1	FBN \| MASS \| MFS1 \| OCTD \| SGS \| WMS	纤维蛋白1	-	HPRD	10547375
FGB	MGC104327 \| MGC120405	纤维蛋白原β链	-	HPRD,BioGRID	7592883
HLA-A	HLAA	major histocompatibility complex, class I, A	CRT interacts with HLA-A2. This interaction was modeled on a demonstrated interaction between rabbit CRT and human HLA-A2.	绑定	15383281
HLA-C	D6S204 \|FLJ27082 \|HLA-CW \|HLA-CW12 \|HLA-JY3 \|HLC-C \|psors1	major histocompatibility complex, class I, C	-	HPRD	8769474
itga2b	CD41 \| CD41B \| GP2B \| GPIIb \| GTA \| HPA3	整合素，α2B（IIB/IIIA复合物的血小板糖蛋白IIB，抗原CD41）	-	HPRD	7559457
itga3	CD49C \| FLJ34631 \| FLJ34704 \| GAP-B3 \| GAPB3 \| MSK18 \| VCA-2 \| VL3A \| VLA3a	整合素，α3（抗原CD49C，alpha 3的VLA-3受体亚基）	-	HPRD	8006073 \| 11327697
itga3	CD49C \| FLJ34631 \| FLJ34704 \| GAP-B3 \| GAPB3 \| MSK18 \| VCA-2 \| VL3A \| VLA3a	整合素，α3（抗原CD49C，alpha 3的VLA-3受体亚基）	-	HPRD	11327697
LRP1	A2MR \|apoer \|APR \|CD91 \|FLJ16451 \|IGFBP3R \|LRP \|MGC88725 \|TGFBR5	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	-	HPRD,BioGRID	12821648\|14980518
MBL2	COLEC1 \| HSMBPC \| MBL \| MBP \| MBP1 \| MGC116832 \| MGC116833	甘露糖结合凝集素（蛋白质C）2，可溶性（Opsonic缺陷）	-	HPRD,BioGRID	8062452
NKX2-1	BCH \|BHC \|NK-2 \|nkx2.1 \|nkx2a \|tebp \|titf1 \|TTF-1 \|TTF1	NK2 homeobox 1	-	HPRD,BioGRID	9988700
NR3C1	GCCR \|GCR \|gr \|grl	核受体亚科3，C组，成员1（糖皮质激素受体）	-	HPRD,BioGRID	8107808\|9089287
PDIA3	ER60 \|ERP57 \|ERP60 \|ERP61 \|Grp57 \|Grp58 \|HST17083 \|P58 \|pi-plc	蛋白质二硫化物异构酶家族A，成员3	-	HPRD,BioGRID	10436013
PDIA3	ER60 \|ERP57 \|ERP60 \|ERP61 \|Grp57 \|Grp58 \|HST17083 \|P58 \|pi-plc	蛋白质二硫化物异构酶家族A，成员3	ERP57与CRT相互作用。这种相互作用是根据来自未指定的源和兔子CRT的ERP57之间的相互作用进行建模的。	绑定	12052826
PLAT	DKFZp686I03148 \| T-PA \| TPA	plasminogen activator, tissue	-	HPRD,BioGRID	9359841
PRF1	flh2 \|HPLH2 \|MGC65093 \|P1 \|PFN1 \|PFP	perforin 1 (pore forming protein)	-	HPRD,BioGRID	9671507
PRKCSH	Age-R2 \|G19P1 \|PCLD \|PLD1	protein kinase C substrate 80K-H	-	HPRD	8910335
SEC14L2	C22orf6 \|KIAA1186 \|KIAA1658 \|MGC65053 \|SPF \|点击\|TAP1	Sec14样2（S. cerevisiae）	-	HPRD	9036970
SLC2A1	dyt17 \|dyt18 \|glut \|glut1 \|MGC141895 \|MGC141896 \|ped	solute carrier family 2 (facilitated glucose transporter), member 1	重构的复合物	Biogrid	8662691
SLC6A4	5-HTT \| 5HTT \| HTT \| OCD1 \| SERT \| hSERT	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	重构的复合物	Biogrid	10364189
TAPBP	NGS17 \|塔帕\|TPN \|tpsn \|拿花	TAP binding protein (tapasin)	-	HPRD,BioGRID	8769474
TF	DKFZp781D0156 \| PRO1557 \| PRO2086	转铁蛋白	-	HPRD,BioGRID	9312001
TSHR	chng1 \|lgr3 \|MGC75129 \|htshr-i	thyroid stimulating hormone receptor	-	HPRD	12383251
TSHR	chng1 \|lgr3 \|MGC75129 \|htshr-i	thyroid stimulating hormone receptor	TSHR与分子伴侣蛋白钙网蛋白相互作用。这种相互作用是建立在人类TSHR和兔钙网蛋白之间的相互作用上的模型。	绑定	12383251
vwf	F8vwf\|VWD	冯·威勒布兰德因素	亲和力捕获 - 韦斯特恩	Biogrid	10887119

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG抗原处理和演示	89	65	All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY	56	45	All SZGR 2.0 genes in this pathway
Reactome抗原加工交叉呈现	76	48	All SZGR 2.0 genes in this pathway
REACTOME ER PHAGOSOME PATHWAY	61	40	All SZGR 2.0 genes in this pathway
Reactome糖尿病途径	133	91	All SZGR 2.0 genes in this pathway
蛋白质的反应组代谢	518	242	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	13	9	All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE	80	51	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	11	8	All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	188	116	All SZGR 2.0 genes in this pathway
Reactome天冬酰胺N连接的糖基化	81	54	All SZGR 2.0 genes in this pathway
Reactome钙网蛋白钙网蛋白周期	11	7	All SZGR 2.0 genes in this pathway
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	13	9	All SZGR 2.0 genes in this pathway
Reactome流感生命周期	203	72	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统	539	350	All SZGR 2.0 genes in this pathway
Reactome抗原表现折叠组件和I类MHC的肽载荷	21	17	All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	251	156	All SZGR 2.0 genes in this pathway
刘前列腺癌	96	57	All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤	783	507	All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血红斑dn	493	298	All SZGR 2.0 genes in this pathway
Fulcher炎症反应凝集素与LPS DN	463	290	All SZGR 2.0 genes in this pathway
Gary CD5目标	473	314	All SZGR 2.0 genes in this pathway
Doane对雄激素的反应	184	125	All SZGR 2.0 genes in this pathway
Wang LMO4靶向	372	227	All SZGR 2.0 genes in this pathway
王攀登目标	269	146	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN	335	193	All SZGR 2.0 genes in this pathway
胶原蛋白凝胶中的Oswald造血干细胞	233	161	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP	55	34	All SZGR 2.0 genes in this pathway
Tien肠益生菌24小时DN	214	133	All SZGR 2.0 genes in this pathway
HWANG PROSTATE CANCER MARKERS	28	19	All SZGR 2.0 genes in this pathway
LI LUNG CANCER	41	30	All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER	178	108	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向	414	287	All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲	479	299	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
带有E盒的WEI MYCN目标	795	478	All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发6小时DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX1 DN	10	7	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
Benporath SOX2目标	734	436	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED	100	68	All SZGR 2.0 genes in this pathway
唱歌转移基质	110	70	All SZGR 2.0 genes in this pathway
Ross AML与PML RARA FUSION	77	62	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP	52	40	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
棕色髓样细胞发育DN	129	86	All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION UP	39	29	All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP	81	52	All SZGR 2.0 genes in this pathway
faelt b cll与VH3 21	44	30	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
伊万诺娃造血细胞和祖细胞	681	420	All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN	49	34	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时DN的响应	911	527	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 24小时DN的反应	1011	592	All SZGR 2.0 genes in this pathway
肺癌和成纤维细胞的钟分泌组	132	93	All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP	64	40	All SZGR 2.0 genes in this pathway
他LLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向DN	591	366	All SZGR 2.0 genes in this pathway
Smid乳腺癌基础	648	398	All SZGR 2.0 genes in this pathway
Honma多西他赛的抵抗	34	23	All SZGR 2.0 genes in this pathway
级结肠癌	871	505	All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP	125	68	All SZGR 2.0 genes in this pathway
CUI葡萄糖剥夺	60	44	All SZGR 2.0 genes in this pathway
Jiang Tip30目标DN	24	14	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP	165	118	All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记DN	138	92	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
Valk AML群集12	30	20	All SZGR 2.0 genes in this pathway
Jison Sickle细胞疾病	181	106	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
马滕斯三维诺蛋白响应DN	841	431	All SZGR 2.0 genes in this pathway
Chicas RB1靶向衰老	572	352	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3靶向	387	225	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP	140	94	All SZGR 2.0 genes in this pathway
Delacroix Rarg Bound MEF	367	231	All SZGR 2.0 genes in this pathway
Delacroix Rar Bound ES	462	273	All SZGR 2.0 genes in this pathway

Gene Page:CALR