Gene Page:ST8SIA2

概括?
基因 8128
象征 ST8SIA2
Synonyms HsT19690|SIAT8B|ST8SIA-II|STX
Description ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 2
Reference MIM:602546|HGNC:HGNC:10870|Ensembl:ENSG00000140557|HPRD:03969|Vega:OTTHUMG00000149843
Gene type protein-coding
Map location 15q26
Pascal p-value 0.154
Fetal beta 1.199
DMG 1 (# studies)
eGene 元

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008），协会研究 2 Link to SZGene
文学 High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias 点击to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23928920 15 92944756 ST8SIA2 3.39E-5 0.649 0.019 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

分子功能 GO term Evidence Neuro keywords PubMed ID
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IEA -
GO:0008373 sialyltransferase activity IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0007399 神经系统的发展 TAS neurite (GO term level: 5) 9054414
GO:0006486 protein amino acid glycosylation IEA -
去：0006491 N-glycan processing TAS 10766765
GO:0005975 carbohydrate metabolic process TAS 7559389|10766765
GO:0009312 寡糖生物合成的过程 TAS 10766765
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000139 Golgi membrane IEA -
GO:0005794 Golgi apparatus IEA -
去：0016020 membrane IEA -
GO：0016021 integral to membrane IEA -
GO:0030173 integral to Golgi membrane IEA -

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME DEVELOPMENTAL BIOLOGY 396 292 该途径中的所有SZGR 2.0基因
REACTOME METABOLISM OF PROTEINS 518 242 该途径中的所有SZGR 2.0基因
REACTOME AXON GUIDANCE 251 188 该途径中的所有SZGR 2.0基因
REACTOME NCAM1 INTERACTIONS 39 27 该途径中的所有SZGR 2.0基因
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 64 49 该途径中的所有SZGR 2.0基因
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 188 116 该途径中的所有SZGR 2.0基因
Reactome天冬酰胺N连接的糖基化 81 54 该途径中的所有SZGR 2.0基因
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 33 24 该途径中的所有SZGR 2.0基因
REACTOME N GLYCAN ANTENNAE ELONGATION 14 10 该途径中的所有SZGR 2.0基因
REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 18 14 该途径中的所有SZGR 2.0基因
PEREZ TP63 TARGETS 355 243 该途径中的所有SZGR 2.0基因
PEREZ TP53 AND TP63 TARGETS 205 145 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS 1062 725 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
BENPORATH PRC2 TARGETS 652 441 该途径中的所有SZGR 2.0基因
SHEPARD CRUSH AND BURN MUTANT DN 185 111 该途径中的所有SZGR 2.0基因
Mody海马新生儿 35 25 该途径中的所有SZGR 2.0基因
YAUCH HEDGEHOG SIGNALING PARACRINE UP 149 85 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142 103 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 该途径中的所有SZGR 2.0基因
ASGHARZADEH NEUROBLASTOMA POOR SURVIVAL DN 46 30 该途径中的所有SZGR 2.0基因
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210 148 该途径中的所有SZGR 2.0基因
Hoelzel NF1靶向DN 115 73 该途径中的所有SZGR 2.0基因
LEE BMP2 TARGETS DN 882 538 该途径中的所有SZGR 2.0基因
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

mirna家族 Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124/506 3998 4004 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
mir-136 645 651 1A hsa-miR-136 Acuccauuuuuuugaugaugaugga
miR-142-5p 4139 4145 m8 hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d 4137 4144 1A,m8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain uaaagugcuuauagugcagguag
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
miR-326 439 445 m8 HSA-MIR-326 ccucugggcccuccag
miR-369-3p 4183 4190 1A,m8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
mir-374 4184 4190 m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-381 4180 4186 m8 hsa-miR-381 uauacaagggcaagcucucugu
mir-495 109 115 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-93.hd/291-3p/294/295/302/372/373/520 4162 4168 1A hsa-miR-93brain aaagugcuguucgugcagguag
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU
hsa-miR-93brain aaagugcuguucgugcagguag
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU